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Home Amines 1059070-10-8
1059070-10-8,MFCD30182245
Catalog No.:AA01ENKU

1059070-10-8 | 6-Amino-2-(butylamino)-9-[[6-[2-(dimethylamino)ethoxy]-3-pyridinyl]methyl]-7,9-dihydro-8H-purin-8-one

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$22.00   $15.00
- +
10mg
98%
in stock  
$77.00   $54.00
- +
25mg
98%
in stock  
$131.00   $92.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA01ENKU
Chemical Name:
6-Amino-2-(butylamino)-9-[[6-[2-(dimethylamino)ethoxy]-3-pyridinyl]methyl]-7,9-dihydro-8H-purin-8-one
CAS Number:
1059070-10-8
Molecular Formula:
C19H28N8O2
Molecular Weight:
400.4780
MDL Number:
MFCD30182245
SMILES:
CCCCNc1nc(N)c2c(n1)n(Cc1ccc(nc1)OCCN(C)C)c(=O)[nH]2
Properties
Computed Properties
 
Complexity:
522  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
10  
XLogP3:
1.3  

Downstream Synthesis Route

[1]CurrentPatentAssignee:ASTRAZENECAPLC;SumitomoPharma(in:SumitomoChemical);SumitomoChemical(w/oDongwooFine-Chem);SUMITOMOCHEMICALCOMPANYLIMITED-WO2010/33074,2010,A1Locationinpatent:Page/Pagecolumn13

[1]Nakamura,Tomoaki;Wada,Hiroki;Kurebayashi,Hirotaka;McInally,Tom;Bonnert,Roger;Isobe,Yoshiaki[BioorganicandMedicinalChemistryLetters,2013,vol.23,#3,p.669-672]

Literature

Title: Synthesis and evaluation of 8-oxoadenine derivatives as potent Toll-like receptor 7 agonists with high water solubility.

Journal: Bioorganic & medicinal chemistry letters 20130201

Title: Nakamura T, et al. Synthesis and evaluation of 8-oxoadenine derivatives as potent Toll-like receptor 7 agonists with high water solubility. Bioorg Med Chem Lett. 2013 Feb 1;23(3):669-72.

Title: Adlard AL, et al. A novel systemically administered Toll-like receptor 7 agonist potentiates the effect of ionizing radiation in murine solid tumor models. Int J Cancer. 2014 Aug 15;135(4):820-9.

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Tags:1059070-10-8 Molecular Formula|1059070-10-8 MDL|1059070-10-8 SMILES|1059070-10-8 6-Amino-2-(butylamino)-9-[[6-[2-(dimethylamino)ethoxy]-3-pyridinyl]methyl]-7,9-dihydro-8H-purin-8-one