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Home Other Building Blocks 1050477-31-0
1050477-31-0,MFCD29047135
Catalog No.:AA0096IA

1050477-31-0 | Finerenone (BAY 94-8862)

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥98%
in stock  
$143.00   $100.00
- +
10mg
≥98%
in stock  
$272.00   $190.00
- +
25mg
≥98%
in stock  
$395.00   $276.00
- +
100mg
98%
in stock  
$684.00   $479.00
- +
250mg
98%
in stock  
$1,001.00   $701.00
- +
1g
98%
in stock  
$2,906.00   $2,034.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0096IA
Chemical Name:
Finerenone (BAY 94-8862)
CAS Number:
1050477-31-0
Molecular Formula:
C21H22N4O3
Molecular Weight:
378.4244
MDL Number:
MFCD29047135
SMILES:
CCOc1ncc(c2c1[C@@H](C(=C(N2)C)C(=O)N)c1ccc(cc1OC)C#N)C
Properties

Downstream Synthesis Route

[1]CurrentPatentAssignee:BAYERAG-KR101614164,2016,B1Locationinpatent:Paragraph0512-0515

[1]CurrentPatentAssignee:ZHEJIANGKEJIANGBIOMEDICAL-CN114605410,2022,ALocationinpatent:Paragraph0046;0064-0066;0067;0076-0077;0087;0091-0092

[2]CurrentPatentAssignee:BAYERAG-US2018/244670,2018,A1Locationinpatent:Paragraph0207-0217

[3]CurrentPatentAssignee:BAYERAG-US2018/244668,2018,A1

[4]CurrentPatentAssignee:BAYERAG-US2018/244668,2018,A1

[5]CurrentPatentAssignee:BAYERAG-US2018/244668,2018,A1

[6]Aggarwal,VarinderK.;Farrar,ElliotH.E.;Gandhamsetty,Narasimhulu;Grayson,MatthewN.;Lerchen,Andreas;Platzek,Johannes;Winter,Nils[AngewandteChemie-InternationalEdition,2020,vol.59,#51,p.23107-23111][Angew.Chem.,2020,vol.132,#51,p.23307-23311,5]

[7]CurrentPatentAssignee:AGS.R.L.;BAYERAG-US2021/163474,2021,A1

139102-34-4    1050477-31-0   
(4R)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide 

[1]Patent:US2017/217957,2017,A1

43192-33-2    1050477-31-0   
(4R)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide 

[1]Patent:US2017/217957,2017,A1

[1]CurrentPatentAssignee:BAYERAG-US2017/217957,2017,A1Locationinpatent:Paragraph0184-0190

[2]CurrentPatentAssignee:BAYERAG-US2018/244668,2018,A1Locationinpatent:Paragraph0217-0229

Literature

Title: Bärfacker L, et al. Discovery of BAY 94-8862: a nonsteroidal antagonist of the mineralocorticoid receptor for the treatment of cardiorenal diseases. ChemMedChem. 2012;7(8):1385-1403.

Title: González-Blázquez R, et al. Finerenone Attenuates Endothelial Dysfunction and Albuminuria in a Chronic Kidney Disease Model by a Reduction in Oxidative Stress. Front Pharmacol. 2018;9:1131. Published 2018 Oct 9.

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SDS
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