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Home Boronic Acids 1072833-77-2
1072833-77-2,MFCD18251438
Catalog No.:AA0037VR

1072833-77-2 | [(1R)-1-{2-[(2,5-dichlorophenyl)formamido]acetamido}-3-methylbutyl]boronic acid

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥95%
in stock  
$63.00   $44.00
- +
25mg
95%
in stock  
$208.00   $145.00
- +
100mg
95%
in stock  
$358.00   $251.00
- +
250mg
98%
in stock  
$394.00   $276.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0037VR
Chemical Name:
[(1R)-1-{2-[(2,5-dichlorophenyl)formamido]acetamido}-3-methylbutyl]boronic acid
CAS Number:
1072833-77-2
Molecular Formula:
C14H19BCl2N2O4
Molecular Weight:
361.0287
MDL Number:
MFCD18251438
SMILES:
OB([C@@H](NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)CC(C)C)O
Properties
Computed Properties
 
Complexity:
412  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
7  

Upstream Synthesis Route

[1]Patent:WO2018/158697,2018,A1,.Locationinpatent:Page/Pagecolumn25

[1]Patent:CN106916177,2017,A,.Locationinpatent:Paragraph0156;0165;0166

[1]RSCAdvances,2018,vol.8,#6,p.3343-3347

[1]Patent:CN106608883,2017,A,

[2]Patent:CN106916177,2017,A,

[3]Patent:WO2018/158697,2018,A1,

[1]Patent:CN106608883,2017,A,

[2]Patent:CN106916177,2017,A,

[3]Patent:WO2018/158697,2018,A1,

Downstream Synthesis Route
105-59-9    1072833-77-2   
2,5-dichloro-N-(R)-3-methyl-1-(6-methyl-1,3,6,2dioxazaborolan-2-yl)-butylcarbamoylmethyl}-benzamide 

[1]Patent:WO2012/177835,2012,A1.Locationinpatent:Page/Pagecolumn95-96

1072833-77-2    111-42-2   
2,5-dichloro-N-(2-((1R)-3-methyl-1-1,3,6,2-dioxaborolan-2-yl)-butylamino)-2-oxyethylbenzamide 

[1]Patent:WO2012/177835,2012,A1.Locationinpatent:Page/Pagecolumn92-93

1072833-77-2    110-97-4   
2,5-dichloro-N-(R)-1-(4,8-dimethyl-1,3,6,2dioxazaborolan-2-yl)-3-methyl-(butylcarbamoyl)methyl-benzamide 

[1]Patent:WO2012/177835,2012,A1.Locationinpatent:Page/Pagecolumn94-95

1072833-77-2   
N-methyliminodiaceticacid 
 
2,5-dichloro-N-(R)-3-methyl-1-(6-methyl-4,8-dioxo-1,3,6,2dioxazaborolan-2-yl)-butylcarbamoylmethyl}-benzamide 

[1]Patent:WO2012/177835,2012,A1.Locationinpatent:Page/Pagecolumn96-97

Literature

Title: The investigational proteasome inhibitor ixazomib for the treatment of multiple myeloma.

Journal: Future oncology (London, England) 20150101

Title: Ixazomib for the treatment of multiple myeloma.

Journal: Expert opinion on investigational drugs 20150101

Title: An evidence-based review of ixazomib citrate and its potential in the treatment of newly diagnosed multiple myeloma.

Journal: OncoTargets and therapy 20140101

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: Molecular mechanisms of acquired proteasome inhibitor resistance.

Journal: Journal of medicinal chemistry 20121213

Title: Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer.

Journal: Cancer research 20100301

Title: Bortezomib-mediated 26S proteasome inhibition causes cell-cycle arrest and induces apoptosis in CD-30+ anaplastic large cell lymphoma.

Journal: Leukemia 20070401

Title: Intracellular protein degradation: from a vague idea, through the lysosome and the ubiquitin-proteasome system, and onto human diseases and drug targeting (Nobel lecture).

Journal: Angewandte Chemie (International ed. in English) 20050919

Title: Kupperman E, et al. Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer. Cancer Res. 2010 Mar 1;70(5):1970-80.

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Tags:1072833-77-2 Molecular Formula|1072833-77-2 MDL|1072833-77-2 SMILES|1072833-77-2 [(1R)-1-{2-[(2,5-dichlorophenyl)formamido]acetamido}-3-methylbutyl]boronic acid