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104821-25-2,MFCD00077335
Catalog No.:AA008RU4

104821-25-2 | Dihydroethidium

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5mg
≥98%
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10mg
≥98%
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$120.00   $84.00
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25mg
≥98%
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$276.00   $193.00
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100mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008RU4
Chemical Name:
Dihydroethidium
CAS Number:
104821-25-2
Molecular Formula:
C14H18BrClN2O2
Molecular Weight:
361.6619
MDL Number:
MFCD00077335
SMILES:
Brc1ccc(cc1)OC(=O)N1CCN2CC[C@@H]1CC2.Cl
Properties
Computed Properties
 
Complexity:
419  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
2  
Undefined Atom Stereocenter Count:
1  
XLogP3:
3.9  

Literature

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Journal: Journal of neurochemistry 20141101

Title: Mitochondrial reactive oxygen species are scavenged by Cockayne syndrome B protein in human fibroblasts without nuclear DNA damage.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20140916

Title: Apolipoprotein e genotype-dependent paradoxical short-term effects of (56)fe irradiation on the brain.

Journal: International journal of radiation oncology, biology, physics 20121101

Title: The effects of direct thrombin inhibition with dabigatran on plaque formation and endothelial function in apolipoprotein E-deficient mice.

Journal: The Journal of pharmacology and experimental therapeutics 20121101

Title: Implication of oxidative stress in size-dependent toxicity of silica nanoparticles in kidney cells.

Journal: Toxicology 20120928

Title: Microbial biofilm proliferation within sealer-root dentin interfaces is affected by sealer type and aging period.

Journal: Journal of endodontics 20120901

Title: Effects of moderate electrical stimulation on reactive species production by primary rat skeletal muscle cells: cross talk between superoxide and nitric oxide production.

Journal: Journal of cellular physiology 20120601

Title: Dynamic optical imaging of metabolic and NADPH oxidase-derived superoxide in live mouse brain using fluorescence lifetime unmixing.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20120101

Title: Insufficient endogenous redox buffer capacity may underlie neuronal vulnerability to cerebral ischemia and reperfusion.

Journal: Journal of neuroscience research 20120101

Title: Effect of passive stretch on intracellular nitric oxide and superoxide activities in single skeletal muscle fibres: influence of ageing.

Journal: Free radical research 20120101

Title: Carbon monoxide protects against ischemia-reperfusion injury in vitro via antioxidant properties.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

Title: A simplified, sensitive phagocytic assay for malaria cultures facilitated by flow cytometry of differentially-stained cell populations.

Journal: PloS one 20120101

Title: ACE2 deficiency enhances angiotensin II-mediated aortic profilin-1 expression, inflammation and peroxynitrite production.

Journal: PloS one 20120101

Title: Oxidative stress-induced glomerular mineralocorticoid receptor activation limits the benefit of salt reduction in Dahl salt-sensitive rats.

Journal: PloS one 20120101

Title: Pyrogallol red oxidation induced by superoxide radicals: application to evaluate redox cycling of nitro compounds.

Journal: Analytical biochemistry 20111215

Title: Expression of nitric oxide synthases in primary ciliary dyskinesia.

Journal: Human pathology 20111201

Title: Mechanisms regulating superoxide generation in experimental models of phenylketonuria: an essential role of NADPH oxidase.

Journal: Molecular genetics and metabolism 20111101

Title: Biophysical properties and functional consequences of reactive oxygen species (ROS)-induced ROS release in intact myocardium.

Journal: The Journal of physiology 20111101

Title: Role of superoxide-nitric oxide interactions in the accelerated age-related loss of muscle mass in mice lacking Cu,Zn superoxide dismutase.

Journal: Aging cell 20111001

Title: Acute and chronic angiotensin-(1-7) restores vasodilation and reduces oxidative stress in mesenteric arteries of salt-fed rats.

Journal: American journal of physiology. Heart and circulatory physiology 20111001

Title: Differential effects of NADPH oxidase and xanthine oxidase inhibition on sympathetic reinnervation in postinfarct rat hearts.

Journal: Free radical biology & medicine 20110601

Title: Role of reactive oxygen species in the regulation of cardiac contractility.

Journal: Journal of molecular and cellular cardiology 20110501

Title: The enhancement of propyl gallate-induced HeLa cell death by MAPK inhibitors is accompanied by increasing ROS levels.

Journal: Molecular biology reports 20110401

Title: Mitochondrial superoxide anion radicals mediate induction of apoptosis in cardiac myoblasts exposed to chronic hypoxia.

Journal: Archives of biochemistry and biophysics 20110115

Title: NAD+ treatment decreases tumor cell survival by inducing oxidative stress.

Journal: Frontiers in bioscience (Elite edition) 20110101

Title: A single acidic residue can guide binding site selection but does not govern QacR cationic-drug affinity.

Journal: PloS one 20110101

Title: Influence of blue light on photoreceptors in a live retinal explant system.

Journal: Molecular vision 20110101

Title: Reactive oxygen species and the structural remodeling of the visual system after ocular enucleation.

Journal: Neuroscience 20101110

Title: Qo site of mitochondrial complex III is the source of increased superoxide after transient exposure to hydrogen peroxide.

Journal: Journal of molecular and cellular cardiology 20101101

Title: Intrinsic nitric oxide and superoxide production regulates descending vasa recta contraction.

Journal: American journal of physiology. Renal physiology 20101101

Title: Redox-active complexes formed during the interaction between glutathione and mercury and/or copper ions.

Journal: Journal of inorganic biochemistry 20101001

Title: Bone marrow-derived mesenchymal stem cells attenuate amyloid β-induced memory impairment and apoptosis by inhibiting neuronal cell death.

Journal: Current Alzheimer research 20100901

Title: Beneficial effects of a combination of Rho-kinase inhibitor and ACE inhibitor on tubulointerstitial fibrosis induced by unilateral ureteral obstruction.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20100901

Title: Persistent facial pain increases superoxide anion production in the spinal trigeminal nucleus.

Journal: Molecular and cellular biochemistry 20100601

Title: GTPase-Rac enhances depolarization-induced superoxide production by the macula densa during tubuloglomerular feedback.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20100201

Title: The ambiguous role of the Na+-H+ exchanger isoform 1 (NHE1) in leptin-induced oxidative stress in human monocytes.

Journal: Cell stress & chaperones 20091101

Title: Cytotoxicity of dopaminochrome in the mesencephalic cell line, MN9D, is dependent upon oxidative stress.

Journal: Neurotoxicology 20091101

Title: Inhibitory effects of a dihydropyridine calcium channel blocker on renal injury in aldosterone-infused rats.

Journal: Journal of hypertension 20090901

Title: Reactive oxygen species-mediated effects on vascular remodeling induced by human atrial natriuretic peptide T2238C molecular variant in endothelial cells in vitro.

Journal: Journal of hypertension 20090901

Title: Evaluation of different methods detecting intracellular generation of free radicals.

Journal: Molecular and cellular biochemistry 20090801

Title: Administration of sesamol improved blood-brain barrier function in streptozotocin-induced diabetic rats.

Journal: Experimental brain research 20090701

Title: Chlorpyrifos induces oxidative stress in oligodendrocyte progenitor cells.

Journal: Toxicology 20090502

Title: Participation of mitochondrial respiratory complex III in neutrophil activation and lung injury.

Journal: American journal of physiology. Lung cellular and molecular physiology 20090401

Title: Vascular protective effects of ezetimibe in ApoE-deficient mice.

Journal: Atherosclerosis 20090301

Title: Generation of superoxide radicals by copper-glutathione complexes: redox-consequences associated with their interaction with reduced glutathione.

Journal: Bioorganic & medicinal chemistry 20090301

Title: [Flavonoids extracts from Inula britannica inhibit oxidative stress in vessel after balloon injury].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090301

Title: The mitochondrial ATP-sensitive potassium channel blocker 5-hydroxydecanoate inhibits toxicity of 6-hydroxydopamine on dopaminergic neurons.

Journal: Neurotoxicity research 20090101

Title: Increased superoxide levels in ganglia and sympathoexcitation are involved in sarafotoxin 6c-induced hypertension.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20081101

Title: Cu(I)-glutathione complex: a potential source of superoxide radicals generation.

Journal: Bioorganic & medicinal chemistry 20080701

Title: Aldosterone and the autocrine modulation of potassium currents and oxidative stress in the diabetic rat heart.

Journal: British journal of pharmacology 20080601

Title: Impact of estrogenic compounds on DNA integrity in human spermatozoa: evidence for cross-linking and redox cycling activities.

Journal: Mutation research 20080510

Title: In vivo effect of the natural antioxidant hydroxytyrosol on cyclosporine nephrotoxicity in rats.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20080401

Title: In vivo reactive oxygen species production induced by ischemia in muscle arterioles of mice: involvement of xanthine oxidase and mitochondria.

Journal: American journal of physiology. Heart and circulatory physiology 20080201

Title: Opposing effects of coupled and uncoupled NOS activity on the Na+-K+ pump in cardiac myocytes.

Journal: American journal of physiology. Cell physiology 20080201

Title: Cellular stretch increases superoxide production in the thick ascending limb.

Journal: Hypertension (Dallas, Tex. : 1979) 20080201

Title: A carboxyfullerene SOD mimetic improves cognition and extends the lifespan of mice.

Journal: Neurobiology of aging 20080101

Title: The influence of visible light exposure on cultured RGC-5 cells.

Journal: Molecular vision 20080101

Title: Assessment of superoxide production and NADPH oxidase activity by HPLC analysis of dihydroethidium oxidation products.

Journal: Methods in enzymology 20080101

Title: Aldosterone-induced increases in superoxide production counters nitric oxide inhibition of epithelial Na channel activity in A6 distal nephron cells.

Journal: American journal of physiology. Renal physiology 20071101

Title: NOX4 activity is determined by mRNA levels and reveals a unique pattern of ROS generation.

Journal: The Biochemical journal 20070815

Title: Superoxide (*O2- ) production in CA1 neurons of rat hippocampal slices exposed to graded levels of oxygen.

Journal: Journal of neurophysiology 20070801

Title: Endothelial cell seeding onto various biomaterials causes superoxide-induced cell death.

Journal: Journal of biomaterials applications 20070701

Title: Respiratory chain components involved in the glycerophosphate dehydrogenase-dependent ROS production by brown adipose tissue mitochondria.

Journal: Biochimica et biophysica acta 20070701

Title: Analysis of dihydroethidium fluorescence for the detection of intracellular and extracellular superoxide produced by NADPH oxidase.

Journal: Free radical research 20070601

Title: Asymmetric dimethylarginine induces oxidative and nitrosative stress in murine lung epithelial cells.

Journal: American journal of respiratory cell and molecular biology 20070501

Title: Macrocyclic copper(II) complexes: superoxide scavenging activity, structural studies and cytotoxicity evaluation.

Journal: Journal of inorganic biochemistry 20070501

Title: Transient exposure to hydrogen peroxide causes an increase in mitochondria-derived superoxide as a result of sustained alteration in L-type Ca2+ channel function in the absence of apoptosis in ventricular myocytes.

Journal: Circulation research 20070413

Title: Glucose down-regulation of cGMP-dependent protein kinase I expression in vascular smooth muscle cells involves NAD(P)H oxidase-derived reactive oxygen species.

Journal: Free radical biology & medicine 20070315

Title: High-dose morphine impairs vascular endothelial function by increased production of superoxide anions.

Journal: Anesthesiology 20070301

Title: The influence of visible light exposure on cultured RGC-5 cells.

Journal: Molecular vision 20070211

Title: Generation of superoxide anion by equine spermatozoa as detected by dihydroethidium.

Journal: Theriogenology 20070201

Title: Oxidant generation by single infected monocytes after short-term fluorescence labeling of a protozoan parasite.

Journal: Infection and immunity 20070201

Title: Analysis of DHE-derived oxidation products by HPLC in the assessment of superoxide production and NADPH oxidase activity in vascular systems.

Journal: American journal of physiology. Cell physiology 20070101

Title: Nitric oxide generation by NO donors is enhanced following balloon injury in the porcine coronary artery.

Journal: Endothelium : journal of endothelial cell research 20070101

Title: Gender differences in free radical homeostasis during aging: shorter-lived female C57BL6 mice have increased oxidative stress.

Journal: Aging cell 20061201

Title: An E. coli lon mutant conferring partial resistance to colicin may reveal a novel role in regulating proteins involved in the translocation of colicin.

Journal: Biochemical and biophysical research communications 20060714

Title: NAD(P)H oxidase-induced oxidative stress in sympathetic ganglia of apolipoprotein E deficient mice.

Journal: Autonomic neuroscience : basic & clinical 20060630

Title: NADPH oxidases are in part responsible for increased cardiovascular superoxide production during aging.

Journal: Free radical biology & medicine 20060615

Title: Increased oxidative stress in lambs with increased pulmonary blood flow and pulmonary hypertension: role of NADPH oxidase and endothelial NO synthase.

Journal: American journal of physiology. Lung cellular and molecular physiology 20060601

Title: Definitive evidence for the nonmitochondrial production of superoxide anion by human spermatozoa.

Journal: The Journal of clinical endocrinology and metabolism 20060501

Title: Mitochondrial reactive oxygen species in mice lacking superoxide dismutase 2: attenuation via antioxidant treatment.

Journal: The Journal of biological chemistry 20060210

Title: Hyperglycemia increases superoxide production in the CA1 pyramidal neurons after global cerebral ischemia.

Journal: Neuroscience letters 20060130

Title: Cardiac mitochondrial preconditioning by Big Ca2+-sensitive K+ channel opening requires superoxide radical generation.

Journal: American journal of physiology. Heart and circulatory physiology 20060101

Title: Manganese superoxide dismutase protects from TNF-alpha-induced apoptosis by increasing the steady-state production of H2O2.

Journal: Antioxidants & redox signaling 20060101

Title: Involvement of oxidative stress response genes in redox homeostasis, the level of reactive oxygen species, and ageing in Saccharomyces cerevisiae.

Journal: FEMS yeast research 20051201

Title: Endothelin-1 activation of JAK2 in vascular smooth muscle cells involves NAD(P)H oxidase-derived reactive oxygen species.

Journal: Vascular pharmacology 20051101

Title: Cytochrome p450 2C inhibition reduces post-ischemic vascular dysfunction.

Journal: Vascular pharmacology 20051001

Title: Cyclosporin A generates superoxide in smooth muscle cells.

Journal: Free radical research 20050901

Title: Mitochondrial Dok-4 recruits Src kinase and regulates NF-kappaB activation in endothelial cells.

Journal: The Journal of biological chemistry 20050715

Title: Vascular dysfunction of venous bypass conduits is mediated by reactive oxygen species in diabetes: role of endothelin-1.

Journal: The Journal of pharmacology and experimental therapeutics 20050401

Title: Mitochondrial T9957C mutation in association with NAION and seizures but not MELAS.

Journal: Ophthalmic genetics 20050301

Title: Detection of mitochondrial DNA depletion in living human cells using PicoGreen staining.

Journal: Experimental cell research 20050215

Title: Effects of silencing leukocyte-type 12/15-lipoxygenase using short interfering RNAs.

Journal: Journal of lipid research 20050201

Title: Chronic ANG II infusion increases NO generation by rat descending vasa recta.

Journal: American journal of physiology. Heart and circulatory physiology 20050101

Title: Neuroprotective effects of the free radical scavenger Edaravone (MCI-186) in mice permanent focal brain ischemia.

Journal: Brain research 20041217

Title: Detection of intracellular superoxide formation in endothelial cells and intact tissues using dihydroethidium and an HPLC-based assay.

Journal: American journal of physiology. Cell physiology 20041001

Title: Involvement of NAD(P)H oxidase in the enhanced expression of cell adhesion molecules in the aorta of diabetic mice.

Journal: Life sciences 20041001

Title: Arachidonic acid-induced carbon-centered radicals and phospholipid peroxidation in cyclo-oxygenase-2-transfected PC12 cells.

Journal: Journal of neurochemistry 20040901

Title: SOD2 gene transfer protects against optic neuropathy induced by deficiency of complex I.

Journal: Annals of neurology 20040801

Title: Reactive oxygen species play no role in the candidacidal activity of the salivary antimicrobial peptide histatin 5.

Journal: The Biochemical journal 20040715

Title: Neuroprotective effect of fraxetin and myricetin against rotenone-induced apoptosis in neuroblastoma cells.

Journal: Brain research 20040529

Title: NAD(P)H:quinone oxidoreductase 1: role as a superoxide scavenger.

Journal: Molecular pharmacology 20040501

Title: Pulsatile versus oscillatory shear stress regulates NADPH oxidase subunit expression: implication for native LDL oxidation.

Journal: Circulation research 20031212

Title: Mitochondrial impairment is accompanied by impaired oxidative DNA repair in the nucleus.

Journal: Mutagenesis 20031101

Title: Amplification of a reactive oxygen species signal in axotomized retinal ganglion cells.

Journal: Antioxidants & redox signaling 20031001

Title: Involvement of poly ADP ribosyl polymerase-1 in acute but not chronic zinc toxicity.

Journal: The European journal of neuroscience 20030901

Title: Protective role of glucose-6-phosphate dehydrogenase activity in the metabolic response of C6 rat glioma cells to polyunsaturated fatty acid exposure.

Journal: Glia 20030801

Title: Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning.

Journal: American journal of physiology. Heart and circulatory physiology 20030801

Title: Reactive oxygen species precede the epsilon isoform of protein kinase C in the anesthetic preconditioning signaling cascade.

Journal: Anesthesiology 20030801

Title: Treatment with dihydroethidium reduces infarct size after transient focal cerebral ischemia in mice.

Journal: Brain research 20030718

Title: Sevoflurane exposure generates superoxide but leads to decreased superoxide during ischemia and reperfusion in isolated hearts.

Journal: Anesthesia and analgesia 20030401

Title: Hydroxyl radical formation is greater in striatal core than in penumbra in a rat model of ischemic stroke.

Journal: Journal of neuroscience research 20030315

Title: Calcineurin transgenic mice have mitochondrial dysfunction and elevated superoxide production.

Journal: American journal of physiology. Cell physiology 20030201

Title: Ischemic preconditioning alters real-time measure of O2 radicals in intact hearts with ischemia and reperfusion.

Journal: American journal of physiology. Heart and circulatory physiology 20030201

Title: Nifedipine inhibits tumor necrosis factor-alpha-induced monocyte chemoattractant protein-1 overexpression by blocking NADPH oxidase-mediated reactive oxygen species generation.

Journal: Drugs under experimental and clinical research 20030101

Title: Deficiency of glutathione peroxidase-1 sensitizes hyperhomocysteinemic mice to endothelial dysfunction.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20021201

Title: Protective effect of metallothionein-III on DNA damage in response to reactive oxygen species.

Journal: Biochimica et biophysica acta 20021010

Title: The vascular NADPH oxidase subunit p47phox is involved in redox-mediated gene expression.

Journal: Free radical biology & medicine 20020601

Title: Role of mitochondrial oxidant generation in endothelial cell responses to hypoxia.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20020401

Title: ET-1 stimulates pulmonary arterial smooth muscle cell proliferation via induction of reactive oxygen species.

Journal: American journal of physiology. Lung cellular and molecular physiology 20011101

Title: BMCP1: a mitochondrial uncoupling protein in neurons which regulates mitochondrial function and oxidant production.

Journal: Journal of neurochemistry 20011101

Title: Novel competitive inhibitor of NAD(P)H oxidase assembly attenuates vascular O(2)(-) and systolic blood pressure in mice.

Journal: Circulation research 20010831

Title: Lipopolysaccharide induces Rac1-dependent reactive oxygen species formation and coordinates tumor necrosis factor-alpha secretion through IKK regulation of NF-kappa B.

Journal: The Journal of biological chemistry 20010810

Title: Gliotoxin induces apoptosis in cultured macrophages via production of reactive oxygen species and cytochrome c release without mitochondrial depolarization.

Journal: Free radical research 20010701

Title: NAD(P)H oxidase: marker of the dedifferentiated neointimal smooth muscle cell?

Journal: Arteriosclerosis, thrombosis, and vascular biology 20010201

Title: Enhanced superoxide production in experimental venous bypass graft intimal hyperplasia: role of NAD(P)H oxidase.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20010201

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