+1 858-523-8231
Login | Register
AA Blocks, Building Blocks, Catalysts, Inhibitors
Login | Register
Home Other Building Blocks 1092499-93-8
1092499-93-8,MFCD22419018
Catalog No.:AA008TFT

1092499-93-8 | Nvp-bsk805

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
99%
in stock  
$303.00   $212.00
- +
10mg
98%
in stock  
$516.00   $362.00
- +
25mg
99%
in stock  
$892.00   $625.00
- +
50mg
98%
in stock  
$1,524.00   $1,067.00
- +
100mg
98%
in stock  
$2,407.00   $1,685.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA008TFT
Chemical Name:
Nvp-bsk805
CAS Number:
1092499-93-8
Molecular Formula:
C27H28F2N6O
Molecular Weight:
490.5476
MDL Number:
MFCD22419018
SMILES:
Fc1cc(cc(c1CN1CCOCC1)F)c1cccc2c1nc(cn2)c1cnn(c1)C1CCNCC1
Properties
Computed Properties
 
Complexity:
696  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
2.5  

Downstream Synthesis Route

[1]Patent:WO2008/148867,2008,A2.Locationinpatent:Page/Pagecolumn139-140

[1]Patent:WO2008/148867,2008,A2.Locationinpatent:Page/Pagecolumn135-136

[1]Patent:WO2008/148867,2008,A2.Locationinpatent:Page/Pagecolumn140-141

1092500-75-8   
3,5-difluoro-4-(morpholin-4-ylmethyl)phenylborane 
  1092499-93-8 

[1]BioorganicandMedicinalChemistryLetters,2010,vol.20,p.2609-2613

Literature

Title: Baffert F, et al. Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805. Mol Cancer Ther. 2010 Jul;9(7):1945-55.

Title: Cheon JH, et al. The JAK2 inhibitors CEP-33779 and NVP-BSK805 have high P-gp inhibitory activity and sensitize drug-resistant cancer cells to vincristine. Biochem Biophys Res Commun. 2017 Sep 2;490(4):1176-1182.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 1092499-93-8
1942919-79-0

1942919-79-0

 1942919-79-0

1942919-79-0
Building Blocks
More >
Tags:1092499-93-8 Molecular Formula|1092499-93-8 MDL|1092499-93-8 SMILES|1092499-93-8 Nvp-bsk805