Home Amines 1124329-14-1
1124329-14-1,MFCD18384959
Catalog No.:AA007B0B

1124329-14-1 | 9-Cyclopentyl-2-({2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]phenyl}amino)-7-methylpurin-8-one

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Purity
Availability
Price(USD)
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1mg
98+%
in stock  
$6.00   $4.00
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5mg
98+%
in stock  
$9.00   $7.00
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10mg
98+%
in stock  
$14.00   $10.00
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50mg
98+%
in stock  
$36.00   $25.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA007B0B
Chemical Name:
9-Cyclopentyl-2-({2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]phenyl}amino)-7-methylpurin-8-one
CAS Number:
1124329-14-1
Molecular Formula:
C24H32N6O3
Molecular Weight:
452.5493
MDL Number:
MFCD18384959
SMILES:
COc1cc(ccc1Nc1ncc2c(n1)n(C1CCCC1)c(=O)n2C)OC1CCN(CC1)C
Properties
Computed Properties
 
Complexity:
669  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  
XLogP3:
3.2  

Downstream Synthesis Route
Literature

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex.

Journal: The Journal of cell biology 20100712

Title: Hewitt L, et al. Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex. J Cell Biol. 2010 Jul 12;190(1):25-34.

Title: Liu X, et al. TTK activates Akt and promotes proliferation and migration of hepatocellular carcinoma cells. Oncotarget. 2015 Oct 27;6(33):34309-20.

Title: Gurden MD, et al. Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. Cancer Res. 2015 Aug 15;75(16):3340-54.

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SDS
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Tags:1124329-14-1 Molecular Formula|1124329-14-1 MDL|1124329-14-1 SMILES|1124329-14-1 9-Cyclopentyl-2-({2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]phenyl}amino)-7-methylpurin-8-one