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1054-88-2,MFCD00055134
Catalog No.:AA007WA6

1054-88-2 | Spiroxatrine (R 5188)

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Purity
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Price(USD)
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5mg
98%
in stock  
$182.00   $128.00
- +
10mg
98%
in stock  
$272.00   $190.00
- +
25mg
98%
in stock  
$468.00   $328.00
- +
50mg
98%
in stock  
$718.00   $503.00
- +
100mg
98%
in stock  
$1,129.00   $790.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA007WA6
Chemical Name:
Spiroxatrine (R 5188)
CAS Number:
1054-88-2
Molecular Formula:
C22H25N3O3
Molecular Weight:
379.4522
MDL Number:
MFCD00055134
SMILES:
O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1
NSC Number:
665322
Properties
Computed Properties
 
Complexity:
557  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
Undefined Atom Stereocenter Count:
1  
XLogP3:
3.1  

Literature

Title: Involvement of the first transmembrane segment of human α(2) -adrenoceptors in the subtype-selective binding of chlorpromazine, spiperone and spiroxatrine.

Journal: British journal of pharmacology 20111101

Title: Identification of clinically used drugs that activate pregnane X receptors.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20110101

Title: Physical binding pocket induction for affinity prediction.

Journal: Journal of medicinal chemistry 20091008

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: The roles of alpha2-adrenoceptor subtypes in the control of cervical resistance in the late-pregnant rat.

Journal: European journal of pharmacology 20090801

Title: Different roles of alpha2-adrenoceptor subtypes in non-pregnant and late-pregnant uterine contractility in vitro in the rat.

Journal: Neurochemistry international 20071001

Title: Alpha2-adrenoceptor subtypes involved in the regulation of catecholamine release from the adrenal medulla of mice.

Journal: British journal of pharmacology 20061201

Title: Antidepressant-like effects of Trichilia catigua (Catuaba) extract: evidence for dopaminergic-mediated mechanisms.

Journal: Psychopharmacology 20051001

Title: Analgesic effect of electroacupuncture on inflammatory pain in the rat model of collagen-induced arthritis: mediation by cholinergic and serotonergic receptors.

Journal: Brain research 20050928

Title: Facilitation of serotonergic activity and amnesia in rats caused by intravenous anesthetics.

Journal: Anesthesiology 20050301

Title: Mechanisms intrinsic to 5-HT2B receptor-induced potentiation of NMDA receptor responses in frog motoneurones.

Journal: British journal of pharmacology 20041001

Title: All three alpha2-adrenoceptor types serve as autoreceptors in postganglionic sympathetic neurons.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20031201

Title: Pharmacological characterization of alpha 2-adrenoceptor-mediated responses in pig nasal mucosa.

Journal: Autonomic & autacoid pharmacology 20030801

Title: Investigation of neurotransmission in vas deferens from alpha(2A/D)-adrenoceptor knockout mice.

Journal: British journal of pharmacology 20020701

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Involvement of 5-hydroxytryptamine(1A) receptors in the descending anti-nociceptive pathway from periaqueductal gray to the spinal dorsal horn in intact rats, rats with nerve injury and rats with inflammation.

Journal: Neuroscience 20020101

Title: Affinity of serotonin receptor antagonists and agonists to recombinant and native alpha1-adrenoceptor subtypes.

Journal: Japanese journal of pharmacology 20010601

Title: Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study.

Journal: European journal of pharmacology 19980821

Title: [3H]Rauwolscine: an antagonist radioligand for the cloned human 5-hydroxytryptamine2b (5-HT2B) receptor.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 19980101

Title: The novel alpha-2 adrenergic radioligand [3H]-MK912 is alpha-2C selective among human alpha-2A, alpha-2B and alpha-2C adrenoceptors.

Journal: The Journal of pharmacology and experimental therapeutics 19941201

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