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112924-45-5,MFCD00887769
Catalog No.:AA008RFQ

112924-45-5 | 1,1-Dimethylheptyl-11-hydroxytetrahydrocannabinol

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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008RFQ
Chemical Name:
1,1-Dimethylheptyl-11-hydroxytetrahydrocannabinol
CAS Number:
112924-45-5
Molecular Formula:
C25H38O3
Molecular Weight:
386.5674
MDL Number:
MFCD00887769
SMILES:
CCCCCCC(c1cc(O)c2c(c1)OC([C@@H]1[C@@H]2CC(=CC1)CO)(C)C)(C)C
Properties
Computed Properties
 
Complexity:
550  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
7  
XLogP3:
6.4  

Literature

Title: Cytotoxicity of synthetic cannabinoids on primary neuronal cells of the forebrain: the involvement of cannabinoid CB1 receptors and apoptotic cell death.

Journal: Toxicology and applied pharmacology 20140101

Title: Therapeutic utility of cannabinoid receptor type 2 (CB(2)) selective agonists.

Journal: Journal of medicinal chemistry 20131114

Title: Effects of cannabinoids and related fatty acids upon the viability of P19 embryonal carcinoma cells.

Journal: Archives of toxicology 20131101

Title: Chemical probes for the recognition of cannabinoid receptors in native systems.

Journal: Angewandte Chemie (International ed. in English) 20120709

Title: Differential modulations of striatal tyrosine hydroxylase and dopamine metabolism by cannabinoid agonists as evidence for functional selectivity in vivo.

Journal: Neuropharmacology 20120601

Title: Tentative identification of phase I metabolites of HU-210, a classical synthetic cannabinoid, by LC-MS/MS.

Journal: Journal of pharmaceutical and biomedical analysis 20120501

Title: Prediction of outcome after moderate and severe traumatic brain injury: external validation of the International Mission on Prognosis and Analysis of Clinical Trials (IMPACT) and Corticoid Randomisation After Significant Head injury (CRASH) prognostic models.

Journal: Critical care medicine 20120501

Title: Cannabinoids prevent lipopolysaccharide-induced neurodegeneration in the rat substantia nigra in vivo through inhibition of microglial activation and NADPH oxidase.

Journal: Brain research 20120427

Title: Unbalance of CB1 receptors expressed in GABAergic and glutamatergic neurons in a transgenic mouse model of Huntington's disease.

Journal: Neurobiology of disease 20120301

Title: Increased brain metabolism after acute administration of the synthetic cannabinoid HU210: a small animal PET imaging study with 18F-FDG.

Journal: Brain research bulletin 20120210

Title: Differential treatment regimen-related effects of HU210 on CB(1) and D(2)-like receptor functionality in the rat basal ganglia.

Journal: Pharmacology 20120101

Title: Cannabinoid receptor type 1 protects nigrostriatal dopaminergic neurons against MPTP neurotoxicity by inhibiting microglial activation.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20111215

Title: Loss of striatal cannabinoid CB1 receptor function in attention-deficit / hyperactivity disorder mice with point-mutation of the dopamine transporter.

Journal: The European journal of neuroscience 20111101

Title: Opposite function of dopamine D1 and N-methyl-D-aspartate receptors in striatal cannabinoid-mediated signaling.

Journal: The European journal of neuroscience 20111101

Title: Identification of essential cannabinoid-binding domains: structural insights into early dynamic events in receptor activation.

Journal: The Journal of biological chemistry 20110923

Title: Cannabinoid CB1 receptors regulate neuronal TNF-α effects in experimental autoimmune encephalomyelitis.

Journal: Brain, behavior, and immunity 20110801

Title: Cannabinoid receptor agonists modulate oligodendrocyte differentiation by activating PI3K/Akt and the mammalian target of rapamycin (mTOR) pathways.

Journal: British journal of pharmacology 20110801

Title: The effects of cannabinoid drugs on abnormal involuntary movements in dyskinetic and non-dyskinetic 6-hydroxydopamine lesioned rats.

Journal: Brain research 20101202

Title: Differential treatment regimen-related effects of cannabinoids on D1 and D2 receptors in adolescent and adult rat brain.

Journal: Journal of chemical neuroanatomy 20101201

Title: The neurobiology of the switch process in bipolar disorder: a review.

Journal: The Journal of clinical psychiatry 20101101

Title: Revisiting the complex influences of cannabinoids on motor functions unravels pharmacodynamic differences between cannabinoid agonists.

Journal: Neuropharmacology 20101101

Title: Cannabinoid effects on CB1 receptor density in the adolescent brain: an autoradiographic study using the synthetic cannabinoid HU210.

Journal: Synapse (New York, N.Y.) 20101101

Title: Behavioural and molecular consequences of chronic cannabinoid treatment in Huntington's disease transgenic mice.

Journal: Neuroscience 20100929

Title: GABA(A) receptor density is altered by cannabinoid treatment in the hippocampus of adult but not adolescent rats.

Journal: Brain research 20100910

Title: Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery.

Journal: British journal of pharmacology 20100901

Title: Cannabinoid administration increases 5HT1A receptor binding and mRNA expression in the hippocampus of adult but not adolescent rats.

Journal: Neuroscience 20100811

Title: Effects of cannabinoids on capsaicin receptor activity following exposure of primary sensory neurons to inflammatory mediators.

Journal: Life sciences 20100731

Title: Brain-derived neurotrophic factor controls cannabinoid CB1 receptor function in the striatum.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20100616

Title: Abnormal mGlu 5 receptor/endocannabinoid coupling in mice lacking FMRP and BC1 RNA.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20100601

Title: Cannabinoid-1 receptor activation induces reactive oxygen species-dependent and -independent mitogen-activated protein kinase activation and cell death in human coronary artery endothelial cells.

Journal: British journal of pharmacology 20100601

Title: Neuroprotective potential of CB1 receptor agonists in an in vitro model of Huntington's disease.

Journal: British journal of pharmacology 20100601

Title: Effect of synthetic cannabinoid HU210 on memory deficits and neuropathology in Alzheimer's disease mouse model.

Journal: Current Alzheimer research 20100501

Title: Lack of positive allosteric modulation of mutated alpha(1)S267I glycine receptors by cannabinoids.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20100501

Title: CB1 cannabinoid receptors increase neuronal precursor proliferation through AKT/glycogen synthase kinase-3beta/beta-catenin signaling.

Journal: The Journal of biological chemistry 20100326

Title: Precipitated withdrawal counters the adverse effects of subchronic cannabinoid administration on male rat sexual behavior.

Journal: Neuroscience letters 20100326

Title: Involvement of cannabinoid-1 and cannabinoid-2 receptors in septic ileus.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20100301

Title: Abnormal sensitivity of cannabinoid CB1 receptors in the striatum of mice with experimental amyotrophic lateral sclerosis.

Journal: Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 20100101

Title: Voluntary exercise and sucrose consumption enhance cannabinoid CB1 receptor sensitivity in the striatum.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20100101

Title: The endocannabinoid system links gut microbiota to adipogenesis.

Journal: Molecular systems biology 20100101

Title: Suppression of amygdalar endocannabinoid signaling by stress contributes to activation of the hypothalamic-pituitary-adrenal axis.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20091201

Title: Exercise attenuates the clinical, synaptic and dendritic abnormalities of experimental autoimmune encephalomyelitis.

Journal: Neurobiology of disease 20091001

Title: Cannabinoid 1 receptor activation inhibits transient receptor potential vanilloid type 1 receptor-mediated cationic influx into rat cultured primary sensory neurons.

Journal: Neuroscience 20090915

Title: Protracted cannabinoid administration elicits antidepressant behavioral responses in rats: role of gender and noradrenergic transmission.

Journal: Physiology & behavior 20090804

Title: Cannabinoid CB(1) receptor activation stimulates neurite outgrowth and inhibits capsaicin-induced Ca(2+) influx in an in vitro model of diabetic neuropathy.

Journal: Neuropharmacology 20090801

Title: HU210-induced downregulation in cannabinoid CB1 receptor binding strongly correlates with body weight loss in the adult rat.

Journal: Neurochemical research 20090701

Title: Cannabinoid receptor 1 is a potential drug target for treatment of translocation-positive rhabdomyosarcoma.

Journal: Molecular cancer therapeutics 20090701

Title: Effect of abdominal surgery on the intestinal absorption of lipophilic drugs: possible role of the lymphatic transport.

Journal: Translational research : the journal of laboratory and clinical medicine 20090601

Title: Cannabinoid receptor-independent cytotoxic effects of cannabinoids in human colorectal carcinoma cells: synergism with 5-fluorouracil.

Journal: Cancer chemotherapy and pharmacology 20090301

Title: Activation of CB1 cannabinoid receptors impairs memory consolidation and hippocampal polysialylated neural cell adhesion molecule expression in contextual fear conditioning.

Journal: Neuroscience 20090218

Title: Concomitant activation of adenylyl cyclase suppresses the opposite influences of CB(1) cannabinoid receptor agonists on tyrosine hydroxylase expression.

Journal: Biochemical pharmacology 20090115

Title: Multifunctional drugs for head injury.

Journal: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20090101

Title: Modulation of glycine receptor function by the synthetic cannabinoid HU210.

Journal: Pharmacology 20090101

Title: ERK signalling pathway is not involved in PSA-NCAM-dependent alterations of hippocampal plasticity evoked by CB1 receptor activation.

Journal: Pharmacological reports : PR 20090101

Title: Repeated cannabinoid injections into the rat periaqueductal gray enhance subsequent morphine antinociception.

Journal: Neuropharmacology 20081201

Title: Methamphetamine-seeking behavior is due to inhibition of nicotinic cholinergic transmission by activation of cannabinoid CB1 receptors.

Journal: Neuropharmacology 20081201

Title: Reciprocal influences of CB1 cannabinoid receptor agonists on ERK and JNK signalling in N1E-115 cells.

Journal: FEBS letters 20081126

Title: Tat-3L4F does not significantly affect spatial learning and memory.

Journal: Behavioural brain research 20081121

Title: A novel high-throughput assay for the quantitative assessment of receptor trafficking.

Journal: Clinical and experimental pharmacology & physiology 20081101

Title: Subunit-specific modulation of glycine receptors by cannabinoids and N-arachidonyl-glycine.

Journal: Biochemical pharmacology 20081015

Title: The protective effect of dexanabinol (HU-211) on nitric oxide and cysteine protease-mediated neuronal death in focal cerebral ischemia.

Journal: Neurochemical research 20080901

Title: Differential modulation of AP-1- and CRE-driven transcription by cannabinoid agonists emphasizes functional selectivity at the CB1 receptor.

Journal: British journal of pharmacology 20080901

Title: Release of arachidonic acid by 2-arachidonoyl glycerol and HU210 in PC12 cells; roles of Src, phospholipase C and cytosolic phospholipase A(2)alpha.

Journal: European journal of pharmacology 20080820

Title: Chronic psychoemotional stress impairs cannabinoid-receptor-mediated control of GABA transmission in the striatum.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20080716

Title: TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20080611

Title: Importance of screening logs in clinical trials for severe traumatic brain injury.

Journal: Neurosurgery 20080601

Title: Locomotor effects of morphine or alcohol in mice after a repeated treatment with the cannabinoid agonist HU 210.

Journal: European journal of pharmacology 20080531

Title: Effects of chronic treatment with citalopram on cannabinoid and opioid receptor-mediated G-protein coupling in discrete rat brain regions.

Journal: Psychopharmacology 20080501

Title: Dexanabinol prevents development of vasospasm in the rat femoral artery model.

Journal: Neurosurgical review 20080401

Title: Actions of N-arachidonyl-glycine in a rat neuropathic pain model.

Journal: Neuropharmacology 20080101

Title: [Role of cannabinoid receptors in regulation of cardiac tolerance to ischemia and reperfusion].

Journal: Izvestiia Akademii nauk. Seriia biologicheskaia 20080101

Title: Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death.

Journal: Biochemical and biophysical research communications 20071207

Title: The endocannabinoid system is dysregulated in multiple sclerosis and in experimental autoimmune encephalomyelitis.

Journal: Brain : a journal of neurology 20071001

Title: Agonist selective modulation of tyrosine hydroxylase expression by cannabinoid ligands in a murine neuroblastoma cell line.

Journal: Journal of neurochemistry 20070901

Title: Local enhancement of cannabinoid CB1 receptor signalling in the dorsal hippocampus elicits an antidepressant-like effect.

Journal: Behavioural pharmacology 20070901

Title: Helix 8 Leu in the CB1 cannabinoid receptor contributes to selective signal transduction mechanisms.

Journal: The Journal of biological chemistry 20070824

Title: Design, synthesis, binding, and molecular modeling studies of new potent ligands of cannabinoid receptors.

Journal: Bioorganic & medicinal chemistry 20070815

Title: Mechanisms for the coupling of cannabinoid receptors to intracellular calcium mobilization in rat insulinoma beta-cells.

Journal: Experimental cell research 20070815

Title: Different impacts of intestinal lymphatic transport on the oral bioavailability of structurally similar synthetic lipophilic cannabinoids: dexanabinol and PRS-211,220.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20070801

Title: Effects of anandamide and noxious heat on intracellular calcium concentration in nociceptive drg neurons of rats.

Journal: Journal of neurophysiology 20070801

Title: Sch35966 is a potent, selective agonist at the peripheral cannabinoid receptor (CB2) in rodents and primates.

Journal: British journal of pharmacology 20070801

Title: The synthetic cannabinoid HU-210 attenuates neural damage in diabetic mice and hyperglycemic pheochromocytoma PC12 cells.

Journal: Neurobiology of disease 20070801

Title: The synthetic cannabinoid HU210 induces spatial memory deficits and suppresses hippocampal firing rate in rats.

Journal: British journal of pharmacology 20070701

Title: Acute activation of CB1 cannabinoid receptors transiently decreases PSA-NCAM expression in the dentate gyrus of the rat hippocampus.

Journal: Brain research 20070507

Title: Cannabinoids ameliorate pain and reduce disease pathology in cerulein-induced acute pancreatitis.

Journal: Gastroenterology 20070501

Title: Modulation of morphine and alcohol motor stimulant effects by cannabinoid receptors ligands.

Journal: Behavioural brain research 20070328

Title: Chronic cocaine sensitizes striatal GABAergic synapses to the stimulation of cannabinoid CB1 receptors.

Journal: The European journal of neuroscience 20070301

Title: Characterization of cannabinoid-binding sites in zebrafish brain.

Journal: Neuroscience letters 20070221

Title: CB2 cannabinoid receptors promote mouse neural stem cell proliferation.

Journal: The European journal of neuroscience 20070201

Title: In vivo modulation of LPS-induced alterations in brain and peripheral cytokines and HPA axis activity by cannabinoids.

Journal: Journal of neuroimmunology 20061201

Title: Role of cannabinoid receptors in the regulation of cardiac contractility during ischemia/reperfusion.

Journal: Bulletin of experimental biology and medicine 20061101

Title: The cannabinoid agonist WIN 55,212-2 inhibits TNF-alpha-induced neutrophil transmigration across ECV304 cells.

Journal: European journal of pharmacology 20061010

Title: Negative chronotropic effect of cannabinoids and their water-soluble emulsion is related to activation of cardiac CB1 receptors.

Journal: Bulletin of experimental biology and medicine 20061001

Title: Interactions between CB1 cannabinoid and mu opioid receptors mediating inhibition of neurotransmitter release in rat nucleus accumbens core.

Journal: Neuropharmacology 20060901

Title: Alterations in behavioral flexibility by cannabinoid CB1 receptor agonists and antagonists.

Journal: Psychopharmacology 20060801

Title: Altered responsiveness of serotonin receptor subtypes following long-term cannabinoid treatment.

Journal: The international journal of neuropsychopharmacology 20060601

Title: Mutations of CB1 T210 produce active and inactive receptor forms: correlations with ligand affinity, receptor stability, and cellular localization.

Journal: Biochemistry 20060502

Title: Increased sensitivity to restraint stress and novelty-induced emotionality following long-term, high dose cannabinoid exposure.

Journal: Psychoneuroendocrinology 20060501

Title: Expression of functional CB1 cannabinoid receptors in retinoic acid-differentiated P19 embryonal carcinoma cells.

Journal: Journal of neuroscience research 20060501

Title: Effects of intra-amygdala infusion of CB1 receptor agonists on the reconsolidation of fear-potentiated startle.

Journal: Learning & memory (Cold Spring Harbor, N.Y.) 20060501

Title: [Paticipation of cannabinoid receptors in the regulation of cardiac rhythm and cardiac contractility].

Journal: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20060401

Title: Therapeutic action of cannabinoid on axonal injury induced by peroxynitrite.

Journal: Brain research 20060303

Title: Differential activation of G-proteins by mu-opioid receptor agonists.

Journal: British journal of pharmacology 20060301

Title: Arthritis and cannabinoids: HU-210 and Win-55,212-2 prevent IL-1alpha-induced matrix degradation in bovine articular chondrocytes in-vitro.

Journal: The Journal of pharmacy and pharmacology 20060301

Title: The analgesic activity of paracetamol is prevented by the blockade of cannabinoid CB1 receptors.

Journal: European journal of pharmacology 20060215

Title: F200A substitution in the third transmembrane helix of human cannabinoid CB1 receptor converts AM2233 from receptor agonist to inverse agonist.

Journal: European journal of pharmacology 20060215

Title: The cannabinoid receptor antagonist SR-141716A induces penile erection in male rats: involvement of paraventricular glutamic acid and nitric oxide.

Journal: Neuropharmacology 20060201

Title: Effects of cannabinoid receptor agonists on rat gastric acid secretion: discrepancy between in vitro and in vivo data.

Journal: Digestive diseases and sciences 20060201

Title: Efficacy and safety of dexanabinol in severe traumatic brain injury: results of a phase III randomised, placebo-controlled, clinical trial.

Journal: The Lancet. Neurology 20060101

Title: The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20051227

Title: Activation of CB1 and CB2 receptors attenuates the induction and maintenance of inflammatory pain in the rat.

Journal: Pain 20051205

Title: Pharmacological enhancement of cannabinoid CB1 receptor activity elicits an antidepressant-like response in the rat forced swim test.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20051201

Title: Virtual screening of novel CB2 ligands using a comparative model of the human cannabinoid CB2 receptor.

Journal: Journal of medicinal chemistry 20051117

Title: Design, synthesis, and binding studies of new potent ligands of cannabinoid receptors.

Journal: Journal of medicinal chemistry 20051117

Title: 1-Benzhydryl-3-phenylurea and 1-benzhydryl-3-phenylthiourea derivatives: new templates among the CB1 cannabinoid receptor inverse agonists.

Journal: Journal of medicinal chemistry 20051117

Title: Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects.

Journal: The Journal of clinical investigation 20051101

Title: Cannabinoids.

Journal: Current drug targets. CNS and neurological disorders 20051001

Title: The G alpha(o/i)-coupled cannabinoid receptor-mediated neurite outgrowth involves Rap regulation of Src and Stat3.

Journal: The Journal of biological chemistry 20050930

Title: Differential effects of two cannabinoid receptor agonists on progressive ratio responding for food and free-feeding in rats.

Journal: Behavioural pharmacology 20050901

Title: Behavioural effects of quinpirole following withdrawal of chronic treatment with the CB1 agonist, HU-210, in rats.

Journal: Behavioural pharmacology 20050901

Title: Hemodynamic profile, responsiveness to anandamide, and baroreflex sensitivity of mice lacking fatty acid amide hydrolase.

Journal: American journal of physiology. Heart and circulatory physiology 20050801

Title: Effect of the cannabinoid ajulemic acid on rat models of neuropathic and inflammatory pain.

Journal: Neuroscience letters 20050715

Title: Pharmacological effects mediated by UDP-glucose that are independent of P2Y14 receptor expression.

Journal: Pharmacological research 20050601

Title: Occurrence and possible biological role of the endocannabinoid system in the sea squirt Ciona intestinalis.

Journal: Journal of neurochemistry 20050601

Title: CB1 cannabinoid receptor agonists increase intracranial self-stimulation thresholds in the rat.

Journal: Psychopharmacology 20050501

Title: Cannabinoid receptor antagonists SR141716 and SR144528 exhibit properties of partial agonists in experiments on isolated perfused rat heart.

Journal: Bulletin of experimental biology and medicine 20050501

Title: Substituted 5,5'-diphenyl-2-thioxoimidazolidin-4-one as CB1 cannabinoid receptor ligands: synthesis and pharmacological evaluation.

Journal: Journal of medicinal chemistry 20050407

Title: CB(1) cannabinoid receptor stimulation modulates transient receptor potential vanilloid receptor 1 activities in calcium influx and substance P Release in cultured rat dorsal root ganglion cells.

Journal: Journal of pharmacological sciences 20050301

Title: Prevention of Alzheimer's disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050223

Title: Neuroprotective effects of the synthetic cannabinoid HU-210 in primary cortical neurons are mediated by phosphatidylinositol 3-kinase/AKT signaling.

Journal: Molecular and cellular neurosciences 20050101

Title: Cocaine- and amphetamine-related transcript is involved in the orexigenic effect of endogenous anandamide.

Journal: Neuroendocrinology 20050101

Title: Gastric antisecretory effects of synthetic cannabinoids after central or peripheral administration in the rat.

Journal: Brain research bulletin 20041215

Title: Selective cannabinoid receptor agonist HU-210 decreases pump function of isolated perfused heart: role of cAMP and cGMP.

Journal: Bulletin of experimental biology and medicine 20041201

Title: Discriminative stimulus effects of the structurally novel cannabinoid CB1/CB2 receptor partial agonist BAY 59-3074 in the rat.

Journal: European journal of pharmacology 20041128

Title: Management of traumatic brain injury: some current evidence and applications.

Journal: Postgraduate medical journal 20041101

Title: Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension.

Journal: Circulation 20041005

Title: Recent advances in the development of multifactorial therapies for the treatment of traumatic brain injury.

Journal: Expert opinion on investigational drugs 20041001

Title: Enhancement of anxiety-like responsiveness to the cannabinoid CB(1) receptor agonist HU-210 following chronic stress.

Journal: European journal of pharmacology 20040924

Title: The cannabinoid dexanabinol is an inhibitor of the nuclear factor-kappa B (NF-kappa B).

Journal: Neuropharmacology 20040901

Title: A critical interaction between dopamine D2 receptors and endocannabinoids mediates the effects of cocaine on striatal gabaergic Transmission.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040801

Title: Prolonged cannabinoid treatment results in spatial working memory deficits and impaired long-term potentiation in the CA1 region of the hippocampus in vivo.

Journal: The European journal of neuroscience 20040801

Title: Differential modulation of withdrawal reflexes by a cannabinoid in the rabbit.

Journal: Brain research 20040625

Title: The endogenous cannabinoid system protects against colonic inflammation.

Journal: The Journal of clinical investigation 20040415

Title: Cannabinoids induce cancer cell proliferation via tumor necrosis factor alpha-converting enzyme (TACE/ADAM17)-mediated transactivation of the epidermal growth factor receptor.

Journal: Cancer research 20040315

Title: Detection of cannabinoid agonist evoked increase in BOLD contrast in rats using functional magnetic resonance imaging.

Journal: Neuropharmacology 20040301

Title: Cannabinoids modulate ultrasound-induced aversive responses in rats.

Journal: Psychopharmacology 20040201

Title: Behavioral effects of cannabinoids show differential sensitivity to cannabinoid receptor blockade and tolerance development.

Journal: Behavioural pharmacology 20040201

Title: Corticotropin-releasing hormone (CRH) mRNA expression in rat central amygdala in cannabinoid tolerance and withdrawal: evidence for an allostatic shift?

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040101

Title: Augmentation of the development of behavioral tolerance to cannabinoid administration through pavlovian conditioning.

Journal: Neuropsychobiology 20040101

Title: Synergism between tumor necrosis factor-alpha and H2O2 enhances cell damage in rat PC12 cells.

Journal: Neuroscience letters 20031219

Title: G protein-coupled endothelial receptor for atypical cannabinoid ligands modulates a Ca2+-dependent K+ current.

Journal: The Journal of biological chemistry 20031114

Title: Neuroscience. Stout guards of the central nervous system.

Journal: Science (New York, N.Y.) 20031003

Title: Effects of direct periaqueductal grey administration of a cannabinoid receptor agonist on nociceptive and aversive responses in rats.

Journal: Neuropharmacology 20031001

Title: Dexanabinol: a novel cannabinoid with neuroprotective properties.

Journal: IDrugs : the investigational drugs journal 20031001

Title: Cannabinoid receptor activation in the rostral ventrolateral medulla oblongata evokes cardiorespiratory effects in anaesthetised rats.

Journal: British journal of pharmacology 20030901

Title: [Alterations of inotropic function of isolated heart and extent of injury of cardiomyocytes after cannabinoid receptor activation during ischemia and reperfusion].

Journal: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20030901

Title: Drug-induced hypothermia reduces ischemic damage: effects of the cannabinoid HU-210.

Journal: Stroke 20030801

Title: Combination of dexanabinol and tempol in focal cerebral ischemia: is there a ceiling effect?

Journal: Experimental neurology 20030801

Title: The CB1 cannabinoid receptor agonist, HU-210, reduces levodopa-induced rotations in 6-hydroxydopamine-lesioned rats.

Journal: Pharmacology & toxicology 20030801

Title: Histamine induced responses are attenuated by a cannabinoid receptor agonist in human skin.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20030601

Title: Kinin-induced anion-dependent secretion in porcine ileum: characterization and involvement of opioid- and cannabinoid-sensitive enteric neural circuits.

Journal: The Journal of pharmacology and experimental therapeutics 20030501

Title: Differential cannabinoid-induced electrophysiological effects in rat ventral tegmentum.

Journal: Neuropharmacology 20030401

Title: Cannabinoid agonists attenuate capsaicin-induced responses in human skin.

Journal: Pain 20030401

Title: Effects of cannabinoid receptor agonists on immunologically induced histamine release from rat peritoneal mast cells.

Journal: European journal of pharmacology 20030319

Title: Effects of cannabinoids on lithium-induced conditioned rejection reactions in a rat model of nausea.

Journal: Psychopharmacology 20030301

Title: Dual effect of cannabinoid CB1 receptor stimulation on a vanilloid VR1 receptor-mediated response.

Journal: Cellular and molecular life sciences : CMLS 20030301

Title: Dexanabinol (HU-211) has a beneficial effect on axonal sprouting and survival after rat optic nerve crush injury.

Journal: Vision research 20030201

Title: Cannabinoids ablate release of TNFalpha in rat microglial cells stimulated with lypopolysaccharide.

Journal: Glia 20030115

Title: Antiemetic and motor-depressive actions of CP55,940: cannabinoid CB1 receptor characterization, distribution, and G-protein activation.

Journal: European journal of pharmacology 20030110

Title: Differential distribution of functional cannabinoid CB1 receptors in the mouse gastroenteric tract.

Journal: European journal of pharmacology 20030110

Title: Dexanabinol: dexanabinone, HU 211, PA 50211, PRS 211007, sinnabidol.

Journal: Drugs in R&D 20030101

Title: Cannabinoid agonists and antagonists modulate lithium-induced conditioned gaping in rats.

Journal: Integrative physiological and behavioral science : the official journal of the Pavlovian Society 20030101

Title: [Garbage disposal in a large multidisciplinary hospital: organizational and epidemiological aspects].

Journal: Gigiena i sanitariia 20030101

Title: Anandamide induces cough in conscious guinea-pigs through VR1 receptors.

Journal: British journal of pharmacology 20021101

Title: Functional role of serine residues of transmembrane dopamin VII in signal transduction of CB2 cannabinoid receptor.

Journal: Journal of veterinary science 20020901

Title: Experimental parkinsonism alters endocannabinoid degradation: implications for striatal glutamatergic transmission.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20020815

Title: CB1 cannabinoid receptor-mediated tyrosine phosphorylation of focal adhesion kinase-related non-kinase.

Journal: FEBS letters 20020814

Title: Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease.

Journal: Blood 20020715

Title: The extracellular regulated kinases (ERK) 1/2 mediate cannabinoid-induced inhibition of gap junctional communication in endothelial cells.

Journal: British journal of pharmacology 20020701

Title: Influence of the CB(1) receptor antagonist, AM 251, on the regional haemodynamic effects of WIN-55212-2 or HU 210 in conscious rats.

Journal: British journal of pharmacology 20020601

Title: Cannabinoids inhibit excitatory inputs to neurons in the shell of the nucleus accumbens: an in vivo electrophysiological study.

Journal: The European journal of neuroscience 20020601

Title: Postsynaptic endocannabinoid release is critical to long-term depression in the striatum.

Journal: Nature neuroscience 20020501

Title: [Increase of the heart arrhythmogenic resistance and decrease of the myocardial necrosis zone during activation of cannabinoid receptors].

Journal: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20020501

Title: Gastric antisecretory role and immunohistochemical localization of cannabinoid receptors in the rat stomach.

Journal: British journal of pharmacology 20020401

Title: CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain.

Journal: Pain 20020401

Title: Role of CB1 and CB2 receptors in the inhibitory effects of cannabinoids on lipopolysaccharide-induced nitric oxide release in astrocyte cultures.

Journal: Journal of neuroscience research 20020315

Title: Modulation of cannabinoid agonist binding by 5-HT in the rat cerebellum.

Journal: Journal of neurochemistry 20020301

Title: Dexanabinol (HU-211) in the treatment of severe closed head injury: a randomized, placebo-controlled, phase II clinical trial.

Journal: Critical care medicine 20020301

Title: Dexanabinol as a treatment for traumatic brain injury: will another therapeutic promise be broken?

Journal: Critical care medicine 20020301

Title: Cannabinoids and brain injury: therapeutic implications.

Journal: Trends in molecular medicine 20020201

Title: Activation of cannabinoid receptors decreases the area of ischemic myocardial necrosis.

Journal: Bulletin of experimental biology and medicine 20020201

Title: Neuroleptic-like profile of the cannabinoid agonist, HU 210, on rodent behavioural models.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20020101

Title: Prevention of cannabinoid withdrawal syndrome by lithium: involvement of oxytocinergic neuronal activation.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20011215

Title: Functional changes in the inhibitory effect of spinal cannabinoid (CB) receptor activation in nerve injured rats.

Journal: Neuropharmacology 20011201

Title: The anti-inflammatory activities of cannabinoid receptor ligands in mouse peritonitis models.

Journal: European journal of pharmacology 20011130

Title: HU-210 shows higher efficacy and potency than morphine after intrathecal administration in the mouse formalin test.

Journal: European journal of pharmacology 20011019

Title: Cannabinoid activity curtails cocaine craving.

Journal: Nature medicine 20011001

Title: A cannabinoid mechanism in relapse to cocaine seeking.

Journal: Nature medicine 20011001

Title: 2-Arachidonoylglycerol and anandamide oppositely modulate norepinephrine release from the rat heart sympathetic nerves.

Journal: Japanese journal of pharmacology 20010901

Title: CB1 cannabinoid receptor-mediated neurite remodeling in mouse neuroblastoma N1E-115 cells.

Journal: Journal of neuroscience research 20010815

Title: Endogenous cannabinoid, 2-arachidonoylglycerol, attenuates naloxone-precipitated withdrawal signs in morphine-dependent mice.

Journal: Brain research 20010803

Title: Modulation of cytokine responses in Corynebacterium parvum-primed endotoxemic mice by centrally administered cannabinoid ligands.

Journal: European journal of pharmacology 20010803

Title: Hemodynamic effects of cannabinoids: coronary and cerebral vasodilation mediated by cannabinoid CB(1) receptors.

Journal: European journal of pharmacology 20010706

Title: Activation of type II cannabinoid receptors improves myocardial tolerance to arrhythmogenic effects of coronary occlusion and reperfusion.

Journal: Bulletin of experimental biology and medicine 20010601

Title: Long term cerebroprotective effects of dexanabinol in a model of focal cerebral ischemia.

Journal: Brain research 20010518

Title: The role of central and peripheral Cannabinoid1 receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain.

Journal: Pain 20010501

Title: Cannabinoid inhibition of capsaicin-sensitive sensory neurotransmission in the rat mesenteric arterial bed.

Journal: European journal of pharmacology 20010420

Title: Cannabinoid inhibition of the capsaicin-induced calcium response in rat dorsal root ganglion neurones.

Journal: British journal of pharmacology 20010301

Title: Cannabinoidergic and opioidergic inhibition of spinal reflexes in the decerebrated, spinalized rabbit.

Journal: Neuropharmacology 20010301

Title: Behavioral suppression induced by cannabinoids is due to activation of the arachidonic acid cascade in rats.

Journal: Brain research 20010119

Title: CB1 cannabinoid receptor inhibits synaptic release of glutamate in rat dorsolateral striatum.

Journal: Journal of neurophysiology 20010101

Title: Cannabinoid-induced motor incoordination through the cerebellar CB(1) receptor in mice.

Journal: Pharmacology, biochemistry, and behavior 20010101

Title: Hu 210: a potent tool for investigations of the cannabinoid system.

Journal: CNS drug reviews 20010101

Title: [Antiarrhythmic properties of a cannabinoid (CB) receptor agonist].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20010101

Title: Involvement of central and peripheral cannabinoid receptors in the regulation of heart resistance to arrhythmogenic effects of epinephrine.

Journal: Bulletin of experimental biology and medicine 20001101

Title: CB1 cannabinoid receptor-mediated cell migration.

Journal: The Journal of pharmacology and experimental therapeutics 20000701

Title: Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation.

Journal: Nature medicine 20000301

Title: Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19991123

Title: Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19990511

Title: Protection against septic shock and suppression of tumor necrosis factor alpha and nitric oxide production by dexanabinol (HU-211), a nonpsychotropic cannabinoid.

Journal: The Journal of pharmacology and experimental therapeutics 19971101

Title: Cannabinoid-induced hypotension and bradycardia in rats mediated by CB1-like cannabinoid receptors.

Journal: The Journal of pharmacology and experimental therapeutics 19970601

Title: Cardiovascular effects of (-)-11-OH-delta 8-tetrahydrocannabinol-dimethylheptyl in rats.

Journal: Journal of cardiovascular pharmacology 19960801

Title: A novel probe for the cannabinoid receptor.

Journal: Journal of medicinal chemistry 19920529

Title: He X, et al. Antidepressant effects of curcumin and HU-211 coencapsulated solid lipid nanoparticles against corticosterone-induced cellular and animal models of major depression. Int J Nanomedicine. 2016 Oct 3;11:4975-4990.

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Tags:112924-45-5 Molecular Formula|112924-45-5 MDL|112924-45-5 SMILES|112924-45-5 1,1-Dimethylheptyl-11-hydroxytetrahydrocannabinol