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112859-71-9,MFCD00874717
Catalog No.:AA0078NA

112859-71-9 | Fluasterone

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5mg
98%
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$443.00   $310.00
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0078NA
Chemical Name:
Fluasterone
CAS Number:
112859-71-9
Molecular Formula:
C19H27FO
Molecular Weight:
290.4155
MDL Number:
MFCD00874717
SMILES:
FC1CC2C(C1=O)(C)CCC1C2CC=C2C1(C)CCCC2
Properties
Computed Properties
 
Complexity:
510  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
6  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
2  
XLogP3:
5.1  

Literature

Title: Pharmacokinetic and tissue distribution study of [14C]fluasterone in male Beagle dogs following intravenous, oral and subcutaneous dosing routes.

Journal: Chemico-biological interactions 20100127

Title: Identification of [14C]fluasterone metabolites in urine and feces collected from dogs after subcutaneous and oral administration of [14C]fluasterone.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20090501

Title: Chemoprevention of rat prostate carcinogenesis by dietary 16alpha-fluoro-5-androsten-17-one (fluasterone), a minimally androgenic analog of dehydroepiandrosterone.

Journal: Carcinogenesis 20070201

Title: Dehydroepiandrosterone inhibits the progression phase of mammary carcinogenesis by inducing cellular senescence via a p16-dependent but p53-independent mechanism.

Journal: Breast cancer research : BCR 20050101

Title: Prostate intraepithelial neoplasia in Noble rats, a potential intermediate endpoint for chemoprevention studies.

Journal: European journal of cancer (Oxford, England : 1990) 20040601

Title: A synthetic androstene analogue inhibits collagen-induced arthritis in the mouse.

Journal: Clinical immunology (Orlando, Fla.) 20040201

Title: Solubilization of Fluasterone in cosolvent/cyclodextrin combinations.

Journal: International journal of pharmaceutics 20031002

Title: A novel dehydroepiandrosterone analog improves functional recovery in a rat traumatic brain injury model.

Journal: Journal of neurotrauma 20030501

Title: A synthetic androstene derivative and a natural androstene metabolite inhibit relapsing-remitting EAE.

Journal: Journal of neuroimmunology 20020901

Title: Inhibition of carcinogen-activating enzymes by 16alpha-fluoro-5-androsten-17-one.

Journal: Cancer research 20020701

Title: Inhibition of adjuvant-induced arthritis by 16 alpha-fluoro-5-androsten-17-one.

Journal: Military medicine 20020201

Title: Suppression of 12-O-tetradecanoylphorbol-13-acetate-induced epidermal hyperplasia and inflammation by the dehydroepiandrosterone analog 16alpha-fluoro-5-androsten-17-one and its reversal by NADPH liposomes.

Journal: Cancer letters 20010710

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