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1097638-00-0,MFCD28386153
Catalog No.:AA01DZIC

1097638-00-0 | BGC-945TrisodiumSalt

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Technical Information
Catalog Number:
AA01DZIC
Chemical Name:
BGC-945TrisodiumSalt
CAS Number:
1097638-00-0
Molecular Formula:
C33H31N4Na3O10
Molecular Weight:
712.5894
MDL Number:
MFCD28386153
SMILES:
C#CCN([C@H]1CCc2c1cc1C(=O)N=C(Cc1c2)CO)c1ccc(cc1)C(=O)N[C@H](C(=O)O[Na])CCC(=O)N[C@@H](C(=O)O[Na])CCC(=O)O[Na]
Properties

Literature

Title: Anna Tochowicz, et al. Development and binding mode assessment of N---propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[gquinazolin-6-ylaminobenzoyl-l-γ-glutamyl-D-glutamic acid (BGC 945), a novel thymidylate synthase inhibitor that targets tumor cells. J Med Chem. 2013 Jul 11;56(13):5446-55.

Title: David D Gibbs, et al. BGC 945, a novel tumor-selective thymidylate synthase inhibitor targeted to alpha-folate receptor-overexpressing tumors. Cancer Res. 2005 Dec 15;65(24):11721-8.

Title: Chau Ng, et al. Efficacy and tolerability of the thymidylate synthase (TS) inhibitor, BGC 945 is mediated through its selective uptake via the α-folate receptor (α-FR) in IGROV-1 human tumor xenografts. AACR Annual Meeting-- Apr 12-16, 2008; San Diego, CA.

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