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1088991-73-4,MFCD28100674
Catalog No.:AA008TFF

1088991-73-4 | Mk-6096

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Purity
Availability
Price(USD)
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5mg
≥98%
in stock  
$202.00   $141.00
- +
10mg
≥98%
in stock  
$362.00   $253.00
- +
25mg
≥98%
in stock  
$602.00   $421.00
- +
50mg
≥98%
in stock  
$899.00   $629.00
- +
  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008TFF
Chemical Name:
Mk-6096
CAS Number:
1088991-73-4
Molecular Formula:
C24H25FN4O2
Molecular Weight:
420.4793
MDL Number:
MFCD28100674
SMILES:
Cc1ccc(c(c1)C(=O)N1C[C@@H](CC[C@H]1C)COc1ccc(cn1)F)c1ncccn1
Properties
Computed Properties
 
Complexity:
588  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
6  
Rotatable Bond Count:
5  
XLogP3:
3.9  

Literature

Title: Dual orexin receptor antagonists - promising agents in the treatment of sleep disorders.

Journal: The international journal of neuropsychopharmacology 20140101

Title: Selective orexin receptor antagonists.

Journal: Bioorganic & medicinal chemistry letters 20130901

Title: Discovery of [(2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): a dual orexin receptor antagonist with potent sleep-promoting properties.

Journal: ChemMedChem 20120305

Title: Pharmacological characterization of MK-6096 - a dual orexin receptor antagonist for insomnia.

Journal: Neuropharmacology 20120201

Title: Winrow CJ, et al. Pharmacological characterization of MK-6096 - a dual orexin receptor antagonist for insomnia. Neuropharmacology. 2012 Feb;62(2):978-87.

Title: Coleman PJ, et al. Discovery of [(2R,5R)-5-{[(5-fluoropyridin-2-yl)oxymethyl}-2-methylpiperidin-1-yl-methyl-2-(pyrimidin-2-yl)phenylmethanone (MK-6096): a dual orexin receptor antagonist with potent sleep-promoting properties. ChemMedChem. 2012 Mar 5;7(3):415-24, 337.

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