Home Bromides 10457-90-6
10457-90-6,MFCD00866670
Catalog No.:AA008SAO

10457-90-6 | BROMPERIDOL

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1mg
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008SAO
Chemical Name:
BROMPERIDOL
CAS Number:
10457-90-6
Molecular Formula:
C21H23BrFNO2
Molecular Weight:
420.3152
MDL Number:
MFCD00866670
SMILES:
Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Br
NSC Number:
759275
Properties
Computed Properties
 
Complexity:
451  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  
XLogP3:
3.3  

Literature

Title: Why are most phospholipidosis inducers also hERG blockers?

Journal: Archives of toxicology 20171201

Title: Screening of a chemical library reveals novel PXR-activating pharmacologic compounds.

Journal: Toxicology letters 20150105

Title: Association of typical versus atypical antipsychotics with symptoms and quality of life in schizophrenia.

Journal: PloS one 20120101

Title: Bromperidol decanoate (depot) for schizophrenia.

Journal: The Cochrane database of systematic reviews 20110907

Title: Synergistic drug combinations for tuberculosis therapy identified by a novel high-throughput screen.

Journal: Antimicrobial agents and chemotherapy 20110801

Title: Folie à deux: double case-report of shared delusions with a fatal outcome.

Journal: La Clinica terapeutica 20110101

Title: Number needed to treat and number needed to harm with paliperidone palmitate relative to long-acting haloperidol, bromperidol, and fluphenazine decanoate for treatment of patients with schizophrenia.

Journal: Neuropsychiatric disease and treatment 20110101

Title: Criterion and construct validity of the CogState Schizophrenia Battery in Japanese patients with schizophrenia.

Journal: PloS one 20110101

Title: Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.

Journal: Healthcare informatics research 20101201

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Identification and quantification of 30 antipsychotics in blood using LC-MS/MS.

Journal: Journal of mass spectrometry : JMS 20100801

Title: Improvement of mutism in a catatonic schizophrenia case by add-on treatment with amantadine.

Journal: Pharmacopsychiatry 20100601

Title: Mechanisms of action of antipsychotic drugs of different classes, refractoriness to therapeutic effects of classical neuroleptics, and individual variation in sensitivity to their actions: Part I.

Journal: Current neuropharmacology 20091201

Title: Automated on-line in-tube solid-phase microextraction coupled with HPLC/MS/MS for the determination of butyrophenone derivatives in human plasma.

Journal: Analytical and bioanalytical chemistry 20090601

Title: Drugs associated with more suicidal ideations are also associated with more suicide attempts.

Journal: PloS one 20090101

Title: The effects of atypical and conventional antipsychotics on reduced processing speed and psychomotor slowing in schizophrenia: a cross-sectional exploratory study.

Journal: Clinical therapeutics 20080401

Title: Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.

Journal: Journal of medicinal chemistry 20080124

Title: The effect of antipsychotic medication on sexual function and serum prolactin levels in community-treated schizophrenic patients: results from the Schizophrenia Trial of Aripiprazole (STAR) study (NCT00237913).

Journal: BMC psychiatry 20080101

Title: Pharmacogenetics of antipsychotic adverse effects: Case studies and a literature review for clinicians.

Journal: Neuropsychiatric disease and treatment 20071201

Title: Minimizing antipsychotic medication obviated the need for enema against severe constipation leading to paralytic ileus: a case report.

Journal: Journal of clinical pharmacy and therapeutics 20071001

Title: Donepezil in Alzheimer's disease: From conventional trials to pharmacogenetics.

Journal: Neuropsychiatric disease and treatment 20070601

Title: Dopamine D2 receptor gene polymorphisms predict well the response to dopamine antagonists at therapeutic dosages in patients with schizophrenia.

Journal: Psychiatry and clinical neurosciences 20070401

Title: Sensitive determination of 4-(4-bromophenyl)-4-hydroxypiperidine, a metabolite of bromperidol, in rat plasma by HPLC with fluorescence detection after pre-column derivatization using 4-fluoro-7-nitro-2,1,3-benzoxadiazole.

Journal: Biological & pharmaceutical bulletin 20061201

Title: Pharmacokinetic parameters of bromperidol in Korean subjects.

Journal: Human psychopharmacology 20060801

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Association between multidrug resistance 1 (MDR1) gene polymorphisms and therapeutic response to bromperidol in schizophrenic patients: a preliminary study.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20060301

Title: Treatment with the new antipsychotic sertindole for late-occurring undesirable movement effects.

Journal: International clinical psychopharmacology 20051101

Title: Influence of duration of untreated psychosis on auditory P300 in drug-naive and first-episode schizophrenia.

Journal: Psychiatry and clinical neurosciences 20050401

Title: [Butyrophenone derivatives].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20041201

Title: Atypical properties of several classes of antipsychotic drugs on the basis of differential induction of Fos-like immunoreactivity in the rat brain.

Journal: Life sciences 20041126

Title: Two cases of deep vein thrombosis associated with antipsychotic drug use.

Journal: Psychiatry and clinical neurosciences 20040801

Title: Simultaneous determination of haloperidol and bromperidol and their reduced metabolites by liquid-liquid extraction and automated column-switching high-performance liquid chromatography.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040605

Title: Establishment of new cloned enzyme donor immunoassays (CEDIA) for haloperidol and bromperidol.

Journal: Therapeutic drug monitoring 20040601

Title: Effect of quetiapine in the treatment of panic attacks in patients with schizophrenia: 3 case reports.

Journal: The Journal of neuropsychiatry and clinical neurosciences 20040101

Title: Depot bromperidol decanoate for schizophrenia.

Journal: The Cochrane database of systematic reviews 20040101

Title: Poor reliability of therapeutic drug monitoring data for haloperidol and bromperidol using enzyme immunoassay.

Journal: Therapeutic drug monitoring 20031201

Title: Combination of dopamine D2 receptor gene polymorphisms as a possible predictor of treatment-resistance to dopamine antagonists in schizophrenic patients.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20030901

Title: Screening, library-assisted identification and validated quantification of fifteen neuroleptics and three of their metabolites in plasma by liquid chromatography/mass spectrometry with atmospheric pressure chemical ionization.

Journal: Journal of mass spectrometry : JMS 20030301

Title: [Frontal dementia or dementia praecox? A case report of a psychotic disorder with a severe decline].

Journal: L'Encephale 20030101

Title: Switching to amisulpride due to hepatic complications.

Journal: European psychiatry : the journal of the Association of European Psychiatrists 20020501

Title: Comparison of prolactin concentrations between haloperidol and bromperidol treatments in schizophrenic patients.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20020401

Title: The characteristics of side-effects of bromperidol in schizophrenic patients.

Journal: Psychiatry and clinical neurosciences 20020201

Title: Therapeutic effects of bromperidol on the five dimensions of schizophrenic symptoms.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20020101

Title: [Malignant syndrome caused by a combination of bromperidol and donepezil hydrochloride in a patient with probable dementia with Lewy bodies].

Journal: Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 20011101

Title: The -141C Ins/Del polymorphism in the dopamine D2 receptor gene promoter region is associated with anxiolytic and antidepressive effects during treatment with dopamine antagonists in schizophrenic patients.

Journal: Pharmacogenetics 20010801

Title: Relationship between Taq1 A dopamine D2 receptor (DRD2) polymorphism and prolactin response to bromperidol.

Journal: American journal of medical genetics 20010408

Title: No relationship between--141C Ins/Del polymorphism in the promoter region of dopamine D2 receptor and extrapyramidal adverse effects of selective dopamine D2 antagonists in schizophrenic patients: a preliminary study.

Journal: Psychiatry research 20010214

Title: Association between TaqI A dopamine D2 receptor polymorphism and therapeutic response to bromperidol: a preliminary report.

Journal: European archives of psychiatry and clinical neuroscience 20010101

Title: Lesioning the thalamus for dyskinesia.

Journal: Stereotactic and functional neurosurgery 20010101

Title: [Involvement of cytochromeP4503A4 in the metabolism of haloperidol and bromperidol].

Journal: Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 19980201

Title: Possible interaction between cisapride and bromperidol.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 19970101

Title: [Clinical study of neuroleptic malignant syndrome in demented patients--examination of our case and reported cases].

Journal: No to shinkei = Brain and nerve 19940901

Title: Positive and negative symptoms, depression and social disability in chronic schizophrenia: a comparative trial of bromperidol and fluphenazine decanoates.

Journal: International clinical psychopharmacology 19921101

Title: Neuroleptic malignant syndrome after clozapine plus carbamazepine.

Journal: Lancet (London, England) 19881201

Title: Clinical evaluation of bromperidol versus haloperidol in psychotic patients.

Journal: International pharmacopsychiatry 19800101

Title: Open study with bromperidol (C-C 2489), a new neuroleptic, for the determination of the neuroleptic threshold and the neuroleptic-therapeutic range.

Journal: Pharmakopsychiatrie, Neuro-Psychopharmakologie 19780301

Title: The initial US clinical experience in the management of schizophrenic patients with bromperidol.

Journal: Acta psychiatrica Belgica 19780101

Title: Double-blind- evaluation of bromperidol versus haloperidol treatment in chronic psychotic patients.

Journal: Acta psychiatrica Belgica 19780101

Title: Effects and side-effects of bromperidol in comparison with other antipsychotic drugs.

Journal: Acta psychiatrica Belgica 19780101

Title: Clinical experiences in an open and a double-blind trial.

Journal: Acta psychiatrica Belgica 19780101

Title: Benfield P, et al. Bromperidol. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in psychoses. Drugs. 1988 Jun;35(6):670-84.

Title: Ramón-García S, et al. Synergistic drug combinations for tuberculosis therapy identified by a novel high-throughput screen. Antimicrob Agents Chemother. 2011 Aug;55(8):3861-9.

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