Home Fluorides 10596-32-4
10596-32-4,MFCD00233600
Catalog No.:AA0084Q7

10596-32-4 | Difluoromethylenediphosphonic Acid

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2.5mg
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25mg
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA0084Q7
Chemical Name:
Difluoromethylenediphosphonic Acid
CAS Number:
10596-32-4
Molecular Formula:
CH4F2O6P2
Molecular Weight:
211.9832
MDL Number:
MFCD00233600
SMILES:
FC(P(=O)(O)O)(P(=O)(O)O)F
Properties
Computed Properties
 
Complexity:
211  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
11  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
2  
XLogP3:
-2.6  

Literature

Title: Cofactor-type inhibitors of inosine monophosphate dehydrogenase via modular approach: targeting the pyrophosphate binding sub-domain.

Journal: Bioorganic & medicinal chemistry 20110301

Title: Design and synthesis of nonpeptidic, small molecule inhibitors for the Mycobacterium tuberculosis protein tyrosine phosphatase PtpB.

Journal: Organic & biomolecular chemistry 20100921

Title: Antiproliferative activity of purine nucleoside phosphorylase multisubstrate analogue inhibitors containing difluoromethylene phosphonic acid against leukaemia and lymphoma cells.

Journal: Chemical biology & drug design 20100401

Title: 9-Deazaguanine derivatives connected by a linker to difluoromethylene phosphonic acid are slow-binding picomolar inhibitors of trimeric purine nucleoside phosphorylase.

Journal: The FEBS journal 20100401

Title: The alpha,alpha-difluorinated phosphonate L-pSer-analogue: an accessible chemical tool for studying kinase-dependent signal transduction.

Journal: Chemistry & biology 20090925

Title: A re-examination of the difluoromethylenesulfonic acid group as a phosphotyrosine mimic for PTP1B inhibition.

Journal: Bioorganic & medicinal chemistry 20080715

Title: PTP1B inhibitors: synthesis and evaluation of difluoro-methylenephosphonate bioisosteres on a sulfonamide scaffold.

Journal: Bioorganic & medicinal chemistry letters 20080415

Title: Chelation of vanadium(V) by difluoromethylene bisphosphonate, a structural analogue of pyrophosphate.

Journal: Inorganic chemistry 20070806

Title: Synthesis and biological evaluation of 9-deazaguanine derivatives connected by a linker to difluoromethylene phosphonic acid as multi-substrate analogue inhibitors of PNP.

Journal: Bioorganic & medicinal chemistry letters 20070801

Title: Inhibitory properties of nucleotides with difluoromethylenephosphonic acid as a phosphate mimic versus calf spleen purine nucleoside phosphorylase and effect of these analogues on the viability of human blood lymphocytes.

Journal: Nucleosides, nucleotides & nucleic acids 20070101

Title: Synthesis of methylene- and difluoromethylenephosphonate analogues of uridine-4-phosphate and 3-deazauridine-4-phosphate.

Journal: The Journal of organic chemistry 20061208

Title: Synthesis and biological evaluation of 9-(5',5'-difluoro-5'-phosphonopentyl)guanine derivatives for PNP-inhibitors.

Journal: Bioorganic & medicinal chemistry 20060301

Title: Difluoromethylenediphosphonate: a convenient, scalable, and high-yielding synthesis.

Journal: Organic letters 20060119

Title: New metabolically stabilized analogues of lysophosphatidic acid: agonists, antagonists and enzyme inhibitors.

Journal: Biochemical Society transactions 20051201

Title: Discovery and structure-activity relationships of novel sulfonamides as potent PTP1B inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20051001

Title: Alkyl lysophosphatidic acid and fluoromethylene phosphonate analogs as metabolically-stabilized agonists for LPA receptors.

Journal: Bioorganic & medicinal chemistry letters 20041101

Title: [Synthesis of phosphonic acid and phosphinic acid derivatives for development of biologically active compounds].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20041101

Title: Efficient synthesis of protected cyclopropyl beta-aspartylphosphates.

Journal: Organic & biomolecular chemistry 20040221

Title: Synthesis of non-competitive inhibitors of sphingomyelinases with significant activity.

Journal: Bioorganic & medicinal chemistry letters 20030120

Title: Aspartyl phosphonates and phosphoramidates: the first synthetic inhibitors of bacterial aspartate-semialdehyde dehydrogenase.

Journal: Chembiochem : a European journal of chemical biology 20020902

Title: Structure of protein tyrosine phosphatase 1B in complex with inhibitors bearing two phosphotyrosine mimetics.

Journal: Journal of medicinal chemistry 20011220

Title: PPi analogs as inhibitors of human T-lymphotropic virus type III reverse transcriptase.

Journal: Antimicrobial agents and chemotherapy 19860501

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