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103475-41-8,MFCD00866620
Catalog No.:AA008R7B

103475-41-8 | Tepoxalin

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1mg
≥98%
in stock  
$53.00   $37.00
- +
5mg
≥98%
in stock  
$230.00   $161.00
- +
10mg
≥98%
in stock  
$330.00   $231.00
- +
25mg
≥98%
in stock  
$758.00   $530.00
- +
50mg
98%
in stock  
$1,147.00   $803.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008R7B
Chemical Name:
Tepoxalin
CAS Number:
103475-41-8
Molecular Formula:
C20H20ClN3O3
Molecular Weight:
385.8441
MDL Number:
MFCD00866620
SMILES:
COc1ccc(cc1)n1nc(cc1c1ccc(cc1)Cl)CCC(=O)N(O)C
Properties
Computed Properties
 
Complexity:
479  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  
XLogP3:
3.4  

Literature

Title: Prevalence of 5-lipoxygenase expression in canine osteosarcoma and the effects of a dual 5-lipoxygenase/cyclooxygenase inhibitor on osteosarcoma cells in vitro and in vivo.

Journal: Veterinary pathology 20120901

Title: Pro-apoptotic effects of tepoxalin, a cyclooxygenase/lipoxygenase dual inhibitor, on canine synovial fibroblasts.

Journal: The Journal of veterinary medical science 20120601

Title: 5-lipoxygenase expression and tepoxalin-induced cell death in squamous cell carcinomas in cats.

Journal: American journal of veterinary research 20111001

Title: Pharmacodynamics of tepoxalin, sodium-salicylate and ketoprofen in an intravenous lipopolysaccharide inflammation model in broiler chickens.

Journal: Journal of veterinary pharmacology and therapeutics 20101201

Title: [Novel synthetic method and analgesic activity of tepoxalin].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20101001

Title: Effects of firocoxib, meloxicam, and tepoxalin administration on eicosanoid production in target tissues of healthy cats.

Journal: American journal of veterinary research 20100901

Title: Characterization and modulation of canine mast cell derived eicosanoids.

Journal: Veterinary immunology and immunopathology 20100515

Title: Comparison of tepoxalin, carprofen, and meloxicam for reducing intraocular inflammation in dogs.

Journal: American journal of veterinary research 20090701

Title: Effects of firocoxib and tepoxalin on healing in a canine gastric mucosal injury model.

Journal: Journal of veterinary internal medicine 20090101

Title: An exploration of the ability of tepoxalin to ameliorate the degradation of articular cartilage in a canine in vitro model.

Journal: BMC veterinary research 20090101

Title: Effects of firocoxib, meloxicam, and tepoxalin on prostanoid and leukotriene production by duodenal mucosa and other tissues of osteoarthritic dogs.

Journal: American journal of veterinary research 20080901

Title: A comparison of tepoxalin-buprenorphine combination and buprenorphine for postoperative analgesia in dogs: a clinical study.

Journal: Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20070901

Title: Effect of preoperative administration of tepoxalin on induction dose of injectable anesthetics in dogs.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20070101

Title: Effect of 1- and 10-day administration of tepoxalin on minimum alveolar concentration of isoflurane and sevoflurane in dogs.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20070101

Title: The clinical pharmacology of cyclooxygenase-2-selective and dual inhibitors.

Journal: The Veterinary clinics of North America. Small animal practice 20060901

Title: Effect of tepoxalin on renal function in healthy dogs receiving an angiotensin-converting enzyme inhibitor.

Journal: Journal of veterinary pharmacology and therapeutics 20051201

Title: In vivo effects of tepoxalin, an inhibitor of cyclooxygenase and lipoxygenase, on prostanoid and leukotriene production in dogs with chronic osteoarthritis.

Journal: American journal of veterinary research 20050601

Title: Nonsteroidal antiinflammatory drugs: a review.

Journal: Journal of the American Animal Hospital Association 20050101

Title: Aromatic hydroxamic acids and hydrazides as inhibitors of the peroxidase activity of prostaglandin H2 synthase-2.

Journal: Archives of biochemistry and biophysics 20041101

Title: Toxicity of human monocytic THP-1 cells and microglia toward SH-SY5Y neuroblastoma cells is reduced by inhibitors of 5-lipoxygenase and its activating protein FLAP.

Journal: Journal of leukocyte biology 20030301

Title: Dual inhibition of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) as a new strategy to provide safer non-steroidal anti-inflammatory drugs.

Journal: European journal of medicinal chemistry 20030101

Title: Dual acting anti-inflammatory drugs: a reappraisal.

Journal: Pharmacological research 20011201

Title: Effects of tepoxalin, a dual inhibitor of cyclooxygenase/5-lipoxygenase, on events associated with NSAID-induced gastrointestinal inflammation.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 19970601

Title: Tepoxalin blocks neutrophil migration into cutaneous inflammatory sites by inhibiting Mac-1 and E-selectin expression.

Journal: European journal of immunology 19960101

Title: Tepoxalin, a novel dual inhibitor of the prostaglandin-H synthase cyclooxygenase and peroxidase activities.

Journal: The Journal of biological chemistry 19950609

Title: Suppression of NF kappa B activation and NF kappa B-dependent gene expression by tepoxalin, a dual inhibitor of cyclooxygenase and 5-lipoxygenase.

Journal: Journal of cellular biochemistry 19950201

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