Home Amines 90779-69-4
90779-69-4,MFCD00672436
Catalog No.:AA006AEG

90779-69-4 | 1-({(4r,7s,13s,16r)-7-(2-amino-2-oxoethyl)-13-[(2s)-butan-2-yl]-16-(4-ethoxybenzyl)-10-[(1r)-1-hydroxyethyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)-l-prolyl-l-ornithylglycinamide

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5mg
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA006AEG
Chemical Name:
1-({(4r,7s,13s,16r)-7-(2-amino-2-oxoethyl)-13-[(2s)-butan-2-yl]-16-(4-ethoxybenzyl)-10-[(1r)-1-hydroxyethyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)-l-prolyl-l-ornithylglycinamide
CAS Number:
90779-69-4
Molecular Formula:
C43H67N11O12S2
Molecular Weight:
994.1886
MDL Number:
MFCD00672436
SMILES:
NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)NC(C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C
Properties
Properties
 
Form:
Solid  
MP:
>165℃ (dec.)  
Storage:
Light sensitive;Inert atmosphere;-20 ℃;  

Computed Properties
 
Complexity:
1770  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
9  
Heavy Atom Count:
68  
Hydrogen Bond Acceptor Count:
15  
Hydrogen Bond Donor Count:
11  
Rotatable Bond Count:
18  
XLogP3:
-1.9  

Literature

Title: Oxytocin is involved in the proconvulsant effects of Sildenafil: Possible role of CREB.

Journal: Toxicology letters 20160810

Title: Therapeutic efficiency of Atosiban, an oxytocin receptor blocking agent in the treatment of experimental endometriosis.

Journal: Archives of gynecology and obstetrics 20120901

Title: Atosiban improves implantation and pregnancy rates in patients with repeated implantation failure.

Journal: Reproductive biomedicine online 20120901

Title: Expression of selected genes in preterm premature rupture of fetal membranes.

Journal: Acta obstetricia et gynecologica Scandinavica 20120801

Title: The effect of acute stress exposure on ischemia and reperfusion injury in rat heart: role of oxytocin.

Journal: Stress (Amsterdam, Netherlands) 20120701

Title: Oxytocin regulates changes of extracellular glutamate and GABA levels induced by methamphetamine in the mouse brain.

Journal: Addiction biology 20120701

Title: Is preconditioning by oxytocin administration mediated by iNOS and/or mitochondrial K(ATP) channel activation in the in vivo anesthetized rabbit heart?

Journal: Life sciences 20120522

Title: Oxytocin hyperpolarizes cultured duodenum myenteric intrinsic primary afferent neurons by opening BK(Ca) channels through IP₃ pathway.

Journal: Journal of neurochemistry 20120501

Title: Modulation of anxiety behavior in the elevated plus maze using peptidic oxytocin and vasopressin receptor ligands in the rat.

Journal: Journal of psychopharmacology (Oxford, England) 20120401

Title: Elevated cardiac oxidative stress in newborn rats from mothers treated with atosiban.

Journal: Archives of gynecology and obstetrics 20120301

Title: Functional selective oxytocin-derived agonists discriminate between individual G protein family subtypes.

Journal: The Journal of biological chemistry 20120203

Title: Oxytocin inhibits the membrane depolarization-induced increase in intracellular calcium in capsaicin sensitive sensory neurons: a peripheral mechanism of analgesic action.

Journal: Anesthesia and analgesia 20120201

Title: Pyridyl-2,5-diketopiperazines as potent, selective, and orally bioavailable oxytocin antagonists: synthesis, pharmacokinetics, and in vivo potency.

Journal: Journal of medicinal chemistry 20120126

Title: Three Dimensional Power Doppler evaluation of human endometrium after administration of oxytocine receptor antagonist (OTRa) in an IVF program.

Journal: Archives of gynecology and obstetrics 20120101

Title: Atosiban and non-cardiogenic pulmonary oedema.

Journal: International journal of obstetric anesthesia 20120101

Title: Allosteric interactions between the oxytocin receptor and the β2-adrenergic receptor in the modulation of ERK1/2 activation are mediated by heterodimerization.

Journal: Cellular signalling 20120101

Title: Oxytocin prolongs the gastric emptying time in patients with diabetes mellitus and gastroparesis, but does not affect satiety or volume intake in patients with functional dyspepsia.

Journal: BMC research notes 20120101

Title: Who plays the strings in newborn analgesia at birth, vasopressin or oxytocin?

Journal: Frontiers in neuroscience 20120101

Title: The effects of benzoylecgonine, oxytocin, ritodrine and atosiban on the contractility of myometrium. An experimental study.

Journal: Clinical and experimental obstetrics & gynecology 20120101

Title: Tocolytic therapy for preterm delivery: systematic review and network meta-analysis.

Journal: BMJ (Clinical research ed.) 20120101

Title: Using atosiban in uterine contractions of early pregnancies after assisted reproduction.

Journal: Journal of the Formosan Medical Association = Taiwan yi zhi 20111201

Title: Targeting the prostaglandin F2α receptor for preventing preterm labor with azapeptide tocolytics.

Journal: Journal of medicinal chemistry 20110908

Title: Atosiban versus betamimetics in the treatment of preterm labour in Italy: clinical and economic importance of side-effects.

Journal: European journal of obstetrics, gynecology, and reproductive biology 20110801

Title: The design of orally bioavailable 2, 5-diketopiperazine oxytocin antagonists: from concept to clinical candidate for premature labor.

Journal: Medicinal research reviews 20110701

Title: Oxytocin antagonists for the management of preterm birth: a review.

Journal: American journal of perinatology 20110601

Title: The influence of tocolytic drugs on cardiac function, large arteries, and resistance vessels.

Journal: European journal of clinical pharmacology 20110601

Title: Use of an oxytocin antagonist in in vitro fertilization-embryo transfer for women with repeated implantation failure: a retrospective study.

Journal: Taiwanese journal of obstetrics & gynecology 20110601

Title: Oxytocin antagonist successfully prevents from threatened abortion in 15 weeks' gestation.

Journal: Taiwanese journal of obstetrics & gynecology 20110601

Title: [Atosiban treatment for preterm labor--financial considerations and savings by implementing clinical guidelines].

Journal: Harefuah 20110601

Title: Examining the role of oxytocin in the interoceptive effects of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') using a drug discrimination paradigm in the rat.

Journal: Addiction biology 20110401

Title: Severe non-cardiogenic pulmonary oedema secondary to atosiban and steroids.

Journal: International journal of obstetric anesthesia 20110401

Title: Role of endogenous oxytocin in cardiac ischemic preconditioning.

Journal: Regulatory peptides 20110225

Title: Different effects of tocolytic medication on blood pressure and blood pressure amplification.

Journal: European journal of clinical pharmacology 20110101

Title: Possible involvement of oxytocin and its receptor in the local regulation of prostaglandin secretion in the cat endometrium.

Journal: Animal reproduction science 20110101

Title: Oxytocin and vasopressin V(1A) receptors as new therapeutic targets in assisted reproduction.

Journal: Reproductive biomedicine online 20110101

Title: Placental leucine aminopeptidase- and aminopeptidase A- deficient mice offer insight concerning the mechanisms underlying preterm labor and preeclampsia.

Journal: Journal of biomedicine & biotechnology 20110101

Title: Maternal thyroid function and the outcome of external cephalic version: a prospective cohort study.

Journal: BMC pregnancy and childbirth 20110101

Title: Preterm birth.

Journal: BMJ clinical evidence 20110101

Title: Newborn Analgesia Mediated by Oxytocin during Delivery.

Journal: Frontiers in cellular neuroscience 20110101

Title: The effect of combined tocolysis on in vitro uterine contractility in preterm labour.

Journal: Advances in medical sciences 20110101

Title: Prevention of preterm labour: 2011 update on tocolysis.

Journal: Journal of pregnancy 20110101

Title: The oxytocin-oxytocin receptor system and its antagonists as tocolytic agents.

Journal: International journal of endocrinology 20110101

Title: Use of atosiban in a twin pregnancy with extremely preterm premature rupture in the membrane of one twin: a case report and literature review.

Journal: Taiwanese journal of obstetrics & gynecology 20101201

Title: CCK mediated the inhibitory effect of oxytocin on the contraction of longitudinal muscle strips of duodenum in male rats.

Journal: Pflugers Archiv : European journal of physiology 20101101

Title: Oxytocin mediates the antidepressant effects of mating behavior in male mice.

Journal: Neuroscience research 20101001

Title: REVIEW: Oxytocin: Crossing the bridge between basic science and pharmacotherapy.

Journal: CNS neuroscience & therapeutics 20101001

Title: Treatment with oxytocin antagonists before embryo transfer may increase implantation rates after IVF.

Journal: Reproductive biomedicine online 20100901

Title: Oxytocin protects rat heart against ischemia-reperfusion injury via pathway involving mitochondrial ATP-dependent potassium channel.

Journal: Peptides 20100701

Title: Oxytocin is neuroprotective against oxygen-glucose deprivation and reoxygenation in immature hippocampal cultures.

Journal: Neuroscience letters 20100614

Title: Comparison between atosiban and nicardipine in inducing hypotension during in-utero transfers for threatening premature delivery.

Journal: European journal of emergency medicine : official journal of the European Society for Emergency Medicine 20100601

Title: [Effects of abdominal breathing on state anxiety, stress, and tocolytic dosage for pregnant women in preterm labor].

Journal: Journal of Korean Academy of Nursing 20100601

Title: Assessing the antidepressant-like effects of carbetocin, an oxytocin agonist, using a modification of the forced swimming test.

Journal: Psychopharmacology 20100501

Title: Quantitative determination of oxytocin receptor antagonist atosiban in rat plasma by liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100501

Title: [Parturient at full term with inferior vena cava thrombosis: anesthesia during surgical delivery].

Journal: Revista espanola de anestesiologia y reanimacion 20100501

Title: Oxytocin treatment alleviates stress-aggravated colitis by a receptor-dependent mechanism.

Journal: Regulatory peptides 20100225

Title: Atosiban vs. ritodrine as a tocolytic in external cephalic version at term: a prospective cohort study.

Journal: Journal of perinatal medicine 20100101

Title: Critical appraisal and clinical utility of atosiban in the management of preterm labor.

Journal: Therapeutics and clinical risk management 20100101

Title: Meconium pseudocyst secondary to ileum volvulus perforation without peritoneal calcification: a case report.

Journal: Journal of medical case reports 20100101

Title: Expression of stretch-activated two-pore potassium channels in human myometrium in pregnancy and labor.

Journal: PloS one 20100101

Title: Management of preterm labor: atosiban or nifedipine?

Journal: International journal of women's health 20100101

Title: Indirect comparisons: a review of reporting and methodological quality.

Journal: PloS one 20100101

Title: Management of foetal asphyxia by intrauterine foetal resuscitation.

Journal: Indian journal of anaesthesia 20100101

Title: Biphasic protective effect of oxytocin on cardiac ischemia/reperfusion injury in anaesthetized rats.

Journal: Peptides 20091201

Title: Once-daily milking effects in high-yielding Alpine dairy goats.

Journal: Journal of dairy science 20091101

Title: [Effectiveness and safety of atosiban vs. pulsatile administration of fenoterol in the treatment of preterm labour].

Journal: Zeitschrift fur Geburtshilfe und Neonatologie 20091001

Title: Oxytocin antagonist for repeated implantation failure and delay of delivery.

Journal: Taiwanese journal of obstetrics & gynecology 20090901

Title: Healthcare evaluation of the use of atosiban and fibronectin for the management of pre-term labour.

Journal: Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 20090801

Title: [Management of preterm labor].

Journal: Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia 20090801

Title: Effect of an OT antagonist on the control of the midcycle LH surge in women.

Journal: Clinical endocrinology 20090701

Title: Anaesthesiological considerations on tocolytic and uterotonic therapy in obstetrics.

Journal: Acta anaesthesiologica Scandinavica 20090701

Title: The effects of the tocolytics atosiban and nifedipine on fetal movements, heart rate and blood flow.

Journal: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 20090601

Title: Randomized trial of oxytocin antagonist atosiban versus beta-adrenergic agonists in the treatment of spontaneous preterm labor in Taiwanese women.

Journal: Journal of the Formosan Medical Association = Taiwan yi zhi 20090601

Title: Estradiol upregulates the expression of oxytocin receptor in colon in rats.

Journal: American journal of physiology. Endocrinology and metabolism 20090501

Title: Adverse reactions to tocolytics. Atosiban v nifedipine.

Journal: BMJ (Clinical research ed.) 20090414

Title: Computerized evaluation of fetal heart rate during tocolytic treatment: comparison between atosiban and ritodrine.

Journal: American journal of perinatology 20090401

Title: Oxytocin receptor expressed on the smooth muscle mediates the excitatory effect of oxytocin on gastric motility in rats.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20090401

Title: Effects of oxytocin on methamphetamine-induced conditioned place preference and the possible role of glutamatergic neurotransmission in the medial prefrontal cortex of mice in reinstatement.

Journal: Neuropharmacology 20090401

Title: [Twin gestation in a single horn of a bicornuate uterus].

Journal: Ugeskrift for laeger 20090309

Title: Tocolytics and preterm labour.

Journal: BMJ (Clinical research ed.) 20090305

Title: [Acute pulmonary edema occurred during tocolytic treatment using nicardipine in a twin pregnancy. Report of three cases].

Journal: Journal de gynecologie, obstetrique et biologie de la reproduction 20090201

Title: Discovery and optimization of highly ligand-efficient oxytocin receptor antagonists using structure-based drug design.

Journal: Bioorganic & medicinal chemistry letters 20090201

Title: Maintenance therapy with oxytocin antagonists for inhibiting preterm birth after threatened preterm labour.

Journal: The Cochrane database of systematic reviews 20090121

Title: Bidirectional communication between neural and cardiac cells in human amniotic fluid.

Journal: Fetal diagnosis and therapy 20090101

Title: Gastroparesis is associated with oxytocin deficiency, oesophageal dysmotility with hyperCCKemia, and autonomic neuropathy with hypergastrinemia.

Journal: BMC gastroenterology 20090101

Title: Adverse drug reactions to tocolytic treatment for preterm labour: prospective cohort study.

Journal: BMJ (Clinical research ed.) 20090101

Title: Atosiban versus betamimetics in the treatment of preterm labour in Germany: an economic evaluation.

Journal: BMC pregnancy and childbirth 20090101

Title: Assessment of perinatal outcome after sustained tocolysis in early labour (APOSTEL-II trial).

Journal: BMC pregnancy and childbirth 20090101

Title: Oxytocin and carbetocin effects on spontaneous behavior of male rats: modulation by oxytocin receptor antagonists.

Journal: Neuro endocrinology letters 20090101

Title: Medical therapy in the management of preterm birth.

Journal: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 20090101

Title: Polymorphism in the oxytocin promoter region in patients with lactase non-persistence is not related to symptoms.

Journal: BMC gastroenterology 20090101

Title: Prolonged use of atosiban and grade IV intraventricular haemorrhage in an infant born at 29 weeks and 4 days.

Journal: BMJ case reports 20090101

Title: Evaluation of udder cisterns and effects on milk yield of dairy ewes.

Journal: Journal of dairy science 20081201

Title: Management of threatened preterm delivery in France: a national practice survey (the EVAPRIMA study).

Journal: BJOG : an international journal of obstetrics and gynaecology 20081101

Title: [Non-invasive ventilation for pulmonary edema associated with tocolytic agents during labour for a twin pregnancy].

Journal: Canadian journal of anaesthesia = Journal canadien d'anesthesie 20081101

Title: A prospective randomized trial of acute tocolysis in term labour with atosiban or ritodrine.

Journal: European journal of obstetrics, gynecology, and reproductive biology 20080801

Title: Preterm birth.

Journal: BMJ clinical evidence 20080602

Title: Acute tocolysis for uterine activity reduction in term labor: a review.

Journal: Obstetrical & gynecological survey 20080601

Title: Developments in the pharmacotherapeutic management of spontaneous preterm labor.

Journal: Expert opinion on pharmacotherapy 20080501

Title: Involvement of cholecystokinin receptor in the inhibition of gastrointestinal motility by oxytocin in ovariectomized rats.

Journal: European journal of pharmacology 20080212

Title: Inhibition by oxytocin of methamphetamine-induced hyperactivity related to dopamine turnover in the mesolimbic region in mice.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20080201

Title: [Clinical experience of using oxytocin antagonist atosiban in the rescue therapy of preterm labour].

Journal: Zhonghua fu chan ke za zhi 20080201

Title: [Atosiban as a tocolytic agent: a new proposal of a therapeutic approach].

Journal: Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia 20080201

Title: The discovery of GSK221149A: a potent and selective oxytocin antagonist.

Journal: Bioorganic & medicinal chemistry letters 20080101

Title: Market failure and the poverty of new drugs in maternal health.

Journal: PLoS medicine 20080101

Title: Non-cardiogenic lung edema in a woman treated with atosiban for preterm labor.

Journal: Journal of perinatal medicine 20080101

Title: Peptide and non-peptide agonists and antagonists for the vasopressin and oxytocin V1a, V1b, V2 and OT receptors: research tools and potential therapeutic agents.

Journal: Progress in brain research 20080101

Title: Expression profiles of the pluripotency marker gene POU5F1 and validation of reference genes in rabbit oocytes and preimplantation stage embryos.

Journal: BMC molecular biology 20080101

Title: Commentary: a case of non-cardiogenic lung edema in a woman treated with atosiban for preterm labor.

Journal: Journal of perinatal medicine 20080101

Title: Prevention of preterm delivery.

Journal: The New England journal of medicine 20071108

Title: Preterm labour. The present and future of tocolysis.

Journal: Best practice & research. Clinical obstetrics & gynaecology 20071001

Title: No effect of tocolytic therapy with atosiban on maternal serum interleukin-6 and tumor necrosis factor-alpha in threatened preterm labor.

Journal: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 20071001

Title: Systemic oxytocin and vasopressin excite gastrointestinal motility through oxytocin receptor in rabbits.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20071001

Title: Clinical practice evaluation of combination of atosiban, ritodrine and ketoprofen for inhibiting preterm labor.

Journal: Minerva ginecologica 20071001

Title: The effects of atosiban on abnormal fetal heart rate patterns.

Journal: European journal of obstetrics, gynecology, and reproductive biology 20070801

Title: Clinical practice evaluation of atosiban in preterm labour management in six European countries.

Journal: BJOG : an international journal of obstetrics and gynaecology 20070801

Title: Secretory and cytosolic phospholipase A2 activities and expression are regulated by oxytocin and estradiol during labor.

Journal: Reproduction (Cambridge, England) 20070801

Title: Oxytocin antagonists may improve infertility treatment.

Journal: Fertility and sterility 20070701

Title: Synthesis and biological activity of oxytocin analogues containing conformationally-restricted residues in position 7.

Journal: European journal of medicinal chemistry 20070601

Title: In vitro and in vivo pharmacological characterization of ethyl-4-[trans-4-[((2S)-2-hydroxy-3-[4-hydroxy-3[(methylsulfonyl)amino]-phenoxy]propyl) amino]cyclohexyl]benzoate hydrochloride (SAR150640), a new potent and selective human beta3-adrenoceptor agonist for the treatment of preterm labor.

Journal: The Journal of pharmacology and experimental therapeutics 20070601

Title: Oxytocin is not important for the control of gonadotrophin secretion in the late follicular phase of the cycle.

Journal: Clinical endocrinology 20070601

Title: The choice of a tocolytic for the treatment of preterm labor: a critical evaluation of nifedipine versus atosiban.

Journal: Expert opinion on investigational drugs 20070601

Title: Effect of atosiban on rabbit embryo development and human sperm motility.

Journal: Fertility and sterility 20070501

Title: Novel in vitro system for functional assessment of oxytocin action.

Journal: American journal of physiology. Endocrinology and metabolism 20070101

Title: Oxytocin--a stimulator of directed sperm transport in humans.

Journal: Reproductive biomedicine online 20070101

Title: Is the beta3-adrenoceptor (ADRB3) a potential target for uterorelaxant drugs?

Journal: BMC pregnancy and childbirth 20070101

Title: Barusiban suppresses oxytocin-induced preterm labour in non-human primates.

Journal: BMC pregnancy and childbirth 20070101

Title: Overview. Preterm labour: mechanisms and management.

Journal: BMC pregnancy and childbirth 20070101

Title: New research models and novel signal analysis in studies on preterm labor: a key to progress?

Journal: BMC pregnancy and childbirth 20070101

Title: Atosiban versus usual care for the management of preterm labor.

Journal: Journal of perinatal medicine 20070101

Title: The use of atosiban and ritodrine in external cephalic version.

Journal: Acta obstetricia et gynecologica Scandinavica 20070101

Title: New insights into the understanding of gastrointestinal dysmotility.

Journal: Drug target insights 20070101

Title: Maternal oxytocin triggers a transient inhibitory switch in GABA signaling in the fetal brain during delivery.

Journal: Science (New York, N.Y.) 20061215

Title: Use of tocolytics: what is the benefit of gaining 48 hours for the fetus?

Journal: BJOG : an international journal of obstetrics and gynaecology 20061201

Title: Use of tocolytics: what is the benefit of gaining even more time?

Journal: BJOG : an international journal of obstetrics and gynaecology 20061201

Title: A quality assessment tool to evaluate tocolytic studies.

Journal: BJOG : an international journal of obstetrics and gynaecology 20061201

Title: Clinical practice evaluation of atosiban in preterm labour management in six European countries.

Journal: BJOG : an international journal of obstetrics and gynaecology 20061201

Title: Emerging tocolytics for maintenance therapy of preterm labour: oxytocin antagonists and calcium channel blockers.

Journal: BJOG : an international journal of obstetrics and gynaecology 20061201

Title: 'Normal' pregnancy with adverse events on initial tocolytic treatment.

Journal: BJOG : an international journal of obstetrics and gynaecology 20061201

Title: Multicentre, parallel group, randomised, single-blind study of the safety and efficacy of atosiban versus ritodrine in the treatment of acute preterm labour in Korean women.

Journal: BJOG : an international journal of obstetrics and gynaecology 20061101

Title: 2,5-diketopiperazines as potent, selective, and orally bioavailable oxytocin antagonists. 3. Synthesis, pharmacokinetics, and in vivo potency.

Journal: Journal of medicinal chemistry 20060713

Title: Atosiban vs ritodrine used prophylactically with cerclage in ICSI pregnancies to prevent pre-term birth in women identified as being at high risk on the basis of transvaginal ultrasound scan.

Journal: Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 20060701

Title: Atosiban for prophylactic tocolysis following transabdominal cervico-isthmic cerclage.

Journal: Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 20060701

Title: Targeting the oxytocin receptor to relax the myometrium.

Journal: Expert opinion on therapeutic targets 20060601

Title: Preterm birth.

Journal: Clinical evidence 20060601

Title: The extracorporeal perfusion of the swine uterus as an experimental model: The effect of tocolytic drugs.

Journal: European journal of obstetrics, gynecology, and reproductive biology 20060501

Title: Tocolytic treatment for the management of preterm labour: a systematic review.

Journal: Singapore medical journal 20060501

Title: Role of intraluteal prostaglandin F(2alpha), progesterone and oxytocin in basal and pulsatile progesterone release from developing bovine corpus luteum.

Journal: Prostaglandins & other lipid mediators 20060501

Title: Pyridobenzodiazepines: a novel class of orally active, vasopressin V2 receptor selective agonists.

Journal: Bioorganic & medicinal chemistry letters 20060215

Title: The inhibitory effects of oxytocin on distal colonic contractile activity in rabbits are enhanced by ovarian steroids.

Journal: Acta physiologica (Oxford, England) 20060201

Title: Oxytocin stimulates secretory processes in lactating rabbit mammary epithelial cells.

Journal: The Journal of physiology 20060101

Title: Atosiban and nifedipine in acute tocolysis: a comparative study.

Journal: European journal of obstetrics, gynecology, and reproductive biology 20060101

Title: Pragmatic comparison of beta2-agonist side effects within the Worldwide Atosiban versus Beta Agonists study.

Journal: European journal of obstetrics, gynecology, and reproductive biology 20060101

Title: Intrauterine pressure, ischemia markers, and experienced pain during administration of a vasopressin V1a receptor antagonist in spontaneous and vasopressin-induced dysmenorrhea.

Journal: Acta obstetricia et gynecologica Scandinavica 20060101

Title: The oxytocin/vasopressin receptor antagonist atosiban delays the gastric emptying of a semisolid meal compared to saline in human.

Journal: BMC gastroenterology 20060101

Title: A case report on a patient suffering from recurrent vomiting episodes, whose condition improved markedly during pregnancy and breast feeding.

Journal: BMC gastroenterology 20060101

Title: Discovery and development of a new class of potent, selective, orally active oxytocin receptor antagonists.

Journal: Journal of medicinal chemistry 20051201

Title: Visual compatibility of atosiban acetate with four drugs.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20051201

Title: Social and sexual motivation in the mouse.

Journal: Behavioral neuroscience 20051201

Title: Does insulin release kinins in rats?

Journal: European journal of pharmacology 20051121

Title: 2,5-diketopiperazines as potent, selective, and orally bioavailable oxytocin antagonists. 2. Synthesis, chirality, and pharmacokinetics.

Journal: Journal of medicinal chemistry 20051103

Title: Pharmacokinetic interaction studies of atosiban with labetalol or betamethasone in healthy female volunteers.

Journal: BJOG : an international journal of obstetrics and gynaecology 20051101

Title: Design of peptide oxytocin antagonists with strikingly higher affinities and selectivities for the human oxytocin receptor than atosiban.

Journal: Journal of peptide science : an official publication of the European Peptide Society 20051001

Title: Atosiban and nifedipin for the treatment of preterm labor.

Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20051001

Title: Synthesis of oxytocin analogues with replacement of sulfur by carbon gives potent antagonists with increased stability.

Journal: The Journal of organic chemistry 20050930

Title: Possible neural mediation of the central effects of oxytocin on uterine motility.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20050901

Title: Oxytocin mediates the estrogen-dependent contractile activity of endothelin-1 in human and rabbit epididymis.

Journal: Endocrinology 20050801

Title: Oxytocin receptor antagonists for inhibiting preterm labour.

Journal: The Cochrane database of systematic reviews 20050720

Title: Tocolysis with atosiban: experience in the management of premature labor before 24 weeks of pregnancy.

Journal: Archives of gynecology and obstetrics 20050601

Title: The oxytocin receptor antagonist atosiban inhibits cell growth via a 'biased agonist' mechanism.

Journal: The Journal of biological chemistry 20050422

Title: Barusiban, a new highly potent and long-acting oxytocin antagonist: pharmacokinetic and pharmacodynamic comparison with atosiban in a cynomolgus monkey model of preterm labor.

Journal: The Journal of clinical endocrinology and metabolism 20050401

Title: Acute tocolysis.

Journal: Current opinion in obstetrics & gynecology 20050401

Title: [Licensed or non-licensed tocolysis?].

Journal: Gynecologie, obstetrique & fertilite 20050401

Title: [Tocolysis by first intention with atosiban].

Journal: Gynecologie, obstetrique & fertilite 20050401

Title: Binding domains of the oxytocin receptor for the selective oxytocin receptor antagonist barusiban in comparison to the agonists oxytocin and carbetocin.

Journal: European journal of pharmacology 20050307

Title: Adverse effects of tocolytic therapy.

Journal: BJOG : an international journal of obstetrics and gynaecology 20050301

Title: Tocolytic therapy and clinical experience. Combination therapy.

Journal: BJOG : an international journal of obstetrics and gynaecology 20050301

Title: Maintenance tocolysis.

Journal: BJOG : an international journal of obstetrics and gynaecology 20050301

Title: Identification, localization and functional in vitro and in vivo activity of oxytocin receptor in the rat penis.

Journal: The Journal of endocrinology 20050301

Title: Inhibition of trigemino-hypoglossal reflex in rats by oxytocin is mediated by mu and kappa opioid receptors.

Journal: Brain research 20050221

Title: Oxytocin microinjected into dorsal motor nucleus of the vagus excites gallbladder motility via NMDA receptor-NO-cGMP pathway.

Journal: Brain research 20050125

Title: Ontogenesis and functional aspects of oxytocin and vasopressin gene expression in the thymus network.

Journal: Journal of neuroimmunology 20050101

Title: [Pharmacoeconomic assessment of two tocolysis protocols for the inhibition of premature delivery].

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Title: Tocolysis and preterm labour.

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Title: Current medical therapy in the prevention and treatment of preterm labour.

Journal: Seminars in fetal & neonatal medicine 20041201

Title: Evaluation of the maternal and neonatal effects of the oxytocin antagonist, atosiban, in a cross-fostering study in rats.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20041101

Title: Recent pharmacological advances in the treatment of preterm membrane rupture, labour and delivery.

Journal: Expert opinion on pharmacotherapy 20040901

Title: The Gordian knot of developing tocolytics.

Journal: Journal of the Society for Gynecologic Investigation 20040901

Title: Inhibitory effect of barusiban and atosiban on oxytocin-induced contractions of myometrium from preterm and term pregnant women.

Journal: Journal of the Society for Gynecologic Investigation 20040901

Title: Roles of oxytocin in spatial learning and memory in the nucleus basalis of Meynert in rats.

Journal: Regulatory peptides 20040815

Title: Spinal effects of oxytocin on uterine motility in anesthetized rats.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20040801

Title: Delaying preterm delivery at the threshold of viability.

Journal: Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 20040601

Title: Centrally administered oxytocin elicits exaggerated grooming in oxytocin null mice.

Journal: Pharmacology, biochemistry, and behavior 20040601

Title: Preterm birth.

Journal: Clinical evidence 20040601

Title: SSR126768A (4-chloro-3-[(3R)-(+)-5-chloro-1-(2,4-dimethoxybenzyl)-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl]-N-ethyl-N-(3-pyridylmethyl)-benzamide, hydrochloride): a new selective and orally active oxytocin receptor antagonist for the prevention of preterm labor.

Journal: The Journal of pharmacology and experimental therapeutics 20040401

Title: A prospective randomised trial of atosiban versus hexoprenaline for acute tocolysis and intrauterine resuscitation.

Journal: BJOG : an international journal of obstetrics and gynaecology 20040401

Title: The drugs we deserve.

Journal: BJOG : an international journal of obstetrics and gynaecology 20040401

Title: Management options for preterm labour in Canada.

Journal: Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC 20040401

Title: Tocolysis: current controversies, future directions.

Journal: Current opinion in investigational drugs (London, England : 2000) 20040401

Title: Emerging issues over the choice of nifedipine, beta-agonists and atosiban for tocolysis in spontaneous preterm labour--a proposed systematic review by the International Preterm Labour Council.

Journal: Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 20040401

Title: Sex differences and developmental effects of manipulations of oxytocin on alloparenting and anxiety in prairie voles.

Journal: Developmental psychobiology 20040301

Title: [Comparison of the cost of treatment of premature labor with atosiban or beta-sympathomimetics from the perspective of the health care payer--a pharmacoeconomic model].

Journal: Ceska gynekologie 20040301

Title: Atosiban for preterm labour.

Journal: Drugs 20040101

Title: Atosiban treatment for uterine hyperactivity during active labor: a pilot study.

Journal: Journal of perinatal medicine 20040101

Title: Effectiveness of nifedipine versus atosiban for tocolysis in preterm labour: a meta-analysis with an indirect comparison of randomised trials.

Journal: BJOG : an international journal of obstetrics and gynaecology 20031201

Title: FE 200 440: a selective oxytocin antagonist on the term-pregnant human uterus.

Journal: BJOG : an international journal of obstetrics and gynaecology 20031101

Title: Endogenous oxytocin excites phasic contraction of gallbladder in rabbits through oxytocin receptor.

Journal: The Chinese journal of physiology 20030930

Title: Involvement of oxytocin in spinal antinociception in rats with inflammation.

Journal: Brain research 20030905

Title: Preterm delivery: an overview.

Journal: Acta obstetricia et gynecologica Scandinavica 20030801

Title: Preterm labour: an overview of current and emerging therapeutics.

Journal: Current medicinal chemistry 20030801

Title: The in vitro effect of dual combinations of ritodrine, nicardipine and atosiban on contractility of pregnant rat myometrium.

Journal: BJOG : an international journal of obstetrics and gynaecology 20030801

Title: Effects of alpha- and beta-adrenergic receptor stimulation and oxytocin receptor blockade on milking characteristics in dairy cows before and after removal of the teat sphincter.

Journal: The Journal of dairy research 20030801

Title: The oxytocin receptor.

Journal: Trends in endocrinology and metabolism: TEM 20030701

Title: Evidence that oxytocin is a physiological component of LH regulation in non-pregnant women.

Journal: Human reproduction (Oxford, England) 20030701

Title: Female oxytocin-deficient mice display enhanced anxiety-related behavior.

Journal: Endocrinology 20030601

Title: The effects of a progesterone metabolite, 5 beta-dihydroprogesterone, on oxytocin receptor binding in human myometrial membranes.

Journal: BJOG : an international journal of obstetrics and gynaecology 20030601

Title: Oxytocin and fetal membranes in preterm labor: current concepts and clinical implication.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20030601

Title: Molecular modeling of the neurohypophyseal receptor/atosiban complexes.

Journal: Protein and peptide letters 20030601

Title: Significant delay of birth in advanced preterm labour at 23 gestational weeks with an oxytocin antagonist.

Journal: European journal of obstetrics, gynecology, and reproductive biology 20030501

Title: Pharmacological effects of oxytocin on gastric emptying and intestinal transit of a non-nutritive liquid meal in female rats.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20030401

Title: [In utero medicalized transfers: medical regulation and transport process].

Journal: Journal de gynecologie, obstetrique et biologie de la reproduction 20030401

Title: The development and introduction of anti-oxytocic tocolytics.

Journal: BJOG : an international journal of obstetrics and gynaecology 20030401

Title: Exploring the role of Tractocile in everyday clinical practice.

Journal: BJOG : an international journal of obstetrics and gynaecology 20030401

Title: Review of clinical experience with atosiban and the Tractocile Efficacy Assessment Survey in Europe (TREASURE) study protocol.

Journal: International journal of clinical practice 20030301

Title: Effectiveness and safety of the oxytocin antagonist atosiban versus beta-adrenergic agonists in the treatment of preterm labour.

Journal: BJOG : an international journal of obstetrics and gynaecology 20030101

Title: An update on the controversies of tocolytic therapy for the prevention of preterm birth.

Journal: Acta obstetricia et gynecologica Scandinavica 20030101

Title: Oxytocin antagonists for tocolysis in preterm labour -- a systematic review.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20021101

Title: [Tocolysis: indications and contraindications. When to start and when to stop].

Journal: Journal de gynecologie, obstetrique et biologie de la reproduction 20021101

Title: [Which tocolytic drugs in case of preterm labor?].

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Title: [Special management for threatened preterm delivery in multiple pregnancies].

Journal: Journal de gynecologie, obstetrique et biologie de la reproduction 20021101

Title: Involvement of cholecystokinin receptor in the inhibition of gastric emptying by oxytocin in male rats.

Journal: Pflugers Archiv : European journal of physiology 20021101

Title: Effect of weaning system on milk composition and distribution of milk fat within the udder of East Friesian dairy ewes.

Journal: Journal of dairy science 20021001

Title: In vitro study of tocolytic effect of rofecoxib, a specific cyclo-oxygenase 2 inhibitor. Comparison and combination with other tocolytic agents.

Journal: BJOG : an international journal of obstetrics and gynaecology 20020901

Title: Development and clinical experience with the new evidence-based tocolytic atosiban.

Journal: Acta obstetricia et gynecologica Scandinavica 20020701

Title: Effects of mating stimuli and oxytocin on plasma cortisol concentration in gilts.

Journal: Reproductive biology 20020301

Title: Involvement of oxytocin and vasopressin in the pathophysiology of preterm labor and primary dysmenorrhea.

Journal: Progress in brain research 20020101

Title: Review on prostaglandin and oxytocin activity in preterm labor.

Journal: Collegium antropologicum 20011201

Title: Gastric antisecretory and antiulcer activity of oxytocin in rats and guinea pigs.

Journal: Life sciences 20011121

Title: Treatment of preterm labor with the oxytocin antagonist atosiban: a double-blind, randomized, controlled comparison with salbutamol.

Journal: European journal of obstetrics, gynecology, and reproductive biology 20011001

Title: Adverse and beneficial effects of tocolytic therapy.

Journal: Seminars in perinatology 20011001

Title: Oxytocin decreases carrageenan induced inflammation in rats.

Journal: Peptides 20010901

Title: NO-induced relaxation of labouring and non-labouring human myometrium is not mediated by cyclic GMP.

Journal: British journal of pharmacology 20010901

Title: Spontaneous contractions of myometrium from humans, non-human primate and rodents are sensitive to selective oxytocin receptor antagonism in vitro.

Journal: BJOG : an international journal of obstetrics and gynaecology 20010901

Title: Design of oxytocin antagonists, which are more selective than atosiban.

Journal: Journal of peptide science : an official publication of the European Peptide Society 20010901

Title: Atosiban for the primary prevention of preterm labour.

Journal: BJOG : an international journal of obstetrics and gynaecology 20010801

Title: Tocolysis with beta-adrenergic receptor agonists.

Journal: Seminars in perinatology 20010801

Title: Effects of oxytocin receptor antagonist atosiban on pregnant myometrium in vitro.

Journal: Obstetrics and gynecology 20010701

Title: Effect of centrally administered oxytocin on gastric and duodenal ulcers in rats.

Journal: Acta pharmacologica Sinica 20010601

Title: The oxytocin antagonist atosiban versus the beta-agonist terbutaline in the treatment of preterm labor. A randomized, double-blind, controlled study.

Journal: Acta obstetricia et gynecologica Scandinavica 20010501

Title: [Tocolysis. Atosiban, an ocytcin-receptor antagonist].

Journal: Journal de gynecologie, obstetrique et biologie de la reproduction 20010501

Title: The oxytocin receptor system: structure, function, and regulation.

Journal: Physiological reviews 20010401

Title: Oxytocin antagonist disrupts hypotension-evoked renin secretion and other responses in conscious rats.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20010301

Title: Oxytocin antagonists: clinical and scientific considerations.

Journal: Experimental physiology 20010301

Title: Effectiveness and safety of the oxytocin antagonist atosiban versus beta-adrenergic agonists in the treatment of preterm labour. The Worldwide Atosiban versus Beta-agonists Study Group.

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Title: Inhibition of prostaglandin synthesis and its effect on uterine activity during established premature labor in sheep.

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Title: Double-blind, randomized, controlled trial of atosiban and ritodrine in the treatment of preterm labor: a multicenter effectiveness and safety study.

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Title: Receptor binding of oxytocin and vasopressin antagonists and inhibitory effects on isolated myometrium from preterm and term pregnant women.

Journal: British journal of obstetrics and gynaecology 19991001

Title: Oxytocin and vasopressin constrict rat isolated uterine resistance arteries by activating vasopressin V1A receptors.

Journal: European journal of pharmacology 19990702

Title: Intrathecal injection of an oxytocin-receptor antagonist attenuated postnephrectomy natriuresis in the male rat.

Journal: Neuroscience letters 19950728

Title: Characterization of the human oxytocin receptor stably expressed in 293 human embryonic kidney cells.

Journal: Life sciences 19950101

Title: Mechanism of PKA-dependent and lipid-raft independent stimulation of Connexin43 expression by oxytoxin in mouse embryonic stem cells.

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Title: Philip J Ryan, et al. Oxytocin-receptor-expressing Neurons in the Parabrachial Nucleus Regulate Fluid Intake. Nat Neurosci. 2017 Dec;20(12):1722-1733.

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Tags:90779-69-4 Molecular Formula|90779-69-4 MDL|90779-69-4 SMILES|90779-69-4 1-({(4r,7s,13s,16r)-7-(2-amino-2-oxoethyl)-13-[(2s)-butan-2-yl]-16-(4-ethoxybenzyl)-10-[(1r)-1-hydroxyethyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)-l-prolyl-l-ornithylglycinamide