[1]CurrentPatentAssignee:NOVARTISAG;Novartis(w/oSandoz)-US6156907,2000,A
[1]CurrentPatentAssignee:PERMIRAHOLDINGSLIMITED-WO2011/135105,2011,A1Locationinpatent:Page/Pagecolumn18
[2]CurrentPatentAssignee:PERMIRAHOLDINGSLIMITED-EP2465853,2012,A1Locationinpatent:Page/Pagecolumn7
[3]CurrentPatentAssignee:NOVARTISAG;Novartis(w/oSandoz)-US4789680,1988,A
[4]CurrentPatentAssignee:INDOCOREMEDIESLIMITED-WO2012/32540,2012,A1Locationinpatent:Page/Pagecolumn15
[1]TetrahedronLetters,2010,vol.51,p.3229-3231
[2]RSCAdvances,2015,vol.5,p.88816-88820
[3]Patent:US2010/234616,2010,A1.Locationinpatent:Page/Pagecolumn4
[4]Patent:EP2230234,2010,A1.Locationinpatent:Page/Pagecolumn7
[5]Patent:WO2013/105029,2013,A1.Locationinpatent:Page/Pagecolumn8
[6]Patent:US2014/357871,2014,A1.Locationinpatent:Paragraph0040
[7]Science,2019,vol.363
[8]Patent:WO2010/43849,2010,A1.Locationinpatent:Page/Pagecolumn13-14
[9]Patent:WO2012/25936,2012,A2
[10]TetrahedronLetters,2013,vol.54,p.3406-3409
[11]Patent:WO2014/72992,2014,A1.Locationinpatent:Page/Pagecolumn18-19
[1]TetrahedronLetters,2010,vol.51,p.3229-3231
[1]OrganicProcessResearchandDevelopment,2014,vol.18,p.1567-1570
[2]Patent:US2010/234616,2010,A1.Locationinpatent:Page/Pagecolumn4
[3]Patent:EP2230234,2010,A1.Locationinpatent:Page/Pagecolumn6-7
[4]AdvancedSynthesisandCatalysis,2018,vol.360,p.4615-4624
[5]ResearchonChemicalIntermediates,2017,vol.43,p.4711-4717
[6]Chemistry-AEuropeanJournal,2013,vol.19,p.16036-16043
[7]GreenChemistry,2019,vol.21,p.2677-2685
Title: Rufinamide, an antiepileptic drug, improves cognition and increases neurogenesis in the aged gerbil hippocampal dentate gyrus via increasing expressions of IGF-1, IGF-1R and p-CREB.
Journal: Chemico-biological interactions 20180425
Title: Rufinamide efficacy and safety as adjunctive treatment in children with focal drug resistant epilepsy: the first Italian prospective study.
Journal: Epilepsy research 20121101
Title: Rufinamide in children with refractory epilepsy: pharmacokinetics, efficacy, and safety.
Journal: Neuropediatrics 20121001
Title: First long-term experience with the orphan drug rufinamide in children with myoclonic-astatic epilepsy (Doose syndrome).
Journal: European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 20120901
Title: Chemical properties of antiepileptic drugs (AEDs).
Journal: Advanced drug delivery reviews 20120701
Title: Recent and future antiepileptic drugs and their impact on cognition: what can we expect?
Journal: Expert review of neurotherapeutics 20120601
Title: Drug-induced QT-interval shortening following antiepileptic treatment with oral rufinamide.
Journal: Heart rhythm 20120501
Title: Rufinamide as an adjuvant treatment in children with Lennox-Gastaut syndrome.
Journal: Seizure 20120501
Title: Rufinamide: a pharmacoeconomic profile of its use as adjunctive therapy in Lennox-Gastaut syndrome.
Journal: PharmacoEconomics 20120301
Title: [Therapeutic drug monitoring of rufinamide].
Journal: Therapie 20120101
Title: Investigation of the metabolism of rufinamide and its interaction with valproate.
Journal: Drug metabolism letters 20111201
Title: Development and validation of an HPLC-UV detection assay for the determination of rufinamide in human plasma and saliva.
Journal: Analytical and bioanalytical chemistry 20110801
Title: Low long-term efficacy and tolerability of add-on rufinamide in patients with Dravet syndrome.
Journal: Epilepsy & behavior : E&B 20110701
Title: Efficacy of rufinamide in drug-resistant epilepsy: a meta-analysis.
Journal: Pediatric neurology 20110501
Title: Rufinamide from clinical trials to clinical practice in the United States and Europe.
Journal: Epileptic disorders : international epilepsy journal with videotape 20110501
Title: New and forthcoming anti-epileptic drugs.
Journal: Current opinion in neurology 20110401
Title: Rufinamide for the treatment of Lennox-Gastaut syndrome.
Journal: Expert opinion on pharmacotherapy 20110401
Title: Rufinamide for pediatric patients with Lennox-Gastaut syndrome: a comprehensive overview.
Journal: Paediatric drugs 20110401
Title: Management of seizures in Lennox-Gastaut syndrome.
Journal: Paediatric drugs 20110401
Title: Serum concentrations of rufinamide in children and adults with epilepsy: the influence of dose, age, and comedication.
Journal: Therapeutic drug monitoring 20110401
Title: Methyl 1-(2,6-difluoro-benz-yl)-1H-1,2,3-triazole-4-carboxyl-ate.
Journal: Acta crystallographica. Section E, Structure reports online 20110401
Title: Treatment of malignant migrating partial epilepsy of infancy with rufinamide: report of five cases.
Journal: Epileptic disorders : international epilepsy journal with videotape 20110301
Title: Rufinamide in refractory childhood epileptic encephalopathies other than Lennox-Gastaut syndrome.
Journal: European journal of neurology 20110201
Title: A randomized, double-blind, placebo-controlled, parallel-group study of rufinamide as adjunctive therapy for refractory partial-onset seizures.
Journal: Epilepsia 20110201
Title: Activation of suicidal ideation with adjunctive rufinamide in bipolar disorder.
Journal: Epilepsy & behavior : E&B 20110201
Title: Rufinamide for the treatment of epileptic spasms.
Journal: Epilepsy & behavior : E&B 20110201
Title: Pharmacotherapy of epilepsy: newly approved and developmental agents.
Journal: CNS drugs 20110201
Title: Refractory focal epilepsy in a patient with methylmalonic aciduria: case report on positive and long-lasting effect of rufinamide.
Journal: Neuropediatrics 20110201
Title: Epilepsy with myoclonic absences - favourable response to add-on rufinamide treatment in 3 cases.
Journal: Neuropediatrics 20110201
Title: [Lennox-Gastaut syndrome--course and treatment].
Journal: Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20110107
Title: Rapid assay of rufinamide in dried blood spots by a new liquid chromatography-tandem mass spectrometric method.
Journal: Journal of pharmaceutical and biomedical analysis 20110105
Title: Rufinamide for refractory epilepsy in a pediatric and young adult population.
Journal: Epilepsy research 20110101
Title: Bioavailability of three rufinamide oral suspensions compared with the marketed 400-mg tablet formulation: results from a randomized-sequence, open-label, four-period, four-sequence crossover study in healthy subjects.
Journal: Clinical therapeutics 20110101
Title: Ethyl 1-(2,6-difluoro-benz-yl)-1H-1,2,3-triazole-4-carboxyl-ate.
Journal: Acta crystallographica. Section E, Structure reports online 20110101
Title: Update on rufinamide in childhood epilepsy.
Journal: Neuropsychiatric disease and treatment 20110101
Title: Clobazam as an adjunctive therapy in treating seizures associated with Lennox-Gastaut syndrome.
Journal: Neuropsychiatric disease and treatment 20110101
Title: Post-treatment with voltage-gated Na(+) channel blocker attenuates kainic acid-induced apoptosis in rat primary hippocampal neurons.
Journal: Neurochemical research 20101201
Title: New drugs for pediatric epilepsy.
Journal: Seminars in pediatric neurology 20101201
Title: 'Epileptic encephalopathy' of infancy and childhood: electro-clinical pictures and recent understandings.
Journal: Current neuropharmacology 20101201
Title: Rufinamide in children and adults with Lennox-Gastaut syndrome: first Italian multicenter experience.
Journal: Seizure 20101101
Title: Adjunctive rufinamide in Lennox-Gastaut syndrome: a long-term, open-label extension study.
Journal: Acta neurologica Scandinavica 20100901
Title: Emerging drugs for partial onset seizures.
Journal: Expert opinion on emerging drugs 20100901
Title: Experience with rufinamide in a pediatric population: a single center's experience.
Journal: Pediatric neurology 20100901
Title: Antiepileptic drug interactions - principles and clinical implications.
Journal: Current neuropharmacology 20100901
Title: Update on anticonvulsant drugs.
Journal: Current neurology and neuroscience reports 20100701
Title: New antiepileptic drugs: lacosamide, rufinamide, and vigabatrin.
Journal: Current treatment options in neurology 20100701
Title: Rufinamide: a new antiepileptic drug treatment for Lennox-Gastaut syndrome.
Journal: Expert review of neurotherapeutics 20100601
Title: Medical management of Lennox-Gastaut syndrome.
Journal: CNS drugs 20100501
Title: [Antiepileptic drugs in North America].
Journal: Brain and nerve = Shinkei kenkyu no shinpo 20100501
Title: Severe constipation associated with the use of rufinamide (Banzel) in an adolescent.
Journal: Epilepsy & behavior : E&B 20100501
Title: First European long-term experience with the orphan drug rufinamide in childhood-onset refractory epilepsy.
Journal: Epilepsy & behavior : E&B 20100401
Title: Rufinamide: a new antiepileptic medication for the treatment of seizures associated with lennox-gastaut syndrome.
Journal: The Annals of pharmacotherapy 20100401
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20100401
Title: Recent advances in adjunctive therapy for epilepsy: focus on sodium channel blockers as third-generation antiepileptic drugs.
Journal: Drugs of today (Barcelona, Spain : 1998) 20100401
Title: Stability of extemporaneously prepared rufinamide oral suspensions.
Journal: The Annals of pharmacotherapy 20100301
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20100301
Title: Simultaneous HPLC-UV analysis of rufinamide, zonisamide, lamotrigine, oxcarbazepine monohydroxy derivative and felbamate in deproteinized plasma of patients with epilepsy.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100201
Title: A 24-week multicenter, randomized, double-blind, parallel-group, dose-ranging study of rufinamide in adults and adolescents with inadequately controlled partial seizures.
Journal: Epilepsy research 20100201
Title: New Drugs2010, PART 1.
Journal: Nursing 20100201
Title: Supporting the recommended paediatric dosing regimen for rufinamide in Lennox-Gastaut syndrome using clinical trial simulation.
Journal: Journal of pharmacokinetics and pharmacodynamics 20100201
Title: Drug-induced QT interval shortening: potential harbinger of proarrhythmia and regulatory perspectives.
Journal: British journal of pharmacology 20100101
Title: Cost-utility analysis of rufinamide versus topiramate and lamotrigine for the treatment of children with Lennox-Gastaut Syndrome in the United Kingdom.
Journal: Seizure 20100101
Title: Drug interactions involving the new second- and third-generation antiepileptic drugs.
Journal: Expert review of neurotherapeutics 20100101
Title: Rufinamide: a novel broad-spectrum antiepileptic drug.
Journal: Epilepsy currents 20100101
Title: The cost effectiveness of rufinamide in the treatment of Lennox-Gastaut syndrome in the UK.
Journal: PharmacoEconomics 20100101
Title: The possible antianxiety and mood-stabilizing effects of rufinamide.
Journal: Psychotherapy and psychosomatics 20100101
Title: Treating Lennox-Gastaut syndrome in epileptic pediatric patients with third-generation rufinamide.
Journal: Neuropsychiatric disease and treatment 20100101
Title: Lennox-Gastaut syndrome: An overview.
Journal: Journal of pediatric neurosciences 20100101
Title: Expression, regulation and function of phosphofructo-kinase/fructose-biphosphatases (PFKFBs) in glucocorticoid-induced apoptosis of acute lymphoblastic leukemia cells.
Journal: BMC cancer 20100101
Title: Selected pharmacokinetic issues of the use of antiepileptic drugs and parenteral nutrition in critically ill patients.
Journal: Nutrition journal 20100101
Title: Safety and tolerability of rufinamide in children with epilepsy: a pooled analysis of 7 clinical studies.
Journal: Journal of child neurology 20091201
Title: Treatment of Lennox-Gastaut Syndrome (LGS).
Journal: European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 20091101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20091101
Title: Rufinamide for the adjunctive treatment of partial seizures in adults and adolescents: a randomized placebo-controlled trial.
Journal: Epilepsia 20090801
Title: Treatment of Lennox-Gastaut syndrome.
Journal: The Cochrane database of systematic reviews 20090708
Title: Antiepileptic drug monotherapy: the initial approach in epilepsy management.
Journal: Current neuropharmacology 20090601
Title: Transitional polytherapy: tricks of the trade for monotherapy to monotherapy AED conversions.
Journal: Current neuropharmacology 20090601
Title: Truly 'rational' polytherapy: maximizing efficacy and minimizing drug interactions, drug load, and adverse effects.
Journal: Current neuropharmacology 20090601
Title: Minimizing AED adverse effects: improving quality of life in the interictal state in epilepsy care.
Journal: Current neuropharmacology 20090601
Title: Adopting an orphan drug: rufinamide for Lennox-Gastaut syndrome.
Journal: Epilepsy currents 20090501
Title: Rufinamide (Banzel) for epilepsy.
Journal: The Medical letter on drugs and therapeutics 20090309
Title: Effectiveness and tolerability of rufinamide in children and adults with refractory epilepsy: first European experience.
Journal: Epilepsy & behavior : E&B 20090301
Title: American Epilepsy Society--62nd Annual Meeting. 5-9 December 2008, Seattle, USA.
Journal: IDrugs : the investigational drugs journal 20090201
Title: Product: Banzel.
Journal: JAAPA : official journal of the American Academy of Physician Assistants 20090201
Title: New drugs: Febuxostat, lacosamide, and rufinamide.
Journal: Journal of the American Pharmacists Association : JAPhA 20090101
Title: Third-generation antiepileptic drugs: mechanisms of action, pharmacokinetics and interactions.
Journal: Pharmacological reports : PR 20090101
Title: Onset of action and seizure control in Lennox-Gaustaut syndrome: focus on rufinamide.
Journal: Therapeutics and clinical risk management 20090101
Title: Update on the management of Lennox-Gastaut syndrome with a focus on rufinamide.
Journal: Neuropsychiatric disease and treatment 20090101
Title: Treatment of Lennox-Gastaut syndrome: overview and recent findings.
Journal: Neuropsychiatric disease and treatment 20081201
Title: Pregabalin for the management of partial epilepsy.
Journal: Neuropsychiatric disease and treatment 20081201
Title: [Rufinamide. A review of its pharmacokinetic and pharmacodynamic properties].
Journal: Revista de neurologia 20081001
Title: Rufinamide: Further evaluation is needed in Lennox-Gastaut syndrome.
Journal: Prescrire international 20080801
Title: The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models.
Journal: Epilepsia 20080701
Title: Rufinamide: clinical pharmacokinetics and concentration-response relationships in patients with epilepsy.
Journal: Epilepsia 20080701
Title: Rufinamide for generalized seizures associated with Lennox-Gastaut syndrome.
Journal: Neurology 20080520
Title: Use of second-generation antiepileptic drugs in the pediatric population.
Journal: Paediatric drugs 20080101
Title: Pharmacological management of epilepsy: recent advances and future prospects.
Journal: Drugs 20080101
Title: [Rufinamide. An orphan drug for treatment of Lennox-Gastaut syndrome].
Journal: Medizinische Monatsschrift fur Pharmazeuten 20071001
Title: Rufinamide: a new anti-epileptic medication.
Journal: Expert opinion on pharmacotherapy 20070801
Title: Rufinamide.
Journal: Drugs of today (Barcelona, Spain : 1998) 20070701
Title: Physicochemical characterization of solid dispersions of three antiepileptic drugs prepared by solvent evaporation method.
Journal: The Journal of pharmacy and pharmacology 20070501
Title: [A new aspect in the research on antiepileptic drugs].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20070201
Title: Role of rufinamide in the management of Lennox-Gastaut syndrome (childhood epileptic encephalopathy).
Journal: Neuropsychiatric disease and treatment 20070201
Title: Progress report on new antiepileptic drugs: a summary of the Eigth Eilat Conference (EILAT VIII).
Journal: Epilepsy research 20070101
Title: Rufinamide.
Journal: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20070101
Title: Rufinamide: Pharmacology, clinical trials, and role in clinical practice.
Journal: International journal of clinical practice 20061101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20061001
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20060901
Title: The effect of the new antiepileptic drug rufinamide on cognitive functions.
Journal: Epilepsia 20060701
Title: Diverse mechanisms of antiepileptic drugs in the development pipeline.
Journal: Epilepsy research 20060601
Title: New antiepileptic drugs that are second generation to existing antiepileptic drugs.
Journal: Expert opinion on investigational drugs 20060601
Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20060101
Title: Rufinamide.
Journal: CNS drugs 20060101
Title: Rufinamide: CGP 33101, E 2080, RUF 331, Xilep.
Journal: Drugs in R&D 20050101
Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
Journal: The Journal of biological chemistry 20020419
Title: Practice of solid-phase extraction and protein precipitation in the 96-well format combined with high-performance liquid chromatography-ultraviolet detection for the analysis of drugs in plasma and brain.
Journal: Journal of chromatography. B, Biomedical sciences and applications 20010415
Title: Rufinamide: a double-blind, placebo-controlled proof of principle trial in patients with epilepsy.
Journal: Epilepsy research 20010201
Title: Progress report on new antiepileptic drugs: a summary of the Fifth Eilat Conference (EILAT V).
Journal: Epilepsy research 20010101
Title: Effects of antiepileptic drugs on cognition.
Journal: Epilepsia 20010101
Title: Suter MR, Kirschmann G, Laedermann CJ, Rufinamide attenuates mechanical allodynia in a model of neuropathic pain in the mouse and stabilizes voltage-gated sodium channel inactivated state. Anesthesiology. 2013 Jan;118(1):160-72.
Title: White HS, Franklin MR, Kupferberg HJ, The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models. Epilepsia. 2008 Jul;49(7):1213-20.