Home Carboxes 10463-20-4
10463-20-4,MFCD00007122
Catalog No.:AA0033Z7

10463-20-4 | 4-Hydroxy-3-nitrophenylacetic acid

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1g
95%
in stock  
$18.00   $13.00
- +
5g
95%
in stock  
$54.00   $38.00
- +
25g
95%
in stock  
$234.00   $164.00
- +
100g
95%
in stock  
$915.00   $640.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0033Z7
Chemical Name:
4-Hydroxy-3-nitrophenylacetic acid
CAS Number:
10463-20-4
Molecular Formula:
C8H7NO5
Molecular Weight:
197.1449
MDL Number:
MFCD00007122
SMILES:
OC(=O)Cc1ccc(c(c1)[N+](=O)[O-])O
Properties
Properties
 
BP:
396.4 °C at 760 mmHg  
Form:
Solid  
MP:
146-148 °C  
Refractive Index:
1.5700 (estimate)  
Solubility:
ethanol: soluble5%, clear, yellow to orange  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
236  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
2  
XLogP3:
1.5  

Literature

Title: Early B blasts acquire a capacity for Ig class switch recombination that is lost as they become plasmablasts.

Journal: European journal of immunology 20111201

Title: Characterization of memory B cells responsible for affinity maturation of anti- (4-hydroxy-3-nitrophenyl)acetyl (NP) antibodies.

Journal: International immunology 20110401

Title: IL-21 receptor is critical for the development of memory B cell responses.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20110115

Title: A soluble form of the high affinity IgE receptor, Fc-epsilon-RI, circulates in human serum.

Journal: PloS one 20110101

Title: Innate retroviral restriction by Apobec3 promotes antibody affinity maturation in vivo.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20100715

Title: The pericyte and stromal cell marker CD248 (endosialin) is required for efficient lymph node expansion.

Journal: European journal of immunology 20100701

Title: Augmented antibody response with premature germinal center regression in CD40L transgenic mice.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20100701

Title: A role for lysosomal-associated protein transmembrane 5 in the negative regulation of surface B cell receptor levels and B cell activation.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20100701

Title: The amino acid residue at position 95 and the third CDR region in the H chain determine the ceiling affinity and the maturation pathway of an anti-(4-hydroxy-3-nitrophenyl)acetyl antibody.

Journal: Molecular immunology 20100101

Title: Effects of antibody affinity and antigen valence on molecular forms of immune complexes.

Journal: Molecular immunology 20091201

Title: Quantification of Modified Tyrosines in Healthy and Diabetic Human Urine using Liquid Chromatography/Tandem Mass Spectrometry.

Journal: Journal of clinical biochemistry and nutrition 20090101

Title: Intraclonal competition inhibits the formation of high-affinity antibody-secreting cells.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20081101

Title: Escherichia coli NsrR regulates a pathway for the oxidation of 3-nitrotyramine to 4-hydroxy-3-nitrophenylacetate.

Journal: Journal of bacteriology 20080901

Title: A role for DRAK2 in the germinal center reaction and the antibody response.

Journal: Autoimmunity 20080801

Title: ICOS, CD40, and lymphotoxin beta receptors signal sequentially and interdependently to initiate a germinal center reaction.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20080215

Title: IgM-mediated signaling is required for the development of a normal B cell memory response.

Journal: Molecular immunology 20080201

Title: Urinary excretion of the nitrotyrosine metabolite 3-nitro-4-hydroxyphenylacetic acid in preterm and term infants.

Journal: Neonatology 20080101

Title: Thymus-independent class switch recombination is affected by APRIL.

Journal: Immunology and cell biology 20080101

Title: Assay of 3-nitrotyrosine in tissues and body fluids by liquid chromatography with tandem mass spectrometric detection.

Journal: Methods in enzymology 20080101

Title: A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20071218

Title: TACI is required for efficient plasma cell differentiation in response to T-independent type 2 antigens.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20070815

Title: Correction of age-associated deficiency in germinal center response by immunization with immune complexes.

Journal: Clinical immunology (Orlando, Fla.) 20070801

Title: Recirculating CD4 memory T cells mount rapid secondary responses without major contributions from follicular CD4 effectors and B cells.

Journal: European journal of immunology 20070601

Title: Analysis of antigen-stimulated B cell migration into germinal centers during the early stage of a T-dependent immune response.

Journal: Immunology letters 20070315

Title: Strategy for affinity maturation of an antibody with high evolvability to (4-hydroxy-3-nitrophenyl) acetyl hapten.

Journal: Molecular immunology 20070301

Title: Germinal-center-derived B-cell memory.

Journal: Advances in experimental medicine and biology 20070101

Title: Novel in vitro screening system for monoclonal antibodies using hypermutating chicken B cell library.

Journal: Journal of bioscience and bioengineering 20061101

Title: pH-dependent nitration of para-hydroxyphenylacetic acid in the stomach.

Journal: Free radical biology & medicine 20060915

Title: Characterization of (4-hydroxy-3-nitrophenyl)acetyl (NP)-specific germinal center B cells and antigen-binding B220- cells after primary NP challenge in mice.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20060815

Title: Re-evaluating the recycling hypothesis in the germinal centre.

Journal: Immunology and cell biology 20060801

Title: Fc gamma RIIa, not Fc gamma RIIb, is constitutively and functionally expressed on skin-derived human mast cells.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20060701

Title: Metabolism of 3-nitrotyrosine induces apoptotic death in dopaminergic cells.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20060607

Title: Analysis of antigen-specific and naturally occurring IgM and IgA steady-state levels in J-chain negative C57BL/6 mice.

Journal: Scandinavian journal of immunology 20060601

Title: Initial repertoire of anti-(4-hydroxy-3-nitrophenylacetyl) antibodies as potential donors for effective affinity maturation.

Journal: Molecular immunology 20060401

Title: Biodegradation of 3-nitrotyrosine by Burkholderia sp. strain JS165 and Variovorax paradoxus JS171.

Journal: Applied and environmental microbiology 20060201

Title: Cutting edge: egress of newly generated plasma cells from peripheral lymph nodes depends on beta 2 integrin.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20050615

Title: Quercetin-dependent inhibition of nitration induced by peroxidase/H2O2/nitrite systems in human saliva and characterization of an oxidation product of quercetin formed during the inhibition.

Journal: Journal of agricultural and food chemistry 20050504

Title: Insulin-like growth factor-1 controls type 2 T cell-independent B cell response.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20050501

Title: Dynamic assessment of nitration reactions in vivo.

Journal: Methods in enzymology 20050101

Title: Affinity maturation of secreted IgM pentamers on B cells.

Journal: International immunology 20040501

Title: Rectification of age-related impairment in Ig gene hypermutation during a memory response.

Journal: International immunology 20040401

Title: Functional folding of a cytoplasmic single-chain variable fragment and its use as elutable protein purification tag.

Journal: Immunology letters 20040329

Title: Segmental flexibility and avidity of IgM in the interaction of polyvalent antigens.

Journal: Molecular immunology 20040101

Title: Analysis of the germinal center reaction and in vivo long-lived plasma cells.

Journal: Methods in molecular biology (Clifton, N.J.) 20040101

Title: Ligation of CD27 on B cells in vivo during primary immunization enhances commitment to memory B cell responses.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20031201

Title: Cutting edge: gamma delta T cells provide help to B cells with altered clonotypes and are capable of inducing Ig gene hypermutation.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20031115

Title: Nitration of endogenous para-hydroxyphenylacetic acid and the metabolism of nitrotyrosine.

Journal: The Biochemical journal 20030901

Title: Cutting edge: germinal centers formed in the absence of B cell-activating factor belonging to the TNF family exhibit impaired maturation and function.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20030715

Title: Why are there so few key mutant clones? The influence of stochastic selection and blocking on affinity maturation in the germinal center.

Journal: International immunology 20030701

Title: Estimation of the relative affinity of B cell receptor by flow cytometry.

Journal: Journal of immunological methods 20030501

Title: Thermodynamic and kinetic aspects of antibody evolution during the immune response to hapten.

Journal: Molecular immunology 20030301

Title: Rapid development of Th2 activity during T cell priming.

Journal: Clinical & developmental immunology 20030301

Title: Lack of oxidative stress during sustained therapy with isosorbide dinitrate and pentaerythrityl tetranitrate in healthy humans: a randomized, double-blind crossover study.

Journal: Journal of cardiovascular pharmacology 20030201

Title: B cell selection and affinity maturation during an antibody response in the mouse with limited B cell diversity.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20021215

Title: TRAIL/Apo-2 ligand induces primary plasma cell apoptosis.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20021115

Title: Repertoire of antibody response in bone marrow and the memory response are differentially affected in aging mice.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20021101

Title: Expression of a 4-(hydroxy-3-nitro-phenyl) acetyl (NP) specific equi-murine IgE antibody that mediates histamine release in vitro and a type I skin reaction in vivo.

Journal: Equine veterinary journal 20021101

Title: Th2 activities induced during virgin T cell priming in the absence of IL-4, IL-13, and B cells.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20020915

Title: Altered affinity maturation in primary response to (4-hydroxy-3-nitrophenyl) acetyl (NP) after autologous reconstitution of irradiated C57BL/6 mice.

Journal: Developmental immunology 20020901

Title: Effect of environmental antigens on the Ig diversification and the selection of productive V-J joints in the bursa.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20020715

Title: The presence of 4-hydroxyphenylacetic acid in human saliva and the possibility of its nitration by salivary nitrite in the stomach.

Journal: FEBS letters 20020508

Title: Role of antigen receptor affinity in T cell-independent antibody responses in vivo.

Journal: Nature immunology 20020401

Title: [Exploring high affinity monoclonal antibodies for drug invention].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20020301

Title: The impact of H2-DM on humoral immune responses.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20011201

Title: Development and maintenance of a B220- memory B cell compartment.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20010801

Title: Inhibition of antigen-induced mediator release from IgE-sensitized cells by a monoclonal anti-Fc epsilon RI alpha-chain receptor antibody: implications for the involvement of the membrane-proximal alpha-chain region in Fc epsilon RI-mediated cell activation.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20010515

Title: Cigarette smoke impairs neutrophil respiratory burst activation by aldehyde-induced thiol modifications.

Journal: Toxicology 20010307

Title: Waiting times to appearance and dominance of advantageous mutants: estimation based on the likelihood.

Journal: Mathematical biosciences 20010301

Title: The prototypic Th2 autoimmunity induced by mercury is dependent on IFN-gamma and not Th1/Th2 imbalance.

Journal: Journal of immunology (Baltimore, Md. : 1950) 19980701

Title: Three-dimensional structures of the Fab fragment of murine N1G9 antibody from the primary immune response and of its complex with (4-hydroxy-3-nitrophenyl)acetate.

Journal: Journal of molecular biology 19951124

Title: Murine lupus anti-DNA antibodies cross-react with the hapten (4-hydroxy-5-iodo-3-nitrophenyl)acetyl, but immunization-induced anti-DNA antibodies do not.

Journal: European journal of immunology 19870401

Title: Hapten-specific T cell response to 4-hydroxy-3-nitrophenyl acetyl. X. Characterization of distinct T cell subsets mediating cutaneous sensitivity responses.

Journal: Journal of immunology (Baltimore, Md. : 1950) 19810801

Title: Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. VI. Evidence for different T cell receptors in cells that mediate H-21-restricted and H-2D-restricted cutaneous sensitivity responses.

Journal: The Journal of experimental medicine 19801201

Title: Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl.

Journal: Journal of immunology (Baltimore, Md. : 1950) 19801001

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:10463-20-4 Molecular Formula|10463-20-4 MDL|10463-20-4 SMILES|10463-20-4 4-Hydroxy-3-nitrophenylacetic acid |Organic_Building_Blocks