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1054543-47-3,MFCD19443178
Catalog No.:AA008TM5

1054543-47-3 | Apoptozole

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$11.00   $8.00
- +
5mg
98%
in stock  
$25.00   $18.00
- +
10mg
98%
in stock  
$37.00   $26.00
- +
50mg
98%
in stock  
$106.00   $75.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008TM5
Chemical Name:
Apoptozole
CAS Number:
1054543-47-3
Molecular Formula:
C33H25F6N3O3
Molecular Weight:
625.5603
MDL Number:
MFCD19443178
SMILES:
COc1ccc(cc1)c1n(Cc2ccc(cc2)C(=O)N)c(nc1c1ccc(cc1)OC)c1cc(cc(c1)C(F)(F)F)C(F)(F)F
Properties
Computed Properties
 
Complexity:
936  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
45  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
8  
XLogP3:
7.2  

Literature

Title: A small molecule that binds to an ATPase domain of Hsc70 promotes membrane trafficking of mutant cystic fibrosis transmembrane conductance regulator.

Journal: Journal of the American Chemical Society 20111221

Title: Urea-hydrolyzing activity of a T-strain mycoplasma: Ureaplasma urealyticum.

Journal: Journal of bacteriology 19760201

Title: Williams DR, et al. An apoptosis-inducing small molecule that binds to heat shock protein 70. Angew Chem Int Ed Engl. 2008;47(39):7466-9.

Title: Cho HJ, et al. Probing the effect of an inhibitor of an ATPase domain of Hsc70 on clathrin-mediated endocytosis. Mol Biosyst. 2015 Oct;11(10):2763-9.

Title: Ko SK, et al. A small molecule inhibitor of ATPase activity of HSP70 induces apoptosis and has antitumor activities. Chem Biol. 2015 Mar 19;22(3):391-403.

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Tags:1054543-47-3 Molecular Formula|1054543-47-3 MDL|1054543-47-3 SMILES|1054543-47-3 Apoptozole