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104-35-8,MFCD09037582
Catalog No.:AA008S32

104-35-8 | 4-NONYLPHENOL-MONO-ETHOXYLATE

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2.5mg
3 weeks  
$385.00   $269.00
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5mg
3 weeks  
$536.00   $375.00
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25mg
3 weeks  
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008S32
Chemical Name:
4-NONYLPHENOL-MONO-ETHOXYLATE
CAS Number:
104-35-8
Molecular Formula:
C17H28O2
Molecular Weight:
264.4030
MDL Number:
MFCD09037582
SMILES:
CCCCCCCCCC1=CC=C(C=C1)OCCO
Properties
Computed Properties
 
Complexity:
186  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
11  
XLogP3:
5.5  

Literature

Title: The effects of nonyl phenoxypolyethoxyl ethanol on cell damage pathway gene expression in SK-NSH cells.

Journal: The Korean journal of internal medicine 20151101

Title: A quantitative multiplex nuclease protection assay reveals immunotoxicity gene expression profiles in the rabbit model for vaginal drug safety evaluation.

Journal: Toxicology and applied pharmacology 20150615

Title: Rat sperm immobilisation effects of a protein from Ricinus communis (Linn.): an in vitro comparative study with nonoxynol-9.

Journal: Andrologia 20121201

Title: False positives observed on the Seratec® PSA SemiQuant Cassette Test with condom lubricants.

Journal: Journal of forensic sciences 20121101

Title: Colposcopy: still useful in microbicide safety trials?

Journal: Sexually transmitted diseases 20120601

Title: In vitro susceptibility of Staphylococcus aureus strains isolated from cows with subclinical mastitis to different antimicrobial agents.

Journal: Journal of veterinary science 20120601

Title: Direct analysis in real time mass spectrometry for analysis of sexual assault evidence.

Journal: Rapid communications in mass spectrometry : RCM 20120515

Title: Detection of the spermicide nonoxynol-9 via GC-MS.

Journal: Journal of the American Society for Mass Spectrometry 20120501

Title: Acceptability of optical coherence tomography and abstinence requirements among women participating in microbicide safety trials.

Journal: Sexually transmitted diseases 20120101

Title: Optical coherence tomography compared with colposcopy for assessment of vaginal epithelial damage: a randomized controlled trial.

Journal: Obstetrics and gynecology 20111201

Title: Mucosal integrity and inflammatory markers in the female lower genital tract as potential screening tools for vaginal microbicides.

Journal: Contraception 20111101

Title: Spermicidal action of a protein isolated from ethanolic root extracts of Achyranthes aspera: an in vitro study.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20110615

Title: Increased COX-2 expression in human vaginal epithelial cells exposed to nonoxynol-9, a vaginal contraceptive microbicide that failed to protect women from HIV-1 infection.

Journal: American journal of reproductive immunology (New York, N.Y. : 1989) 20110601

Title: Discovery of novel SERCA inhibitors by virtual screening of a large compound library.

Journal: European journal of medicinal chemistry 20110501

Title: Female genital tract secretions and semen impact the development of microbicides for the prevention of HIV and other sexually transmitted infections.

Journal: American journal of reproductive immunology (New York, N.Y. : 1989) 20110301

Title: Development of an in vitro alternative assay method for vaginal irritation.

Journal: Toxicology 20110111

Title: Contraceptive efficacy, acceptability, and safety of C31G and nonoxynol-9 spermicidal gels: a randomized controlled trial.

Journal: Obstetrics and gynecology 20101201

Title: Establishing a Th17 based mouse model for preclinical assessment of the toxicity of candidate microbicides.

Journal: Chinese medical journal 20101201

Title: Induction, structural characterization, and genome sequence of Lv1, a prophage from a human vaginal Lactobacillus jensenii strain.

Journal: International microbiology : the official journal of the Spanish Society for Microbiology 20100901

Title: Development of an in vitro dual-chamber model of the female genital tract as a screening tool for epithelial toxicity.

Journal: Journal of virological methods 20100501

Title: Functional attenuation of human sperm by novel, non-surfactant spermicides: precise targeting of membrane physiology without affecting structure.

Journal: Human reproduction (Oxford, England) 20100501

Title: Development and characterization of a three-dimensional organotypic human vaginal epithelial cell model.

Journal: Biology of reproduction 20100301

Title: Mixture effects of the nonylphenyl polyethoxylate, R-11 and the insecticide, imidacloprid on population growth rate and other parameters of the crustacean, Ceriodaphnia dubia.

Journal: Ecotoxicology and environmental safety 20100201

Title: The effect of a combination of 0.1% octenidine dihydrochloride and 2% 2-phenoxyethanol (octenisept) on wound healing in pigs in vivo and its in vitro percutaneous permeation through intact and barrier disrupted porcine skin.

Journal: International wound journal 20100201

Title: Increased CCL2 expression and macrophage/monocyte migration during microbicide-induced vaginal irritation.

Journal: Current HIV research 20091101

Title: In vivo effects of nonoxynol-9 on endometrial immune cell populations.

Journal: Journal of acquired immune deficiency syndromes (1999) 20090901

Title: The safety of candidate vaginal microbicides since nonoxynol-9: a systematic review of published studies.

Journal: AIDS (London, England) 20090619

Title: Use of high-resolution confocal imaging of the vaginal epithelial microstructure to detect microbicide toxicity.

Journal: The Journal of infectious diseases 20090515

Title: Rectal and vaginal immunization of mice with human papillomavirus L1 virus-like particles.

Journal: Vaccine 20090414

Title: Effects of diquat and fomesafen applied alone and in combination with a nonylphenol polyethoxylate adjuvant on Lemna minor in aquatic indoor microcosms.

Journal: Ecotoxicology and environmental safety 20090301

Title: In vitro testing of rationally designed spermicides for selectively targeting human sperm in vagina to ensure safe contraception.

Journal: Human reproduction (Oxford, England) 20090301

Title: Altering mucus rheology to 'solidify' human mucus at the nanoscale.

Journal: PloS one 20090101

Title: Susceptibility to genital herpes as a biomarker predictive of increased HIV risk: expansion of a murine model of microbicide safety.

Journal: Antiviral therapy 20090101

Title: Update on nonoxynol-9 as vaginal spermicide.

Journal: The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception 20081201

Title: SILCS diaphragm: postcoital testing of a new single-size contraceptive device.

Journal: Contraception 20080901

Title: Cloud-point preconcentration and spectrophotometric determination of trace amounts of molybdenum(VI) in steels and water samples.

Journal: Journal of hazardous materials 20080501

Title: FDA issues warning for nonoxynol-9 products.

Journal: AIDS alert 20080501

Title: FDA issues warning for nonoxynol-9 products.

Journal: AIDS alert 20080401

Title: The effects of spermicides containing nonoxynol-9 on cervical cytology.

Journal: Contraception 20080301

Title: Cervicovaginal colposcopic lesions associated with 5 nonoxynol-9 vaginal spermicide formulations.

Journal: American journal of obstetrics and gynecology 20080101

Title: Nonoxynol-9 does not protect against HIV.

Journal: AIDS patient care and STDs 20080101

Title: New options for barrier contraception.

Journal: Journal of obstetric, gynecologic, and neonatal nursing : JOGNN 20080101

Title: Contraceptive efficacy of a novel spermicidal microbicide used with a diaphragm: a randomized controlled trial.

Journal: Obstetrics and gynecology 20070901

Title: Genital transmission of HPV in a mouse model is potentiated by nonoxynol-9 and inhibited by carrageenan.

Journal: Nature medicine 20070701

Title: A comprehensive murine model to evaluate topical vaginal microbicides: mucosal inflammation and susceptibility to genital herpes as surrogate markers of safety.

Journal: The Journal of infectious diseases 20070501

Title: Awareness and attitudes regarding microbicides and Nonoxynol-9 use in a probability sample of gay men.

Journal: AIDS and behavior 20070301

Title: Novel disulphide esters of carbothioic acid as potent, non-detergent spermicides with low toxicity to Lactobacillus and HeLa cells in vitro.

Journal: Human reproduction (Oxford, England) 20070301

Title: Biomarkers of leukocyte traffic and activation in the vaginal mucosa.

Journal: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20070101

Title: Microbicide research in developing countries: have we given the ethical concerns due consideration?

Journal: BMC medical ethics 20070101

Title: Reconstitution of monooxygenase activity of membrane cytochromes P450 in vitro and detergents.

Journal: Doklady. Biochemistry and biophysics 20070101

Title: A potential anti-implantation and spermicidal strategy: putative derivatives of nonoxynol-9 and anti-inflammatory agents and their spermicidal activity.

Journal: The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception 20061201

Title: The impact of the use of COL-1492, a nonoxynol-9 vaginal gel, on the presence of cervical human papillomavirus in female sex workers.

Journal: Virus research 20061101

Title: [Contraceptive efficacy of bioadhesive benzalkonium chloride gel in comparison with nonoxynol-9 gel].

Journal: Zhonghua fu chan ke za zhi 20061001

Title: Distribution and dissipation pathways of nonylphenol polyethoxylates in the Yellow River: Site investigation and lab-scale studies.

Journal: Environment international 20060901

Title: Vaginal safety after use of a bioadhesive, acid-buffering, microbicidal contraceptive gel (ACIDFORM) and a 2% nonoxynol-9 product.

Journal: Contraception 20060501

Title: Sorption of small metabolites of nonylphenol polyethoxylates in single and complex systems on aquatic suspended particulate matter.

Journal: Chemosphere 20060301

Title: Tracking of the physical ageing of amorphous pharmaceutical polymeric excipients by positron annihilation spectroscopy.

Journal: Journal of pharmaceutical and biomedical analysis 20060213

Title: In vitro preclinical testing of nonoxynol-9 as potential anti-human immunodeficiency virus microbicide: a retrospective analysis of results from five laboratories.

Journal: Antimicrobial agents and chemotherapy 20060201

Title: Lactobacillus species isolated from the vagina: identification, hydrogen peroxide production and nonoxynol-9 resistance.

Journal: Contraception 20060101

Title: Effects of long-term use of nonoxynol-9 on vaginal flora.

Journal: Obstetrics and gynecology 20060101

Title: Vaginal microbicides: detecting toxicities in vivo that paradoxically increase pathogen transmission.

Journal: BMC infectious diseases 20060101

Title: Nonoxynol-9 vaginal pessary: a preliminary Indian experience.

Journal: The National medical journal of India 20060101

Title: Stereospecific and regioselective hydrolysis of cannabinoid esters by ES46.5K, an esterase from mouse hepatic microsomes, and its differences from carboxylesterases of rabbit and porcine liver.

Journal: Biological & pharmaceutical bulletin 20050901

Title: Prolonged exposure to the candidate microbicide C31G differentially reduces cellular sensitivity to agent re-exposure.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20050901

Title: Polybiguanides, particularly polyethylene hexamethylene biguanide, have activity against human immunodeficiency virus type 1.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20050901

Title: [Effect of compound nonoxinol on the inhibition of bacteria in vitro].

Journal: Zhonghua nan ke xue = National journal of andrology 20050901

Title: Nonoxynol-9 induces apoptosis of endometrial explants by both caspase-dependent and -independent apoptotic pathways.

Journal: Biology of reproduction 20050801

Title: Why nonoxynol-9 may have failed to prevent acquisition of Neisseria gonorrhoeae in clinical trials.

Journal: Sexually transmitted diseases 20050801

Title: Lea's Shield: colposcopic and microbiological testing during 8 weeks of use.

Journal: Contraception 20050701

Title: Acceptability of five nonoxynol-9 spermicides.

Journal: Contraception 20050601

Title: Review of non-hormonal contraception (condoms, intrauterine devices, nonoxynol-9 and combos) on HIV acquisition.

Journal: Journal of acquired immune deficiency syndromes (1999) 20050301

Title: The effect of nonoxynol-9 on human endometrium.

Journal: Contraception 20050201

Title: Spermicidal effect of Jieze No. 1 in combination with nonoxynol-9 in vitro.

Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20050101

Title: Microbicides for prevention of transmission of sexually transmitted diseases.

Journal: Current pharmaceutical design 20050101

Title: Postcoital testing after the use of a bio-adhesive acid buffering gel (ACIDFORM) and a 2% nonoxynol-9 product.

Journal: Contraception 20041201

Title: Clinical microbicide research: an overview.

Journal: Tropical medicine & international health : TM & IH 20041201

Title: Nonoxynol-9 100 mg gel: multi-site safety study from sub-Saharan Africa.

Journal: AIDS (London, England) 20041105

Title: Mutagenicity of vaginal spermicides containing nonoxynol-9 in a bacterial assay.

Journal: The Journal of reproductive medicine 20041001

Title: Preclinical assessment of the proinflammatory potential of microbicide candidates.

Journal: Journal of acquired immune deficiency syndromes (1999) 20041001

Title: Interleukin (IL)-1, IL-6, and IL-8 predict mucosal toxicity of vaginal microbicidal contraceptives.

Journal: Biology of reproduction 20040901

Title: Male tolerance study of 1% C31G.

Journal: Contraception 20040901

Title: A randomized Phase I vaginal safety study of three concentrations of C31G vs. Extra Strength Gynol II.

Journal: Contraception 20040901

Title: A case study on forensic polymer analysis by DIOS-MS: the suspect who gave us the SLIP.

Journal: Journal of forensic sciences 20040901

Title: Lubricants containing N-9 may enhance rectal transmission of HIV and other STIs.

Journal: Contraception 20040801

Title: Synthesis and spermicidal activity of a putative nitric oxide-releasing derivative of nonoxynol-9.

Journal: Contraception 20040701

Title: Acceptability of COL-1492, a vaginal gel, among sex workers in one Asian and three African cities.

Journal: Sexually transmitted infections 20040601

Title: Efficacy of animal anti-fertility compounds against sea lamprey (Petromyzon marinus) spermatozoa.

Journal: Theriogenology 20040415

Title: The evaluation of the local tolerance of vaginal formulations, with or without nonoxynol-9, using the slug mucosal irritation test.

Journal: Sexually transmitted diseases 20040401

Title: Contraceptive effectiveness and safety of five nonoxynol-9 spermicides: a randomized trial.

Journal: Obstetrics and gynecology 20040301

Title: Participant characteristics associated with withdrawal from a large randomized trial of spermicide effectiveness.

Journal: BMC medical research methodology 20040101

Title: Sorption of biodegradation end products of nonylphenol polyethoxylates onto activated sludge.

Journal: Journal of environmental sciences (China) 20040101

Title: Disruption of the upper female reproductive tract epithelium by nonoxynol-9.

Journal: Contraception 20031001

Title: [Contraceptive efficacy of bioadhesive nonoxynol-9 Gel: comparison with nonoxynol-9 suppository].

Journal: Zhonghua fu chan ke za zhi 20031001

Title: In vitro release of nonoxynol-9 from silicone matrix intravaginal rings.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20030904

Title: Coprecipitation of nonoxynol-9 with polyvinylpyrrolidone to decrease vaginal irritation potential while maintaining spermicidal potency.

Journal: AAPS PharmSciTech 20030901

Title: Thermoreversible gel formulation containing sodium lauryl sulfate as a potential contraceptive device.

Journal: Biology of reproduction 20030801

Title: Effect of spermicides on Lactobacillus acidophilus in vitro-nonoxynol-9 vs. Sapindus saponins.

Journal: Contraception 20030801

Title: Rectal use of nonoxynol-9 among men who have sex with men.

Journal: AIDS (London, England) 20030411

Title: Nonoxynol-9 ineffective in preventing HIV infection.

Journal: Tropical doctor 20030401

Title: The combined contraceptive ring NuvaRing and spermicide co-medication.

Journal: Contraception 20030401

Title: Contraceptive activity of a spermicidal aryl phosphate derivative of bromo-methoxy-zidovudine (compound WHI-07) in rabbits.

Journal: Fertility and sterility 20030401

Title: Phase I safety & preliminary acceptability of nonoxynol-9 vaginal pessary as a vaginal microbicide in low risk women in Pune, India.

Journal: The Indian journal of medical research 20030401

Title: Nonoxynol-9 and sexually transmitted infections.

Journal: The Lancet. Infectious diseases 20030201

Title: Microbicide efficacy and toxicity tests in a mouse model for vaginal transmission of Chlamydia trachomatis.

Journal: Sexually transmitted diseases 20021101

Title: WHO/CONRAD technical consultation on nonoxynol-9, World Health Organization, Geneva, 9-10 October 2001: summary report.

Journal: Reproductive health matters 20021101

Title: Nonoxynol-9 dangers: health experts warn against rectal use.

Journal: AIDS treatment news 20021018

Title: Rectal applications of nonoxynol-9 cause tissue disruption in a monkey model.

Journal: Sexually transmitted diseases 20021001

Title: Entry of inflammatory cells into the mouse vagina following application of candidate microbicides: comparison of detergent-based and sulfated polymer-based agents.

Journal: Sexually transmitted diseases 20021001

Title: Synthesis of novel iodinated derivatives of nonoxynol-9 and their bioavailability in rats.

Journal: Nuclear medicine and biology 20021001

Title: Nonoxynol-9 spermicide for prevention of vaginally acquired HIV and other sexually transmitted infections: systematic review and meta-analysis of randomised controlled trials including more than 5000 women.

Journal: The Lancet. Infectious diseases 20021001

Title: Nonoxynol-9 fails to prevents STDs, but microbicide research continues.

Journal: Lancet (London, England) 20020928

Title: Effectiveness of COL-1492, a nonoxynol-9 vaginal gel, on HIV-1 transmission in female sex workers: a randomised controlled trial.

Journal: Lancet (London, England) 20020928

Title: Nonoxynol-9 ineffective in preventing HIV infection.

Journal: Indian journal of medical sciences 20020901

Title: Considerations and development of topical microbicides to inhibit the sexual transmission of HIV.

Journal: Expert opinion on investigational drugs 20020801

Title: Incidence of acute urinary tract infection in young women and use of male condoms with and without nonoxynol-9 spermicides.

Journal: Epidemiology (Cambridge, Mass.) 20020701

Title: Nonoxynol-9 harmful, should not be used in condoms, lube.

Journal: AIDS treatment news 20020628

Title: From the Centers for Disease Control and Prevention. Nonoxynol-9 spermicide contraception use--United States, 1999.

Journal: JAMA 20020612

Title: Effects of chelating agents on the rheological property of cervical mucus.

Journal: Contraception 20020601

Title: Safety and tolerability of the new contraceptive sponge Protectaid.

Journal: The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception 20020601

Title: Nonoxynol-9 spermicide contraception use--United States, 1999.

Journal: MMWR. Morbidity and mortality weekly report 20020510

Title: Effect of nonoxynol-9 gel on urogenital gonorrhea and chlamydial infection: a randomized controlled trial.

Journal: JAMA 20020306

Title: Nonoxynol-9 as a vaginal microbicide for prevention of sexually transmitted infections: it's time to move on.

Journal: JAMA 20020306

Title: Sponge versus diaphragm for contraception.

Journal: The Cochrane database of systematic reviews 20020101

Title: Biological and chemical quality control of spermicidal raw material nonoxynol-9 and nonoxynol-9 containing vaginal contraceptive (ABF contraceptive film): determination of spermicidal activity and assay of nonoxynol-9.

Journal: Bollettino chimico farmaceutico 20020101

Title: Nonoxynol-9 for preventing vaginal acquisition of HIV infection by women from men.

Journal: The Cochrane database of systematic reviews 20020101

Title: Nonoxynol-9 for preventing vaginal acquisition of sexually transmitted infections by women from men.

Journal: The Cochrane database of systematic reviews 20020101

Title: Spermicidal activity of a new contraceptive sponge.

Journal: Advances in therapy 20020101

Title: A brief sexual barrier intervention for women living with AIDS: acceptability, use, and ethnicity.

Journal: Journal of urban health : bulletin of the New York Academy of Medicine 20011201

Title: Cellulose sulfate: tolerance and acceptability of penile application.

Journal: Contraception 20011201

Title: Single and multiple exposure tolerance study of cellulose sulfate gel: a Phase I safety and colposcopy study.

Journal: Contraception 20011201

Title: A multinational evaluation of the efficacy, safety and acceptability of the Protectaid contraceptive sponge.

Journal: The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception 20010901

Title: 'Chemical condoms' for the prevention of HIV infection: evaluation of novel agents against SHIV(89.6PD) in vitro and in vivo.

Journal: AIDS (London, England) 20010817

Title: The molecular basis of nonoxynol-9-induced vaginal inflammation and its possible relevance to human immunodeficiency virus type 1 transmission.

Journal: The Journal of infectious diseases 20010815

Title: Cellular approaches for diagnostic effects assessment in ecotoxicology: introductory remarks to an EU-funded project.

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20010801

Title: Awareness and use of untested barrier methods by HIV-seropositive gay and bisexual men.

Journal: AIDS education and prevention : official publication of the International Society for AIDS Education 20010801

Title: Evaluation of a low-dose nonoxynol-9 gel for the prevention of sexually transmitted diseases: a randomized clinical trial.

Journal: Sexually transmitted diseases 20010701

Title: Evaluation of the effect of a cervical cap device on sperm functional characteristics in vitro.

Journal: Andrologia 20010701

Title: Distribution of a spermicide containing Nonoxynol-9 in the vaginal canal and the upper female reproductive tract.

Journal: Human reproduction (Oxford, England) 20010601

Title: Study of crystallization of endogenous surfactant in Eudragit NE30D-free films and its influence on drug-release properties of controlled-release diphenhydramine HCl pellets coated with Eudragit NE30D.

Journal: AAPS pharmSci 20010601

Title: GM-144, a novel lipophilic vaginal contraceptive gel-microemulsion.

Journal: AAPS PharmSciTech 20010601

Title: Nonoxynol-9 or Frankenstein?

Journal: Survival news (Atlanta, Ga.) 20010501

Title: Properties of a new, long-lasting vaginal delivery system (LASRS) for contraceptive and antimicrobial agents.

Journal: Journal of andrology 20010101

Title: Nonoxynol-9 may increase HIV transmission risk.

Journal: Positive living (Los Angeles, Calif.) 20010101

Title: In vitro anti-HIV-1 virucidal activity of tyrosine-conjugated tri- and dihydroxy bile salt derivatives.

Journal: The Journal of antimicrobial chemotherapy 20000501

Title: Synthesis of dual function (5R,6R)- and (5S,6S)-5-bromo-6-methoxy-5,6-dihydro-AZT-5'-(para-bromophenyl methoxyalaninyl phosphate) as novel spermicidal and anti-HIV agents.

Journal: Antiviral chemistry & chemotherapy 19990101

Title: The activity of candidate virucidal agents, low pH and genital secretions against HIV-1 in vitro.

Journal: International journal of STD & AIDS 19950101

Title: The protective effect of nonoxynol-9 against HIV infection.

Journal: American journal of public health 19940601

Title: Comparative in vitro study of contraceptive agents with anti-HIV activity: gramicidin, nonoxynol-9, and gossypol.

Journal: Contraception 19940201

Title: Efficacy of nonoxynol 9 contraceptive sponge use in preventing heterosexual acquisition of HIV in Nairobi prostitutes.

Journal: JAMA 19920701

Title: Resolution of resistant vaginal trichomoniasis associated with the use of intravaginal nonoxynol-9.

Journal: Obstetrics and gynecology 19911101

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Tags:104-35-8 Molecular Formula|104-35-8 MDL|104-35-8 SMILES|104-35-8 4-NONYLPHENOL-MONO-ETHOXYLATE