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1082949-68-5,MFCD29054739
Catalog No.:AA008TJO

1082949-68-5 | Ly2584702 tosylate

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$12.00   $8.00
- +
5mg
98+%
in stock  
$26.00   $18.00
- +
10mg
98+%
in stock  
$38.00   $27.00
- +
50mg
98+%
in stock  
$110.00   $77.00
- +
  • Technical Information
  • Properties
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008TJO
Chemical Name:
Ly2584702 tosylate
CAS Number:
1082949-68-5
Molecular Formula:
C28H27F4N7O3S
Molecular Weight:
617.6177
MDL Number:
MFCD29054739
SMILES:
Cn1cc(nc1C1CCN(CC1)c1ncnc2c1cn[nH]2)c1ccc(c(c1)C(F)(F)F)F.Cc1ccc(cc1)S(=O)(=O)O
Properties
Computed Properties
 
Complexity:
851  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
43  
Hydrogen Bond Acceptor Count:
12  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  

Literature

Title: A phase I trial of LY2584702 tosylate, a p70 S6 kinase inhibitor, in patients with advanced solid tumours.

Journal: European journal of cancer (Oxford, England : 1990) 20140301

Title: A phase Ib trial of LY2584702 tosylate, a p70 S6 inhibitor, in combination with erlotinib or everolimus in patients with solid tumours.

Journal: European journal of cancer (Oxford, England : 1990) 20140301

Title: Tolcher A, et al. A phase I trial of LY2584702 tosylate, a p70 S6 kinase inhibitor, in patients with advanced solid tumors. Eur J Cancer. 2014 Mar;50(5):867-75.

Title: Phung TL, et al. Akt1 and akt3 exert opposing roles in the regulation of vascular tumor growth. Cancer Res. 2015 Jan 1;75(1):40-50.

Title: Chen B, et al. Hyperphosphorylation of RPS6KB1, rather than overexpression, predicts worse prognosis in non-small cell lung cancer patients. PLoS One. 2017 Aug 9;12(8):e0182891.

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SDS
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Tags:1082949-68-5 Molecular Formula|1082949-68-5 MDL|1082949-68-5 SMILES|1082949-68-5 Ly2584702 tosylate