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1055412-47-9,MFCD08443928
Catalog No.:AA008T1X

1055412-47-9 | su-5614

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Purity
Availability
Price(USD)
Quantity
  
1mg
96%
in stock  
$26.00   $18.00
- +
5mg
95%
in stock  
$90.00   $63.00
- +
25mg
96%
in stock  
$99.00   $69.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008T1X
Chemical Name:
su-5614
CAS Number:
1055412-47-9
Molecular Formula:
C15H13ClN2O
Molecular Weight:
272.7295
MDL Number:
MFCD08443928
SMILES:
Clc1ccc2c(c1)/C(=C/c1[nH]c(cc1C)C)/C(=O)N2
Properties
Computed Properties
 
Complexity:
409  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  
XLogP3:
3.1  

Literature

Title: Synthesis, structure-activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors.

Journal: Bioorganic & medicinal chemistry 20100215

Title: FMS-like tyrosine kinase 3-internal tandem duplication tyrosine kinase inhibitors display a nonoverlapping profile of resistance mutations in vitro.

Journal: Cancer research 20090401

Title: Phosphoinositide 3-kinase-delta inhibitor reduces vascular permeability in a murine model of asthma.

Journal: The Journal of allergy and clinical immunology 20060801

Title: Effects of the protein tyrosine kinase inhibitor, SU5614, on leukemic and normal stem cells.

Journal: Haematologica 20051101

Title: In vitro activity of the flt3-inhibitor su5614 and standard cytotoxic agents in tumour cells from patients with wild type and mutated flt3 acute myeloid leukaemia.

Journal: Leukemia research 20050901

Title: Cysteinyl leukotriene receptor antagonist regulates vascular permeability by reducing vascular endothelial growth factor expression.

Journal: The Journal of allergy and clinical immunology 20041101

Title: Anti-chemorepulsive effects of vascular endothelial growth factor and placental growth factor-2 in dorsal root ganglion neurons are mediated via neuropilin-1 and cyclooxygenase-derived prostanoid production.

Journal: The Journal of biological chemistry 20040716

Title: Localization of VEGFR-2 and PLD2 in endothelial caveolae is involved in VEGF-induced phosphorylation of MEK and ERK.

Journal: American journal of physiology. Heart and circulatory physiology 20040501

Title: Mutations in the tyrosine kinase domain of FLT3 define a new molecular mechanism of acquired drug resistance to PTK inhibitors in FLT3-ITD-transformed hematopoietic cells.

Journal: Blood 20040315

Title: Sensitivity toward tyrosine kinase inhibitors varies between different activating mutations of the FLT3 receptor.

Journal: Blood 20030715

Title: Overexpression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030601

Title: A novel early chorioallantoic membrane assay demonstrates quantitative and qualitative changes caused by antiangiogenic substances.

Journal: The Journal of laboratory and clinical medicine 20030301

Title: The protein tyrosine kinase inhibitor SU5614 inhibits FLT3 and induces growth arrest and apoptosis in AML-derived cell lines expressing a constitutively activated FLT3.

Journal: Blood 20030215

Title: Flt3 in acute myelogenous leukemia: biology, prognosis, and therapeutic implications.

Journal: Medical oncology (Northwood, London, England) 20030101

Title: A new and recurrent activating length mutation in exon 20 of the FLT3 gene in acute myeloid leukemia.

Journal: Blood 20021101

Title: SU5416 and SU5614 inhibit kinase activity of wild-type and mutant FLT3 receptor tyrosine kinase.

Journal: Blood 20021015

Title: The protein tyrosine kinase inhibitor SU5614 inhibits VEGF-induced endothelial cell sprouting and induces growth arrest and apoptosis by inhibition of c-kit in AML cells.

Journal: Experimental hematology 20020701

Title: Contribution of vascular endothelial growth factor to airway hyperresponsiveness and inflammation in a murine model of toluene diisocyanate-induced asthma.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20020401

Title: The antiangiogenic agents SU5416 and SU6668 increase the antitumor effects of fractionated irradiation.

Journal: Radiation research 20020101

Title: Effects of vascular endothelial and platelet-derived growth factor receptor inhibitors on long-term cultures from normal human bone marrow.

Journal: Growth factors (Chur, Switzerland) 20010101

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