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Home Other Building Blocks 1037792-44-1
1037792-44-1,MFCD22628771
Catalog No.:AA008TEY

1037792-44-1 | MBX-2982

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$13.00   $9.00
- +
5mg
98%
in stock  
$35.00   $25.00
- +
10mg
98%
in stock  
$60.00   $42.00
- +
25mg
98%
in stock  
$101.00   $71.00
- +
100mg
98%
in stock  
$235.00   $165.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA008TEY
Chemical Name:
MBX-2982
CAS Number:
1037792-44-1
Molecular Formula:
C22H24N8OS
Molecular Weight:
448.5440
MDL Number:
MFCD22628771
SMILES:
CCc1cnc(nc1)N1CCC(CC1)c1ncc(s1)COc1ccc(cc1)n1cnnn1
Properties
Computed Properties
 
Complexity:
564  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
9  
Rotatable Bond Count:
7  
XLogP3:
3.6  

Downstream Synthesis Route

[1]CurrentPatentAssignee:CYMABAYTHERAPEUTICS,INC.-WO2011/41154,2011,A1Locationinpatent:Page/Pagecolumn25

[1]Patent:WO2011/41154,2011,A1

[2]Patent:WO2011/153435,2011,A1

[3]Patent:US2011/318418,2011,A1

[4]BioorganicandMedicinalChemistryLetters,2017,vol.27,p.5213-5220

[1]CurrentPatentAssignee:CYMABAYTHERAPEUTICS,INC.-WO2011/41154,2011,A1

[2]CurrentPatentAssignee:CYMABAYTHERAPEUTICS,INC.-WO2011/153435,2011,A1

[3]CurrentPatentAssignee:CYMABAYTHERAPEUTICS,INC.-US2011/318418,2011,A1

[4]Kim,Hyojin;Cho,SukJoon;Yoo,Minjin;Kang,SeungKyu;Kim,KwangRok;Lee,HwanHee;Song,JinSook;Rhee,SangDal;Jung,WonHoon;Ahn,JinHee;Jung,Jae-Kyung;Jung,Kwan-Young[BioorganicandMedicinalChemistryLetters,2017,vol.27,#23,p.5213-5220]

[1]CurrentPatentAssignee:CYMABAYTHERAPEUTICS,INC.-WO2011/153435,2011,A1

[2]CurrentPatentAssignee:CYMABAYTHERAPEUTICS,INC.-US2011/318418,2011,A1

[3]Kim,Hyojin;Cho,SukJoon;Yoo,Minjin;Kang,SeungKyu;Kim,KwangRok;Lee,HwanHee;Song,JinSook;Rhee,SangDal;Jung,WonHoon;Ahn,JinHee;Jung,Jae-Kyung;Jung,Kwan-Young[BioorganicandMedicinalChemistryLetters,2017,vol.27,#23,p.5213-5220]

Literature

Title: Hothersall JD, et al. Sustained wash-resistant receptor activation responses of GPR119 agonists. Eur J Pharmacol. 2015 Sep 5;762:430-42.

Title: Lan H, et al. Agonists at GPR119 mediate secretion of GLP-1 from mouse enteroendocrine cells through glucose-independent pathways. Br J Pharmacol. 2012 Apr;165(8):2799-807.

Title: Yang JW, et al. GPR119: a promising target for nonalcoholic fatty liver disease. FASEB J. 2016 Jan;30(1):324-35.

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SDS
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