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Home Other Building Blocks 1092939-17-7
1092939-17-7,MFCD18452860
Catalog No.:AA008R3K

1092939-17-7 | (R)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile phosphate

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$11.00   $8.00
- +
5mg
98%
in stock  
$15.00   $11.00
- +
10mg
98%
in stock  
$21.00   $15.00
- +
25mg
98%
in stock  
$26.00   $18.00
- +
1g
97%
in stock  
$585.00   $409.00
- +
5g
97%
in stock  
$1,585.00   $1,109.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA008R3K
Chemical Name:
(R)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile phosphate
CAS Number:
1092939-17-7
Molecular Formula:
C17H21N6O4P
Molecular Weight:
404.3602
MDL Number:
MFCD18452860
SMILES:
OP(=O)(O)O.N#CC[C@@H](n1ncc(c1)c1ncnc2c1cc[nH]2)C1CCCC1
Properties
Computed Properties
 
Complexity:
503  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
4  

Downstream Synthesis Route

[1]Patent:US2010/190981,2010,A1.Locationinpatent:Page/Pagecolumn80

[2]Patent:US2008/312259,2008,A1.Locationinpatent:Page/Pagecolumn6

[3]Patent:WO2013/23119,2013,A1.Locationinpatent:Page/Pagecolumn33

[4]Patent:WO2016/35014,2016,A1.Locationinpatent:Page/Pagecolumn29

[5]Patent:WO2016/24232,2016,A1.Locationinpatent:Paragraph00676

[6]Patent:WO2016/24230,2016,A1.Locationinpatent:Paragraph00651

[7]Patent:EP2574168,2016,B1.Locationinpatent:Paragraph0151-0153

[8]Patent:CN107759623,2018,A.Locationinpatent:Paragraph0118;0119

[1]Patent:WO2013/23119,2013,A1

[2]Patent:WO2016/24232,2016,A1

[3]Patent:WO2016/24230,2016,A1

[4]Patent:US9358229,2016,B2

[1]Patent:WO2013/23119,2013,A1

[2]Patent:WO2016/24232,2016,A1

[3]Patent:WO2016/24230,2016,A1

[4]Patent:US9358229,2016,B2

[1]CurrentPatentAssignee:NOVARTISAG;INCYTECORP;Novartis(w/oSandoz)-WO2013/23119,2013,A1

[2]CurrentPatentAssignee:ASTRAZENECAPLC-WO2016/24232,2016,A1

[3]CurrentPatentAssignee:ASTRAZENECAPLC-WO2016/24230,2016,A1

[4]CurrentPatentAssignee:NOVARTISAG;INCYTECORP;Novartis(w/oSandoz)-US9358229,2016,B2

[1]CurrentPatentAssignee:NANJINGBAIMAIBIOTECHNOLOGYCOLTD-CN114044777,2022,ALocationinpatent:Paragraph0010;0049-0053

[2]CurrentPatentAssignee:NOVARTISAG;INCYTECORP;Novartis(w/oSandoz)-WO2013/23119,2013,A1

[3]CurrentPatentAssignee:ASTRAZENECAPLC-WO2016/24232,2016,A1

[4]CurrentPatentAssignee:ASTRAZENECAPLC-WO2016/24230,2016,A1

[5]CurrentPatentAssignee:NOVARTISAG;INCYTECORP;Novartis(w/oSandoz)-US9358229,2016,B2Locationinpatent:Page/Pagecolumn23

Literature

Title: Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors.

Journal: Journal of medicinal chemistry 20120628

Title: Quintas-Cardama A, et al. Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms. Blood, 2010, 115(15), 3109-3117.

Title: Fleischman AG, et al. The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in mice that is responsive to therapeutic JAK inhibition. Blood. 2013 Nov 21;122(22):3628-31.

Title: de Bock CE, et al. HOXA9 Cooperates with Activated JAK/STAT Signaling to Drive Leukemia Development. Cancer Discov. 2018 May;8(5):616-631.

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SDS
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Tags:1092939-17-7 Molecular Formula|1092939-17-7 MDL|1092939-17-7 SMILES|1092939-17-7 (R)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile phosphate