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Title: Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relationships.
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Title: Resistin is associated with mortality in patients with traumatic brain injury.
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Title: NMDA-mediated modulation of dopamine release is modified in rat prefrontal cortex and nucleus accumbens after chronic nicotine treatment.
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Title: Molecular mechanisms of traumatic brain injury: the missing link in management.
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Title: Cerebral vasospasm following traumatic subarachnoid hemorrhage.
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Title: Risks associated with magnetic resonance imaging and cervical collar in comatose, blunt trauma patients with negative comprehensive cervical spine computed tomography and no apparent spinal deficit.
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Title: Pharmacology of traumatic brain injury: where is the 'golden bullet'?
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Title: Repeated treatment with N-methyl-d-aspartate antagonists in neonatal, but not adult, rats causes long-term deficits of radial-arm maze learning.
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Title: Increased cerebral oxygen consumption in Eker rats and effects of N-methyl-D-aspartate blockade: Implications for autism.
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Title: Intracranial pressure monitoring in intensive care: clinical advantages of a computerized system over manual recording.
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Title: NMDA receptor activity in learning spatial procedural strategies I. The influence of hippocampal lesions.
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Title: NMDA receptor activity in learning spatial procedural strategies II. The influence of cerebellar lesions.
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Title: Acute D2/D3 dopaminergic agonism but chronic D2/D3 antagonism prevents NMDA antagonist neurotoxicity.
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Title: Neuroprotection associated with alternative splicing of NMDA receptors in rat cortical neurons.
Journal: British journal of pharmacology 20060301
Title: Some prognostic models for traumatic brain injury were not valid.
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Title: The NMDA receptor antagonist CGS 19755 disrupts recovery following cerebellar lesions.
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Title: Glutamate receptors in neuroinflammatory demyelinating disease.
Journal: Mediators of inflammation 20060101
Title: Severe brain injury ICU outcomes are associated with Cranial-Arterial Pressure Index and noninvasive Bispectral Index and transcranial oxygen saturation: a prospective, preliminary study.
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Title: 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.
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Title: Methodological quality of animal studies on neuroprotection in focal cerebral ischaemia.
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Title: Development of a three-dimensional model for the N-methyl-D-aspartate NR2A subunit.
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Title: Cognitive effects of dopaminergic and glutamatergic blockade in nucleus accumbens in pigeons.
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Title: Homocysteine, a risk factor for atherosclerosis, biphasically changes the endothelial production of kynurenic acid.
Journal: European journal of pharmacology 20050711
Title: Effects of the N-methyl-D-aspartate receptor antagonist perzinfotel [EAA-090; [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)-ethyl]phosphonic acid] on chemically induced thermal hypersensitivity.
Journal: The Journal of pharmacology and experimental therapeutics 20050601
Title: The NMDA receptor complex: a long and winding road to therapeutics.
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Title: Cerebral perfusion pressure and risk of brain hypoxia in severe head injury: a prospective observational study.
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Title: Acute nociceptive somatic stimulus sensitizes neurones in the spinal cord to colonic distension in the rat.
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Title: Neuroprotection against ischemic/hypoxic brain damage: blockers of ionotropic glutamate receptor and voltage sensitive calcium channels.
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Title: Nicotine exerts a permissive role on NMDA receptor function in hippocampal noradrenergic terminals.
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Title: The rise and fall of NMDA antagonists for ischemic stroke.
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Title: Lessons from epidemiologic studies in clinical trials of traumatic brain injury.
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Title: NMDA-evoked consumption and recovery of mitochondrially targeted aequorin suggests increased Ca2+ uptake by a subset of mitochondria in hippocampal neurons.
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Title: Cannabinoid CB1 receptor activation does not prevent the toxicity of glutamate towards embryonic chick telencephalon primary cultures.
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Title: Neuroprotective effects of N-methyl-D-aspartate receptor antagonist on aspartate induced neurotoxicity in the spinal cord in vivo.
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Title: Glutamate receptor antagonists modulate heat shock protein response in focal brain ischemia.
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Title: Stroke: trial by jury.
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Title: Excitatory amino acid antagonists for acute stroke.
Journal: The Cochrane database of systematic reviews 20030101
Title: Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?
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Title: Multisubstrate analogue inhibitors of glucosamine-6-phosphate synthase from Candida albicans.
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Title: Neuroprotective agents in acute ischemic stroke.
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Title: Antiepileptic drugs and agents that inhibit voltage-gated sodium channels prevent NMDA antagonist neurotoxicity.
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Title: Glutamate AMPA receptor antagonist treatment for ischaemic stroke.
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Title: Effects of antagonism of NMDA receptors on transient lower esophageal sphincter relaxations in the dog.
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Title: Design, synthesis, SAR, and biological evaluation of highly potent benzimidazole-spaced phosphono-alpha-amino acid competitive NMDA antagonists of the AP-6 type.
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Title: A comparative assessment of the efficacy and side-effect liability of neuroprotective compounds in experimental stroke.
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Title: Regional distribution and pharmacological characteristics of [3H]N-acetyl-aspartyl-glutamate (NAAG) binding sites in rat brain.
Journal: Neurochemistry international 20010101
Title: The 26th Congress of the Scandinavian Society of Anaesthesiology and Intensive Care Medicine, Tromso, Norway, 13-17 June 2001.
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Title: Anticonvulsant efficacy of N-methyl-D-aspartate antagonists against convulsions induced by cocaine.
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Title: NMDA antagonists potentiate scopolamine-induced amnesic effect.
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Title: Glutamatergic antagonism: effects on lidocaine-induced seizures in the rat.
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Title: Yohimbine-induced seizures involve NMDA and GABAergic transmission.
Journal: Neuropharmacology 19920401
