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Home Other Building Blocks 1061353-68-1
1061353-68-1,MFCD28125506
Catalog No.:AA008TGB

1061353-68-1 | Pnd-1186

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$11.00   $8.00
- +
2mg
98%
in stock  
$15.00   $11.00
- +
5mg
98%
in stock  
$23.00   $16.00
- +
10mg
98%
in stock  
$33.00   $23.00
- +
50mg
98%
in stock  
$84.00   $59.00
- +
250mg
98%
in stock  
$216.00   $151.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA008TGB
Chemical Name:
Pnd-1186
CAS Number:
1061353-68-1
Molecular Formula:
C25H26F3N5O3
Molecular Weight:
501.5008
MDL Number:
MFCD28125506
SMILES:
CNC(=O)c1ccccc1Nc1cc(ncc1C(F)(F)F)Nc1ccc(cc1OC)N1CCOCC1
Properties
Computed Properties
 
Complexity:
709  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
7  
XLogP3:
4.7  

Upstream Synthesis Route

[1]Patent:WO2009/105498,2009,A1,.Locationinpatent:Page/Pagecolumn27-28

[1]Patent:WO2009/105498,2009,A1,

[1]Patent:WO2009/105498,2009,A1,

[1]Patent:WO2012/12139,2012,A1,.Locationinpatent:Page/Pagecolumn27

[1]Patent:WO2012/12139,2012,A1,.Locationinpatent:Page/Pagecolumn29

Downstream Synthesis Route

[1]Patent:WO2009/105498,2009,A1.Locationinpatent:Page/Pagecolumn27-28

2-methoxy-4-morpholinoanilinedihydrochloride 
  1061358-71-1    1061353-68-1 

[1]Patent:WO2012/12139,2012,A1.Locationinpatent:Page/Pagecolumn27

[1]Patent:WO2012/12139,2012,A1.Locationinpatent:Page/Pagecolumn30-31

Literature

Title: FAK signaling in human cancer as a target for therapeutics.

Journal: Pharmacology & therapeutics 20150201

Title: FAK Inhibition disrupts a β5 integrin signaling axis controlling anchorage-independent ovarian carcinoma growth.

Journal: Molecular cancer therapeutics 20140801

Title: PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments.

Journal: Cancer biology & therapy 20100501

Title: Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models.

Journal: Cancer biology & therapy 20100501

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SDS
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