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108050-54-0,MFCD00864842
Catalog No.:AA0083VP

108050-54-0 | Tilmicosin

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Purity
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Price(USD)
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1g
95%
in stock  
$54.00   $38.00
- +
5g
95%
in stock  
$145.00   $102.00
- +
10g
95%
in stock  
$211.00   $148.00
- +
25g
95%
in stock  
$311.00   $218.00
- +
100g
95%
in stock  
$809.00   $567.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0083VP
Chemical Name:
Tilmicosin
CAS Number:
108050-54-0
Molecular Formula:
C46H80N2O13
Molecular Weight:
869.1330
MDL Number:
MFCD00864842
SMILES:
CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](OC2OC(C)C(C(C2O)N(C)C)O)[C@@H](CCN2C[C@H](C)C[C@@H](C2)C)C[C@H](C(=O)/C=C/C(=C/[C@@H]1COC1OC(C)C(C(C1OC)OC)O)/C)C
Properties
Computed Properties
 
Complexity:
1420  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
19  
Defined Bond Stereocenter Count:
2  
Heavy Atom Count:
61  
Hydrogen Bond Acceptor Count:
15  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
12  
XLogP3:
3.6  

Literature

Title: Comparative minimum inhibitory and mutant prevention drug concentrations of enrofloxacin, ceftiofur, florfenicol, tilmicosin and tulathromycin against bovine clinical isolates of Mannheimia haemolytica.

Journal: Veterinary microbiology 20121109

Title: Visualizing the 16-membered ring macrolides tildipirosin and tilmicosin bound to their ribosomal site.

Journal: ACS chemical biology 20120817

Title: Use estimates of in-feed antimicrobials in swine production in the United States.

Journal: Foodborne pathogens and disease 20120301

Title: Development and validation of an indirect competitive enzyme-linked immunosorbent assay for the screening of tylosin and tilmicosin in muscle, liver, milk, honey and eggs.

Journal: Journal of agricultural and food chemistry 20120111

Title: Enhancement of antibacterial activity of tilmicosin against Staphylococcus aureus by solid lipid nanoparticles in vitro and in vivo.

Journal: Veterinary journal (London, England : 1997) 20120101

Title: Comparison of enrofloxacin and ceftiofur sodium for the treatment of relapse of undifferentiated fever/bovine respiratory disease in feedlot cattle.

Journal: The Canadian veterinary journal = La revue veterinaire canadienne 20120101

Title: Pharmacokinetics of tilmicosin in beef cattle following intravenous and subcutaneous administration.

Journal: Journal of veterinary pharmacology and therapeutics 20111201

Title: Anti-inflammatory effects of tilmicosin in a noninfectious mouse model of allergic asthma.

Journal: Immunopharmacology and immunotoxicology 20111201

Title: Feed supplemented with 3 different antibiotics improved food intake and decreased the activation of the humoral immune response in healthy weaned pigs but had differing effects on intestinal microbiota.

Journal: Journal of animal science 20111201

Title: Relationship of in vitro minimum inhibitory concentrations of tilmicosin against Mannheimia haemolytica and Pasteurella multocida and in vivo tilmicosin treatment outcome among calves with signs of bovine respiratory disease.

Journal: Journal of the American Veterinary Medical Association 20110701

Title: Immunosuppressive activity of tilmicosin on the immune responses in mice.

Journal: Immunopharmacology and immunotoxicology 20110601

Title: The controlled release of tilmicosin from silica nanoparticles.

Journal: Drug development and industrial pharmacy 20110601

Title: Antimicrobial susceptibility of Actinobacillus pleuropneumoniae isolates from clinical outbreaks of porcine respiratory diseases.

Journal: Veterinary microbiology 20110512

Title: Molecularly imprinted solid-phase extraction for determination of tilmicosin in feed using high performance liquid chromatography.

Journal: Analytica chimica acta 20110401

Title: Human health hazards of veterinary medications: information for emergency departments.

Journal: The Journal of emergency medicine 20110201

Title: Generation of reduced macrolide analogs by regio-specific biotransformation.

Journal: The Journal of antibiotics 20110101

Title: Characterization of in vivo-acquired resistance to macrolides of Mycoplasma gallisepticum strains isolated from poultry.

Journal: Veterinary research 20110101

Title: Acute toxicity study of tilmicosin-loaded hydrogenated castor oil-solid lipid nanoparticles.

Journal: Particle and fibre toxicology 20110101

Title: Kinetics and intrapulmonary disposition of tilmicosin after single and repeated oral bolus administrations to rabbits.

Journal: Veterinary research communications 20100601

Title: Evaluation of oral tilmicosin efficacy against severe cryptosporidiosis in neonatal kids under field conditions.

Journal: Veterinary parasitology 20100528

Title: Sensitive determination of tilmicosin, erythromycin ethylsuccinate and clindamycin by CE with electrochemiluminescence detection using azithromycin as internal standard and its applications.

Journal: Journal of separation science 20100501

Title: Immuno-modulation and anti-inflammatory benefits of antibiotics: the example of tilmicosin.

Journal: Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20100101

Title: [Binding of tylosin, tilmicosin and oxytetracycline to proteins from honeybees, larvae and beehive products].

Journal: Revista Argentina de microbiologia 20100101

Title: Control of Ornithobacterium rhinotracheale in poultry.

Journal: The Veterinary record 20091128

Title: Assessment of humoral and cellular-mediated immune response in chickens treated with tilmicosin, florfenicol, or enrofloxacin at the time of Newcastle disease vaccination.

Journal: Poultry science 20091001

Title: Administration of micotil.

Journal: The Veterinary record 20090919

Title: Hydrogenated castor oil nanoparticles as carriers for the subcutaneous administration of tilmicosin: in vitro and in vivo studies.

Journal: Journal of veterinary pharmacology and therapeutics 20090401

Title: Elimination kinetics of tilmicosin following intramammary administration in lactating dairy cattle.

Journal: Journal of the American Veterinary Medical Association 20090115

Title: Adverse outcome of using tilmicosin in a lamb with multiple ventricular septal defects.

Journal: The Canadian veterinary journal = La revue veterinaire canadienne 20090101

Title: Pharmacokinetics and tissue depletion of tilmicosin in turkeys.

Journal: Journal of veterinary pharmacology and therapeutics 20081201

Title: American association of poison control centers database characterization of human tilmicosin exposures, 2001-2005.

Journal: Journal of medical toxicology : official journal of the American College of Medical Toxicology 20081201

Title: Effectiveness of tilmicosin against Paenibacillus larvae, the causal agent of American Foulbrood disease of honeybees.

Journal: Veterinary microbiology 20081125

Title: Efficacy of metaphylactic florfenicol therapy during natural outbreaks of bovine respiratory disease.

Journal: Journal of veterinary pharmacology and therapeutics 20081001

Title: Effects of dietary energy source and level and injection of tilmicosin phosphate on immune function in lipopolysaccharide-challenged beef steers.

Journal: Journal of animal science 20080801

Title: Identification of the related substances of tilmicosin by liquid chromatography/ion trap mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20080601

Title: Pharmacokinetics of tilmicosin in equine tissues and plasma.

Journal: Journal of veterinary pharmacology and therapeutics 20080201

Title: Diagnosis | pasteurellosis.

Journal: Lab animal 20080101

Title: Comparison of short-term health and performance effects related to prophylactic administration of tulathromycin versus tilmicosin in long-hauled, highly stressed beef stocker calves.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20080101

Title: Comparative efficacy of tilmicosin versus tulathromycin as a metaphylactic antimicrobial in feedlot calves at moderate risk for respiratory disease.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20080101

Title: Minimal inhibitory concentration of tilmicosin against isolates of Histophilus somni from Australian cattle.

Journal: Australian veterinary journal 20071201

Title: Effect of parenteral administration of erythromycin, tilmicosin, and tylosin on abomasal emptying rate in suckling calves.

Journal: American journal of veterinary research 20071201

Title: Micotil: safe use and administration.

Journal: The Veterinary record 20071124

Title: Early detection and treatment of vesicular adenitis in bulls.

Journal: Animal reproduction science 20071001

Title: Quantitative determination of tilmicosin in canine serum by high performance liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070915

Title: Pharmacokinetics of tilmicosin (Provitil powder and Pulmotil liquid AC) oral formulations in chickens.

Journal: Veterinary research communications 20070501

Title: The possible protective effect of L-carnitine on tilmicosin-induced cardiotoxicity in mice.

Journal: Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20070401

Title: Evaluation of the efficacy of tulathromycin as a metaphylactic antimicrobial in feedlot calves.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20070101

Title: Pulmonary disposition of tilmicosin in foals and in vitro activity against Rhodococcus equi and other common equine bacterial pathogens.

Journal: Journal of veterinary pharmacology and therapeutics 20061201

Title: In vitro susceptibilities of Leptospira spp. and Borrelia burgdorferi isolates to amoxicillin, tilmicosin, and enrofloxacin.

Journal: Journal of veterinary science 20061201

Title: Analysis of reports of human exposure to Micotil 300 (tilmicosin injection).

Journal: Journal of the American Veterinary Medical Association 20061201

Title: Industry guidance on the administration of tilmicosin.

Journal: The Veterinary record 20060805

Title: Residue depletion of tilmicosin in cattle after subcutaneous administration.

Journal: Journal of agricultural and food chemistry 20060712

Title: Tilmicosin and tylosin have anti-inflammatory properties via modulation of COX-2 and iNOS gene expression and production of cytokines in LPS-induced macrophages and monocytes.

Journal: International journal of antimicrobial agents 20060501

Title: Influence of the genotype of Staphylococcus aureus, determined by pulsed-field gel electrophoresis, on dry-period elimination of subclinical mastitis in Canadian dairy herds.

Journal: Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20060401

Title: Synthesis and in vitro antibiotic activity of 16-membered 9-O-arylalkyloxime macrolides.

Journal: Bioorganic & medicinal chemistry letters 20060301

Title: An evaluation of the metaphylactic effect of ceftiofur crystalline free Acid in feedlot calves.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20060101

Title: Production and characterization of monoclonal antibodies against the antibiotic tilmicosin.

Journal: Journal of agricultural and food chemistry 20051214

Title: Induction of macrolide resistance in Mycoplasma gallisepticum in vitro and its resistance-related mutations within domain V of 23S rRNA.

Journal: FEMS microbiology letters 20050615

Title: Pharmacokinetics of tilmicosin after oral administration in swine.

Journal: American journal of veterinary research 20050601

Title: Human exposures to tilmicosin reported to poison centres, Texas, 1998-2003.

Journal: Human & experimental toxicology 20050501

Title: Assessment of the efficacy of tilmicosin phosphate to eliminate Actinobacillus pleuropneumoniae from carrier pigs.

Journal: Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20050401

Title: Determination of five macrolide antibiotic residues in eggs using liquid chromatography/electrospray ionization tandem mass spectrometry.

Journal: Journal of agricultural and food chemistry 20050323

Title: Effects of oral administration of tilmicosin on pulmonary inflammation in piglets experimentally infected with Actinobacillus pleuropneumoniae.

Journal: American journal of veterinary research 20050101

Title: Efficacy of tulathromycin in the treatment and prevention of natural outbreaks of bovine respiratory disease in European cattle.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20050101

Title: Clinical effectiveness of tulathromycin, a novel triamilide antimicrobial, for the control of respiratory disease in cattle at high risk for developing bovine respiratory disease.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20050101

Title: Therapeutic efficacy of tulathromycin, a novel triamilide antimicrobial, against bovine respiratory disease in feeder calves.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20050101

Title: Efficacy of tulathromycin compared with tilmicosin and florfenicol for the control of respiratory disease in cattle at high risk of developing bovine respiratory disease.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20050101

Title: Comparative efficacy of tulathromycin, tilmicosin, and florfenicol in the treatment of bovine respiratory disease in stocker cattle.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20050101

Title: Comparative efficacy of tulathromycin versus florfenicol and tilmicosin against undifferentiated bovine respiratory disease in feedlot cattle.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20050101

Title: Clinical efficacy of carprofen as an adjunct to the antibacterial treatment of bovine respiratory disease.

Journal: Journal of veterinary pharmacology and therapeutics 20041001

Title: A preliminary investigation of the disposition of tilmicosin residues in elk tissues and serum.

Journal: Journal of veterinary pharmacology and therapeutics 20041001

Title: Susceptibility of Mycobacterium avium sbsp paratuberculosis to monensin sodium or tilmicosin phosphate in vitro and resulting infectivity in a murine model.

Journal: Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20040701

Title: Change to user warning for Micotil.

Journal: The Veterinary record 20040529

Title: Efficacy of danofloxacin in the treatment of respiratory disease in European cattle.

Journal: The Veterinary record 20040508

Title: Residue depletion of tilmicosin in chicken tissues.

Journal: Journal of agricultural and food chemistry 20040505

Title: Effect of danofloxacin and tilmicosin on body temperatures of beef calves with pneumonia experimentally induced by inoculation with Mannheimia haemolytica.

Journal: American journal of veterinary research 20040501

Title: Effect of simulated ambient particulate matter exposure on performance, rectal temperature, and leukocytosis of young Spanish goats with or without tilmicosin phosphate.

Journal: Journal of animal science 20040401

Title: Effect of mass medication with antibiotics at feedlot entry on the health and growth rate of cattle destined for the Australian domestic market.

Journal: Australian veterinary journal 20040301

Title: Determination of five macrolide antibiotic residues in honey by LC-ESI-MS and LC-ESI-MS/MS.

Journal: Journal of agricultural and food chemistry 20040128

Title: Metabolism of tilmicosin by rabbit liver microsomes and hepatocytes.

Journal: Veterinary journal (London, England : 1997) 20040101

Title: Efficacy of tilmicosin in the control of experimentally induced Actinobacillus pleuropneumoniae infection in swine.

Journal: Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20040101

Title: [Immunogenic properties of the colloidal gold].

Journal: Izvestiia Akademii nauk. Seriia biologicheskaia 20040101

Title: Tilmicosin-induced bovine neutrophil apoptosis is cell-specific and downregulates spontaneous LTB4 synthesis without increasing Fas expression.

Journal: Veterinary research 20040101

Title: The effects of danofloxacin and tilmicosin on neutrophil function and lung consolidation in beef heifer calves with induced Pasteurella (Mannheimia) haemolytica pneumonia.

Journal: Journal of veterinary pharmacology and therapeutics 20030601

Title: [Determination of spiramycin and tilmicosin in meat and fish by LC/MS].

Journal: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20030601

Title: Facile synthesis of tilmicosin and tylosin related haptens for use as protein conjugates.

Journal: The Journal of antibiotics 20030501

Title: Efficacy of intramammary tilmicosin and risk factors for cure of Staphylococcus aureus infection in the dry period.

Journal: Journal of dairy science 20030101

Title: Unintentional human exposure to tilmicosin (Micotil 300).

Journal: Journal of toxicology. Clinical toxicology 20030101

Title: The efficacy of intramammary tilmicosin at drying-off, and other risk factors for the prevention of new intramammary infections during the dry period.

Journal: Journal of dairy science 20021201

Title: Tilmicosin administration to young lambs with respiratory infection: safety and efficacy considerations.

Journal: Journal of veterinary pharmacology and therapeutics 20021001

Title: Minimum inhibitory concentration breakpoints and disk diffusion inhibitory zone interpretive criteria for tilmicosin susceptibility testing against Pasteurella multocida and Actinobacillus pleuropneumoniae associated with porcine respiratory disease.

Journal: Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc 20020901

Title: Relationship of vitamin E supplementation and antimicrobial treatment with acute-phase protein responses in cattle affected by naturally acquired respiratory tract disease.

Journal: American journal of veterinary research 20020801

Title: A comparison of prophylactic efficacy of tilmicosin and a new formulation of oxytetracycline in feedlot calves.

Journal: The Canadian veterinary journal = La revue veterinaire canadienne 20020501

Title: The effect of tilmicosin on cardiac superoxide dismutase and glutathione peroxidase activities.

Journal: Journal of veterinary medicine. B, Infectious diseases and veterinary public health 20020501

Title: Investigation of haematological and biochemical side effects of tilmicosin in healthy New Zealand rabbits.

Journal: Journal of veterinary medicine. B, Infectious diseases and veterinary public health 20020301

Title: Tilmicosin reduces lipopolysaccharide-stimulated bovine alveolar macrophage prostaglandin E(2) production via a mechanism involving phospholipases.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20020101

Title: Dose determination and confirmation for ceftiofur crystalline-free acid administered in the posterior aspect of the ear for control and treatment of bovine respiratory disease.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20020101

Title: Interlaboratory comparison of methods for the determination of incurred tilmicosin residues in bovine liver.

Journal: Journal of AOAC International 20020101

Title: Effect of tilmicosin on chemotactic, phagocytic, and bactericidal activities of bovine and porcine alveolar macrophages.

Journal: American journal of veterinary research 20020101

Title: Efficacy of different dosage levels and administration routes of tilmicosin in a natural outbreak of infectious bovine keratoconjunctivitis (pinkeye).

Journal: Veterinary therapeutics : research in applied veterinary medicine 20020101

Title: A comparative study of the preventive use of tilmicosin phosphate (Pulmotil premix) and Mycoplasma hyopneumoniae vaccination in a pig herd with chronic respiratory disease.

Journal: Journal of veterinary medicine. B, Infectious diseases and veterinary public health 20011201

Title: Efficacy of tilmicosin phosphate (Pulmotil premix) in feed for the treatment of a clinical outbreak of Actinobacillus pleuropneumoniae infection in growing-finishing pigs.

Journal: Journal of veterinary medicine. B, Infectious diseases and veterinary public health 20011101

Title: A field comparison of the efficacy and tolerance of marbofloxacin in the treatment of bovine respiratory disease.

Journal: Journal of veterinary pharmacology and therapeutics 20011001

Title: Evaluation of antibiotics for treatment of cattle infected with Leptospira borgpetersenii serovar hardjo.

Journal: Journal of the American Veterinary Medical Association 20010901

Title: Variability in residue concentrations of tilmicosin in cattle muscle.

Journal: The Veterinary record 20010811

Title: Confirmatory method for macrolide residues in bovine tissues by micro-liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. A 20010810

Title: Effectiveness and kinetic behaviour of tilmicosin in the treatment of respiratory infections in sheep.

Journal: The Veterinary record 20010623

Title: Postantibiotic effects and postantibiotic sub-MIC effects of erythromycin, roxithromycin, tilmicosin, and tylosin on Pasteurella multocida.

Journal: International journal of antimicrobial agents 20010601

Title: Evaluation of the ability of tilmicosin to prevent adherence of Mycoplasma hyopneumoniae to cilia using a differentiated swine respiratory epithelial culture system.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20010101

Title: Micotil 300 New Animal Drug Application

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