106375-28-4,MFCD00076620
Catalog No.:AA008RKB

106375-28-4 | OMEGA-CONOTOXIN GVIA

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Purity
Availability
Price(USD)
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1mg
>98%
1 week  
$1,099.00   $769.00
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  • Literature
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Technical Information
Catalog Number:
AA008RKB
Chemical Name:
OMEGA-CONOTOXIN GVIA
CAS Number:
106375-28-4
Molecular Formula:
C120H182N38O43S6
Molecular Weight:
3037.3479
MDL Number:
MFCD00076620
SMILES:
NCCCCC1NC(=O)C(NC(=O)C(Cc2ccc(cc2)O)NC(=O)C2C(O)CCN2C(=O)C(CC(=O)N)NC(=O)C2CSSCC3NC(=O)C(CO)NC(=O)C(CO)NC(=O)CNC(=O)C4N(C(=O)C(NC(=O)C(NC(=O)C(CSSCC(NC(=O)C(CSSCC(NC(=O)C(NC1=O)CCCNC(=N)N)C(=O)NC(C(=O)N)Cc1ccc(cc1)O)NC(=O)C(CC(=O)N)NC(=O)C(Cc1ccc(cc1)O)NC(=O)C(CO)NC(=O)C(NC(=O)C1N(C(=O)C(NC3=O)CO)CCC1O)C(O)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(C(=O)N2)CO)N)CCCCN)CO)CCC4O)C(O)C
Properties
Computed Properties
 
Complexity:
6820  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
31  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
207  
Hydrogen Bond Acceptor Count:
54  
Hydrogen Bond Donor Count:
49  
Isotope Atom Count:
0  
Rotatable Bond Count:
39  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
-15.8  

Literature

Title: Facilitation of sympathetic neurotransmission by phosphatidylinositol-4,5-bisphosphate-dependent regulation of KCNQ channels in rat mesenteric arteries.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20120901

Title: Increased cavernosal relaxation by Phoneutria nigriventer toxin, PnTx2-6, via activation at NO/cGMP signaling.

Journal: International journal of impotence research 20120101

Title: Dissecting a role of evolutionary-conserved but noncritical disulfide bridges in cysteine-rich peptides using ω-conotoxin GVIA and its selenocysteine analogs.

Journal: Biopolymers 20120101

Title: Carisbamate (RWJ-333369) inhibits glutamate transmission in the granule cell of the dentate gyrus.

Journal: Neuropharmacology 20111201

Title: α7-Containing and non-α7-containing nicotinic receptors respond differently to spillover of acetylcholine.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20111019

Title: Mast cells drive mesenteric afferent signalling during acute intestinal ischaemia.

Journal: The Journal of physiology 20110801

Title: Mechanism behind gamma band activity in the pedunculopontine nucleus.

Journal: The European journal of neuroscience 20110801

Title: Pacemaker neurons within newborn spinal pain circuits.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110615

Title: NMDA receptor activation enhances inhibitory GABAergic transmission onto hippocampal pyramidal neurons via presynaptic and postsynaptic mechanisms.

Journal: Journal of neurophysiology 20110601

Title: Calcium microdomains near R-type calcium channels control the induction of presynaptic long-term potentiation at parallel fiber to purkinje cell synapses.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110406

Title: Non-quantal release of acetylcholine in guinea-pig airways: role of choline transporter.

Journal: Experimental physiology 20110401

Title: β-nicotinamide adenine dinucleotide is an enteric inhibitory neurotransmitter in human and nonhuman primate colons.

Journal: Gastroenterology 20110201

Title: Propionate-induced epithelial K(+) and Cl(-)/HCO3(-) secretion and free fatty acid receptor 2 (FFA2, GPR43) expression in the guinea pig distal colon.

Journal: Pflugers Archiv : European journal of physiology 20110101

Title: Nitric oxide-induced vasorelaxation in response to PnTx2-6 toxin from Phoneutria nigriventer spider in rat cavernosal tissue.

Journal: The journal of sexual medicine 20101201

Title: Calcium channel subtypes for cholinergic and nonadrenergic noncholinergic neurotransmission in isolated guinea pig trachea.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20101201

Title: Characterization of ionic currents and electrophysiological properties of goldfish somatotropes in primary culture.

Journal: General and comparative endocrinology 20101201

Title: R-type Ca(2+) channels contribute to fast synaptic excitation and action potentials in subsets of myenteric neurons in the guinea pig intestine.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20101201

Title: Depolarization-induced Ca2+ entry preferentially evokes release of large quanta in the developing Xenopus neuromuscular junction.

Journal: Journal of neurophysiology 20101101

Title: Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relationships.

Journal: Bioorganic & medicinal chemistry 20101101

Title: Modulation of N-type calcium currents by presynaptic imidazoline receptor activation in rat superior cervical ganglion neurons.

Journal: Experimental physiology 20101001

Title: Opioid inhibition of N-type Ca2+ channels and spinal analgesia couple to alternative splicing.

Journal: Nature neuroscience 20101001

Title: Allethrin differentially modulates voltage-gated calcium channel subtypes in rat PC12 cells.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20100801

Title: Developmental increase in D1-like dopamine receptor-mediated inhibition of glutamatergic transmission through P/Q-type channel regulation in the basal forebrain of rats.

Journal: The European journal of neuroscience 20100801

Title: Antioxidant treatment restores prejunctional regulation of purinergic transmission in mesenteric arteries of deoxycorticosterone acetate-salt hypertensive rats.

Journal: Neuroscience 20100630

Title: Acute restraint stress enhances calcium mobilization and glutamate exocytosis in cerebrocortical synaptosomes from mice.

Journal: Neurochemical research 20100501

Title: Site-specific effects of diselenide bridges on the oxidative folding of a cystine knot peptide, omega-selenoconotoxin GVIA.

Journal: Biochemistry 20100330

Title: Voltage-gated calcium channels involved in the inhibitory motor responses and vasoactive intestinal polypeptide release in the rat gastric fundus.

Journal: European journal of pharmacology 20100225

Title: Regulation of glutamatergic and GABAergic neurotransmission in the chick nucleus laminaris: role of N-type calcium channels.

Journal: Neuroscience 20091215

Title: alpha-Synuclein modulation of Ca2+ signaling in human neuroblastoma (SH-SY5Y) cells.

Journal: Journal of neurochemistry 20091201

Title: Phoneutria spider toxins block ischemia-induced glutamate release, neuronal death, and loss of neurotransmission in hippocampus.

Journal: Hippocampus 20091101

Title: Isoflurane inhibits cyclic adenosine monophosphate response element-binding protein phosphorylation and calmodulin translocation to the nucleus of SH-SY5Y cells.

Journal: Anesthesia and analgesia 20091001

Title: Omega-conotoxin GVIA mimetics based on an anthranilamide core: effect of variation in ammonium side chain lengths and incorporation of fluorine.

Journal: Bioorganic & medicinal chemistry 20090915

Title: Nonequilibrium calcium dynamics regulate the autonomous firing pattern of rat striatal cholinergic interneurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20090701

Title: Role of n-type voltage-dependent calcium channels in autoimmune optic neuritis.

Journal: Annals of neurology 20090701

Title: Retrograde opioid signaling regulates glutamatergic transmission in the hypothalamus.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20090603

Title: A functional link between T-type calcium channels and mu-opioid receptor expression in adult primary sensory neurons.

Journal: Journal of neurochemistry 20090501

Title: Inhibition of sympathetic N-type voltage-gated Ca2+ current underlies the reduction in norepinephrine release during colitis.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20090501

Title: KCC2 expression promotes the termination of cortical interneuron migration in a voltage-sensitive calcium-dependent manner.

Journal: Neuron 20090416

Title: Inhibition of transmitter release from rat sympathetic neurons via presynaptic M(1) muscarinic acetylcholine receptors.

Journal: British journal of pharmacology 20090401

Title: omega-Conotoxin-GVIA-sensitive calcium channels on preganglionic nerve terminals in mouse pelvic and celiac ganglia.

Journal: Autonomic neuroscience : basic & clinical 20090312

Title: N-type and P/Q-type calcium channels regulate differentially the release of noradrenaline, ATP and beta-NAD in blood vessels.

Journal: Neuropharmacology 20090201

Title: Deletion of N-type Ca(2+) channel Ca(v)2.2 results in hyperaggressive behaviors in mice.

Journal: The Journal of biological chemistry 20090130

Title: Block of voltage-gated calcium channels stimulates dopamine efflux in rat mesocorticolimbic system.

Journal: Neuropharmacology 20090101

Title: Evaluation of the inhibitory effect of dihydropyridines on N-type calcium channel by virtual three-dimensional pharmacophore modeling.

Journal: Arzneimittel-Forschung 20090101

Title: The inhibition of release by mGlu7 receptors is independent of the Ca2+ channel type but associated to GABAB and adenosine A1 receptors.

Journal: Neuropharmacology 20080901

Title: Coupling specificity of NOP opioid receptors to pertussis-toxin-sensitive Galpha proteins in adult rat stellate ganglion neurons using small interference RNA.

Journal: Journal of neurophysiology 20080901

Title: An experimentally constrained computational model of NMDA oscillations in lamprey CPG neurons.

Journal: Journal of computational neuroscience 20080801

Title: Differential contribution of L-, N-, and P/Q-type calcium channels to [Ca2+]i changes evoked by kainate in hippocampal neurons.

Journal: Neurochemical research 20080801

Title: Oxytocin induces penile erection when injected into the ventral tegmental area of male rats: role of nitric oxide and cyclic GMP.

Journal: The European journal of neuroscience 20080801

Title: Distinct inhibition of voltage-activated Ca2+ channels by delta-opioid agonists in dorsal root ganglion neurons devoid of functional T-type Ca2+ currents.

Journal: Neuroscience 20080602

Title: Role of spinal Cav2.2 and Cav2.1 ion channels in bladder nociception.

Journal: The Journal of urology 20080601

Title: Ibritumomab tiuxetan (Zevalin) combined with reduced-intensity conditioning and allogeneic stem-cell transplantation (SCT) in patients with chemorefractory non-Hodgkin's lymphoma.

Journal: Bone marrow transplantation 20080201

Title: Modulation of Ca2+ channel current by mu opioid receptors in prefrontal cortex pyramidal neurons in rats.

Journal: Acta neurobiologiae experimentalis 20080101

Title: Effects of resveratrol, a grape polyphenol, on catecholamine secretion and synthesis in cultured bovine adrenal medullary cells.

Journal: Biochemical pharmacology 20071203

Title: Prolonged attenuation of amygdala-kindled seizure measures in rats by convection-enhanced delivery of the N-type calcium channel antagonists omega-conotoxin GVIA and omega-conotoxin MVIIA.

Journal: The Journal of pharmacology and experimental therapeutics 20071101

Title: Effects of celecoxib on voltage-gated calcium channel currents in rat pheochromocytoma (PC12) cells.

Journal: Pharmacological research 20070901

Title: Assessment of the effects of L- and N-type Ca2+ channel blocking drugs using canine blood-perfused papillary muscle preparations.

Journal: The Tohoku journal of experimental medicine 20070801

Title: Dehydration increases L-type Ca(2+) current in rat supraoptic neurons.

Journal: The Journal of physiology 20070401

Title: Inhibitory effects of artemisinin on voltage-gated ion channels in intact nodose ganglion neurones of adult rats.

Journal: Basic & clinical pharmacology & toxicology 20070401

Title: Co-assembly of N-type Ca2+ and BK channels underlies functional coupling in rat brain.

Journal: Journal of cell science 20070315

Title: Pyrethroid action on calcium channels: neurotoxicological implications.

Journal: Invertebrate neuroscience : IN 20070301

Title: Voltage-gated currents of tilapia prolactin cells.

Journal: General and comparative endocrinology 20070115

Title: Depletion of ATP and release of presynaptic inhibition in the CA1 region of hippocampal slices during hypoglycemic hypoxia.

Journal: Neuroscience letters 20070103

Title: Alpha-synuclein potentiates Ca2+ influx through voltage-dependent Ca2+ channels.

Journal: Neuroreport 20061218

Title: Unexpected inhibitory regulation of glutamate release from rat cerebrocortical nerve terminals by presynaptic 5-hydroxytryptamine-2A receptors.

Journal: Journal of neuroscience research 20061115

Title: Effects of nimodipine, an L-type calcium channel antagonist, on the chicken's cochlear potentials.

Journal: Hearing research 20061101

Title: M(1) and M(2) muscarinic acetylcholine receptor subtypes mediate Ca(2+) channel current inhibition in rat sympathetic stellate ganglion neurons.

Journal: Journal of neurophysiology 20061101

Title: The SK channel blocker apamin inhibits slow afterhyperpolarization currents in rat gonadotropin-releasing hormone neurones.

Journal: The Journal of physiology 20060715

Title: Voltage-dependent N-type Ca2+ channel activity regulates the interaction between FGF-1 and S100A13 for stress-induced non-vesicular release.

Journal: Cellular and molecular neurobiology 20060501

Title: Impaired feedforward inhibition of the thalamocortical projection in epileptic Ca2+ channel mutant mice, tottering.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20060315

Title: Calcium signaling pathways mediating synaptic potentiation triggered by amyotrophic lateral sclerosis IgG in motor nerve terminals.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20060308

Title: A 'sample-and-hold' pulse-counting integrator as a mechanism for graded memory underlying sensorimotor adaptation.

Journal: Neuron 20060216

Title: Secretion of brain-derived neurotrophic factor from PC12 cells in response to oxidative stress requires autocrine dopamine signaling.

Journal: Journal of neurochemistry 20060201

Title: Effects of the blockade of high voltage-activated calcium channels on in vitro pineal melatonin synthesis.

Journal: Cell biochemistry and function 20060101

Title: PACAP 38 is involved in the non-adrenergic non-cholinergic inhibitory neurotransmission in the pig urinary bladder neck.

Journal: Neurourology and urodynamics 20060101

Title: Pharmacological investigation of voltage-dependent Ca2+ channels in human ejaculatory sperm in vitro.

Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20060101

Title: Inhibition [corrected] of olfactory receptor neuron input to olfactory bulb glomeruli mediated by suppression of presynaptic calcium influx.

Journal: Journal of neurophysiology 20051001

Title: Presynaptic N-type and P/Q-type Ca2+ channels mediating synaptic transmission at the calyx of Held of mice.

Journal: The Journal of physiology 20051001

Title: CCL2 and CXCL1 trigger calcitonin gene-related peptide release by exciting primary nociceptive neurons.

Journal: Journal of neuroscience research 20051001

Title: Behaviorally relevant endocannabinoid action in hippocampus: dependence on temporal summation of multiple inputs.

Journal: Behavioural pharmacology 20050901

Title: Involvement of different calcium channels in the depolarization-evoked release of noradrenaline from sympathetic neurones in rabbit carotid artery.

Journal: Basic & clinical pharmacology & toxicology 20050801

Title: Effect of a cyclohexenonic long-chain fatty alcohol on calcium mobilization.

Journal: European journal of pharmacology 20050615

Title: Kynurenine 3-mono-oxygenase inhibitors reduce glutamate concentration in the extracellular spaces of the basal ganglia but not in those of the cortex or hippocampus.

Journal: Neuropharmacology 20050501

Title: Characteristics of omega-conotoxin GVI A and MVIIC binding to Cav 2.1 and Cav 2.2 channels captured by anti-Ca2+ channel peptide antibodies.

Journal: Neurochemical research 20050401

Title: Gabapentin fails to alter P/Q-type Ca2+ channel-mediated synaptic transmission in the hippocampus in vitro.

Journal: Synapse (New York, N.Y.) 20050315

Title: Emergence of a R-type Ca2+ channel (CaV 2.3) contributes to cerebral artery constriction after subarachnoid hemorrhage.

Journal: Circulation research 20050304

Title: Pharmacological investigation of hydrogen sulfide (H2S) contractile activity in rat detrusor muscle.

Journal: European journal of pharmacology 20050221

Title: Involvement of cyclooxygenase-dependent pathway in contraction of isolated ileum by urotensin II.

Journal: Peptides 20050201

Title: Sensitization of mesenteric afferents to chemical and mechanical stimuli following systemic bacterial lipopolysaccharide.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20050201

Title: Intracellular calcium store filling by an L-type calcium current in the basolateral amygdala at subthreshold membrane potentials.

Journal: The Journal of physiology 20050115

Title: Omega-agatoxin-TK is a useful tool to study P-type Ca2+ channel-mediated changes in internal Ca2+ and glutamate release in depolarised brain nerve terminals.

Journal: Neurochemistry international 20050101

Title: Melanotrope cells of Xenopus laevis express multiple types of high-voltage-activated Ca2+ channels.

Journal: Journal of neuroendocrinology 20050101

Title: Testosterone modulates Ca(v2.2) calcium channels' functional expression at rat levator ani neuromuscular junction.

Journal: Neuroscience 20050101

Title: Release of beta-nicotinamide adenine dinucleotide upon stimulation of postganglionic nerve terminals in blood vessels and urinary bladder.

Journal: The Journal of biological chemistry 20041119

Title: Developmental changes in release properties of the CA3-CA1 glutamate synapse in rat hippocampus.

Journal: Journal of neurophysiology 20041101

Title: Isoflurane reduces the carbachol-evoked Ca2+ influx in neuronal cells.

Journal: Anesthesiology 20041001

Title: Adenosine A(1)-receptor-mediated tonic inhibition of glutamate release at rat hippocampal CA3-CA1 synapses is primarily due to inhibition of N-type Ca(2+) channels.

Journal: European journal of pharmacology 20040924

Title: Determination of exocytosis mechanisms of DOPA in rat striatum using in vivo microdialysis.

Journal: Neuroscience letters 20040902

Title: Dual effects of gabapentin and pregabalin on glutamate release at rat entorhinal synapses in vitro.

Journal: The European journal of neuroscience 20040901

Title: R-type calcium channels in myenteric neurons of guinea pig small intestine.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20040701

Title: Effects of Ca2+ channel antagonists on acetylcholine and catecholamine releases in the in vivo rat adrenal medulla.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20040701

Title: A model of reverse spike frequency adaptation and repetitive firing of subthalamic nucleus neurons.

Journal: Journal of neurophysiology 20040501

Title: High expression of the R-type voltage-gated Ca2+ channel and its involvement in Ca2+-dependent gonadotropin-releasing hormone release in GT1-7 cells.

Journal: Endocrinology 20040501

Title: Capacitance measurements of exocytosis in mouse pancreatic alpha-, beta- and delta-cells within intact islets of Langerhans.

Journal: The Journal of physiology 20040501

Title: Gamma-aminobutyric acid type B receptors facilitate L-type and attenuate N-type Ca(2+) currents in isolated hippocampal neurons.

Journal: Journal of neuroscience research 20040501

Title: Distinct properties of presynaptic group II and III metabotropic glutamate receptor-mediated inhibition of perforant pathway-CA1 EPSCs.

Journal: The European journal of neuroscience 20040501

Title: Role of the epithelium and acetylcholine in mediating the contraction to 5-hydroxytryptamine in the mouse isolated trachea.

Journal: British journal of pharmacology 20040401

Title: Impaired nitric oxide production of the myenteric plexus in colitis detected by a new bioimaging system.

Journal: The Journal of surgical research 20040401

Title: Spatial Distribution of Calcium Entry Evoked by Single Action Potentials within the Presynaptic Active Zone.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20040324

Title: Low-threshold L-type calcium channels in rat dopamine neurons.

Journal: Journal of neurophysiology 20040301

Title: Opioid-mediated modulation of calcium currents in striatal and pallidal neurons following reserpine treatment: focus on kappa response.

Journal: Synapse (New York, N.Y.) 20040301

Title: 5-Hydroxytryptamine 1B receptors mediate presynaptic inhibition of monosynaptic IPSC in the rat dorsolateral septal nucleus.

Journal: Neuroscience research 20040301

Title: Modulation of voltage-gated Ca2+ current by 4-hydroxynonenal in dentate granule cells.

Journal: Biological & pharmaceutical bulletin 20040201

Title: Heterogeneity of neuronal and smooth muscle receptors involved in the VIP- and PACAP-induced relaxations of the pig intravesical ureter.

Journal: British journal of pharmacology 20040101

Title: Pharmacological dissection of calcium channel subtype-related components of strontium inflow in large mossy fiber boutons of mouse hippocampus.

Journal: Hippocampus 20040101

Title: NG-nitro-L-arginine methyl ester-induced norepinephrine release from cardiac sympathetic nerve endings in anesthetized cats.

Journal: Neuroscience letters 20031226

Title: Calcium current subtypes in GnRH neurons.

Journal: Biology of reproduction 20031201

Title: Adenosine A(1) receptor-mediated presynaptic inhibition at the calyx of Held of immature rats.

Journal: The Journal of physiology 20031201

Title: Neurotensin stimulates both calcium mobilization from inositol trisphosphate-sensitive intracellular stores and calcium influx through membrane channels in frog pituitary melanotrophs.

Journal: Endocrinology 20031201

Title: Contraction of isolated guinea-pig ileum by urotensin II via activation of ganglionic cholinergic neurons and acetylcholine release.

Journal: Neuropharmacology 20031201

Title: Plastic change of N-type Ca channel expression after preconditioning is responsible for prostaglandin E2-induced long-lasting allodynia.

Journal: Anesthesiology 20031201

Title: Structural specificity for the inhibitory effect of calmodulin on specific 125I-omega-conotoxin GVIA binding.

Journal: Neurochemical research 20031201

Title: 5-HT inhibits N-type but not L-type Ca(2+) channels via 5-HT1A receptors in lamprey spinal neurons.

Journal: The European journal of neuroscience 20031201

Title: Gabapentin actions on Kir3 currents and N-type Ca2+ channels via GABAB receptors in hippocampal pyramidal cells.

Journal: Synapse (New York, N.Y.) 20031101

Title: Effects of acetylcholinesterase and butyrylcholinesterase on cell survival, neurite outgrowth, and voltage-dependent calcium currents of embryonic ventral mesencephalic neurons.

Journal: Experimental neurology 20031101

Title: Dynamics of Ca(2+) and Na(+) in the dendrites of mouse cerebellar Purkinje cells evoked by parallel fibre stimulation.

Journal: The European journal of neuroscience 20031101

Title: Development of Ca2+-channel and BK-channel expression in embryos and larvae of Xenopus laevis.

Journal: The European journal of neuroscience 20031001

Title: Atypical relaxation by scorpion venom in the lamb urethral smooth muscle involves both NO-dependent and -independent responses.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20030901

Title: Tumor necrosis factor alpha increases cytosolic calcium responses to AMPA and KCl in primary cultures of rat hippocampal neurons.

Journal: Brain research 20030815

Title: Functional significance of cannabinoid-mediated, depolarization-induced suppression of inhibition (DSI) in the hippocampus.

Journal: Journal of neurophysiology 20030701

Title: Expression and modulation of an invertebrate presynaptic calcium channel alpha1 subunit homolog.

Journal: The Journal of biological chemistry 20030606

Title: Gabapentin blocks L-type and P/Q-type Ca2+ channels involved in depolarization-stimulated nitric oxide synthase activity in primary cultures of neurons from mouse cerebral cortex.

Journal: Pharmaceutical research 20030601

Title: Calcium channels involved in noradrenaline release from sympathetic neurones in rabbit carotid artery.

Journal: Pharmacology & toxicology 20030501

Title: A comparison of Ca2+ channel blocking mode between gabapentin and verapamil: implication for protection against hypoxic injury in rat cerebrocortical slices.

Journal: British journal of pharmacology 20030501

Title: Palytoxin-induced increase in cytosolic-free Ca(2+) in mouse spleen cells.

Journal: European journal of pharmacology 20030328

Title: Effect of arvanil (N-arachidonoyl-vanillyl-amine), a nonpungent anandamide-capsaicin hybrid, on ion currents in NG108-15 neuronal cells.

Journal: Biochemical pharmacology 20030215

Title: Therapeutically relevant concentrations of neomycin selectively inhibit P-type Ca2+ channels in rat striatum.

Journal: European journal of pharmacology 20030214

Title: Endogenous and exogenous dopamine presynaptically inhibits glutamatergic reticulospinal transmission via an action of D2-receptors on N-type Ca2+ channels.

Journal: The European journal of neuroscience 20030201

Title: Functional interaction between neuropeptide Y receptors and modulation of calcium channels in the rat hippocampus.

Journal: Neuropharmacology 20030201

Title: Parallel decrease in omega-conotoxin-sensitive transmission and dopamine-induced inhibition at the striatal synapse of developing rats.

Journal: The Journal of physiology 20030115

Title: Role of voltage-gated cation channels and axon reflexes in the release of sensory neuropeptides by capsaicin from isolated rat trachea.

Journal: European journal of pharmacology 20030105

Title: Modulation of ACh release by presynaptic muscarinic autoreceptors in the neuromuscular junction of the newborn and adult rat.

Journal: The European journal of neuroscience 20030101

Title: Pharmacological evidence that tetraethylammonium-sensitive, iberiotoxin-insensitive K+ channels function as a negative feedback element for sympathetic neurotransmission by suppressing omega-conotoxin-GVIA-insensitive Ca2+ channels in the relaxation of rabbit facial vein.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20030101

Title: Activation of group II mGlu receptors inhibits voltage-gated Ca2+ currents in myenteric neurons.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20021201

Title: Mechanism of nicotine-evoked release of 3H-noradrenaline in human cerebral cortex slices.

Journal: British journal of pharmacology 20021201

Title: Modulation of Ca2+ channel currents in primary cultures of rat cortical neurones by amyloid beta protein (1-40) is dependent on solubility status.

Journal: Brain research 20021129

Title: Involvement of T-type calcium channels in excitatory junction potentials in rat resistance mesenteric arteries.

Journal: British journal of pharmacology 20021101

Title: Nociceptin/orphanin FQ modulation of ionic conductances in rat basal forebrain neurons.

Journal: The Journal of pharmacology and experimental therapeutics 20021001

Title: Actions of intrathecal omega-conotoxins CVID, GVIA, MVIIA, and morphine in acute and neuropathic pain in the rat.

Journal: European journal of pharmacology 20020920

Title: Inhibitory effects of intravenous anaesthetic agents on K(+)-evoked glutamate release from rat cerebrocortical slices. Involvement of voltage-sensitive Ca(2+) channels and GABA(A) receptors.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20020901

Title: Presynaptic factors in the regulation of DSI expression in hippocampus.

Journal: Neuropharmacology 20020901

Title: PICK1 is required for the control of synaptic transmission by the metabotropic glutamate receptor 7.

Journal: The EMBO journal 20020617

Title: A perforated patch-clamp study of calcium currents and exocytosis in chromaffin cells of wild-type and alpha(1A) knockout mice.

Journal: Journal of neurochemistry 20020601

Title: Block of L-type Ca2+ current by beauvericin, a toxic cyclopeptide, in the NG108-15 neuronal cell line.

Journal: Chemical research in toxicology 20020601

Title: Differential Ca2+-dependence of transmitter release mediated by P/Q- and N-type calcium channels at neonatal rat neuromuscular junctions.

Journal: The European journal of neuroscience 20020601

Title: Antagonistic interaction between BIIE 0246, a neuropeptide Y Y2-receptor antagonist, and omega-conotoxin GVIA, a Ca2+ channel antagonist, in presynaptic transmitter releases in dog splenic arteries.

Journal: Japanese journal of pharmacology 20020601

Title: Functional characterization of calcium channels localized on the growth cones of cultured rat dorsal root ganglion cells.

Journal: Neuroscience letters 20020531

Title: Modulatory effects of ketamine on catecholamine efflux from in vivo cardiac sympathetic nerve endings in cats.

Journal: Neuroscience letters 20020524

Title: Neuropeptide Y inhibits spontaneous alpha-melanocyte-stimulating hormone (alpha-MSH) release via a Y(5) receptor and suppresses thyrotropin-releasing hormone-induced alpha-MSH secretion via a Y(1) receptor in frog melanotrope cells.

Journal: Endocrinology 20020501

Title: Recombinant GABA(B) receptors formed from GABA(B1) and GABA(B2) subunits selectively inhibit N-type Ca(2+) channels in NG108-15 cells.

Journal: European journal of pharmacology 20020405

Title: Ca2+ involvement in the action potential generation of myenteric neurones in the rat oesophagus.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20020401

Title: The cognition-enhancer nefiracetam is protective in BDNF-independent neuronal cell death under the serum-free condition.

Journal: Neurochemistry international 20020201

Title: Inhibitory effect of the plant-extract osthole on L-type calcium current in NG108-15 neuronal cells.

Journal: Biochemical pharmacology 20020115

Title: Selective blockade of N-type calcium channels by levetiracetam.

Journal: Epilepsia 20020101

Title: High-affinity inhibition of glutamate release from corticostriatal synapses by omega-agatoxin TK.

Journal: European journal of pharmacology 20011102

Title: Evidence against an action of mibefradil at N-type voltage-operated calcium channels.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20011101

Title: Effects of calcium antagonists on the nitrergic nerve function in canine corpus cavernosum.

Journal: Japanese journal of pharmacology 20011101

Title: Histological demonstration of voltage dependent calcium channels on calcitonin gene-related peptide-immunoreactive nerve fibres in the mouse knee joint.

Journal: Neuroscience letters 20011026

Title: Changes in Ca(2+) channel expression upon differentiation of SN56 cholinergic cells.

Journal: Brain research 20011019

Title: Effects of calcium channel antagonists on the corpora allata of adult male loreyi leafworm Mythimna loreyi: juvenile hormone acids release and intracellular calcium level.

Journal: Archives of insect biochemistry and physiology 20011001

Title: Attenuation of Zn2+ neurotoxicity by aspirin: role of N-type Ca2+ channel and the carboxyl acid group.

Journal: Neurobiology of disease 20011001

Title: Glutamate-mediated extrasynaptic inhibition: direct coupling of NMDA receptors to Ca(2+)-activated K+ channels.

Journal: Neuron 20010927

Title: Modulation of voltage-dependent calcium currents by serotonin in acutely isolated rat amygdala neurons.

Journal: Synapse (New York, N.Y.) 20010915

Title: Nitric oxide-cGMP pathway facilitates acetylcholine release and bradycardia during vagal nerve stimulation in the guinea-pig in vitro.

Journal: The Journal of physiology 20010901

Title: Somatostatin inhibits exocytosis in rat pancreatic alpha-cells by G(i2)-dependent activation of calcineurin and depriming of secretory granules.

Journal: The Journal of physiology 20010901

Title: E(f)-current contributes to whole-cell calcium current in low calcium in frog sympathetic neurons.

Journal: Journal of neurophysiology 20010901

Title: Norepinephrine acts via alpha(2) adrenergic receptors to suppress N-type calcium channels in dissociated rat median preoptic nucleus neurons.

Journal: Neuropharmacology 20010901

Title: The chemokine interleukin-8 acutely reduces Ca(2+) currents in identified cholinergic septal neurons expressing CXCR1 and CXCR2 receptor mRNAs.

Journal: Journal of neurochemistry 20010901

Title: Modulation of N-type Ca2+ channel current kinetics by PMA in rat sympathetic neurons.

Journal: Pflugers Archiv : European journal of physiology 20010901

Title: Suppression of Ca2+ influx through L-type voltage-dependent calcium channels by hydroxyl radical in mouse cerebral cortical neurons.

Journal: Brain research. Molecular brain research 20010815

Title: Differential nociceptive responses in mice lacking the alpha(1B) subunit of N-type Ca(2+) channels.

Journal: Neuroreport 20010808

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Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20010801

Title: Calcium channels in Xenopus spinal neurons differ in somas and presynaptic terminals.

Journal: Journal of neurophysiology 20010701

Title: Nitric oxide modulates Ca(2+) channels in dorsal root ganglion neurons innervating rat urinary bladder.

Journal: Journal of neurophysiology 20010701

Title: Substance P and neurokinin A mediate sensory synaptic transmission in young rat dorsal horn neurons.

Journal: Brain research bulletin 20010701

Title: Levetiracetam inhibits the high-voltage-activated Ca(2+) current in pyramidal neurones of rat hippocampal slices.

Journal: Neuroscience letters 20010622

Title: Dopamine D(2)-like receptors selectively block N-type Ca(2+) channels to reduce GABA release onto rat striatal cholinergic interneurones.

Journal: The Journal of physiology 20010601

Title: Pharmacological discrimination between effects of carbamazepine on hippocampal basal, Ca(2+)- and K(+)-evoked serotonin release.

Journal: British journal of pharmacology 20010601

Title: Nicotine-evoked transmitter release from synaptosomes: functional association of specific presynaptic acetylcholine receptors and voltage-gated calcium channels.

Journal: Journal of neurochemistry 20010601

Title: Control of secretion by mitochondria depends on the size of the local [Ca2+] after chromaffin cell stimulation.

Journal: The European journal of neuroscience 20010601

Title: Residue Gly1326 of the N-type calcium channel alpha 1B subunit controls reversibility of omega-conotoxin GVIA and MVIIA block.

Journal: The Journal of biological chemistry 20010511

Title: Coupling of L-type voltage-sensitive calcium channels to P2X(2) purinoceptors in PC-12 cells.

Journal: American journal of physiology. Cell physiology 20010501

Title: Arachidonic acid both inhibits and enhances whole cell calcium currents in rat sympathetic neurons.

Journal: American journal of physiology. Cell physiology 20010501

Title: Arachidonic acid reversibly enhances N-type calcium current at an extracellular site.

Journal: American journal of physiology. Cell physiology 20010501

Title: Oxytocin retrogradely inhibits evoked, but not miniature, EPSCs in the rat supraoptic nucleus: role of N- and P/Q-type calcium channels.

Journal: The Journal of physiology 20010501

Title: Protein kinase C regulation of dopamine transporter initiated by nicotinic receptor activation in slices of rat prefrontal cortex.

Journal: Journal of neurochemistry 20010501

Title: Dystonia and cerebellar atrophy in Cacna1a null mice lacking P/Q calcium channel activity.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010501

Title: Afterhyperpolarization current in myenteric neurons of the guinea pig duodenum.

Journal: Journal of neurophysiology 20010501

Title: Pharmacological and biophysical characterization of voltage-gated calcium currents in the endopiriform nucleus of the guinea pig.

Journal: Journal of neurophysiology 20010501

Title: The activation of mu opioid receptors promotes a small modulation of calcium currents in rat pallidal neurons.

Journal: Brain research 20010406

Title: Omega-conotoxin GVIA potently inhibits the currents mediated by P2X receptors in rat DRG neurons.

Journal: Brain research bulletin 20010315

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Title: Differential effects of omega-conotoxin GVIA, nimodipine, calmidazolium and KN-62 injected intrathecally on the antinociception induced by beta-endorphin, morphine and [D-Ala2,N-MePhe4,Gly-ol5]-enkephalin administered intracerebroventricularly in the mouse.

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Title: Omega-conotoxin prevents apomorphine- and oxytocin-induced penile erection and yawning in male rats.

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Title: Differential effects of acute and repeated electrically and chemically induced seizures on [3H]Nimodipine and [125I]omega-conotoxin GVIA binding in rat brain.

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Tags:106375-28-4 Molecular Formula|106375-28-4 MDL|106375-28-4 SMILES|106375-28-4 OMEGA-CONOTOXIN GVIA
Catalog No.: AA008RKB
106375-28-4,MFCD00076620
106375-28-4 | OMEGA-CONOTOXIN GVIA
Pack Size: 1mg
Purity: >98%
1 week
$1,099.00 $769.00
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Technical Information
Catalog Number: AA008RKB
Chemical Name: OMEGA-CONOTOXIN GVIA
CAS Number: 106375-28-4
Molecular Formula: C120H182N38O43S6
Molecular Weight: 3037.3479
MDL Number: MFCD00076620
SMILES: NCCCCC1NC(=O)C(NC(=O)C(Cc2ccc(cc2)O)NC(=O)C2C(O)CCN2C(=O)C(CC(=O)N)NC(=O)C2CSSCC3NC(=O)C(CO)NC(=O)C(CO)NC(=O)CNC(=O)C4N(C(=O)C(NC(=O)C(NC(=O)C(CSSCC(NC(=O)C(CSSCC(NC(=O)C(NC1=O)CCCNC(=N)N)C(=O)NC(C(=O)N)Cc1ccc(cc1)O)NC(=O)C(CC(=O)N)NC(=O)C(Cc1ccc(cc1)O)NC(=O)C(CO)NC(=O)C(NC(=O)C1N(C(=O)C(NC3=O)CO)CCC1O)C(O)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(C(=O)N2)CO)N)CCCCN)CO)CCC4O)C(O)C
Properties
Complexity: 6820  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 31  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 207  
Hydrogen Bond Acceptor Count: 54  
Hydrogen Bond Donor Count: 49  
Isotope Atom Count: 0  
Rotatable Bond Count: 39  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: -15.8  
Literature fold

Title: Facilitation of sympathetic neurotransmission by phosphatidylinositol-4,5-bisphosphate-dependent regulation of KCNQ channels in rat mesenteric arteries.

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Title: Dissecting a role of evolutionary-conserved but noncritical disulfide bridges in cysteine-rich peptides using ω-conotoxin GVIA and its selenocysteine analogs.

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Title: Carisbamate (RWJ-333369) inhibits glutamate transmission in the granule cell of the dentate gyrus.

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Journal: General and comparative endocrinology20101201

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Title: Depolarization-induced Ca2+ entry preferentially evokes release of large quanta in the developing Xenopus neuromuscular junction.

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Journal: Nature neuroscience20101001

Title: Allethrin differentially modulates voltage-gated calcium channel subtypes in rat PC12 cells.

Journal: Toxicological sciences : an official journal of the Society of Toxicology20100801

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Title: Antioxidant treatment restores prejunctional regulation of purinergic transmission in mesenteric arteries of deoxycorticosterone acetate-salt hypertensive rats.

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Title: Acute restraint stress enhances calcium mobilization and glutamate exocytosis in cerebrocortical synaptosomes from mice.

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Journal: Biochemistry20100330

Title: Voltage-gated calcium channels involved in the inhibitory motor responses and vasoactive intestinal polypeptide release in the rat gastric fundus.

Journal: European journal of pharmacology20100225

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Journal: Neuroscience20091215

Title: alpha-Synuclein modulation of Ca2+ signaling in human neuroblastoma (SH-SY5Y) cells.

Journal: Journal of neurochemistry20091201

Title: Phoneutria spider toxins block ischemia-induced glutamate release, neuronal death, and loss of neurotransmission in hippocampus.

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Title: Nonequilibrium calcium dynamics regulate the autonomous firing pattern of rat striatal cholinergic interneurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20090701

Title: Role of n-type voltage-dependent calcium channels in autoimmune optic neuritis.

Journal: Annals of neurology20090701

Title: Retrograde opioid signaling regulates glutamatergic transmission in the hypothalamus.

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Title: Coupling specificity of NOP opioid receptors to pertussis-toxin-sensitive Galpha proteins in adult rat stellate ganglion neurons using small interference RNA.

Journal: Journal of neurophysiology20080901

Title: An experimentally constrained computational model of NMDA oscillations in lamprey CPG neurons.

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Title: Differential contribution of L-, N-, and P/Q-type calcium channels to [Ca2+]i changes evoked by kainate in hippocampal neurons.

Journal: Neurochemical research20080801

Title: Oxytocin induces penile erection when injected into the ventral tegmental area of male rats: role of nitric oxide and cyclic GMP.

Journal: The European journal of neuroscience20080801

Title: Distinct inhibition of voltage-activated Ca2+ channels by delta-opioid agonists in dorsal root ganglion neurons devoid of functional T-type Ca2+ currents.

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Journal: Biochemical pharmacology20071203

Title: Prolonged attenuation of amygdala-kindled seizure measures in rats by convection-enhanced delivery of the N-type calcium channel antagonists omega-conotoxin GVIA and omega-conotoxin MVIIA.

Journal: The Journal of pharmacology and experimental therapeutics20071101

Title: Effects of celecoxib on voltage-gated calcium channel currents in rat pheochromocytoma (PC12) cells.

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Journal: The Tohoku journal of experimental medicine20070801

Title: Dehydration increases L-type Ca(2+) current in rat supraoptic neurons.

Journal: The Journal of physiology20070401

Title: Inhibitory effects of artemisinin on voltage-gated ion channels in intact nodose ganglion neurones of adult rats.

Journal: Basic & clinical pharmacology & toxicology20070401

Title: Co-assembly of N-type Ca2+ and BK channels underlies functional coupling in rat brain.

Journal: Journal of cell science20070315

Title: Pyrethroid action on calcium channels: neurotoxicological implications.

Journal: Invertebrate neuroscience : IN20070301

Title: Voltage-gated currents of tilapia prolactin cells.

Journal: General and comparative endocrinology20070115

Title: Depletion of ATP and release of presynaptic inhibition in the CA1 region of hippocampal slices during hypoglycemic hypoxia.

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Title: Alpha-synuclein potentiates Ca2+ influx through voltage-dependent Ca2+ channels.

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Journal: Journal of neuroscience research20061115

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Title: M(1) and M(2) muscarinic acetylcholine receptor subtypes mediate Ca(2+) channel current inhibition in rat sympathetic stellate ganglion neurons.

Journal: Journal of neurophysiology20061101

Title: The SK channel blocker apamin inhibits slow afterhyperpolarization currents in rat gonadotropin-releasing hormone neurones.

Journal: The Journal of physiology20060715

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Journal: Cellular and molecular neurobiology20060501

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Title: A 'sample-and-hold' pulse-counting integrator as a mechanism for graded memory underlying sensorimotor adaptation.

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Title: Secretion of brain-derived neurotrophic factor from PC12 cells in response to oxidative stress requires autocrine dopamine signaling.

Journal: Journal of neurochemistry20060201

Title: Effects of the blockade of high voltage-activated calcium channels on in vitro pineal melatonin synthesis.

Journal: Cell biochemistry and function20060101

Title: PACAP 38 is involved in the non-adrenergic non-cholinergic inhibitory neurotransmission in the pig urinary bladder neck.

Journal: Neurourology and urodynamics20060101

Title: Pharmacological investigation of voltage-dependent Ca2+ channels in human ejaculatory sperm in vitro.

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Title: Inhibition [corrected] of olfactory receptor neuron input to olfactory bulb glomeruli mediated by suppression of presynaptic calcium influx.

Journal: Journal of neurophysiology20051001

Title: Presynaptic N-type and P/Q-type Ca2+ channels mediating synaptic transmission at the calyx of Held of mice.

Journal: The Journal of physiology20051001

Title: CCL2 and CXCL1 trigger calcitonin gene-related peptide release by exciting primary nociceptive neurons.

Journal: Journal of neuroscience research20051001

Title: Behaviorally relevant endocannabinoid action in hippocampus: dependence on temporal summation of multiple inputs.

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Title: Involvement of different calcium channels in the depolarization-evoked release of noradrenaline from sympathetic neurones in rabbit carotid artery.

Journal: Basic & clinical pharmacology & toxicology20050801

Title: Effect of a cyclohexenonic long-chain fatty alcohol on calcium mobilization.

Journal: European journal of pharmacology20050615

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Title: Characteristics of omega-conotoxin GVI A and MVIIC binding to Cav 2.1 and Cav 2.2 channels captured by anti-Ca2+ channel peptide antibodies.

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Title: Gabapentin fails to alter P/Q-type Ca2+ channel-mediated synaptic transmission in the hippocampus in vitro.

Journal: Synapse (New York, N.Y.)20050315

Title: Emergence of a R-type Ca2+ channel (CaV 2.3) contributes to cerebral artery constriction after subarachnoid hemorrhage.

Journal: Circulation research20050304

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Journal: European journal of pharmacology20050221

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Title: Sensitization of mesenteric afferents to chemical and mechanical stimuli following systemic bacterial lipopolysaccharide.

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Journal: The Journal of physiology20050115

Title: Omega-agatoxin-TK is a useful tool to study P-type Ca2+ channel-mediated changes in internal Ca2+ and glutamate release in depolarised brain nerve terminals.

Journal: Neurochemistry international20050101

Title: Melanotrope cells of Xenopus laevis express multiple types of high-voltage-activated Ca2+ channels.

Journal: Journal of neuroendocrinology20050101

Title: Testosterone modulates Ca(v2.2) calcium channels' functional expression at rat levator ani neuromuscular junction.

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Journal: The Journal of biological chemistry20041119

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Title: Isoflurane reduces the carbachol-evoked Ca2+ influx in neuronal cells.

Journal: Anesthesiology20041001

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Journal: European journal of pharmacology20040924

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Journal: The European journal of neuroscience20040901

Title: R-type calcium channels in myenteric neurons of guinea pig small intestine.

Journal: American journal of physiology. Gastrointestinal and liver physiology20040701

Title: Effects of Ca2+ channel antagonists on acetylcholine and catecholamine releases in the in vivo rat adrenal medulla.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology20040701

Title: A model of reverse spike frequency adaptation and repetitive firing of subthalamic nucleus neurons.

Journal: Journal of neurophysiology20040501

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Journal: Endocrinology20040501

Title: Capacitance measurements of exocytosis in mouse pancreatic alpha-, beta- and delta-cells within intact islets of Langerhans.

Journal: The Journal of physiology20040501

Title: Gamma-aminobutyric acid type B receptors facilitate L-type and attenuate N-type Ca(2+) currents in isolated hippocampal neurons.

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Journal: The European journal of neuroscience20040501

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Journal: British journal of pharmacology20040401

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Journal: Journal of neurophysiology20040301

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Title: 5-Hydroxytryptamine 1B receptors mediate presynaptic inhibition of monosynaptic IPSC in the rat dorsolateral septal nucleus.

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Journal: British journal of pharmacology20040101

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Journal: Hippocampus20040101

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Journal: The Journal of physiology20031201

Title: Neurotensin stimulates both calcium mobilization from inositol trisphosphate-sensitive intracellular stores and calcium influx through membrane channels in frog pituitary melanotrophs.

Journal: Endocrinology20031201

Title: Contraction of isolated guinea-pig ileum by urotensin II via activation of ganglionic cholinergic neurons and acetylcholine release.

Journal: Neuropharmacology20031201

Title: Plastic change of N-type Ca channel expression after preconditioning is responsible for prostaglandin E2-induced long-lasting allodynia.

Journal: Anesthesiology20031201

Title: Structural specificity for the inhibitory effect of calmodulin on specific 125I-omega-conotoxin GVIA binding.

Journal: Neurochemical research20031201

Title: 5-HT inhibits N-type but not L-type Ca(2+) channels via 5-HT1A receptors in lamprey spinal neurons.

Journal: The European journal of neuroscience20031201

Title: Gabapentin actions on Kir3 currents and N-type Ca2+ channels via GABAB receptors in hippocampal pyramidal cells.

Journal: Synapse (New York, N.Y.)20031101

Title: Effects of acetylcholinesterase and butyrylcholinesterase on cell survival, neurite outgrowth, and voltage-dependent calcium currents of embryonic ventral mesencephalic neurons.

Journal: Experimental neurology20031101

Title: Dynamics of Ca(2+) and Na(+) in the dendrites of mouse cerebellar Purkinje cells evoked by parallel fibre stimulation.

Journal: The European journal of neuroscience20031101

Title: Development of Ca2+-channel and BK-channel expression in embryos and larvae of Xenopus laevis.

Journal: The European journal of neuroscience20031001

Title: Atypical relaxation by scorpion venom in the lamb urethral smooth muscle involves both NO-dependent and -independent responses.

Journal: Naunyn-Schmiedeberg's archives of pharmacology20030901

Title: Tumor necrosis factor alpha increases cytosolic calcium responses to AMPA and KCl in primary cultures of rat hippocampal neurons.

Journal: Brain research20030815

Title: Functional significance of cannabinoid-mediated, depolarization-induced suppression of inhibition (DSI) in the hippocampus.

Journal: Journal of neurophysiology20030701

Title: Expression and modulation of an invertebrate presynaptic calcium channel alpha1 subunit homolog.

Journal: The Journal of biological chemistry20030606

Title: Gabapentin blocks L-type and P/Q-type Ca2+ channels involved in depolarization-stimulated nitric oxide synthase activity in primary cultures of neurons from mouse cerebral cortex.

Journal: Pharmaceutical research20030601

Title: Calcium channels involved in noradrenaline release from sympathetic neurones in rabbit carotid artery.

Journal: Pharmacology & toxicology20030501

Title: A comparison of Ca2+ channel blocking mode between gabapentin and verapamil: implication for protection against hypoxic injury in rat cerebrocortical slices.

Journal: British journal of pharmacology20030501

Title: Palytoxin-induced increase in cytosolic-free Ca(2+) in mouse spleen cells.

Journal: European journal of pharmacology20030328

Title: Effect of arvanil (N-arachidonoyl-vanillyl-amine), a nonpungent anandamide-capsaicin hybrid, on ion currents in NG108-15 neuronal cells.

Journal: Biochemical pharmacology20030215

Title: Therapeutically relevant concentrations of neomycin selectively inhibit P-type Ca2+ channels in rat striatum.

Journal: European journal of pharmacology20030214

Title: Endogenous and exogenous dopamine presynaptically inhibits glutamatergic reticulospinal transmission via an action of D2-receptors on N-type Ca2+ channels.

Journal: The European journal of neuroscience20030201

Title: Functional interaction between neuropeptide Y receptors and modulation of calcium channels in the rat hippocampus.

Journal: Neuropharmacology20030201

Title: Parallel decrease in omega-conotoxin-sensitive transmission and dopamine-induced inhibition at the striatal synapse of developing rats.

Journal: The Journal of physiology20030115

Title: Role of voltage-gated cation channels and axon reflexes in the release of sensory neuropeptides by capsaicin from isolated rat trachea.

Journal: European journal of pharmacology20030105

Title: Modulation of ACh release by presynaptic muscarinic autoreceptors in the neuromuscular junction of the newborn and adult rat.

Journal: The European journal of neuroscience20030101

Title: Pharmacological evidence that tetraethylammonium-sensitive, iberiotoxin-insensitive K+ channels function as a negative feedback element for sympathetic neurotransmission by suppressing omega-conotoxin-GVIA-insensitive Ca2+ channels in the relaxation of rabbit facial vein.

Journal: Naunyn-Schmiedeberg's archives of pharmacology20030101

Title: Activation of group II mGlu receptors inhibits voltage-gated Ca2+ currents in myenteric neurons.

Journal: American journal of physiology. Gastrointestinal and liver physiology20021201

Title: Mechanism of nicotine-evoked release of 3H-noradrenaline in human cerebral cortex slices.

Journal: British journal of pharmacology20021201

Title: Modulation of Ca2+ channel currents in primary cultures of rat cortical neurones by amyloid beta protein (1-40) is dependent on solubility status.

Journal: Brain research20021129

Title: Involvement of T-type calcium channels in excitatory junction potentials in rat resistance mesenteric arteries.

Journal: British journal of pharmacology20021101

Title: Nociceptin/orphanin FQ modulation of ionic conductances in rat basal forebrain neurons.

Journal: The Journal of pharmacology and experimental therapeutics20021001

Title: Actions of intrathecal omega-conotoxins CVID, GVIA, MVIIA, and morphine in acute and neuropathic pain in the rat.

Journal: European journal of pharmacology20020920

Title: Inhibitory effects of intravenous anaesthetic agents on K(+)-evoked glutamate release from rat cerebrocortical slices. Involvement of voltage-sensitive Ca(2+) channels and GABA(A) receptors.

Journal: Naunyn-Schmiedeberg's archives of pharmacology20020901

Title: Presynaptic factors in the regulation of DSI expression in hippocampus.

Journal: Neuropharmacology20020901

Title: PICK1 is required for the control of synaptic transmission by the metabotropic glutamate receptor 7.

Journal: The EMBO journal20020617

Title: A perforated patch-clamp study of calcium currents and exocytosis in chromaffin cells of wild-type and alpha(1A) knockout mice.

Journal: Journal of neurochemistry20020601

Title: Block of L-type Ca2+ current by beauvericin, a toxic cyclopeptide, in the NG108-15 neuronal cell line.

Journal: Chemical research in toxicology20020601

Title: Differential Ca2+-dependence of transmitter release mediated by P/Q- and N-type calcium channels at neonatal rat neuromuscular junctions.

Journal: The European journal of neuroscience20020601

Title: Antagonistic interaction between BIIE 0246, a neuropeptide Y Y2-receptor antagonist, and omega-conotoxin GVIA, a Ca2+ channel antagonist, in presynaptic transmitter releases in dog splenic arteries.

Journal: Japanese journal of pharmacology20020601

Title: Functional characterization of calcium channels localized on the growth cones of cultured rat dorsal root ganglion cells.

Journal: Neuroscience letters20020531

Title: Modulatory effects of ketamine on catecholamine efflux from in vivo cardiac sympathetic nerve endings in cats.

Journal: Neuroscience letters20020524

Title: Neuropeptide Y inhibits spontaneous alpha-melanocyte-stimulating hormone (alpha-MSH) release via a Y(5) receptor and suppresses thyrotropin-releasing hormone-induced alpha-MSH secretion via a Y(1) receptor in frog melanotrope cells.

Journal: Endocrinology20020501

Title: Recombinant GABA(B) receptors formed from GABA(B1) and GABA(B2) subunits selectively inhibit N-type Ca(2+) channels in NG108-15 cells.

Journal: European journal of pharmacology20020405

Title: Ca2+ involvement in the action potential generation of myenteric neurones in the rat oesophagus.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society20020401

Title: The cognition-enhancer nefiracetam is protective in BDNF-independent neuronal cell death under the serum-free condition.

Journal: Neurochemistry international20020201

Title: Inhibitory effect of the plant-extract osthole on L-type calcium current in NG108-15 neuronal cells.

Journal: Biochemical pharmacology20020115

Title: Selective blockade of N-type calcium channels by levetiracetam.

Journal: Epilepsia20020101

Title: High-affinity inhibition of glutamate release from corticostriatal synapses by omega-agatoxin TK.

Journal: European journal of pharmacology20011102

Title: Evidence against an action of mibefradil at N-type voltage-operated calcium channels.

Journal: Naunyn-Schmiedeberg's archives of pharmacology20011101

Title: Effects of calcium antagonists on the nitrergic nerve function in canine corpus cavernosum.

Journal: Japanese journal of pharmacology20011101

Title: Histological demonstration of voltage dependent calcium channels on calcitonin gene-related peptide-immunoreactive nerve fibres in the mouse knee joint.

Journal: Neuroscience letters20011026

Title: Changes in Ca(2+) channel expression upon differentiation of SN56 cholinergic cells.

Journal: Brain research20011019

Title: Effects of calcium channel antagonists on the corpora allata of adult male loreyi leafworm Mythimna loreyi: juvenile hormone acids release and intracellular calcium level.

Journal: Archives of insect biochemistry and physiology20011001

Title: Attenuation of Zn2+ neurotoxicity by aspirin: role of N-type Ca2+ channel and the carboxyl acid group.

Journal: Neurobiology of disease20011001

Title: Glutamate-mediated extrasynaptic inhibition: direct coupling of NMDA receptors to Ca(2+)-activated K+ channels.

Journal: Neuron20010927

Title: Modulation of voltage-dependent calcium currents by serotonin in acutely isolated rat amygdala neurons.

Journal: Synapse (New York, N.Y.)20010915

Title: Nitric oxide-cGMP pathway facilitates acetylcholine release and bradycardia during vagal nerve stimulation in the guinea-pig in vitro.

Journal: The Journal of physiology20010901

Title: Somatostatin inhibits exocytosis in rat pancreatic alpha-cells by G(i2)-dependent activation of calcineurin and depriming of secretory granules.

Journal: The Journal of physiology20010901

Title: E(f)-current contributes to whole-cell calcium current in low calcium in frog sympathetic neurons.

Journal: Journal of neurophysiology20010901

Title: Norepinephrine acts via alpha(2) adrenergic receptors to suppress N-type calcium channels in dissociated rat median preoptic nucleus neurons.

Journal: Neuropharmacology20010901

Title: The chemokine interleukin-8 acutely reduces Ca(2+) currents in identified cholinergic septal neurons expressing CXCR1 and CXCR2 receptor mRNAs.

Journal: Journal of neurochemistry20010901

Title: Modulation of N-type Ca2+ channel current kinetics by PMA in rat sympathetic neurons.

Journal: Pflugers Archiv : European journal of physiology20010901

Title: Suppression of Ca2+ influx through L-type voltage-dependent calcium channels by hydroxyl radical in mouse cerebral cortical neurons.

Journal: Brain research. Molecular brain research20010815

Title: Differential nociceptive responses in mice lacking the alpha(1B) subunit of N-type Ca(2+) channels.

Journal: Neuroreport20010808

Title: Role of calcium channels and adenylate cyclase in the PACAP-induced adrenal catecholamine secretion.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology20010801

Title: Calcium channels in Xenopus spinal neurons differ in somas and presynaptic terminals.

Journal: Journal of neurophysiology20010701

Title: Nitric oxide modulates Ca(2+) channels in dorsal root ganglion neurons innervating rat urinary bladder.

Journal: Journal of neurophysiology20010701

Title: Substance P and neurokinin A mediate sensory synaptic transmission in young rat dorsal horn neurons.

Journal: Brain research bulletin20010701

Title: Levetiracetam inhibits the high-voltage-activated Ca(2+) current in pyramidal neurones of rat hippocampal slices.

Journal: Neuroscience letters20010622

Title: Dopamine D(2)-like receptors selectively block N-type Ca(2+) channels to reduce GABA release onto rat striatal cholinergic interneurones.

Journal: The Journal of physiology20010601

Title: Pharmacological discrimination between effects of carbamazepine on hippocampal basal, Ca(2+)- and K(+)-evoked serotonin release.

Journal: British journal of pharmacology20010601

Title: Nicotine-evoked transmitter release from synaptosomes: functional association of specific presynaptic acetylcholine receptors and voltage-gated calcium channels.

Journal: Journal of neurochemistry20010601

Title: Control of secretion by mitochondria depends on the size of the local [Ca2+] after chromaffin cell stimulation.

Journal: The European journal of neuroscience20010601

Title: Residue Gly1326 of the N-type calcium channel alpha 1B subunit controls reversibility of omega-conotoxin GVIA and MVIIA block.

Journal: The Journal of biological chemistry20010511

Title: Coupling of L-type voltage-sensitive calcium channels to P2X(2) purinoceptors in PC-12 cells.

Journal: American journal of physiology. Cell physiology20010501

Title: Arachidonic acid both inhibits and enhances whole cell calcium currents in rat sympathetic neurons.

Journal: American journal of physiology. Cell physiology20010501

Title: Arachidonic acid reversibly enhances N-type calcium current at an extracellular site.

Journal: American journal of physiology. Cell physiology20010501

Title: Oxytocin retrogradely inhibits evoked, but not miniature, EPSCs in the rat supraoptic nucleus: role of N- and P/Q-type calcium channels.

Journal: The Journal of physiology20010501

Title: Protein kinase C regulation of dopamine transporter initiated by nicotinic receptor activation in slices of rat prefrontal cortex.

Journal: Journal of neurochemistry20010501

Title: Dystonia and cerebellar atrophy in Cacna1a null mice lacking P/Q calcium channel activity.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology20010501

Title: Afterhyperpolarization current in myenteric neurons of the guinea pig duodenum.

Journal: Journal of neurophysiology20010501

Title: Pharmacological and biophysical characterization of voltage-gated calcium currents in the endopiriform nucleus of the guinea pig.

Journal: Journal of neurophysiology20010501

Title: The activation of mu opioid receptors promotes a small modulation of calcium currents in rat pallidal neurons.

Journal: Brain research20010406

Title: Omega-conotoxin GVIA potently inhibits the currents mediated by P2X receptors in rat DRG neurons.

Journal: Brain research bulletin20010315

Title: Dialysate dihydroxyphenylglycol as a window for in situ axoplasmic norepinephrine disposition.

Journal: Neurochemistry international20010301

Title: [Chemical structures and the mechanism of action of peptide toxins from cone shells].

Journal: Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme20010301

Title: Coupling of L-type calcium channels to neurotransmitter release at mouse motor nerve terminals.

Journal: Pflugers Archiv : European journal of physiology20010301

Title: The calcium-dependent [3H]acetylcholine release from synaptosomes of brown trout (Salmo trutta) optic tectum is inhibited by adenosine A1 receptors: effects of enucleation on A1 receptor density and cholinergic markers.

Journal: Brain research20010216

Title: A1 adenosine receptors inhibit multiple voltage-gated Ca2+ channel subtypes in acutely isolated rat basolateral amygdala neurons.

Journal: British journal of pharmacology20010201

Title: Age-related changes in the subtypes of voltage-dependent calcium channels in rat brain cortical synapses.

Journal: Neuroscience research20010201

Title: The combined effects of N-type calcium channel blockers and morphine on A delta versus C fiber mediated nociception.

Journal: Anesthesia and analgesia20010101

Title: Synchronisation of neurotransmitter release during postnatal development in a calyceal presynaptic terminal of rat.

Journal: The Journal of physiology20010101

Title: Calcium channels coupled to neurotransmitter release at dually innervated neuromuscular junctions in the newborn rat.

Journal: Neuroscience20010101

Title: Characterisation of a modified approach to the study of sympathetic neurotransmission and its presynaptic modulation in the isolated rabbit thoracic aorta.

Journal: Journal of pharmacological and toxicological methods20010101

Title: The status of voltage-dependent calcium channels in alpha 1E knock-out mice.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20001201

Title: Inactivation properties of human recombinant class E calcium channels.

Journal: Journal of neurophysiology20000201

Title: Peptide N- and P/Q-type Ca2+ blockers inhibit stimulant-induced hyperactivity in mice.

Journal: Peptides19980101

Title: Differential effects of omega-conotoxin GVIA, nimodipine, calmidazolium and KN-62 injected intrathecally on the antinociception induced by beta-endorphin, morphine and [D-Ala2,N-MePhe4,Gly-ol5]-enkephalin administered intracerebroventricularly in the mouse.

Journal: The Journal of pharmacology and experimental therapeutics19970801

Title: Structure-function relationships of omega-conotoxin GVIA. Synthesis, structure, calcium channel binding, and functional assay of alanine-substituted analogues.

Journal: The Journal of biological chemistry19970502

Title: mu-Opioid receptor activation reduces multiple components of high-threshold calcium current in rat sensory neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience19950601

Title: Depression of high-threshold calcium currents by activation of human D2 (short) dopamine receptors expressed in differentiated NG108-15 cells.

Journal: British journal of pharmacology19940401

Title: A new Conus peptide ligand for mammalian presynaptic Ca2+ channels.

Journal: Neuron19920701

Title: Omega-conotoxin prevents apomorphine- and oxytocin-induced penile erection and yawning in male rats.

Journal: Pharmacology, biochemistry, and behavior19901001

Title: Differential effects of acute and repeated electrically and chemically induced seizures on [3H]Nimodipine and [125I]omega-conotoxin GVIA binding in rat brain.

Journal: Epilepsia19890101

Title: Neuronal calcium channel antagonists. Discrimination between calcium channel subtypes using omega-conotoxin from Conus magus venom.

Journal: Biochemistry19870421

Title: Ya-Kun Cao, et al. Microinjection of urotensin II into the rostral ventrolateral medulla increases sympathetic vasomotor tone via the GPR14/ERK pathway in rats. Hypertens Res. 2020 Aug;43(8):765-771.

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