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1094-61-7,MFCD00038748
Catalog No.:AA003858

1094-61-7 | Beta-nicotinamide mononucleotide

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250mg
98%
in stock  
$9.00   $6.00
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1g
97%
in stock  
$12.00   $8.00
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5g
98%
in stock  
$28.00   $19.00
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10g
98%
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$42.00   $29.00
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25g
98%
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$85.00   $59.00
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100g
98%
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$320.00   $224.00
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500g
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$1,407.00   $985.00
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003858
Chemical Name:
Beta-nicotinamide mononucleotide
CAS Number:
1094-61-7
Molecular Formula:
C11H15N2O8P
Molecular Weight:
334.2192
MDL Number:
MFCD00038748
SMILES:
O[C@@H]1[C@H](O)[C@H](O[C@H]1[n+]1cccc(c1)C(=O)N)COP(=O)(O)[O-]
Properties
Computed Properties
 
Complexity:
455  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
5  
XLogP3:
-3.5  

Literature

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Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20180801

Title: METALLOPROTEINS. A tethered niacin-derived pincer complex with a nickel-carbon bond in lactate racemase.

Journal: Science (New York, N.Y.) 20150703

Title: A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome.

Journal: Cell metabolism 20141104

Title: Elevated microRNA-34a in obesity reduces NAD+ levels and SIRT1 activity by directly targeting NAMPT.

Journal: Aging cell 20131201

Title: Resistin impairs SIRT1 function and induces senescence-associated phenotype in hepatocytes.

Journal: Molecular and cellular endocrinology 20130905

Title: A urinary metabonomics study on biochemical changes in yeast-induced pyrexia rats: a new approach to elucidating the biochemical basis of the febrile response.

Journal: Chemico-biological interactions 20130625

Title: Comparison of the formation of nicotinic acid conjugates in leaves of different plant species.

Journal: Plant physiology and biochemistry : PPB 20121101

Title: Induced fit and the catalytic mechanism of isocitrate dehydrogenase.

Journal: Biochemistry 20120911

Title: Molecular determinants of ligand selectivity for the human multidrug and toxin extruder proteins MATE1 and MATE2-K.

Journal: The Journal of pharmacology and experimental therapeutics 20120601

Title: Enzymatic biofuel cells utilizing a biomimetic cofactor.

Journal: Chemical communications (Cambridge, England) 20120211

Title: Characterization of human nicotinate phosphoribosyltransferase: Kinetic studies, structure prediction and functional analysis by site-directed mutagenesis.

Journal: Biochimie 20120201

Title: Effects of long-acting somatostatin analogues on adrenal growth and phosphoribosyl pyrophosphate formation in experimental diabetes.

Journal: International journal of experimental pathology 20120201

Title: Catalysis-based inhibitors of the calcium signaling function of CD38.

Journal: Biochemistry 20120110

Title: The high-resolution crystal structure of periplasmic Haemophilus influenzae NAD nucleotidase reveals a novel enzymatic function of human CD73 related to NAD metabolism.

Journal: The Biochemical journal 20120101

Title: Identification of mitochondrial electron transport chain-mediated NADH radical formation by EPR spin-trapping techniques.

Journal: Biochemistry 20111220

Title: Nicotinamide mononucleotide protects against pro-inflammatory cytokine-mediated impairment of mouse islet function.

Journal: Diabetologia 20111201

Title: Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice.

Journal: Cell metabolism 20111005

Title: Mitochondria-localized NAD biosynthesis by nicotinamide mononucleotide adenylyltransferase in Jerusalem artichoke (Helianthus tuberosus L.) heterotrophic tissues.

Journal: Planta 20111001

Title: Effect of nicotinamide mononucleotide on insulin secretion and gene expressions of PDX-1 and FoxO1 in RIN-m5f cells.

Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20111001

Title: ArsAB, a novel enzyme from Sporomusa ovata activates phenolic bases for adenosylcobamide biosynthesis.

Journal: Molecular microbiology 20110801

Title: A fluorometric assay for high-throughput screening targeting nicotinamide phosphoribosyltransferase.

Journal: Analytical biochemistry 20110501

Title: Comparative genomics of NAD(P) biosynthesis and novel antibiotic drug targets.

Journal: Journal of cellular physiology 20110201

Title: Wld(S) reduces paraquat-induced cytotoxicity via SIRT1 in non-neuronal cells by attenuating the depletion of NAD.

Journal: PloS one 20110101

Title: Nicotinamide phosphoribosyltransferase/visfatin does not catalyze nicotinamide mononucleotide formation in blood plasma.

Journal: PloS one 20110101

Title: Recognition of nucleoside monophosphate substrates by Haemophilus influenzae class C acid phosphatase.

Journal: Journal of molecular biology 20101210

Title: A possibility of nutriceuticals as an anti-aging intervention: activation of sirtuins by promoting mammalian NAD biosynthesis.

Journal: Pharmacological research 20100701

Title: Visualization and quantification of NAD(H) in brain sections by a novel histo-enzymatic nitrotetrazolium blue staining technique.

Journal: Brain research 20100226

Title: Identification of Isn1 and Sdt1 as glucose- and vitamin-regulated nicotinamide mononucleotide and nicotinic acid mononucleotide [corrected] 5'-nucleotidases responsible for production of nicotinamide riboside and nicotinic acid riboside.

Journal: The Journal of biological chemistry 20091211

Title: Detection and pharmacological modulation of nicotinamide mononucleotide (NMN) in vitro and in vivo.

Journal: Biochemical pharmacology 20090515

Title: Tailoring RNA modular units on a common scaffold: a modular ribozyme with a catalytic unit for beta-nicotinamide mononucleotide-activated RNA ligation.

Journal: RNA (New York, N.Y.) 20090501

Title: Mechanism-based small molecule probes for labeling CD38 on live cells.

Journal: Journal of the American Chemical Society 20090211

Title: Perivascular adipose tissue-derived visfatin is a vascular smooth muscle cell growth factor: role of nicotinamide mononucleotide.

Journal: Cardiovascular research 20090201

Title: Extracellular Nampt promotes macrophage survival via a nonenzymatic interleukin-6/STAT3 signaling mechanism.

Journal: The Journal of biological chemistry 20081212

Title: Theoretical studies of the quinolinic acid to nicotinic acid mononucleotide transformation.

Journal: The Journal of organic chemistry 20081205

Title: Visfatin: a new player in mesangial cell physiology and diabetic nephropathy.

Journal: American journal of physiology. Renal physiology 20081101

Title: Weak coupling of ATP hydrolysis to the chemical equilibrium of human nicotinamide phosphoribosyltransferase.

Journal: Biochemistry 20081021

Title: Covalent and noncovalent intermediates of an NAD utilizing enzyme, human CD38.

Journal: Chemistry & biology 20081020

Title: Biosynthesis of trigonelline from nicotinate mononucleotide in mungbean seedlings.

Journal: Phytochemistry 20080101

Title: Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice.

Journal: Aging cell 20080101

Title: Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme.

Journal: Cell metabolism 20071101

Title: Crystal structure of human nicotinamide riboside kinase.

Journal: Structure (London, England : 1993) 20070801

Title: Nicotinamidase participates in the salvage pathway of NAD biosynthesis in Arabidopsis.

Journal: The Plant journal : for cell and molecular biology 20070301

Title: Arabidopsis thaliana nicotinate/nicotinamide mononucleotide adenyltransferase (AtNMNAT) is required for pollen tube growth.

Journal: The Plant journal : for cell and molecular biology 20070201

Title: Crystal structure of visfatin/pre-B cell colony-enhancing factor 1/nicotinamide phosphoribosyltransferase, free and in complex with the anti-cancer agent FK-866.

Journal: Journal of molecular biology 20060908

Title: Probing hot spots at protein-ligand binding sites: a fragment-based approach using biophysical methods.

Journal: Journal of medicinal chemistry 20060810

Title: The simultaneous measurement of nicotinamide adenine dinucleotide and related compounds by liquid chromatography/electrospray ionization tandem mass spectrometry.

Journal: Analytical biochemistry 20060515

Title: Crystal structure of quinolinic acid phosphoribosyltransferase from Helicobacter pylori.

Journal: Proteins 20060401

Title: The first crystal structure of a thioacylenzyme intermediate in the ALDH family: new coenzyme conformation and relevance to catalysis.

Journal: Biochemistry 20060307

Title: NAD(P) synthesis and pyridine nucleotide cycling in plants and their potential importance in stress conditions.

Journal: Journal of experimental botany 20060101

Title: Construction of an artificial ribozyme which ligates an RNA fragment activated by nicotinamide mononucleotide.

Journal: Nucleic acids symposium series (2004) 20060101

Title: NAD-, NMN-, and NADP-dependent modification of dinitrogenase reductases from Rhodospirillum rubrum and Azotobacter vinelandii.

Journal: FEBS letters 20051024

Title: Interactions between melatonin and nicotinamide nucleotide: NADH preservation in cells and in cell-free systems by melatonin.

Journal: Journal of pineal research 20050901

Title: NAD deamidation 'a new reaction' by an enzyme from Aspergillus terreus DSM 826.

Journal: Antonie van Leeuwenhoek 20050201

Title: NAD+ specificity of bacterial DNA ligase revealed.

Journal: Structure (London, England : 1993) 20040801

Title: Structural rearrangement accompanying NAD+ synthesis within a bacterial DNA ligase crystal.

Journal: Structure (London, England : 1993) 20040801

Title: Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans.

Journal: Cell 20040514

Title: Structure and function of nicotinamide mononucleotide adenylyltransferase.

Journal: Current medicinal chemistry 20040401

Title: ADP-ribosyl cyclase; crystal structures reveal a covalent intermediate.

Journal: Structure (London, England : 1993) 20040301

Title: Effects of hydrogen peroxide upon nicotinamide nucleotide metabolism in Escherichia coli: changes in enzyme levels and nicotinamide nucleotide pools and studies of the oxidation of NAD(P)H by Fe(III).

Journal: The Journal of biological chemistry 20031024

Title: Porin OmpP2 of Haemophilus influenzae shows specificity for nicotinamide-derived nucleotide substrates.

Journal: The Journal of biological chemistry 20030704

Title: Crystallization and preliminary X-ray crystallographic analysis of quinolinate phosphoribosyltransferase of Helicobacter pylori.

Journal: Acta crystallographica. Section D, Biological crystallography 20030701

Title: Identification and characterization of a second NMN adenylyltransferase gene in Saccharomyces cerevisiae.

Journal: Protein expression and purification 20030201

Title: Crystal structure and site-directed mutagenesis of enzymatic components from Clostridium perfringens iota-toxin.

Journal: Journal of molecular biology 20030117

Title: Substrate specificity of mammalian pyridine nucleotide transglycosidases.

Journal: Journal of nutritional science and vitaminology 20020601

Title: Synthesis of pyridine nucleotide analogs consisting of nicotinoylamino acids by means of transglycosidation reactions catalyzed by mammalian pyridine nucleotide transglycosidases.

Journal: Journal of nutritional science and vitaminology 20020601

Title: Crystal structure of human nicotinamide mononucleotide adenylyltransferase in complex with NMN.

Journal: FEBS letters 20020410

Title: Crystallographic studies on human BST-1/CD157 with ADP-ribosyl cyclase and NAD glycohydrolase activities.

Journal: Journal of molecular biology 20020222

Title: Purification and structure of the major product obtained by reaction of NADPH and NMNH with the myeloperoxidase/hydrogen peroxide/chloride system.

Journal: European journal of biochemistry 20010501

Title: A disubstituted NAD+ analogue is a nanomolar inhibitor of trypanosomal glyceraldehyde-3-phosphate dehydrogenase.

Journal: Bioorganic & medicinal chemistry letters 20010122

Title: Mechanism and activation for allosteric adenosine 5'-monophosphate nucleosidase. Kinetic alpha-deuterium isotope effects for the enzyme-catalyzed hydrolysis of adenosine 5'-monophosphate and nicotinamide mononucleotide.

Journal: The Journal of biological chemistry 19860405

Title: Poddar SK, et al. Nicotinamide Mononucleotide: Exploration of Diverse Therapeutic Applications of a Potential Molecule. Biomolecules. 2019;9(1):34. Published 2019 Jan 21.

Title: Lv H, et al. NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion [published online ahead of print, 2020 Nov 3 Cell Metab. 2020;S1550-4131(20)30554-4.

Title: Li J, et al. p53 prevents doxorubicin cardiotoxicity independently of its prototypical tumor suppressor activities. Proc Natl Acad Sci U S A. 2019;116(39):19626-19634.

Title: Yoshino J, et al Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab. 2011;14(4):528-536.

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