Home Bromides 104104-50-9
104104-50-9,MFCD09055424
Catalog No.:AA008SDC

104104-50-9 | Gabazine Hydrobromide

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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA008SDC
Chemical Name:
Gabazine Hydrobromide
CAS Number:
104104-50-9
Molecular Formula:
C15H18BrN3O3
Molecular Weight:
368.2257
MDL Number:
MFCD09055424
SMILES:
COc1ccc(cc1)c1ccc(=[NH2+])n(n1)CCCC(=O)O.[Br-]
Properties
Computed Properties
 
Complexity:
451  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
6  

Downstream Synthesis Route

[1]Wermuth,Camille-Georges;Bourguignon,Jean-Jacques;Schlewer,Gilbert;Gies,Jean-Pierre;Schoenfelder,Angele;etal.[JournalofMedicinalChemistry,1987,vol.30,#2,p.239-249]

[1]Wermuth,Camille-Georges;Bourguignon,Jean-Jacques;Schlewer,Gilbert;Gies,Jean-Pierre;Schoenfelder,Angele;etal.[JournalofMedicinalChemistry,1987,vol.30,#2,p.239-249]

[1]Wermuth,Camille-Georges;Bourguignon,Jean-Jacques;Schlewer,Gilbert;Gies,Jean-Pierre;Schoenfelder,Angele;etal.[JournalofMedicinalChemistry,1987,vol.30,#2,p.239-249]

[1]Wermuth,Camille-Georges;Bourguignon,Jean-Jacques;Schlewer,Gilbert;Gies,Jean-Pierre;Schoenfelder,Angele;etal.[JournalofMedicinalChemistry,1987,vol.30,#2,p.239-249]

[1]Wermuth,Camille-Georges;Bourguignon,Jean-Jacques;Schlewer,Gilbert;Gies,Jean-Pierre;Schoenfelder,Angele;etal.[JournalofMedicinalChemistry,1987,vol.30,#2,p.239-249]

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Title: Behavior and cellular evidence for propofol-induced hypnosis involving brain glycine receptors.

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Title: Modulation of the sympathetic response to acute hypoxia by the caudal ventrolateral medulla in rats.

Journal: The Journal of physiology 20090115

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Title: Differential cAMP signaling at hippocampal output synapses.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20081231

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Journal: American journal of physiology. Lung cellular and molecular physiology 20081201

Title: GABA transporter 1 tunes GABAergic synaptic transmission at output neurons of the mouse neostriatum.

Journal: The Journal of physiology 20081201

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Journal: Journal of neurophysiology 20081201

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Title: Structural determinants for antagonist pharmacology that distinguish the rho1 GABAC receptor from GABAA receptors.

Journal: Molecular pharmacology 20081001

Title: The glycine transporter GlyT2 controls the dynamics of synaptic vesicle refilling in inhibitory spinal cord neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20080924

Title: Blockade of GABA, type A, receptors in the rat pontine reticular formation induces rapid eye movement sleep that is dependent upon the cholinergic system.

Journal: Neuroscience 20080922

Title: Blockade of prostaglandin E2-induced thermogenesis by unilateral microinjection of GABAA receptor antagonist into the preoptic area.

Journal: Brain research 20080916

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Journal: Journal of neurophysiology 20080901

Title: SK channel blockade promotes burst firing in dorsal raphe serotonergic neurons.

Journal: The European journal of neuroscience 20080901

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Title: Prostaglandin E(2) fever mediated by inhibition of the GABAergic transmission in the region immediately adjacent to the organum vasculosum of the lamina terminalis.

Journal: Pflugers Archiv : European journal of physiology 20080801

Title: Inflammation-induced shift in the valence of spinal GABA-A receptor-mediated modulation of nociception in the adult rat.

Journal: The journal of pain : official journal of the American Pain Society 20080801

Title: Pre- and postsynaptic serotoninergic excitation of globus pallidus neurons.

Journal: Journal of neurophysiology 20080801

Title: Imaging synaptic inhibition throughout the brain via genetically targeted Clomeleon.

Journal: Brain cell biology 20080801

Title: Differential effects of iontophoretic application of the GABAA-antagonists bicuculline and gabazine on tone-evoked local field potentials in primary auditory cortex: interaction with ketamine anesthesia.

Journal: Brain research 20080718

Title: The time course of transmitter at glycinergic synapses onto motoneurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20080716

Title: Individually monitoring ligand-induced changes in the structure of the GABAA receptor at benzodiazepine binding site and non-binding-site interfaces.

Journal: Molecular pharmacology 20080701

Title: Development of presynaptic inhibition onto retinal bipolar cell axon terminals is subclass-specific.

Journal: Journal of neurophysiology 20080701

Title: Pathway-dependent modulation by P2-purinoceptors in the mouse retina.

Journal: The European journal of neuroscience 20080701

Title: Multiple functions of GABA A and GABA B receptors during pattern processing in the zebrafish olfactory bulb.

Journal: The European journal of neuroscience 20080701

Title: High-frequency network oscillations in cerebellar cortex.

Journal: Neuron 20080612

Title: Developmental changes in the fidelity and short-term plasticity of GABAergic synapses in the neonatal rat dorsal horn.

Journal: Journal of neurophysiology 20080601

Title: Regulation of cardiac sympathetic afferent reflex by GABA(A) and GABA(B) receptors in paraventricular nucleus in rats.

Journal: The European journal of neuroscience 20080601

Title: Impaired GABAergic transmission disrupts normal homeostatic plasticity in rat cortical networks.

Journal: The European journal of neuroscience 20080601

Title: Gamma-aminobutyric acid (GABA) and pentobarbital induce different conformational rearrangements in the GABA A receptor alpha1 and beta2 pre-M1 regions.

Journal: The Journal of biological chemistry 20080530

Title: Activation of A-type gamma-amino butyric acid receptors excites gonadotrophin-releasing hormone neurones isolated from adult rats.

Journal: Journal of neuroendocrinology 20080501

Title: Glycinergic synaptic currents in the deep cerebellar nuclei.

Journal: Neuropharmacology 20080401

Title: Single-photon absorptions evoke synaptic depression in the retina to extend the operational range of rod vision.

Journal: Neuron 20080327

Title: Imaging of glutamate in brain slices using FRET sensors.

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Title: Influence of inhibitory inputs on rate and timing of responses in the anteroventral cochlear nucleus.

Journal: Journal of neurophysiology 20080301

Title: Effects of striatal GABA A-receptor blockade on striatal and cortical activity in monkeys.

Journal: Journal of neurophysiology 20080301

Title: GABA actions in hippocampal area CA3 during postnatal development: differential shift from depolarizing to hyperpolarizing in somatic and dendritic compartments.

Journal: Journal of neurophysiology 20080301

Title: SK2 channel plasticity contributes to LTP at Schaffer collateral-CA1 synapses.

Journal: Nature neuroscience 20080201

Title: Rhythm generation by the pre-Bötzinger complex in medullary slice and island preparations: effects of adenosine A(1) receptor activation.

Journal: BMC neuroscience 20080101

Title: Role of medullary GABA, opioids, and nociceptin in prolonged inhibition of cardiovascular sympathoexcitatory reflexes during electroacupuncture in cats.

Journal: American journal of physiology. Heart and circulatory physiology 20071201

Title: Visceral afferents directly activate catecholamine neurons in the solitary tract nucleus.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20071128

Title: Unilateral microdialysis of gabazine in the dorsal medulla reverses thermal prolongation of the laryngeal chemoreflex in decerebrate piglets.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20071101

Title: Development of chloride-mediated inhibition in neurons of the anteroventral cochlear nucleus of gerbil (Meriones unguiculatus).

Journal: Journal of neurophysiology 20070901

Title: Voltage imaging reveals the CA1 region at the CA2 border as a focus for epileptiform discharges and long-term potentiation in hippocampal slices.

Journal: Journal of neurophysiology 20070901

Title: Endogenous GABA and glutamate finely tune the bursting of olfactory bulb external tufted cells.

Journal: Journal of neurophysiology 20070801

Title: Dual GABAA receptor-mediated inhibition in rat presympathetic paraventricular nucleus neurons.

Journal: The Journal of physiology 20070715

Title: Role of ventrolateral medulla in generating the 10-Hz rhythm in sympathetic nerve discharge.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20070701

Title: Rat alpha6beta2delta GABAA receptors exhibit two distinct and separable agonist affinities.

Journal: The Journal of physiology 20070615

Title: In the developing rat hippocampus a tonic GABAA-mediated conductance selectively enhances the glutamatergic drive of principal cells.

Journal: The Journal of physiology 20070601

Title: Blockade of GABA(A) receptors within the extended amygdala attenuates D(2) regulation of alcohol-motivated behaviors in the ventral tegmental area of alcohol-preferring (P) rats.

Journal: Neuropharmacology 20070601

Title: Differences in spike train variability in rat vasopressin and oxytocin neurons and their relationship to synaptic activity.

Journal: The Journal of physiology 20070515

Title: Modulation of inhibitory activity by nitric oxide in the thalamus.

Journal: Journal of neurophysiology 20070501

Title: Allosteric uncoupling and up-regulation of benzodiazepine and GABA recognition sites following chronic diazepam treatment of HEK 293 cells stably transfected with alpha1beta2gamma2S subunits of GABA (A) receptors.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20070501

Title: 4-aryl-5-(4-piperidyl)-3-isoxazolol GABAA antagonists: synthesis, pharmacology, and structure-activity relationships.

Journal: Journal of medicinal chemistry 20070419

Title: The kinetics of inhibition of rat recombinant heteromeric alpha1beta glycine receptors by the low-affinity antagonist SR-95531.

Journal: The Journal of physiology 20070401

Title: Glutamatergic inputs in the hypothalamic paraventricular nucleus maintain sympathetic vasomotor tone in hypertension.

Journal: Hypertension (Dallas, Tex. : 1979) 20070401

Title: Effects of the GABA(A) receptor antagonists bicuculline and gabazine on stimulus-induced sharp wave-ripple complexes in adult rat hippocampus in vitro.

Journal: The European journal of neuroscience 20070401

Title: Descending GABAergic projections to the mesencephalic locomotor region in the lamprey Petromyzon marinus.

Journal: The Journal of comparative neurology 20070310

Title: Reactive oxygen species mediate central cardiorespiratory network responses to acute intermittent hypoxia.

Journal: Journal of neurophysiology 20070301

Title: Role of GABA A inhibition in modulation of pyramidal tract neuron activity during postural corrections.

Journal: The European journal of neuroscience 20070301

Title: Regionally selective effects of GABA on hypothalamic GABAA receptor mRNA in vitro.

Journal: Biochemical and biophysical research communications 20070216

Title: Inhibiting the inhibition: a neuronal network for sound localization in reverberant environments.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20070214

Title: GABAergic interneurons facilitate mossy fiber excitability in the developing hippocampus.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20070207

Title: GABA, not glycine, mediates inhibition of latent respiratory motor pathways after spinal cord injury.

Journal: Experimental neurology 20070201

Title: Tonically active GABAA receptors in hippocampal pyramidal neurons exhibit constitutive GABA-independent gating.

Journal: Molecular pharmacology 20070201

Title: Glucose-dependent regulation of gamma-aminobutyric acid (GABA A) receptor expression in mouse pancreatic islet alpha-cells.

Journal: Diabetes 20070201

Title: Unitary IPSPs enhance hilar mossy cell gain in the rat hippocampus.

Journal: The Journal of physiology 20070115

Title: Propagation of postsynaptic currents and potentials via gap junctions in GABAergic networks of the rat hippocampus.

Journal: The Journal of physiology 20070115

Title: Early functional development of interneurons in the zebrafish olfactory bulb.

Journal: The European journal of neuroscience 20070101

Title: Glycine receptors of A-type ganglion cells of the mouse retina.

Journal: Visual neuroscience 20070101

Title: Glycine receptor subunit composition alters the action of GABA antagonists.

Journal: Visual neuroscience 20070101

Title: Multiple types of GABAA receptors mediate inhibition in brain stem parasympathetic cardiac neurons in the nucleus ambiguus.

Journal: Journal of neurophysiology 20061201

Title: A spontaneous tonic chloride conductance in solitary glutamatergic hippocampal neurons.

Journal: Brain research 20061106

Title: Mapping of the functional interconnections between thalamic reticular neurons using photostimulation.

Journal: Journal of neurophysiology 20061101

Title: Neuropeptide Y and corticotropin-releasing factor bi-directionally modulate inhibitory synaptic transmission in the bed nucleus of the stria terminalis.

Journal: Neuropharmacology 20061001

Title: The synaptic mechanism of direction selectivity in distal processes of starburst amacrine cells.

Journal: Neuron 20060921

Title: A new probe to monitor the effects of drugs on local field potentials.

Journal: Journal of neuroscience methods 20060915

Title: Medullary lateral tegmental field neurons influence the timing and pattern of phrenic nerve activity in cats.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20060801

Title: Tonic GABA(A) receptor-mediated currents in human brain.

Journal: The European journal of neuroscience 20060801

Title: The adult rat hippocampal slice revisited with multi-electrode arrays.

Journal: Brain research 20060622

Title: Origins of GABA(A) and GABA(B) receptor-mediated responses of globus pallidus induced after stimulation of the putamen in the monkey.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20060614

Title: Functional GABA(A)-receptor-mediated inhibition in the neonatal dorsal horn.

Journal: Journal of neurophysiology 20060601

Title: The neurosteroid 3alphaDIOL modulates place preference when infused in the basolateral amygdala according to sex.

Journal: Behavioral neuroscience 20060601

Title: Central effects of the anabolic steroid 17alpha methyltestosterone in female anxiety.

Journal: Pharmacology, biochemistry, and behavior 20060601

Title: An in vitro study of horizontal connections in the intermediate layer of the superior colliculus.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20060503

Title: Olfactory nerve stimulation-evoked mGluR1 slow potentials, oscillations, and calcium signaling in mouse olfactory bulb mitral cells.

Journal: Journal of neurophysiology 20060501

Title: Blanes cells mediate persistent feedforward inhibition onto granule cells in the olfactory bulb.

Journal: Neuron 20060316

Title: Regulation of thalamocortical patterning and synaptic maturation by NeuroD2.

Journal: Neuron 20060302

Title: Neuronal basis of the slow (<1 Hz) oscillation in neurons of the nucleus reticularis thalami in vitro.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20060301

Title: GABAA receptor antagonists prevent abnormalities in leptin, insulin and amylin actions on paraventricular hypothalamic neurons of overweight rats.

Journal: The European journal of neuroscience 20060301

Title: Differential effects of iontophoretic in vivo application of the GABA(A)-antagonists bicuculline and gabazine in sensory cortex.

Journal: Hearing research 20060201

Title: Study of the interaction of antiplasmodial strychnine derivatives with the glycine receptor.

Journal: European journal of pharmacology 20060113

Title: A postnatal switch in GABAergic control of spinal cutaneous reflexes.

Journal: The European journal of neuroscience 20060101

Title: Characterization of the glycinergic input to bipolar cells of the mouse retina.

Journal: The European journal of neuroscience 20060101

Title: Depression of retinogeniculate synaptic transmission by presynaptic D(2)-like dopamine receptors in rat lateral geniculate nucleus.

Journal: The European journal of neuroscience 20060101

Title: Slow oscillatory activity of rat globus pallidus neurons in vitro.

Journal: The European journal of neuroscience 20060101

Title: An ionotropic GABA receptor with novel pharmacology at bullfrog cone photoreceptor terminals.

Journal: Neuro-Signals 20060101

Title: Dissociated GABAergic retinal interneurons exhibit spontaneous increases in intracellular calcium.

Journal: Visual neuroscience 20060101

Title: GABAA receptor-mediated tonic inhibition in thalamic neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20051214

Title: GABAergic signaling to newborn neurons in dentate gyrus.

Journal: Journal of neurophysiology 20051201

Title: SK channel regulation of dendritic excitability and dendrodendritic inhibition in the olfactory bulb.

Journal: Journal of neurophysiology 20051201

Title: Nicotinic acetylcholine receptor subtypes involved in facilitation of GABAergic inhibition in mouse superficial superior colliculus.

Journal: Journal of neurophysiology 20051201

Title: Inhibitory sharpening of receptive fields contributes to whisker map plasticity in rat somatosensory cortex.

Journal: Journal of neurophysiology 20051201

Title: SK channels control the firing pattern of midbrain dopaminergic neurons in vivo.

Journal: The European journal of neuroscience 20051201

Title: Anticonvulsant action of GABA in the high potassium-low magnesium model of ictogenesis in the neonatal rat hippocampus in vivo and in vitro.

Journal: Journal of neurophysiology 20051001

Title: Mapping by laser photostimulation of connections between the thalamic reticular and ventral posterior lateral nuclei in the rat.

Journal: Journal of neurophysiology 20051001

Title: Enhancement of excitatory synaptic integration by GABAergic inhibition in the subthalamic nucleus.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050914

Title: Rapid vesicular release, quantal variability, and spillover contribute to the precision and reliability of transmission at a glomerular synapse.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050907

Title: Millisecond-timescale, genetically targeted optical control of neural activity.

Journal: Nature neuroscience 20050901

Title: GABAergic modulation of the activity of globus pallidus neurons in primates: in vivo analysis of the functions of GABA receptors and GABA transporters.

Journal: Journal of neurophysiology 20050801

Title: Regulation of hippocampal synapse remodeling by epileptiform activity.

Journal: Molecular and cellular neurosciences 20050801

Title: Synaptically released GABA activates both pre- and postsynaptic GABA(B) receptors in the rat globus pallidus.

Journal: Journal of neurophysiology 20050801

Title: Mono- and dual-frequency fast cerebellar oscillation in mice lacking parvalbumin and/or calbindin D-28k.

Journal: The European journal of neuroscience 20050801

Title: Target-dependent use of co-released inhibitory transmitters at central synapses.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050713

Title: Globus pallidus neurons dynamically regulate the activity pattern of subthalamic nucleus neurons through the frequency-dependent activation of postsynaptic GABAA and GABAB receptors.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050706

Title: Nanomolar allopregnanolone potentiates rat cerebellar GABAA receptors.

Journal: Neuroscience letters 20050701

Title: The mechanism of SR95531 inhibition at GABA receptors examined in human alpha1beta1 and alpha1beta1gamma2S receptors.

Journal: Journal of neurochemistry 20050701

Title: Effects of chronic infusion of a GABAA receptor agonist or antagonist into the vestibular nuclear complex on vestibular compensation in the guinea pig.

Journal: The Journal of pharmacology and experimental therapeutics 20050601

Title: Synaptic depolarizing GABA Response in adults is excitatory and proconvulsive when GABAB receptors are blocked.

Journal: Journal of neurophysiology 20050501

Title: GABA transporter deficiency causes tremor, ataxia, nervousness, and increased GABA-induced tonic conductance in cerebellum.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050323

Title: Induced sharp wave-ripple complexes in the absence of synaptic inhibition in mouse hippocampal slices.

Journal: The Journal of physiology 20050315

Title: Dendritic sodium spikelets and low-threshold calcium spikes in turtle olfactory bulb granule cells.

Journal: Journal of neurophysiology 20050301

Title: Local calcium transients regulate the spontaneous motility of dendritic filopodia.

Journal: Nature neuroscience 20050301

Title: Pharmacological properties of GABAA receptors in rat hypothalamic neurons expressing the epsilon-subunit.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050105

Title: Movement-related discharge in the cerebellar nuclei persists after local injections of GABA(A) antagonists.

Journal: Journal of neurophysiology 20050101

Title: Factors accounting for perinatal occurrence of pulsatile gonadotropin-releasing hormone secretion in vitro in rats.

Journal: Biology of reproduction 20050101

Title: Fundamental differences in spontaneous synaptic inhibition between deep and superficial layers of the rat entorhinal cortex.

Journal: Hippocampus 20050101

Title: Fast cerebellar oscillation associated with ataxia in a mouse model of Angelman syndrome.

Journal: Neuroscience 20050101

Title: GABA-mediated component in the feedback response of turtle retinal cones.

Journal: Visual neuroscience 20050101

Title: Feed-forward facilitation of glutamate release by presynaptic GABA(A) receptors.

Journal: Neuroscience 20050101

Title: Electrophysiological and neurochemical characterization of neurons of the medial preoptic area in Japanese quail (Coturnix japonica).

Journal: Brain research 20041217

Title: Pentobarbital induces thalamic oscillations in brain slices, modulated by GABA and glycine receptors.

Journal: Neuropharmacology 20041201

Title: Role of ionotropic glutamatergic and GABAergic inputs on the firing activity of neurons in the external pallidum in awake monkeys.

Journal: Journal of neurophysiology 20041101

Title: Cell type-specific synaptic dynamics of synchronized bursting in the juvenile CA3 rat hippocampus.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20041027

Title: The spinal GABAergic system is a strong modulator of burst frequency in the lamprey locomotor network.

Journal: Journal of neurophysiology 20041001

Title: Antagonism by NOS inhibition of the behavioral effects of benzodiazepine and GABAA receptor agonists in the mouse elevated plus-maze.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040801

Title: Slow actions of neuroactive steroids at GABAA receptors.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20040728

Title: GABA( A) synapses shape neuronal responses to sound intensity in the inferior colliculus.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20040526

Title: Glucose inhibition of glucagon secretion from rat alpha-cells is mediated by GABA released from neighboring beta-cells.

Journal: Diabetes 20040401

Title: Mechanisms and significance of reduced activity and responsiveness in resting frog tadpoles.

Journal: The Journal of experimental biology 20040301

Title: Mechanism of irregular firing of suprachiasmatic nucleus neurons in rat hypothalamic slices.

Journal: Journal of neurophysiology 20040101

Title: A rapid increase in the total number of cell surface functional GABAA receptors induced by brain-derived neurotrophic factor in rat visual cortex.

Journal: The Journal of biological chemistry 20031107

Title: Age-related modifications of the morphological organization of pituicytes are associated with alteration of the GABAergic and dopaminergic innervation afferent to the neurohypophysial lobe.

Journal: The European journal of neuroscience 20031001

Title: Cellular and network mechanisms underlying spontaneous sharp wave-ripple complexes in mouse hippocampal slices.

Journal: The Journal of physiology 20030801

Title: Endogenous acetylcholine and nicotine activation enhances GABAergic and glycinergic inputs to cardiac vagal neurons.

Journal: Journal of neurophysiology 20030501

Title: Regulation of backpropagating action potentials in mitral cell lateral dendrites by A-type potassium currents.

Journal: Journal of neurophysiology 20030501

Title: Temporal modulation of scotopic visual signals by A17 amacrine cells in mammalian retina in vivo.

Journal: Journal of neurophysiology 20030401

Title: Design and synthesis of a new series of 4-alkylated 3-isoxazolol GABA A antagonists.

Journal: European journal of medicinal chemistry 20030401

Title: Identified sources and targets of slow inhibition in the neocortex.

Journal: Science (New York, N.Y.) 20030321

Title: GABA(A) receptor blockade antagonizes the immobilizing action of propofol but not ketamine or isoflurane in a dose-related manner.

Journal: Anesthesia and analgesia 20030301

Title: Gamma-aminobutyric acid neuropharmacological investigations on narcosis produced by nitrogen, argon, or nitrous oxide.

Journal: Anesthesia and analgesia 20030301

Title: The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects.

Journal: Anesthesiology 20030201

Title: Functional autaptic neurotransmission in fast-spiking interneurons: a novel form of feedback inhibition in the neocortex.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20030201

Title: Influence of inhibitory and excitatory inputs on serotonin efflux differs in the dorsal and median raphe nuclei.

Journal: Brain research 20030124

Title: Tonically activated GABAA receptors in hippocampal neurons are high-affinity, low-conductance sensors for extracellular GABA.

Journal: Molecular pharmacology 20030101

Title: Competitive GABA(A) receptor antagonists increase the proportion of functional high-affinity alpha6 subunit-containing receptors in granule cells of adult rat cerebellum.

Journal: Neuropharmacology 20030101

Title: Activation of group III metabotropic glutamate receptors presynaptically reduces both GABAergic and glutamatergic transmission in the rat globus pallidus.

Journal: Neuroscience 20030101

Title: The rat ponto-medullary network responsible for paradoxical sleep onset and maintenance: a combined microinjection and functional neuroanatomical study.

Journal: The European journal of neuroscience 20021101

Title: Molecular and pharmacological characterization of GABA(A) receptor alpha1 subunit knockout mice.

Journal: The Journal of pharmacology and experimental therapeutics 20020901

Title: Modulation of spinal nociception by GluR5 kainate receptor ligands in acute and hyperalgesic states and the role of gabaergic mechanisms.

Journal: Neuropharmacology 20020901

Title: Directionally selective calcium signals in dendrites of starburst amacrine cells.

Journal: Nature 20020822

Title: Different residues in the GABA(A) receptor alpha 1T60-alpha 1K70 region mediate GABA and SR-95531 actions.

Journal: The Journal of biological chemistry 20020524

Title: Receptors with different affinities mediate phasic and tonic GABA(A) conductances in hippocampal neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20020515

Title: Selective modulation of tonic and phasic inhibitions in dentate gyrus granule cells.

Journal: Journal of neurophysiology 20020501

Title: Functional independence of layer IV barrels.

Journal: Journal of neurophysiology 20020201

Title: GABA(A) receptor beta 2 Tyr97 and Leu99 line the GABA-binding site. Insights into mechanisms of agonist and antagonist actions.

Journal: The Journal of biological chemistry 20020125

Title: Pallidal administrations of gabazine and 5-AVA affect pressure-induced behavioral disorders in rats.

Journal: Pharmacology, biochemistry, and behavior 20020101

Title: Microscopic kinetics and energetics distinguish GABA(A) receptor agonists from antagonists.

Journal: Biophysical journal 20011101

Title: Function of NMDA receptors and persistent sodium channels in a feedback pathway of the electrosensory system.

Journal: Journal of neurophysiology 20011001

Title: Compartmental models of rat cerebellar Purkinje cells based on simultaneous somatic and dendritic patch-clamp recordings.

Journal: The Journal of physiology 20010901

Title: Inhibitory action of nociceptin/orphanin FQ on functionally different thalamic neurons in urethane-anaesthetized rats.

Journal: British journal of pharmacology 20010901

Title: Enforcement of temporal fidelity in pyramidal cells by somatic feed-forward inhibition.

Journal: Science (New York, N.Y.) 20010810

Title: Paradoxical reduction of synaptic inhibition by vigabatrin.

Journal: Journal of neurophysiology 20010801

Title: Effects of GABA(A) receptor partial agonists in primary cultures of cerebellar granule neurons and cerebral cortical neurons reflect different receptor subunit compositions.

Journal: British journal of pharmacology 20010601

Title: Pharmacological study on recombinant human GABA-A receptor complex containing alpha5 (leucine155 to valine) combined with beta3gamma2s subunits.

Journal: Acta pharmacologica Sinica 20010601

Title: Seizure-like activity in the disinhibited CA1 minislice of adult guinea-pigs.

Journal: The Journal of physiology 20010501

Title: Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by gamma-aminobutyric acid(A) receptors in hippocampal neurons.

Journal: Molecular pharmacology 20010401

Title: Comparison of N2O- and chlordiazepoxide-induced behaviors in the light/dark exploration test.

Journal: Pharmacology, biochemistry, and behavior 20010401

Title: Glycine receptor mediated responses in rat histaminergic neurons.

Journal: Neuroscience letters 20010302

Title: Entropy as the predominant driving force of binding to human recombinant alpha(x)beta(3)gamma(2) GABA(A) receptors.

Journal: European journal of pharmacology 20010105

Title: Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance.

Journal: Nature 20010104

Title: Multireceptor GABAergic regulation of synaptic communication in amphibian retina.

Journal: The Journal of physiology 20010101

Title: Clozapine inhibits synaptic transmission at GABAergic synapses established by ventral tegmental area neurones in culture.

Journal: Neuropharmacology 20000710

Title: Cerebellar gamma-aminobutyric acid type A receptors: pharmacological subtypes revealed by mutant mouse lines.

Journal: Molecular pharmacology 19970901

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