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10488-69-4,MFCD09839767
Catalog No.:AA0037YN

10488-69-4 | Ethyl 4-chloro-3-hydroxybutanoate

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1g
95%
in stock  
$120.00   $84.00
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5g
97%
in stock  
$252.00   $177.00
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10g
97%
in stock  
$404.00   $283.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0037YN
Chemical Name:
Ethyl 4-chloro-3-hydroxybutanoate
CAS Number:
10488-69-4
Molecular Formula:
C6H11ClO3
Molecular Weight:
166.6027
MDL Number:
MFCD09839767
SMILES:
CCOC(=O)CC(CCl)O
Properties
Computed Properties
 
Complexity:
105  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
10  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
Undefined Atom Stereocenter Count:
1  
XLogP3:
0.4  

Literature

Title: Development of a substrate-coupled biocatalytic process driven by an NADPH-dependent sorbose reductase from Candida albicans for the asymmetric reduction of ethyl 4-chloro-3-oxobutanoate.

Journal: Biotechnology letters 20121201

Title: Effect of ribose, xylose, aspartic acid, glutamine and nicotinic acid on ethyl (S)-4-chloro-3-hydroxybutanoate synthesis by recombinant Escherichia coli.

Journal: Bioresource technology 20120801

Title: Expression, purification, crystallization and preliminary X-ray analysis of carbonyl reductase S1 from Candida magnoliae.

Journal: Acta crystallographica. Section F, Structural biology and crystallization communications 20120501

Title: A novel reductase from Candida albicans for the production of ethyl (S)-4-chloro-3-hydroxybutanoate.

Journal: Bioscience, biotechnology, and biochemistry 20120101

Title: Highly stereoselective reduction of prochiral ketones by a bacterial reductase coupled with cofactor regeneration.

Journal: Organic & biomolecular chemistry 20110807

Title: Highly efficient synthesis of chiral alcohols with a novel NADH-dependent reductase from Streptomyces coelicolor.

Journal: Bioresource technology 20110701

Title: A review-biosynthesis of optically pure ethyl (S)-4-chloro-3-hydroxybutanoate ester: recent advances and future perspectives.

Journal: Applied microbiology and biotechnology 20110201

Title: Purification and characterization of a novel NADH-dependent carbonyl reductase from Pichia stipitis involved in biosynthesis of optically pure ethyl (S)-4-chloro-3-hydroxybutanoate.

Journal: Bioresource technology 20110101

Title: Biocatalytic synthesis of (S)-4-chloro-3-hydroxybutanoate ethyl ester using a recombinant whole-cell catalyst.

Journal: Applied microbiology and biotechnology 20101201

Title: Biosynthesis of (S)-4-chloro-3-hydroxybutanoate ethyl using Escherichia coli co-expressing a novel NADH-dependent carbonyl reductase and a glucose dehydrogenase.

Journal: Bioresource technology 20101101

Title: Construction and co-expression of a polycistronic plasmid encoding carbonyl reductase and glucose dehydrogenase for production of ethyl (S)-4-chloro-3-hydroxybutanoate.

Journal: Bioresource technology 20100901

Title: Asymmetric synthesis of (S)-ethyl-4-chloro-3-hydroxy butanoate using a Saccharomyces cerevisiae reductase: enantioselectivity and enzyme-substrate docking studies.

Journal: Biochimica et biophysica acta 20100901

Title: Enantioselective bioconversion using Escherichia coli cells expressing Saccharomyces cerevisiae reductase and Bacillus subtilis glucose dehydrogenase.

Journal: Journal of microbiology and biotechnology 20100901

Title: High-level production of heterologous proteins using untreated cane molasses and corn steep liquor in Escherichia coli medium.

Journal: Applied microbiology and biotechnology 20100601

Title: Asymmetric synthesis of (S)-ethyl-4-chloro-3-hydroxybutanoate using Candida parapsilosis ATCC 7330.

Journal: Journal of industrial microbiology & biotechnology 20100201

Title: A new member of the short-chain dehydrogenases/reductases superfamily: purification, characterization and substrate specificity of a recombinant carbonyl reductase from Pichia stipitis.

Journal: Bioresource technology 20091201

Title: A novel carbonyl reductase from Pichia stipitis for the production of ethyl (S)-4-chloro-3-hydroxybutanoate.

Journal: Biotechnology letters 20090401

Title: Improvement of natural isolates of Saccharomyces cerevisiae strains for synthesis of a chiral building block using classic genetics.

Journal: Applied microbiology and biotechnology 20080301

Title: High-level expression of recombinant glucose dehydrogenase and its application in NADPH regeneration.

Journal: Journal of industrial microbiology & biotechnology 20070101

Title: Enthalpy change on mixing a couple of S- and R-enantiomers of some chiral compounds at 298.15 K.

Journal: Chirality 20060801

Title: Construction of a two-strain system for asymmetric reduction of ethyl 4-chloro-3-oxobutanoate to (S)-4-chloro-3-hydroxybutanoate ethyl ester.

Journal: Applied microbiology and biotechnology 20060301

Title: Robust NADH-regenerator: improved alpha-haloketone-resistant formate dehydrogenase.

Journal: Applied microbiology and biotechnology 20050401

Title: Asymmetric reduction of ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate with two co-existing, recombinant Escherichia coli strains.

Journal: Biotechnology letters 20050101

Title: Efficient production of recombinant aldehyde reductase and its application for asymmetric reduction of ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate.

Journal: Preparative biochemistry & biotechnology 20050101

Title: A novel NADH-dependent carbonyl reductase from Kluyveromyces aestuarii and comparison of NADH-regeneration system for the synthesis of ethyl (S)-4-chloro-3-hydroxybutanoate.

Journal: Bioscience, biotechnology, and biochemistry 20040301

Title: Synthesis of ethyl ( S)-4-chloro-3-hydroxybutanoate using fabG-homologues.

Journal: Applied microbiology and biotechnology 20030401

Title: Applying the Taguchi robust design to the optimization of the asymmetric reduction of ethyl 4-chloro acetoacetate by bakers' yeast.

Journal: Journal of biotechnology 20030213

Title: Applying slow-release biocatalysis to the asymmetric reduction of ethyl 4-chloroacetoacetate.

Journal: Biotechnology letters 20030101

Title: Purification and properties of a carbonyl reductase useful for production of ethyl (S)-4-chloro-3-hydroxybutanoate from Kluyveromyces lactis.

Journal: Bioscience, biotechnology, and biochemistry 20020801

Title: Synthesis of ethyl (R)-4-chloro-3-hydroxybutanoate with recombinant Escherichia coli cells expressing (S)-specific secondary alcohol dehydrogenase.

Journal: Bioscience, biotechnology, and biochemistry 20020201

Title: Design of the pH profile for asymmetric bioreduction of ethyl 4-chloro-3-oxobutyrate on the basis of a data-driven method.

Journal: Biotechnology progress 20020101

Title: Stereoselective reduction of ethyl 4-chloro-3-oxobutanoate by fungi.

Journal: Bioscience, biotechnology, and biochemistry 20010701

Title: Synthesis of optically pure ethyl (S)-4-chloro-3-hydroxybutanoate by Escherichia coli transformant cells coexpressing the carbonyl reductase and glucose dehydrogenase genes.

Journal: Applied microbiology and biotechnology 20010501

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