Title: Hayashi, Shigeo; Hirao, Akiko; Imai, Aki; Nakamura, Hiroshi; Murata, Yoshinori; Ohashi, Katsuyo; Nakata, Eriko. Novel Non-Peptide Nociceptin/Orphanin FQ Receptor Agonist, 1--(1-Methylcyclooctyl)-4-piperidinyl-2-[(3R)-3-piperidinyl-1H-benzimidazole: Design, Synthesis, andStructure-Activity Relationship of Oral Receptor Occupancy in the Brain for Orally Potent Antianxiety Drug. Journal of Medicinal Chemistry (2009), 52(3), 610-625.
Title: Hayashi S, Hirao A, Imai A, Nakamura H, Murata Y, Ohashi K, Nakata E.Novel non-peptide nociceptin/orphanin FQ receptor agonist, 1--(1-Methylcyclooctyl)-4-piperidinyl-2-[(3R)-3-piperidinyl-1H-benzimidazole: design, synthesis, and structure-activity relationship of oral receptor occupancy in the brain for orally potent antianxiety drug.J Med Chem. 2009 Feb 12;52(3):610-25.
Title: Hirao A, Imai A, Sugie Y, Yamada Y, Hayashi S, Toide K.Pharmacological characterization of the newly synthesized nociceptin/orphanin FQ-receptor agonist 1--(1-methylcyclooctyl)-4-piperidinyl-2-[(3R)-3-piperidinyl-1H-benzimidazole as an anxiolytic agent.J Pharmacol Sci. 2008 Mar;106(3):361-8. Epub 2008 Mar 5.
