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112573-73-6,MFCD00864289
Catalog No.:AA008WDZ

112573-73-6 | (S)-Benzyl 2-(3-(acetylthio)-2-benzylpropanamido)acetate

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2.5mg
3 weeks  
$448.00   $313.00
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25mg
3 weeks  
$2,306.00   $1,614.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008WDZ
Chemical Name:
(S)-Benzyl 2-(3-(acetylthio)-2-benzylpropanamido)acetate
CAS Number:
112573-73-6
Molecular Formula:
C21H23NO4S
Molecular Weight:
385.4766
MDL Number:
MFCD00864289
SMILES:
O=C(CNC(=O)[C@H](Cc1ccccc1)CSC(=O)C)OCc1ccccc1
Properties
Computed Properties
 
Complexity:
485  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
11  
XLogP3:
3.3  

Literature

Title: A comprehensive review of the pharmacodynamics, pharmacokinetics, and clinical effects of the neutral endopeptidase inhibitor racecadotril.

Journal: Frontiers in pharmacology 20120101

Title: Racecadotril for childhood gastroenteritis: an individual patient data meta-analysis.

Journal: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20110901

Title: Grading recommendations in clinical practice guidelines: randomised experimental evaluation of four different systems.

Journal: Archives of disease in childhood 20110801

Title: Inhibition of insulin degrading enzyme by racecadotril in the brain of Wistar rats.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20110601

Title: Spectrophotometric and spectrofluorimetric methods for determination of Racecadotril.

Journal: Pakistan journal of pharmaceutical sciences 20110101

Title: Remarks and questions on the article 'Prospective randomized double-blind trial of racecadotril compared with loperamide in elderly people with gastroenteritis living in nursing homes'.

Journal: European journal of clinical pharmacology 20100801

Title: Increase of plasma insulin by racecadotril, an inhibitor of enkephalinase, in Wistar rats.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20100401

Title: Prospective randomized double-blind trial of racecadotril compared with loperamide in elderly people with gastroenteritis living in nursing homes.

Journal: European journal of clinical pharmacology 20100201

Title: Stability-indicating methods for the determination of racecadotril in the presence of its degradation products.

Journal: Bioscience trends 20091201

Title: Use of racecadotril as outpatient treatment for acute gastroenteritis: a prospective, randomized, parallel study.

Journal: The Journal of pediatrics 20090701

Title: Colon in acute intestinal infection.

Journal: Journal of pediatric gastroenterology and nutrition 20090401

Title: [Systematic review of the efficacy of racecadotril in the treatment of acute diarrhoea].

Journal: Anales de pediatria (Barcelona, Spain : 2003) 20081101

Title: Synergy between natriuretic peptides and phosphodiesterase 5 inhibitors ameliorates pulmonary arterial hypertension.

Journal: American journal of respiratory and critical care medicine 20081015

Title: Acute infectious diarrhoea in children: new insights in antisecretory treatment with racecadotril.

Journal: Acta paediatrica (Oslo, Norway : 1992) 20080801

Title: The characterization of selected drugs with infrared laser desorption/tunable synchrotron vacuum ultraviolet photoionization mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20080801

Title: A rapid and validated HPLC method to quantify racecadotril metabolite, thiorphan, in human plasma using solid-phase extraction.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080101

Title: [Prevention and treatment of acute diarrhea in infants].

Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20071101

Title: Systematic review: racecadotril in the treatment of acute diarrhoea in children.

Journal: Alimentary pharmacology & therapeutics 20070915

Title: Quantitative analysis of racecadotril metabolite in human plasma using a liquid chromatography/tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070601

Title: Structural studies of racecadotril and its process impurities by NMR and mass spectroscopy.

Journal: Die Pharmazie 20061201

Title: Current status of anti-diarrheal and anti-secretory drugs in the management of acute childhood diarrhea.

Journal: Indian journal of pediatrics 20060801

Title: Hypersensitivity to racecadotril: a case report.

Journal: European journal of pediatrics 20060601

Title: Mechanism of vasopeptidase inhibitor-induced plasma extravasation: comparison of omapatrilat and the novel neutral endopeptidase 24.11/angiotensin-converting enzyme inhibitor GW796406.

Journal: The Journal of pharmacology and experimental therapeutics 20051201

Title: Racecadotril in acute diarrhea.

Journal: Indian pediatrics 20050501

Title: A blind, randomized comparison of racecadotril and loperamide for stopping acute diarrhea in adults.

Journal: World journal of gastroenterology 20050314

Title: Racecadotril-is there enough evidence to recommend it for treatment of acute diarrhea?

Journal: Indian pediatrics 20041201

Title: Raacecadotril.

Journal: Indian pediatrics 20041201

Title: The effect of acute angiotensin-converting enzyme and neutral endopeptidase 24.11 inhibition on plasma extravasation in the rat.

Journal: The Journal of pharmacology and experimental therapeutics 20040601

Title: Efficacy and tolerability of racecadotril in the treatment of cholera in adults: a double blind, randomised, controlled clinical trial.

Journal: Gut 20031001

Title: Racecadotril versus loperamide: antidiarrheal research revisited.

Journal: Digestive diseases and sciences 20030201

Title: Hormonal, renal, hemodynamic responses to acute neutral endopeptidase inhibition in heart transplant patients.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20020801

Title: [Effect of racecadotril in the management of acute diarrhea in infants and children].

Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20020801

Title: Racecadotril (acetorphan) in the treatment of acute watery diarrhoea in children.

Journal: Journal of the Indian Medical Association 20020801

Title: A multinational comparison of racecadotril and loperamide in the treatment of acute watery diarrhoea in adults.

Journal: Scandinavian journal of gastroenterology 20020601

Title: Strategies for access to enantiomerically pure ecadotril, dexecadotril and fasidotril: a review.

Journal: Mini reviews in medicinal chemistry 20020601

Title: Effects of chronic neutral endopeptidase inhibition on the progression of left ventricular dysfunction and remodeling in dogs with moderate heart failure.

Journal: Cardiovascular drugs and therapy 20020501

Title: The treatment of acute diarrhea in the third millennium: a pediatrician's perspective.

Journal: Acta gastro-enterologica Belgica 20020101

Title: [Role of delta opioid receptors and their ligands in the development of adaptive heart protection against arrhythmogenesis].

Journal: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20011201

Title: Efficacy and tolerability of racecadotril in acute diarrhea in children.

Journal: Gastroenterology 20010301

Title: Perceived benefit after participating in positive or negative/neutral heart failure trials: the patients' perspective.

Journal: European journal of heart failure 20010301

Title: [Anti-arrhythmia effects of enkephalinase inhibitors].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20010101

Title: Effects of acetorphan, an enkephalinase inhibitor, on experimental and acute diarrhoea.

Journal: Gut 19920601

Title: Inhibition of apomorphine-induced yawning and penile erection by neurotensin.

Journal: Peptides 19910101

Title: Naloxone-reversible antidiarrheal effects of enkephalinase inhibitors.

Journal: European journal of pharmacology 19871201

Title: Pharmacological properties of acetorphan, a parenterally active 'enkephalinase' inhibitor.

Journal: The Journal of pharmacology and experimental therapeutics 19860601

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