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107753-78-6,MFCD00864775
Catalog No.:AA007DRD

107753-78-6 | Zafirlukast

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1mg
99%
in stock  
$7.00   $5.00
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10mg
99%
in stock  
$15.00   $11.00
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25mg
99%
in stock  
$21.00   $15.00
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100mg
>98.0%(HPLC)
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$64.00   $45.00
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  • Technical Information
  • Properties
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA007DRD
Chemical Name:
Zafirlukast
CAS Number:
107753-78-6
Molecular Formula:
C31H33N3O6S
Molecular Weight:
575.6752
MDL Number:
MFCD00864775
SMILES:
COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C
Properties
Computed Properties
 
Complexity:
1010  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
41  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
9  
XLogP3:
5.5  

Literature

Title: Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology.

Journal: Journal of medicinal chemistry 20180712

Title: Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals.

Journal: Chemical research in toxicology 20170515

Title: A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20131101

Title: Zafirlukast inhibits complexation of Lsr2 with DNA and growth of Mycobacterium tuberculosis.

Journal: Antimicrobial agents and chemotherapy 20130501

Title: Cysteinyl leukotriene receptor antagonism alleviates renal injury induced by ischemia-reperfusion in rats.

Journal: The Journal of surgical research 20121101

Title: Zafirlukast antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance.

Journal: Anti-cancer drugs 20120901

Title: Efficacy of montelukast as added therapy in patients with chronic idiopathic urticaria.

Journal: Inflammation & allergy drug targets 20120601

Title: The effect of Zafirlukast on capsule formation in post-radiation silicone implants.

Journal: Medical hypotheses 20120601

Title: Fluconazole but not the CYP3A4 inhibitor, itraconazole, increases zafirlukast plasma concentrations.

Journal: European journal of clinical pharmacology 20120501

Title: Higher prevalence of obesity among children with asthma.

Journal: Obesity (Silver Spring, Md.) 20120501

Title: Lipofilling in skin affected by radiodermatitis: clinical and ultrasound aspects. Case report.

Journal: Il Giornale di chirurgia 20120501

Title: In vitro bioactivation of bazedoxifene and 2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol in human liver microsomes.

Journal: Chemico-biological interactions 20120415

Title: Management of chronic urticaria in Asia: 2010 AADV consensus guidelines.

Journal: Asia Pacific allergy 20120401

Title: Role of basic science in the development of new medicines: examples from the eicosanoid field.

Journal: The Journal of biological chemistry 20120323

Title: Effect of zafirlukast on capsular contracture around silicone implants in rats.

Journal: Acta cirurgica brasileira 20120101

Title: Achieving symptom control in patients with moderate asthma.

Journal: Clinical medicine insights. Circulatory, respiratory and pulmonary medicine 20120101

Title: Progress in the management of childhood asthma.

Journal: Asia Pacific allergy 20120101

Title: Allergic asthmatics show divergent lipid mediator profiles from healthy controls both at baseline and following birch pollen provocation.

Journal: PloS one 20120101

Title: Role of leukotrienes on protozoan and helminth infections.

Journal: Mediators of inflammation 20120101

Title: Development of a stability-indicating RP-LC method for the separation of a critical pair of impurities and their degradants in zafirlukast.

Journal: Journal of chromatographic science 20120101

Title: Chapter 16: Asthma in pregnancy.

Journal: Allergy and asthma proceedings 20120101

Title: Subpectoral and precapsular implant repositioning technique: correction of capsular contracture and implant malposition.

Journal: Aesthetic plastic surgery 20111201

Title: Reassessing the evidence hierarchy in asthma: evaluating comparative effectiveness.

Journal: Current allergy and asthma reports 20111201

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: Antiasthmatic drugs targeting the cysteinyl leukotriene receptor 1 alleviate central nervous system inflammatory cell infiltration and pathogenesis of experimental autoimmune encephalomyelitis.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20110901

Title: A computational approach to finding novel targets for existing drugs.

Journal: PLoS computational biology 20110901

Title: Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.

Journal: Journal of medicinal chemistry 20110714

Title: Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20110701

Title: Association between leukotriene-modifying agents and suicide: what is the evidence?

Journal: Drug safety 20110701

Title: Silicone and autoimmunity.

Journal: European journal of clinical investigation 20110201

Title: The CYP2C8 inhibitor gemfibrozil does not affect the pharmacokinetics of zafirlukast.

Journal: European journal of clinical pharmacology 20110201

Title: Identification of clinically used drugs that activate pregnane X receptors.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20110101

Title: Aspirin-exacerbated respiratory disease: evaluation and management.

Journal: Allergy, asthma & immunology research 20110101

Title: Canadian clinical practice guidelines for acute and chronic rhinosinusitis.

Journal: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 20110101

Title: Asthma in sickle cell disease: implications for treatment.

Journal: Anemia 20110101

Title: Differential inhibitory effects of CysLT(1) receptor antagonists on P2Y(6) receptor-mediated signaling and ion transport in human bronchial epithelia.

Journal: PloS one 20110101

Title: Pharmacotherapy of patients with mild persistent asthma: strategies and unresolved issues.

Journal: Frontiers in pharmacology 20110101

Title: Effect of Montelukast on bradykinin-induced contraction of isolated tracheal smooth muscle of guinea pig.

Journal: Indian journal of pharmacology 20110101

Title: Helping patients attain and maintain asthma control: reviewing the role of the nurse practitioner.

Journal: Journal of multidisciplinary healthcare 20110101

Title: Identification of novel functional inhibitors of acid sphingomyelinase.

Journal: PloS one 20110101

Title: Inverse agonism and its therapeutic significance.

Journal: Indian journal of pharmacology 20110101

Title: Relationship between leukotriene-modifying agent prescriptions dispensed and rate of suicide deaths by county in the US.

Journal: Drug, healthcare and patient safety 20110101

Title: Urticaria and angioedema.

Journal: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 20110101

Title: Asthma.

Journal: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 20110101

Title: Allergic rhinitis.

Journal: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 20110101

Title: Chronic urticaria.

Journal: Indian journal of dermatology 20110101

Title: A predictive ligand-based Bayesian model for human drug-induced liver injury.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20101201

Title: Effect of different monotherapies on serum nitric oxide and pulmonary functions in children with mild persistent asthma.

Journal: Archives of medical science : AMS 20101201

Title: Cysteinyl-leukotriene receptor antagonism blunts the acute hypotensive response to endotoxin in cats.

Journal: Journal of feline medicine and surgery 20101001

Title: Systemic therapies in managing sinonasal inflammation.

Journal: Otolaryngologic clinics of North America 20100601

Title: Important elements for the diagnosis of drug-induced liver injury.

Journal: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20100501

Title: Effect of combination of zafirlukast and quercetin on baroreflex sensitivity and endothelin production in rats with myocardial infarction.

Journal: International journal of clinical pharmacology and therapeutics 20100501

Title: Pharmacological characterization of the first potent and selective antagonist at the cysteinyl leukotriene 2 (CysLT(2)) receptor.

Journal: British journal of pharmacology 20100501

Title: Antileukotriene drugs in the treatment of asthma.

Journal: Polskie Archiwum Medycyny Wewnetrznej 20100301

Title: Concentration-dependent noncysteinyl leukotriene type 1 receptor-mediated inhibitory activity of leukotriene receptor antagonists.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20100215

Title: Pharmacogenetics of asthma in children.

Journal: Allergy, asthma & immunology research 20100101

Title: Protection of leukotriene receptor antagonist against aspirin-induced bronchospasm in asthmatics.

Journal: Allergy, asthma & immunology research 20100101

Title: Forced unbinding of GPR17 ligands from wild type and R255I mutant receptor models through a computational approach.

Journal: BMC structural biology 20100101

Title: Treatment of congestion in upper respiratory diseases.

Journal: International journal of general medicine 20100101

Title: Effects of Singulair (montelukast) treatment for capsular contracture.

Journal: Aesthetic surgery journal 20100101

Title: Characterization of leukotrienes in a pilot study of older asthma subjects.

Journal: Immunity & ageing : I & A 20100101

Title: Reproducibility of the airway response to an exercise protocol standardized for intensity, duration, and inspired air conditions, in subjects with symptoms suggestive of asthma.

Journal: Respiratory research 20100101

Title: The employment of leukotriene antagonists in cutaneous diseases belonging to allergological field.

Journal: Mediators of inflammation 20100101

Title: Randomized controlled trial of fish oil and montelukast and their combination on airway inflammation and hyperpnea-induced bronchoconstriction.

Journal: PloS one 20100101

Title: Genome-wide and follow-up studies identify CEP68 gene variants associated with risk of aspirin-intolerant asthma.

Journal: PloS one 20100101

Title: Pharmacogenomics of pediatric asthma.

Journal: Indian journal of human genetics 20100101

Title: A systematic review of economic evaluations of therapy in asthma.

Journal: Journal of asthma and allergy 20100101

Title: Update on recent advances in the management of aspirin exacerbated respiratory disease.

Journal: Yonsei medical journal 20091231

Title: A new look at the pathogenesis of asthma.

Journal: Clinical science (London, England : 1979) 20091223

Title: Montelukast is a potent and durable inhibitor of multidrug resistance protein 2-mediated efflux of taxol and saquinavir.

Journal: Biological & pharmaceutical bulletin 20091201

Title: Leukotriene modifiers in the treatment of asthma in children.

Journal: Therapeutic advances in respiratory disease 20091001

Title: Targeting leukotrienes for the treatment of COPD?

Journal: Inflammation & allergy drug targets 20090901

Title: Identification, characterization and synthesis of impurities of zafirlukast.

Journal: Journal of pharmaceutical and biomedical analysis 20090501

Title: Zafirlukast pocket delivery impairs the capsule healing around textured implants in rats.

Journal: Aesthetic plastic surgery 20090101

Title: Measuring cough severity: Perspectives from the literature and from patients with chronic cough.

Journal: Cough (London, England) 20090101

Title: Genetic effect of CysLTR2 polymorphisms on its mRNA synthesis and stabilization.

Journal: BMC medical genetics 20090101

Title: Variable expression of cysteinyl leukotriene type I receptor splice variants in asthmatic females with different promoter haplotypes.

Journal: BMC immunology 20090101

Title: Focus on collagen: in vitro systems to study fibrogenesis and antifibrosis state of the art.

Journal: Fibrogenesis & tissue repair 20090101

Title: Exercise-induced bronchoconstriction: The effects of montelukast, a leukotriene receptor antagonist.

Journal: Therapeutics and clinical risk management 20090101

Title: Treating rhinitis in the older population: special considerations.

Journal: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 20090101

Title: Leukotrienes in atherosclerosis: new target insights and future therapy perspectives.

Journal: Mediators of inflammation 20090101

Title: Contact urticaria: present scenario.

Journal: Indian journal of dermatology 20090101

Title: Management of difficult urticaria.

Journal: Indian journal of dermatology 20090101

Title: Leukotriene receptor antagonists in monotherapy or in combination with antihistamines in the treatment of chronic urticaria: a systematic review.

Journal: Journal of asthma and allergy 20090101

Title: Exercise-induced asthma: critical analysis of the protective role of montelukast.

Journal: Journal of asthma and allergy 20090101

Title: [Efficacy of leukotriene receptor antagonists in asthma treatment and analysis of background factors evaluated by a questionnaire survey among physicians].

Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20081201

Title: Evidence for a pathophysiological role of cysteinyl leukotrienes in classical Hodgkin lymphoma.

Journal: International journal of cancer 20081115

Title: Cysteinyl leucotriene receptor type 1 mediates contraction in human and guinea-pig oesophagus.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20081001

Title: Development and validation of a sensitive LC-MS/MS method with electrospray ionization for quantitation of zafirlukast, a selective leukotriene antagonist in human plasma: application to a clinical pharmacokinetic study.

Journal: Biomedical chromatography : BMC 20080601

Title: New approaches to managing asthma: a US perspective.

Journal: Therapeutics and clinical risk management 20080401

Title: Metabolic activation of a novel 3-substituted indole-containing TNF-alpha inhibitor: dehydrogenation and inactivation of CYP3A4.

Journal: Chemical research in toxicology 20080201

Title: Pharmacological intervention to the inflammatory response from decompression sickness in rats.

Journal: Aviation, space, and environmental medicine 20080201

Title: The effect of the leukotriene receptor antagonist zafirlukast on neurokinin A-induced bronchoconstriction in patients with asthma--A comparison with leukotriene D4 induced broncoconstriction.

Journal: Pulmonary pharmacology & therapeutics 20080101

Title: Histologic Analysis of Zafirlukast's Effect on Capsule Formation Around Silicone Implants: some considerations.

Journal: Aesthetic plastic surgery 20080101

Title: Effect of montelukast on platelet activating factor- and tachykinin induced mucus secretion in the rat.

Journal: Journal of occupational medicine and toxicology (London, England) 20080101

Title: New drugs targeting Th2 lymphocytes in asthma.

Journal: Journal of occupational medicine and toxicology (London, England) 20080101

Title: Reduction of capsular thickness around silicone breast implants by zafirlukast in rats.

Journal: European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes 20080101

Title: [Impact of new therapeutic products for the treatment of chronic obstructive pulmonary disease and asthma in primary care in Madrid between 1996 and 2005].

Journal: Gaceta sanitaria 20080101

Title: Tolerance and rebound with zafirlukast in patients with persistent asthma.

Journal: Journal of negative results in biomedicine 20080101

Title: Synthesis of tenascin and laminin beta2 chain in human bronchial epithelial cells is enhanced by cysteinyl leukotrienes via CysLT1 receptor.

Journal: Respiratory research 20080101

Title: The timing of implant exchange in the development of capsular contracture after breast reconstruction.

Journal: Eplasty 20080101

Title: [Treatment of the capsular contracture around mammary implants: our experience].

Journal: Il Giornale di chirurgia 20080101

Title: [Leukotrien antagonists in the treatment of allergic rhinitis and comorbidities].

Journal: Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) 20080101

Title: Pharmacological control of neutrophil-mediated inflammation: strategies targeting calcium handling by activated polymorphonuclear leukocytes.

Journal: Drug design, development and therapy 20080101

Title: Aspirin-exacerbated asthma.

Journal: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 20080101

Title: Participation in cysteinyl leukotrienes and thromboxane A2 in nasal congestion model in Brown Norway rats.

Journal: International immunopharmacology 20071101

Title: [Adverse effects of leukotriene-antagonists].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20071028

Title: [Influence of zafirlucast on the content of leukotrienes, biogenic amines and prostaglandins in blood and myocardium in epinephrine-induced heart injury].

Journal: Georgian medical news 20071001

Title: Editorial foreword.

Journal: Therapeutics and clinical risk management 20071001

Title: Montelukast: its role in the treatment of childhood asthma.

Journal: Therapeutics and clinical risk management 20071001

Title: Dehydrogenation of indoline by cytochrome P450 enzymes: a novel 'aromatase' process.

Journal: The Journal of pharmacology and experimental therapeutics 20070801

Title: [Not Available].

Journal: Therapeutics and clinical risk management 20070801

Title: Optimisation, validation and application of a capillary electrophoretic method for the determination of zafirlukast in pharmaceutical formulations.

Journal: Journal of pharmaceutical and biomedical analysis 20070509

Title: [Antileukotrienes and Churg-Strauss syndrome].

Journal: Presse medicale (Paris, France : 1983) 20070501

Title: Leukotriene synthesis inhibitors versus antagonists: the pros and cons.

Journal: Current allergy and asthma reports 20070501

Title: Effects of leukotriene inhibition on pulmonary morphology in rat pup lungs exposed to hyperoxia.

Journal: Comparative medicine 20070401

Title: Safety of leukotriene receptor antagonists in pregnancy.

Journal: The Journal of allergy and clinical immunology 20070301

Title: What do parents want from their child's asthma treatment?

Journal: Therapeutics and clinical risk management 20070301

Title: Prostaglandin I2 enhances cough reflex sensitivity to capsaicin in the asthmatic airway.

Journal: Cough (London, England) 20070101

Title: Leukotriene inhibitors in the treatment of allergy and asthma.

Journal: American family physician 20070101

Title: Safety of zafirlukast: results of a postmarketing surveillance study on 7976 patients in England.

Journal: Drug safety 20070101

Title: [Treatment of asthmatic patients with zafirlukast].

Journal: Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) 20070101

Title: Histologic analysis of zafirlukast's effect on capsule formation around silicone implants.

Journal: Aesthetic plastic surgery 20070101

Title: A class of repeated measures concordance correlation coefficients.

Journal: Journal of biopharmaceutical statistics 20070101

Title: Antileukotriene drugs: clinical application, effectiveness and safety.

Journal: Current medicinal chemistry 20070101

Title: Effects of zafirlukast on capsular contracture: controlled study measuring the mammary compliance.

Journal: International journal of immunopathology and pharmacology 20070101

Title: Comparison of antileukotrienes and antihistamines in the treatment of allergic rhinitis.

Journal: American journal of rhinology 20070101

Title: Salmeterol plus fluticasone propionate versus fluticasone propionate plus montelukast: a randomised controlled trial investigating the effects on airway inflammation in asthma.

Journal: Respiratory research 20070101

Title: Role of genetic polymorphisms in therapeutic response to anti-asthma therapy.

Journal: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 20070101

Title: Effects of KP-496, a novel dual antagonist for leukotriene D4 and thromboxane A2 receptors, on contractions induced by various agonists in the guinea pig trachea.

Journal: Allergology international : official journal of the Japanese Society of Allergology 20061201

Title: The expanding role of leukotriene receptor antagonists in chronic asthma.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20061201

Title: Involvement of cyclooxygenase-2 in allergic nasal inflammation in rats.

Journal: International immunopharmacology 20061101

Title: Personal and ambient air pollution is associated with increased exhaled nitric oxide in children with asthma.

Journal: Environmental health perspectives 20061101

Title: Inhibitory effects of angiotensin II receptor antagonists and leukotriene receptor antagonists on the transport of human organic anion transporter 4.

Journal: The Journal of pharmacy and pharmacology 20061101

Title: Effect of leukotriene modifier drugs on the safety of oral aspirin challenges.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20061101

Title: Long-acting beta2-agonists versus anti-leukotrienes as add-on therapy to inhaled corticosteroids for chronic asthma.

Journal: The Cochrane database of systematic reviews 20061018

Title: Effect of aging on respiratory system physiology and immunology.

Journal: Clinical interventions in aging 20060901

Title: Montelukast and zafirlukast do not affect the pharmacokinetics of the CYP2C8 substrate pioglitazone.

Journal: European journal of clinical pharmacology 20060701

Title: Treating allergic rhinitis and asthma: different sides of the same fence.

Journal: Expert opinion on pharmacotherapy 20060701

Title: Pioglitazone is metabolised by CYP2C8 and CYP3A4 in vitro: potential for interactions with CYP2C8 inhibitors.

Journal: Basic & clinical pharmacology & toxicology 20060701

Title: Daily versus intermittent corticosteroids for the treatment of mild persistent asthma.

Journal: Expert opinion on pharmacotherapy 20060601

Title: Effects of leukotriene receptor antagonists on monocyte chemotaxis, p38 and cytoplasmic calcium.

Journal: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 20060601

Title: Cysteinyl leukotrienes: multi-functional mediators in allergic rhinitis.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20060601

Title: Is there a role for antileukotrienes in urticaria?

Journal: Clinical and experimental dermatology 20060501

Title: [The influence of antileukotrienes on the skin reactivity induced by histamine and allergens by visual evaluation and laser Doppler flowmetry].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20060501

Title: Efficacy of a leukotriene receptor antagonist in the treatment of perennial allergic rhinitis.

Journal: The Journal of otolaryngology 20060401

Title: The role of leukotrienes in the pathophysiology of inflammatory disorders: is there a case for revisiting leukotrienes as therapeutic targets?

Journal: Inflammopharmacology 20060301

Title: Managing asthma in expectant mothers.

Journal: Treatments in respiratory medicine 20060101

Title: CysLT1 receptor-induced human airway smooth muscle cells proliferation requires ROS generation, EGF receptor transactivation and ERK1/2 phosphorylation.

Journal: Respiratory research 20060101

Title: Adverse reaction in a patient with aspirin-induced asthma treated with zafirlukast.

Journal: Journal of investigational allergology & clinical immunology 20060101

Title: Analysis of airway secretions in a model of sulfur dioxide induced chronic obstructive pulmonary disease (COPD).

Journal: Journal of occupational medicine and toxicology (London, England) 20060101

Title: The effects of zafirlukast on capsular contracture: preliminary report.

Journal: Aesthetic plastic surgery 20060101

Title: A reversed-phase high-performance liquid chromatographic method for the determination of zafirlukast in pharmaceutical formulations and human plasma.

Journal: Journal of AOAC International 20060101

Title: 2003 canadian asthma consensus guidelines executive summary.

Journal: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 20060101

Title: The cysteinyl-leukotriene-1 receptor antagonist zafirlukast is a potent secretagogue in rat and human airways.

Journal: European journal of pharmacology 20051219

Title: Effects of antioxidant therapy on leukocyte myeloperoxidase and Cu/Zn-superoxide dismutase and plasma malondialdehyde levels in experimental colitis.

Journal: Mediators of inflammation 20051214

Title: Prediction of CYP2C9-mediated drug-drug interactions: a comparison using data from recombinant enzymes and human hepatocytes.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20051101

Title: Leukotriene receptor antagonists--an update.

Journal: Drug and therapeutics bulletin 20051101

Title: Effects of fexofenadine hydrochloride in a guinea pig model of antigen-induced rhinitis.

Journal: Pharmacology 20051001

Title: Electrochemical characteristics of zafirlukast and its determination in pharmaceutical formulations by voltammetric methods.

Journal: Journal of pharmaceutical and biomedical analysis 20050915

Title: Churg-Strauss vasculitis syndrome and leukotriene receptor antagonists.

Journal: Annals of the rheumatic diseases 20050901

Title: The combined effects of zafirlukast, prednisone, and inhaled budesonide on IL-13 and IFN-gamma secretion.

Journal: Journal of clinical immunology 20050901

Title: Zafirlukast metabolism by cytochrome P450 3A4 produces an electrophilic alpha,beta-unsaturated iminium species that results in the selective mechanism-based inactivation of the enzyme.

Journal: Chemical research in toxicology 20050901

Title: Childhood asthma. Balancing efficacy and adherence for optimum management.

Journal: Postgraduate medicine 20050901

Title: Daily inhaled corticosteroid treatment should not be prescribed for mild persistent asthma. Con.

Journal: American journal of respiratory and critical care medicine 20050815

Title: Treatment of mild asthma.

Journal: The New England journal of medicine 20050728

Title: Differential effect of zileuton, a 5-lipoxygenase inhibitor, against nociceptive paradigms in mice and rats.

Journal: Pharmacology, biochemistry, and behavior 20050701

Title: Expression of functional cysteinyl leukotriene receptors by human basophils.

Journal: The Journal of allergy and clinical immunology 20050701

Title: Effects of drug treatment on inflammation and hyperreactivity of airways and on immune variables in cats with experimentally induced asthma.

Journal: American journal of veterinary research 20050701

Title: Prediction of genotoxicity of chemical compounds by statistical learning methods.

Journal: Chemical research in toxicology 20050601

Title: The role of leukotrienes in allergic rhinitis.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20050601

Title: The linkage between Churg-Strauss syndrome and leukotriene receptor antagonists: fact or fiction?

Journal: Therapeutics and clinical risk management 20050601

Title: Daily versus as-needed corticosteroids for mild persistent asthma.

Journal: The New England journal of medicine 20050414

Title: Does mild persistent asthma require regular treatment?

Journal: The New England journal of medicine 20050414

Title: Evaluating the prophylactic potential of the phtalimide derivative LASSBio 552 on allergen-evoked inflammation in rats.

Journal: European journal of pharmacology 20050328

Title: Treatment of category III A prostatitis with zafirlukast: a randomized controlled feasibility study.

Journal: International journal of STD & AIDS 20050301

Title: Asthma controller therapy during pregnancy.

Journal: American journal of obstetrics and gynecology 20050201

Title: Leukotriene E(4)-induced persistent eosinophilia and airway obstruction are reversed by zafirlukast in patients with asthma.

Journal: The Journal of allergy and clinical immunology 20050201

Title: Long-acting beta2-agonists versus anti-leukotrienes as add-on therapy to inhaled corticosteroids for chronic asthma.

Journal: The Cochrane database of systematic reviews 20050125

Title: Examination of 209 drugs for inhibition of cytochrome P450 2C8.

Journal: Journal of clinical pharmacology 20050101

Title: Leukotrienes: their role in the treatment of asthma and seasonal allergic rhinitis.

Journal: Pediatric nursing 20050101

Title: [Nasal budesonide plus zafirlukast vs nasal budesonide plus loratadine-pseudoephedrine for controlling the symptoms of rhinitis and asthma].

Journal: Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) 20050101

Title: Change in bronchial responsiveness and cough reflex sensitivity in patients with cough variant asthma: effect of inhaled corticosteroids.

Journal: Cough (London, England) 20050101

Title: Cough: are children really different to adults?

Journal: Cough (London, England) 20050101

Title: The effect of zafirlukast (Accolate) on early capsular contracture in the primary augmentation patient: a pilot study.

Journal: Aesthetic surgery journal 20050101

Title: Role of leukotriene receptor antagonists in the treatment of exercise-induced bronchoconstriction: a review.

Journal: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 20050101

Title: Re-establishment of olfactory and taste functions.

Journal: GMS current topics in otorhinolaryngology, head and neck surgery 20050101

Title: The effects of add-on zafirlukast treatment to budesonide on bronchial hyperresponsiveness and serum levels of eosinophilic cationic protein and total antioxidant capacity in asthmatic patients.

Journal: The Tohoku journal of experimental medicine 20041201

Title: Solvates of zafirlukast.

Journal: Acta crystallographica. Section C, Crystal structure communications 20041201

Title: Primary (idiopathic) cold urticaria and cholinergic urticaria.

Journal: Dermatology online journal 20041130

Title: Participation of chemical mediators in the development of experimental allergic conjunctivitis in rats.

Journal: International immunopharmacology 20041101

Title: Zafirlukast treatment for acute asthma: evaluation in a randomized, double-blind, multicenter trial.

Journal: Chest 20041101

Title: Effects of different anti-asthmatic agents on induced sputum and eosinophil cationic protein in mild asthmatics.

Journal: Respirology (Carlton, Vic.) 20041101

Title: Leukotriene antagonists attenuate late phase nitric oxide production during the hypersensitivity response in the conjunctiva.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20040801

Title: Zafirlukast for severe recurrent vulvovaginal candidiasis: an open label pilot study.

Journal: Sexually transmitted infections 20040601

Title: Identification of multidrug resistance-associated protein 1 and glutathione as multidrug resistance mechanisms in human prostate cancer cells: chemosensitization with leukotriene D4 antagonists and buthionine sulfoximine.

Journal: BJU international 20040601

Title: Asthma drug zafirlukast (Accolate): serious hepatic events.

Journal: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20040525

Title: Leukotriene modifier vs inhaled corticosteroid in mild-to-moderate asthma: clinical and anti-inflammatory effects.

Journal: Chest 20040501

Title: Potential of pranlukast and zafirlukast in the inhibition of human liver cytochrome P450 enzymes.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20040501

Title: Inverse agonist activity of selected ligands of the cysteinyl-leukotriene receptor 1.

Journal: The Journal of pharmacology and experimental therapeutics 20040401

Title: Leukotriene receptor antagonism in experimental acute pancreatitis in rats.

Journal: European journal of gastroenterology & hepatology 20040401

Title: Safety of rush immunotherapy to multiple aeroallergens in an adult population.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20040401

Title: Leukotriene receptor antagonists are ineffective for severe atopic dermatitis.

Journal: Journal of the American Academy of Dermatology 20040301

Title: Light and electron microscopic evaluation of antileukotriene therapy for experimental rat endometriosis.

Journal: Fertility and sterility 20040301

Title: Histamine and fluoxetine: common playground in the rat conjunctiva?

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20040301

Title: What doctors aren't being told: using the freedom of information act.

Journal: Plastic and reconstructive surgery 20040201

Title: [Churg-Strauss syndrome induced by anti-leukotrienes: fact or fiction?].

Journal: Revue des maladies respiratoires 20040201

Title: The addition of zafirlukast to cetirizine improves the treatment of chronic urticaria in patients with positive autologous serum skin test results.

Journal: The Journal of allergy and clinical immunology 20040101

Title: A chronic model for evaluating the itching associated with allergic conjunctivitis in rats.

Journal: International immunopharmacology 20040101

Title: Evaluation of the utilization patterns of leukotriene modifiers in a large managed care health plan.

Journal: Journal of managed care pharmacy : JMCP 20040101

Title: Add-on therapy options in asthma not adequately controlled by inhaled corticosteroids: a comprehensive review.

Journal: Respiratory research 20040101

Title: Combination therapy of long-acting beta2-adrenoceptor agonists and corticosteroids for asthma.

Journal: Treatments in respiratory medicine 20040101

Title: Cutaneous vasculitis associated with zafirlukast use in asthma.

Journal: The Journal of asthma : official journal of the Association for the Care of Asthma 20040101

Title: Pycnogenol as an adjunct in the management of childhood asthma.

Journal: The Journal of asthma : official journal of the Association for the Care of Asthma 20040101

Title: Advances in therapy with antileukotriene drugs.

Journal: Annals of clinical and laboratory science 20040101

Title: Single-dose agents in the prevention of exercise-induced asthma: a descriptive review.

Journal: Treatments in respiratory medicine 20040101

Title: Effect of the two different leukotriene receptor antagonists, montelukast and zafirlukast, on quality of life: a 12-week randomized study.

Journal: Allergy and asthma proceedings 20040101

Title: [Therapeutic effects of an antileukotriene in children with moderate-severe persistent asthma].

Journal: Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) 20040101

Title: Structure-activity relationships of indole cytosolic phospholipase A(2)alpha inhibitors: substrate mimetics.

Journal: Bioorganic & medicinal chemistry letters 20031215

Title: Generation and evaluation of a CYP2C9 heteroactivation pharmacophore.

Journal: The Journal of pharmacology and experimental therapeutics 20031201

Title: Evaluating the prophylactic potential of zafirlukast against the toxic effects of acetic acid on the rat colon.

Journal: Toxicology letters 20031101

Title: Interactions among three classes of mediators explain antigen-induced bronchoconstriction in the isolated perfused and ventilated guinea pig lung.

Journal: The Journal of pharmacology and experimental therapeutics 20031001

Title: Acute renal failure and nephrotic syndrome associated with zafirlukast therapy.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20031001

Title: Treatment of acquired cold urticaria with cetirizine and zafirlukast in combination.

Journal: Journal of the American Academy of Dermatology 20031001

Title: Churg-Strauss syndrome: clinical presentation, antineutrophil cytoplasmic antibodies, and leukotriene receptor antagonists.

Journal: The American journal of medicine 20030901

Title: Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2, COX-1 and COX-2 selective inhibitors, and an LTC4 receptor antagonist.

Journal: British journal of pharmacology 20030901

Title: The cysteinyl-leukotriene D4 induces cytosolic Ca2+ elevation and contraction of the human detrusor muscle.

Journal: The Journal of urology 20030801

Title: Zafirlukast improves pulmonary function in patients with moderate persistent asthma receiving regular inhaled steroids: a prospective randomized control study.

Journal: Chang Gung medical journal 20030801

Title: Asthma associated with worsening leg ulcer: a case of vasculitis in primary care.

Journal: Southern medical journal 20030701

Title: Effects of zafirlukast on bronchial asthma and allergic rhinitis.

Journal: Pharmacological research 20030601

Title: [Anosmia as presenting symptom of Churg-Strauss syndrome].

Journal: Revista clinica espanola 20030501

Title: Leukotriene antagonists.

Journal: Clinics in liver disease 20030501

Title: Anti-leukotriene drugs in the prevention and treatment of hepatorenal syndrome.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20030401

Title: The role of chemical mediators in eosinophil infiltration in allergic rhinitis in mice.

Journal: International immunopharmacology 20030401

Title: Effects of leukotriene receptor antagonist on chronic obstructive [correction of obstractive] pulmonary disease induced pulmonary hypertension.

Journal: Chinese medical journal 20030301

Title: A pilot study of zafirlukast as an anti-inflammatory agent in the treatment of adults with cystic fibrosis.

Journal: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 20030301

Title: Investigation of accolate and singulair for treatment of capsular contracture yields safety concerns.

Journal: Aesthetic surgery journal 20030301

Title: Results of using zafirlukast (Accolate) and montelukast (Singulair) for treatment of capsular contracture.

Journal: Aesthetic surgery journal 20030301

Title: Commentary: investigation of accolate and singulair for treatment of capsular contracture yields safety concerns.

Journal: Aesthetic surgery journal 20030301

Title: Pharmacotherapy for allergic rhinitis: a critical review of leukotriene receptor antagonists compared with other treatments.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20030201

Title: Lipoxygenase and cyclooxygenase metabolism: new insights in treatment and chemoprevention of pancreatic cancer.

Journal: Molecular cancer 20030101

Title: Potential use of leukotriene inhibitors in treatment of psoriasis.

Journal: Dermatology (Basel, Switzerland) 20030101

Title: Chronic urticaria: a role for newer immunomodulatory drugs?

Journal: American journal of clinical dermatology 20030101

Title: Pranlukast: a review of its use in the management of asthma.

Journal: Drugs 20030101

Title: Benefit-risk assessment of antileukotrienes in the management of asthma.

Journal: Drug safety 20030101

Title: Short-term effect of the addition of leukotriene receptor antagonists to the current therapy in severe asthmatics.

Journal: Pulmonary pharmacology & therapeutics 20030101

Title: Bronchodilator effect of zafirlukast in subjects with chronic obstructive pulmonary disease.

Journal: Pulmonary pharmacology & therapeutics 20030101

Title: Effect of zafirlukast on methacholine and ultrasonically nebulized distilled water challenge in patients with mild asthma.

Journal: Respiration; international review of thoracic diseases 20030101

Title: Recent advances in the management of asthma using leukotriene modifiers.

Journal: American journal of respiratory medicine : drugs, devices, and other interventions 20030101

Title: Treatment options for initial maintenance therapy of persistent asthma: a review of inhaled corticosteroids and leukotriene receptor antagonists.

Journal: Drugs 20030101

Title: Facial swelling and eosinophilia in a 44-year-old woman.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20021201

Title: Zafirlukast has no beneficial effects in the treatment of chronic urticaria.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20021201

Title: Lipoxin, leukotriene, and PDGF receptors cross-talk to regulate mesangial cell proliferation.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20021101

Title: Zafirlukast-induced acute hepatitis.

Journal: Zhonghua yi xue za zhi = Chinese medical journal; Free China ed 20021101

Title: Use of zafirlucast, cysteine-containing leukotriene antagonist, in epinephrine-induced heart injury.

Journal: Bulletin of experimental biology and medicine 20021101

Title: Determination of zafirlukast by stability indicating LC and derivative spectrophotometry.

Journal: Journal of pharmaceutical and biomedical analysis 20021015

Title: Mediators of adenosine- and ovalbumen-induced bronchoconstriction of sensitized guinea-pig isolated airways.

Journal: European journal of pharmacology 20020906

Title: Fluticasone is associated with lower asthma-related costs than leukotriene modifiers in a real-world analysis.

Journal: Pharmacotherapy 20020901

Title: Participation of chemical mediators other than histamine in nasal allergy signs: a study using mice lacking histamine H(1) receptors.

Journal: European journal of pharmacology 20020809

Title: Chemoprevention by lipoxygenase and leukotriene pathway inhibitors of vinyl carbamate-induced lung tumors in mice.

Journal: Cancer research 20020801

Title: Vasculitis induced by zafirlukast therapy.

Journal: Clinical rheumatology 20020801

Title: Churg-Strauss syndrome in a case of asthma.

Journal: Allergy 20020701

Title: Efficacy and safety of low-dose fluticasone propionate compared with zafirlukast in patients with persistent asthma.

Journal: The American journal of medicine 20020701

Title: Effects of adding either a leukotriene receptor antagonist or low-dose theophylline to a low or medium dose of inhaled corticosteroid in patients with persistent asthma.

Journal: Chest 20020701

Title: Zafirlukast (Accolate): A new treatment for capsular contracture.

Journal: Aesthetic surgery journal 20020701

Title: Novel phthalimide derivatives, designed as leukotriene D(4) receptor antagonists.

Journal: Bioorganic & medicinal chemistry letters 20020603

Title: Pulmonary function changes and immunomodulation of cytokine expression by zafirlukast after sensitization and allergen challenge in brown Norway rats.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20020601

Title: Antitussive effect of the leukotriene receptor antagonist zafirlukast in subjects with cough-variant asthma.

Journal: The Journal of asthma : official journal of the Association for the Care of Asthma 20020601

Title: 5-Lipoxygenase polymorphism and in-vivo response to leukotriene receptor antagonists.

Journal: European journal of clinical pharmacology 20020601

Title: Exercise-induced asthma: is there still a case for histamine?

Journal: The Journal of allergy and clinical immunology 20020501

Title: Influence of zafirlukast and loratadine on exercise-induced bronchoconstriction.

Journal: The Journal of allergy and clinical immunology 20020501

Title: Comparison of second controller medications in addition to inhaled corticosteroid in patients with moderate asthma.

Journal: Respiratory medicine 20020501

Title: [Reflections on antileukotrienes].

Journal: Atencion primaria 20020415

Title: Pharmacological differences among CysLT(1) receptor antagonists with respect to LTC(4) and LTD(4) in human lung parenchyma.

Journal: Biochemical pharmacology 20020415

Title: Pharmacogenetics of asthma.

Journal: American journal of respiratory and critical care medicine 20020401

Title: [Zafirlukast (Accolate): a review of its pharmacological and clinical profile].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20020401

Title: Where do leukotriene modifiers fit in asthma management?

Journal: The Nurse practitioner 20020401

Title: Loss of response to treatment with leukotriene receptor antagonists but not inhaled corticosteroids in patients over 50 years of age.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20020401

Title: Inhaled fluticasone and zafirlukast in persistent asthma.

Journal: The American journal of medicine 20020301

Title: Treatment of canine atopic dermatitis with zafirlukast, a leukotriene-receptor antagonist: a single-blinded, placebo-controlled study.

Journal: The Canadian veterinary journal = La revue veterinaire canadienne 20020301

Title: Prevalence of serious eosinophilia and incidence of Churg-Strauss syndrome in a cohort of asthma patients.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20020301

Title: Leukotriene modifiers: novel therapeutic opportunities in asthma.

Journal: Farmaco (Societa chimica italiana : 1989) 20020301

Title: [Zafirlukast in treatment of nasal polyps in patients with aspirin intolerant bronchial asthma--preliminary report].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20020301

Title: [Churg-Strauss syndrome after treatment with Singulair (montelukast)].

Journal: Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20020220

Title: Receptor preferences of cysteinyl-leukotrienes in the guinea pig lung parenchyma.

Journal: European journal of pharmacology 20020201

Title: Pharmacoeconomic studies of asthma controller drugs: marketing gimmick or icing on the cake?

Journal: Pharmacotherapy 20020201

Title: Economic impact of asthma therapy with fluticasone propionate, montelukast, or zafirlukast in a managed care population.

Journal: Pharmacotherapy 20020201

Title: [Study on relationship between leukotrienes and exercise-induced asthma].

Journal: Zhonghua yi xue za zhi 20020110

Title: Design, synthesis and pharmacological evaluation of novel pyrazolo[3,4-b]thieno[2,3-d]pyridine acid derivatives: a new class of anti-inflammatory and anti-platelet agents.

Journal: Bioorganic & medicinal chemistry letters 20020107

Title: Pharmacokinetic profile of zafirlukast.

Journal: Clinical pharmacokinetics 20020101

Title: [New horizons in the treatment of atopic dermatitis].

Journal: Allergologia et immunopathologia 20020101

Title: [Aspirin induced asthma, urinary leukotriene E4 and zafirlukast].

Journal: Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) 20020101

Title: Leukotriene receptor antagonists in the treatment of asthma: an update.

Journal: Allergy 20020101

Title: [Anti-leukotriene therapy of patients with allergic rhinosinusitis and bronchial asthma].

Journal: Vestnik otorinolaringologii 20020101

Title: [Measurement of cytokines in patients with exercise-induced asthma treated with anti-leukotrienes].

Journal: Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) 20020101

Title: Inhibitory effects of zafirlukast on respiratory bursts of human neutrophils.

Journal: Drugs under experimental and clinical research 20020101

Title: [Leukotriene antagonist drugs].

Journal: Pneumonologia i alergologia polska 20020101

Title: Severe liver injury associated with zafirlukast.

Journal: Annals of internal medicine 20011120

Title: Molecular cloning and functional characterization of murine cysteinyl-leukotriene 1 (CysLT(1)) receptors.

Journal: Biochemical pharmacology 20011101

Title: Chronic asthma.

Journal: BMJ (Clinical research ed.) 20011027

Title: Severe liver injury.

Journal: Annals of internal medicine 20011002

Title: Leukotriene receptor antagonists in the treatment of allergic rhinitis.

Journal: The Annals of pharmacotherapy 20011001

Title: [Leukotriene modifiers].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20011001

Title: Zafirlukast-related hepatitis: report of a further case.

Journal: Journal of hepatology 20011001

Title: Acute hepatocellular injury associated with zafirlukast.

Journal: Journal of hepatology 20011001

Title: Asthma treatment with inhaled corticosteroids versus antileukotrienes: what exhaled nitric oxide studies do and do not tell us.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20011001

Title: The effect of low-dose inhaled fluticasone propionate on exhaled nitric oxide in asthmatic patients and comparison with oral zafirlukast.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20011001

Title: Fulminant eosinophilic endomyocarditis in an asthmatic patient treated with pranlukast after corticosteroid withdrawal.

Journal: Heart (British Cardiac Society) 20010901

Title: Effects of zafirlukast upon clinical, physiologic, and inflammatory responses to natural cat allergen exposure.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20010901

Title: A comparison of short-term treatment with inhaled fluticasone propionate and zafirlukast for patients with persistent asthma.

Journal: The American journal of medicine 20010815

Title: Comparison of inhaled salmeterol and oral zafirlukast in asthmatic patients using concomitant inhaled corticosteroids.

Journal: MedGenMed : Medscape general medicine 20010705

Title: Fluticasone propionate compared with zafirlukast in controlling persistent asthma: a randomized double-blind, placebo-controlled trial.

Journal: The Journal of family practice 20010701

Title: Role of cysteinyl leukotrienes in nociceptive and inflammatory conditions in experimental animals.

Journal: European journal of pharmacology 20010629

Title: [Influence of zafirlukast on pulmonary functions and quality of life in patients with asthma].

Journal: Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University 20010628

Title: Safety of antileukotriene agents in asthma management.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20010601

Title: The role of antileukotrienes in the treatment of asthma.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20010601

Title: Discovery of leukotrienes and development of antileukotriene agents.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20010601

Title: Efficacy of antileukotriene agents in asthma management.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20010601

Title: [The relationship between eosinophils, activated T lymphocyte, leukotreine and the exercise-induced asthma].

Journal: Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20010601

Title: Synergistic antiallergic activity of combined histamine H1- and cysteinyl leukotriene1-receptor blockade in human bronchus.

Journal: Life sciences 20010511

Title: Leukotriene receptor antagonists in chronic urticaria.

Journal: Allergy 20010501

Title: Use of changes in symptoms to predict changes in lung function in assessing the response to asthma therapy.

Journal: Clinical therapeutics 20010501

Title: Modulation of the immediate allergic wheal reaction in the skin by drugs inhibiting the effects of leukotriene C4 and prostaglandin D2.

Journal: European journal of clinical pharmacology 20010401

Title: Enhanced prostaglandin E2 secretion in sputum from asthmatic patients after zafirlukast therapy.

Journal: Journal of the Formosan Medical Association = Taiwan yi zhi 20010401

Title: Efficacy of zafirlukast in the treatment of patients with bronchial asthma.

Journal: Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 20010301

Title: Antileukotrienes in asthma: present situation.

Journal: Expert opinion on pharmacotherapy 20010301

Title: Leukotriene modifiers in pediatric asthma management.

Journal: Pediatrics 20010201

Title: Asthma outcome changes associated with use of the leukotriene-receptor antagonist zafirlukast.

Journal: Managed care interface 20010201

Title: Allergy and angiitis: two aspects of Churg-Strauss syndrome.

Journal: Internal medicine (Tokyo, Japan) 20010201

Title: One-year claims analysis comparing inhaled fluticasone propionate with zafirlukast for the treatment of asthma.

Journal: The Journal of allergy and clinical immunology 20010101

Title: Zafirlukast: an update of its pharmacology and therapeutic efficacy in asthma.

Journal: Drugs 20010101

Title: Leukotriene inhibitors and non-steroidal therapies in the treatment of asthma.

Journal: Expert opinion on pharmacotherapy 20010101

Title: Role of Zafirlukast on skin prick test.

Journal: Allergologia et immunopathologia 20010101

Title: Pathophysiology of the cysteinyl leukotrienes and effects of leukotriene receptor antagonists in asthma.

Journal: Allergy 20010101

Title: The role of leukotriene receptor antagonists in the treatment of chronic asthma in childhood.

Journal: Allergy 20010101

Title: Comparative efficacy of inhaled corticosteroids and antileukotriene drugs in asthma.

Journal: BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 20010101

Title: Cost-efficacy analysis of fluticasone propionate versus zafirlukast in patients with persistent asthma.

Journal: PharmacoEconomics 20010101

Title: Pharmacology of airway afferent nerve activity.

Journal: Respiratory research 20010101

Title: Addition of anti-leukotriene agents to inhaled corticosteroids for chronic asthma.

Journal: The Cochrane database of systematic reviews 20010101

Title: Comparison of the bronchodilating effect of salmeterol and zafirlukast in combination with that of their use as single treatments in asthma and chronic obstructive pulmonary disease.

Journal: Respiration; international review of thoracic diseases 20010101

Title: An open study to evaluate the safety and efficacy of zafirlukast ('Accolate') in patients with mild to moderate asthma in Ibadan, Nigeria.

Journal: West African journal of medicine 20010101

Title: Zafirlukast versus budesonide on bronchial reactivity in subjects with mild-persistent asthma.

Journal: International journal of immunopathology and pharmacology 20010101

Title: A novel hepatointestinal leukotriene B4 receptor. Cloning and functional characterization.

Journal: The Journal of biological chemistry 20001229

Title: Severe liver injury after treatment with the leukotriene receptor antagonist zafirlukast.

Journal: Annals of internal medicine 20001219

Title: Fluticasone propionate versus zafirlukast: effect in patients previously receiving inhaled corticosteroid therapy.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20001101

Title: [Zafirlukast inhibition of leukotriene C4 induced endothelin-1 expression in human airway structural cell].

Journal: Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20001001

Title: Characterization of the human cysteinyl leukotriene 2 receptor.

Journal: The Journal of biological chemistry 20000929

Title: Dose selection and dosing interval determination for LTRA use in asthma.

Journal: Postgraduate medicine 20000915

Title: LTRA inhibition of exercise-induced bronchoconstriction.

Journal: Postgraduate medicine 20000915

Title: The protective effects of leukotriene modifiers in aspirin-induced asthma.

Journal: Postgraduate medicine 20000915

Title: The role of LTRAs in the management of persistent asthma.

Journal: Postgraduate medicine 20000915

Title: Comparative effects of long-acting beta2-agonists, leukotriene receptor antagonists, and a 5-lipoxygenase inhibitor on exercise-induced asthma.

Journal: The Journal of allergy and clinical immunology 20000901

Title: Zafirlukast improves asthma control in patients receiving high-dose inhaled corticosteroids.

Journal: American journal of respiratory and critical care medicine 20000801

Title: Effects of adding a leukotriene antagonist or a long-acting beta(2)-agonist in asthmatic patients with the glycine-16 beta(2)-adrenoceptor genotype.

Journal: The American journal of medicine 20000801

Title: Effect of leukotriene receptor antagonist therapy on the risk of asthma exacerbations in patients with mild to moderate asthma: an integrated analysis of zafirlukast trials.

Journal: Thorax 20000601

Title: A kinetic binding study to evaluate the pharmacological profile of a specific leukotriene C(4) binding site not coupled to contraction in human lung parenchyma.

Journal: Molecular pharmacology 20000601

Title: Recurrent panniculitis in a man with asthma receiving treatment with leukotriene-modifying agents.

Journal: Mayo Clinic proceedings 20000601

Title: Effectiveness and tolerability of zafirlukast for the treatment of asthma in children.

Journal: Clinical therapeutics 20000601

Title: Efficacy and duration of action of the antileukotriene zafirlukast on cold air-induced bronchoconstriction.

Journal: The European respiratory journal 20000401

Title: Montelukast in the prophylaxis of migraine: a potential role for leukotriene modifiers.

Journal: Headache 20000201

Title: Acute effects of antileukotrienes on sinonasal polyposis and sinusitis.

Journal: Ear, nose, & throat journal 20000101

Title: Lung function improvement in smokers suffering from COPD with zafirlukast, a CysLT(1)-receptor antagonist.

Journal: Pulmonary pharmacology & therapeutics 20000101

Title: Efficacy and safety of Zafirlukast ('Accolate') in the management of patients with mild-to-moderate asthma.

Journal: West African journal of medicine 20000101

Title: Discovery of CP-199,330 and CP-199,331: two potent and orally efficacious cysteinyl LT1 receptor antagonists devoid of liver toxicity.

Journal: Bioorganic & medicinal chemistry letters 19990920

Title: Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor.

Journal: Molecular pharmacology 19990901

Title: [Zafirlukast therapy of patients with mild-to-moderate bronchial asthma].

Journal: Orvosi hetilap 19990613

Title: Randomized placebo-controlled study comparing a leukotriene receptor antagonist and a nasal glucocorticoid in seasonal allergic rhinitis.

Journal: American journal of respiratory and critical care medicine 19990601

Title: Comparison of inhaled salmeterol and oral zafirlukast in patients with asthma.

Journal: The Journal of allergy and clinical immunology 19990601

Title: Zafirlukast in clinical practice: results of the Accolate Clinical Experience and Pharmacoepidemiology Trial (ACCEPT) in patients with asthma.

Journal: The Journal of family practice 19990601

Title: Effect of zafirlukast on cough reflex sensitivity in asthmatics.

Journal: The Journal of asthma : official journal of the Association for the Care of Asthma 19990501

Title: The leukotriene D4-receptor antagonist zafirlukast attenuates exercise-induced bronchoconstriction in children.

Journal: The Journal of pediatrics 19990301

Title: Churg-Strauss syndrome after zafirlukast in two patients not receiving systemic steroid treatment.

Journal: Lancet (London, England) 19990227

Title: An evaluation of zafirlukast in the treatment of asthma with exploratory subset analyses.

Journal: The Journal of allergy and clinical immunology 19990201

Title: Therapeutic effect of zafirlukast as monotherapy in steroid-naive patients with severe persistent asthma.

Journal: Chest 19990201

Title: Development of 2,2-dimethylchromanol cysteinyl LT1 receptor antagonists.

Journal: Bioorganic & medicinal chemistry letters 19981215

Title: Zafirlukast improves asthma symptoms and quality of life in patients with moderate reversible airflow obstruction.

Journal: The Journal of allergy and clinical immunology 19981201

Title: Severe neuromuscular complications possibly associated with amlodipine.

Journal: The Annals of pharmacotherapy 19981101

Title: A drug interaction between zafirlukast and theophylline.

Journal: Archives of internal medicine 19980801

Title: Churg-Strauss syndrome associated with zafirlukast.

Journal: Chest 19980701

Title: A single dose of zafirlukast reduces LTD4-induced bronchoconstriction in patients on maintenance inhaled corticosteroid therapy.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 19980701

Title: Pharmacology of leukotriene receptor antagonists.

Journal: American journal of respiratory and critical care medicine 19980601

Title: Clinical pharmacology of leukotriene receptor antagonists and 5-lipoxygenase inhibitors.

Journal: American journal of respiratory and critical care medicine 19980601

Title: Summary of clinical trials with zafirlukast.

Journal: American journal of respiratory and critical care medicine 19980601

Title: Effects of the cysteinyl leukotriene receptor antagonists pranlukast and zafirlukast on tracheal mucus secretion in ovalbumin-sensitized guinea-pigs in vitro.

Journal: British journal of pharmacology 19980601

Title: Inhibition of 5-lipoxygenase diminishes neurally evoked tachykinergic contraction of guinea pig isolated airway.

Journal: The Journal of pharmacology and experimental therapeutics 19980501

Title: Failure of zafirlukast to prevent ibuprofen-induced anaphylaxis.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 19980301

Title: Pharmacological characterization of the cysteinyl-leukotriene antagonists CGP 45715A (iralukast) and CGP 57698 in human airways in vitro.

Journal: British journal of pharmacology 19980201

Title: The leukotriene receptor antagonist zafirlukast inhibits sulfur dioxide-induced bronchoconstriction in patients with asthma.

Journal: American journal of respiratory and critical care medicine 19971201

Title: Combined antagonism of leukotrienes and histamine produces predominant inhibition of allergen-induced early and late phase airway obstruction in asthmatics.

Journal: American journal of respiratory and critical care medicine 19970601

Title: Cysteinyl leukotrienes induce P-selectin expression in human endothelial cells via a non-CysLT1 receptor-mediated mechanism.

Journal: The Journal of pharmacology and experimental therapeutics 19970501

Title: Eosinophil chemotaxis inhibited by 5-lipoxygenase blockade and leukotriene receptor antagonism.

Journal: American journal of respiratory and critical care medicine 19970401

Title: Effectiveness of the leukotriene receptor antagonist zafirlukast for mild-to-moderate asthma. A randomized, double-blind, placebo-controlled trial.

Journal: Annals of internal medicine 19970201

Title: Zafirlukast for symptomatic mild-to-moderate asthma: a 13-week multicenter study. The Zafirlukast Trialists Group.

Journal: Clinical therapeutics 19970101

Title: The leukotriene D4-receptor antagonist, ICI 204,219, relieves symptoms of acute seasonal allergic rhinitis.

Journal: American journal of respiratory and critical care medicine 19950601

Title: Effects of 6 weeks of therapy with oral doses of ICI 204,219, a leukotriene D4 receptor antagonist, in subjects with bronchial asthma. ACCOLATE Asthma Trialists Group.

Journal: American journal of respiratory and critical care medicine 19940901

Title: Leukotriene D4-induced increases in cytosolic calcium in THP-1 cells: dependence on extracellular calcium and inhibition with selective leukotriene D4 receptor antagonists.

Journal: The Journal of pharmacology and experimental therapeutics 19940601

Title: The leukotriene-antagonist ICI-204,219 inhibits the early airway reaction to cumulative bronchial challenge with allergen in atopic asthmatics.

Journal: The European respiratory journal 19940201

Title: Inhibition of leukotriene D4-induced bronchoconstriction in subjects with asthma: a concentration-effect study of ICI 204,219.

Journal: Clinical pharmacology and therapeutics 19931001

Title: The protective effect of inhaled leukotriene D4 receptor antagonist ICI 204,219 against exercise-induced asthma.

Journal: The American review of respiratory disease 19930601

Title: Potent leukotriene D4 receptor antagonist ICI 204,219 given by the inhaled route inhibits the early but not the late phase of allergen-induced bronchoconstriction.

Journal: The American review of respiratory disease 19930601

Title: Characterization of the leukotriene D4 receptor in dimethylsulphoxide-differentiated U937 cells: comparison with the leukotriene D4 receptor in human lung and guinea-pig lung.

Journal: European journal of pharmacology 19930215

Title: Pharmacological investigation of the role of leukotrienes in the pathogenesis of experimental NSAID gastropathy.

Journal: Inflammation 19920601

Title: Role of leukotrienes in exercise-induced asthma. Inhibitory effect of ICI 204219, a potent leukotriene D4 receptor antagonist.

Journal: The American review of respiratory disease 19920401

Title: Lung function improvement in asthma with a cysteinyl-leukotriene receptor antagonist.

Journal: Lancet (London, England) 19910504

Title: Endogenously formed leukotriene C4 activates LTC4 receptors in guinea pig tracheal strips.

Journal: European journal of pharmacology 19910326

Title: Synthesis and in vitro LTD4 antagonist activity of bicyclic and monocyclic cyclopentylurethane and cyclopentylacetamide N-arylsulfonyl amides.

Journal: Journal of medicinal chemistry 19900901

Title: Finnerty JP, et al. Role of leukotrienes in exercise-induced asthma. Inhibitory effect of ICI 204219, a potent leukotriene D4 receptor antagonist. Am Rev Respir Dis. 1992 Apr;145(4 Pt 1):746-9.

Title: Gunning WT, et al. Chemoprevention by lipoxygenase and leukotriene pathway inhibitors of vinyl carbamate-induced lung tumors in mice. Cancer Res. 2002 Aug 1;62(15):4199-201.

Title: Lei C, et al. Zafirlukast attenuates advanced glycation end-products (AGEs)-induced degradation of articular extracellular matrix (ECM). Int Immunopharmacol. 2019;68:68-73.

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Tags:107753-78-6 Molecular Formula|107753-78-6 MDL|107753-78-6 SMILES|107753-78-6 Zafirlukast