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Title: Mechanisms of conotoxin inhibition of N-type (Ca(v)2.2) calcium channels.
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Title: Intrathecal combination of ziconotide and morphine for refractory cancer pain: a rapidly acting and effective choice.
Journal: Pain20120101
Title: Ziconotide adverse events in patients with cancer pain: a multicenter observational study of a slow titration, multidrug protocol.
Journal: Pain physician20120101
Title: Targeting voltage-gated calcium channels for the treatment of neuropathic pain: a review of drug development.
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Title: [Experience in treatment of patients with neuropathic facial pain using ziconotide].
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Title: Regulation of spinal substance p release by intrathecal calcium channel blockade.
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Title: The effect of spider toxin PhTx3-4, ω-conotoxins MVIIA and MVIIC on glutamate uptake and on capsaicin-induced glutamate release and [Ca2+]i in spinal cord synaptosomes.
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Title: Italian registry on long-term intrathecal ziconotide treatment.
Journal: Pain physician20110101
Title: Ziconotide: A rapid detoxification protocol for the conversion from intrathecal morphine--the Raffaeli Detoxification Model.
Journal: Journal of opioid management20110101
Title: Neurotoxins and their binding areas on voltage-gated sodium channels.
Journal: Frontiers in pharmacology20110101
Title: Ziconotide combination intrathecal therapy: rationale and evidence.
Journal: The Clinical journal of pain20100901
Title: Analgesic effects of a substituted N-triazole oxindole (TROX-1), a state-dependent, voltage-gated calcium channel 2 blocker.
Journal: The Journal of pharmacology and experimental therapeutics20100801
Title: Ziconotide for treatment of severe chronic pain.
Journal: Lancet (London, England)20100501
Title: Case report: successful treatment of a patient with trigeminal neuropathy using ziconotide.
Journal: Anesthesia and analgesia20100401
Title: Sustained synaptic-vesicle recycling by bulk endocytosis contributes to the maintenance of high-rate neurotransmitter release stimulated by glycerotoxin.
Journal: Journal of cell science20100401
Title: Silencing neurotransmission with membrane-tethered toxins.
Journal: Nature methods20100301
Title: CNSB004 (Leconotide) causes antihyperalgesia without side effects when given intravenously: a comparison with ziconotide in a rat model of diabetic neuropathic pain.
Journal: Pain medicine (Malden, Mass.)20100201
Title: Formation of two consecutive intrathecal catheter tip granulomas within nine months.
Journal: Central European neurosurgery20100201
Title: Analgesic effect of highly reversible ω-conotoxin FVIA on N type Ca2+ channels.
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Title: Cilnidipine mediates a neuroprotective effect by scavenging free radicals and activating the phosphatidylinositol 3-kinase pathway.
Journal: Journal of neurochemistry20091001
Title: Suppression of formalin-induced nociception by cilnidipine, a voltage-dependent calcium channel blocker.
Journal: Biological & pharmaceutical bulletin20091001
Title: Histological protection by cilnidipine, a dual L/N-type Ca(2+) channel blocker, against neurotoxicity induced by ischemia-reperfusion in rat retina.
Journal: Experimental eye research20090501
Title: Long-term intrathecal ziconotide for chronic pain: an open-label study.
Journal: Journal of pain and symptom management20090301
Title: Intrathecal ziconotide and baclofen provide pain relief in seven patients with neuropathic pain and spasticity: case reports.
Journal: European journal of physical and rehabilitation medicine20090301
Title: Intrathecal ziconotide and opioid combination therapy for noncancer pain: an observational study.
Journal: Pain physician20090101
Title: Intrathecal therapy: what has changed with the introduction of ziconotide.
Journal: Pain practice : the official journal of World Institute of Pain20090101
Title: Intrathecal therapy with ziconotide: clinical experience and considerations on its use.
Journal: Minerva anestesiologica20081201
Title: Small molecule inhibitors of Hsp90 potently affect inflammatory disease pathways and exhibit activity in models of rheumatoid arthritis.
Journal: Arthritis and rheumatism20081201
Title: Ziconotide: new drug. Limited analgesic efficacy, too many adverse effects.
Journal: Prescrire international20081001
Title: Secondary hyperalgesia in the rat first degree burn model is independent of spinal cyclooxygenase and nitric oxide synthase.
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Title: [Central and peripheral mechanisms in antinociception: current and future perspectives].
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Title: Toxins from cone snails: properties, applications and biotechnological production.
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Title: [Chronic intrathecal drug administration for the control of intractable pain].
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Title: Phase II, open-label, multicenter study of combined intrathecal morphine and ziconotide: addition of ziconotide in patients receiving intrathecal morphine for severe chronic pain.
Journal: Pain medicine (Malden, Mass.)20080401
Title: Open-label, multicenter study of combined intrathecal morphine and ziconotide: addition of morphine in patients receiving ziconotide for severe chronic pain.
Journal: Pain medicine (Malden, Mass.)20080401
Title: Intrathecal ziconotide for severe chronic pain: safety and tolerability results of an open-label, long-term trial.
Journal: Anesthesia and analgesia20080201
Title: Intrathecal drug delivery for management of cancer and noncancer pain.
Journal: Journal of opioid management20080101
Title: Successful reduction of neuropathic pain associated with spinal cord injury via of a combination of intrathecal hydromorphone and ziconotide: a case report.
Journal: Spinal cord20071101
Title: Prolonged attenuation of amygdala-kindled seizure measures in rats by convection-enhanced delivery of the N-type calcium channel antagonists omega-conotoxin GVIA and omega-conotoxin MVIIA.
Journal: The Journal of pharmacology and experimental therapeutics20071101
Title: omega-Conotoxin MVIIA inhibits amygdaloid kindled seizures in Sprague-Dawley rats.
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Title: Nonclinical safety of ziconotide: an intrathecal analgesic of a new pharmaceutical class.
Journal: International journal of toxicology20070101
Title: Discussion forum.
Journal: Journal of pain & palliative care pharmacotherapy20070101
Title: A nonadherent cell-based HTS assay for N-type calcium channel using calcium 3 dye.
Journal: Assay and drug development technologies20061201
Title: Ziconotide--a novel neuron-specific calcium channel blocker for the intrathecal treatment of severe chronic pain--a short review.
Journal: International journal of clinical pharmacology and therapeutics20061001
Title: Ziconotide: a new nonopioid intrathecal analgesic for the treatment of chronic pain.
Journal: Expert review of neurotherapeutics20061001
Title: Pharmacological characterization of recombinant N-type calcium channel (Cav2.2) mediated calcium mobilization using FLIPR.
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Title: Development of antibody-based assays for omega-conotoxin MVIIA.
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Title: Blockade of presynaptic voltage-gated calcium channels in the medial prefrontal cortex of neonatal rats leads to post-pubertal alterations in locomotor behavior.
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Title: Treatment challenges and complications with ziconotide monotherapy in established pump patients.
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Title: Measurement of [3H]PN200-110 and [125I]omega-conotoxin MVIIA binding.
Journal: Methods in molecular biology (Clifton, N.J.)20060101
Title: Intrathecal ziconotide for refractory chronic pain.
Journal: The Annals of pharmacotherapy20060101
Title: Ziconotide, an intrathecally administered N-type calcium channel antagonist for the treatment of chronic pain.
Journal: Pharmacotherapy20050801
Title: SO-3, a new O-superfamily conopeptide derived from Conus striatus, selectively inhibits N-type calcium currents in cultured hippocampal neurons.
Journal: British journal of pharmacology20050701
Title: Medullary N-type and P/Q-type calcium channels contribute to neuropathy-induced allodynia.
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Title: Peptide leads new class of chronic pain drugs.
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Title: Antinociceptive effects of intrathecally administered huwentoxin-I, a selective N-type calcium channel blocker, in the formalin test in conscious rats.
Journal: Toxicon : official journal of the International Society on Toxinology20050101
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Journal: The American journal of hospice & palliative care20050101
Title: New drugs: tigecycline, ziconotide, and clofarabine.
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Title: Measurement of [³H]PN200-110 and [¹²⁵I]ω-conotoxin MVIIA binding.
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Title: Ziconotide: neuronal calcium channel blocker for treating severe chronic pain.
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Title: Design, synthesis, and preliminary pharmacological evaluation of 4-aminopiperidine derivatives as N-type calcium channel blockers active on pain and neuropathic pain.
Journal: Journal of medicinal chemistry20041118
Title: Depolarization-induced calcium influx in rat mesenteric small arterioles is mediated exclusively via mibefradil-sensitive calcium channels.
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Title: Intrathecal ziconotide in the treatment of refractory pain in patients with cancer or AIDS: a randomized controlled trial.
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Title: Calcium current subtypes in GnRH neurons.
Journal: Biology of reproduction20031201
Title: A novel alpha-conotoxin identified by gene sequencing is active in suppressing the vascular response to selective stimulation of sensory nerves in vivo.
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Title: Actions of intrathecal omega-conotoxins CVID, GVIA, MVIIA, and morphine in acute and neuropathic pain in the rat.
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Title: Blood pressure changes after intrathecal co-administration of calcium channel blockers with morphine or clonidine at the spinal level.
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Title: The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices.
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Title: Antisympathetic and hemodynamic property of a dual L/N-type Ca(2+) channel blocker cilnidipine in rats.
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Title: Identification and characterization of novel human Ca(v)2.2 (alpha 1B) calcium channel variants lacking the synaptic protein interaction site.
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Title: The influence exerted by the beta(3) subunit on MVIIA omega-conotoxin binding to neuronal N-type calcium channels.
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Title: Residue Gly1326 of the N-type calcium channel alpha 1B subunit controls reversibility of omega-conotoxin GVIA and MVIIA block.
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Title: Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes.
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Title: Inhibition of K(+)-evoked glutamate release from rat neocortical and hippocampal slices by gabapentin.
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Title: Pharmacotherapeutic potential of omega-conotoxin MVIIA (SNX-111), an N-type neuronal calcium channel blocker found in the venom of Conus magus.
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Title: Calcium channel subtypes in rat brain: biochemical characterization of the high-affinity receptors for omega-conopeptides SNX-230 (synthetic MVIIC), SNX-183 (SVIB), and SNX-111 (MVIIA).
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Title: Neuronal calcium channel antagonists. Discrimination between calcium channel subtypes using omega-conotoxin from Conus magus venom.
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