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113-07-5,MFCD09954698
Catalog No.:AA0081J8

113-07-5 | Doxapram hydrochloride

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5mg
98% by HPLC
in stock  
$148.00   $104.00
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10mg
98% by HPLC
in stock  
$206.00   $144.00
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25mg
98% by HPLC
in stock  
$364.00   $255.00
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50mg
98% by HPLC
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$575.00   $403.00
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100mg
98% by HPLC
in stock  
$949.00   $664.00
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500mg
98% by HPLC
in stock  
$2,920.00   $2,044.00
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1000mg
98% by HPLC
in stock  
$4,634.00   $3,244.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0081J8
Chemical Name:
Doxapram hydrochloride
CAS Number:
113-07-5
Molecular Formula:
C24H31ClN2O2
Molecular Weight:
414.9681
MDL Number:
MFCD09954698
SMILES:
CCN1CC(C(C1=O)(c1ccccc1)c1ccccc1)CCN1CCOCC1.Cl
NSC Number:
170958
Properties
Computed Properties
 
Complexity:
487  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  
Undefined Atom Stereocenter Count:
1  

Downstream Synthesis Route

[1]CurrentPatentAssignee:GALLEONPHARMACEUTICALS-US2013/109689,2013,A1Locationinpatent:Paragraph0084

Literature

Title: Effects of obesity on lung function and airway reactivity in healthy dogs.

Journal: Veterinary journal (London, England : 1997) 20120701

Title: Towards evidence based emergency medicine:PRIVATE best BETs from the Manchester Royal Infirmary. Bet 2: doxapram resurrected? Weak evidence of efficacy suggests a potential use in patients ineligible for non-invasive ventilation.

Journal: Emergency medicine journal : EMJ 20120101

Title: Advantages of doxapram for post-anaesthesia recovery and outcomes in bariatric surgery patients with obstructive sleep apnoea.

Journal: European journal of anaesthesiology 20110501

Title: Emergence agitation in adults: risk factors in 2,000 patients.

Journal: Canadian journal of anaesthesia = Journal canadien d'anesthesie 20100901

Title: Chronic hypoxia increases the gain of the hypoxic ventilatory response by a mechanism in the central nervous system.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20100801

Title: Glial cells are involved in the exciting effects of doxapram on brainstem slices in vitro.

Journal: Cellular and molecular neurobiology 20100701

Title: Effects of serotonin agonists and doxapram on respiratory depression and hypoxemia in etorphine-immobilized impala (Aepyceros melampus).

Journal: Journal of wildlife diseases 20100401

Title: Respiratory and cardiovascular effects of doxapram and theophylline for the treatment of asphyxia in neonatal calves.

Journal: Theriogenology 20100315

Title: [Effect of doxapram on the respiratory rhythmical discharge activity in the brainstem slice of neonatal rats].

Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20100201

Title: Respiratory inductive plethysmography as a method for measuring ventilatory parameters in conscious, non-restrained dogs.

Journal: Journal of pharmacological and toxicological methods 20100101

Title: Evaluation of respiratory function in freely moving Beagle dogs using implanted impedance technology.

Journal: Journal of pharmacological and toxicological methods 20100101

Title: Doxapram revisited in patients with cancer.

Journal: Journal of palliative medicine 20090801

Title: Comparative study on effectiveness of doxapram and pethidine for postanaesthetic shivering.

Journal: JNMA; journal of the Nepal Medical Association 20090101

Title: Acid-sensitive channel inhibition prevents fetal alcohol spectrum disorders cerebellar Purkinje cell loss.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20080801

Title: Managing acute on chronic respiratory failure: a guide to non-invasive ventilation.

Journal: British journal of hospital medicine (London, England : 2005) 20080801

Title: Difficult extubation in low birthweight infants.

Journal: Archives of disease in childhood. Fetal and neonatal edition 20080501

Title: Respiratory irregularity and stress hormones in panic disorder: exploring potential linkages.

Journal: Depression and anxiety 20080101

Title: Retrospective comparison of caffeine and doxapram for the treatment of hypercapnia in foals with hypoxic-ischemic encephalopathy.

Journal: Journal of veterinary internal medicine 20080101

Title: [Recommended treatment of apnea in premature infants. A review based on literature and own experience].

Journal: Medycyna wieku rozwojowego 20080101

Title: Comparison of the effects of caffeine and doxapram on respiratory and cardiovascular function in foals with induced respiratory acidosis.

Journal: American journal of veterinary research 20071201

Title: The effect of doxapram on brain imaging in patients with panic disorder.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20071001

Title: HPA axis activity in patients with panic disorder: review and synthesis of four studies.

Journal: Depression and anxiety 20070101

Title: Dynamic QT/RR relationship of cardiac conduction in premature infants treated with low-dose doxapram hydrochloride.

Journal: Journal of perinatal medicine 20070101

Title: Doxapram and aminophylline on bispectral index under sevoflurane anaesthesia: a comparative study.

Journal: European journal of anaesthesiology 20061101

Title: [Analysis of 37 drugs in whole blood by HPLC after solid phase extraction].

Journal: Fa yi xue za zhi 20061015

Title: [Determination of methamphetamine in whole blood by capillary zone electrophoresis after solid phase extraction].

Journal: Fa yi xue za zhi 20061015

Title: [Clinical observation of target-controlled remifentanil infusion combined with propofol and doxapram in painless artificial abortion].

Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20060801

Title: Doxapram shortens recovery following sevoflurane anesthesia.

Journal: Canadian journal of anaesthesia = Journal canadien d'anesthesie 20060501

Title: The ventilatory stimulant doxapram inhibits TASK tandem pore (K2P) potassium channel function but does not affect minimum alveolar anesthetic concentration.

Journal: Anesthesia and analgesia 20060301

Title: Brain hemodynamic effects of doxapram in preterm infants.

Journal: Biology of the neonate 20060101

Title: A new look at the respiratory stimulant doxapram.

Journal: CNS drug reviews 20060101

Title: Ovalbumin sensitization alters the ventilatory responses to chemical challenges in guinea pigs.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20051101

Title: Doxapram only slightly reduces the shivering threshold in healthy volunteers.

Journal: Anesthesia and analgesia 20051101

Title: Doxapram increases corticotropin-releasing factor immunoreactivity and mRNA expression in the rat central nucleus of the amygdala.

Journal: Peptides 20051101

Title: Doxapram and developmental delay at 12 months in children born extremely preterm.

Journal: Acta paediatrica (Oslo, Norway : 1992) 20051101

Title: Prediction of panic response to a respiratory stimulant by reduced orbitofrontal cerebral blood flow in panic disorder.

Journal: The American journal of psychiatry 20050701

Title: Doxapram stimulates the carotid body via a different mechanism than hypoxic chemotransduction.

Journal: Respiratory physiology & neurobiology 20050512

Title: Doxapram inhibits carotid sinus baroreceptors in rabbits.

Journal: Autonomic & autacoid pharmacology 20050401

Title: Doxapram-induced panic attacks and cortisol elevation.

Journal: Psychiatry research 20050227

Title: [Determinants of doxapram utilization: a survey of practice in the French Neonatal and Intensive Care Units].

Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20050201

Title: Olfactory stimulation prevents apnea in premature newborns.

Journal: Pediatrics 20050101

Title: High dose caffeine citrate for extubation of preterm infants: a randomised controlled trial.

Journal: Archives of disease in childhood. Fetal and neonatal edition 20041101

Title: Doxapram treatment for apnea in preterm infants.

Journal: The Cochrane database of systematic reviews 20041018

Title: Effects of doxapram HCl on laryngeal function of normal dogs and dogs with naturally occurring laryngeal paralysis.

Journal: Veterinary anaesthesia and analgesia 20041001

Title: Effect of doxapram on cerebral blood flow velocity in preterm infants.

Journal: Neuropediatrics 20040401

Title: Doxapram produces a dose-dependent reduction in the shivering threshold in rabbits.

Journal: Anesthesia and analgesia 20030901

Title: Rodent doxapram model of panic: behavioral effects and c-Fos immunoreactivity in the amygdala.

Journal: Biological psychiatry 20030515

Title: Visual compatibility of doxapram hydrochloride with drugs commonly administered via a Y-site in the intensive care nursery.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20030115

Title: Doxapram for ventilatory failure due to exacerbations of chronic obstructive pulmonary disease.

Journal: The Cochrane database of systematic reviews 20030101

Title: Treatment of apnea of prematurity.

Journal: Paediatric drugs 20030101

Title: Periextubation caffeine in preterm neonates: a randomized dose response trial.

Journal: Journal of paediatrics and child health 20030101

Title: Doxapram stimulates carotid body with different mechanisms from hypoxic chemotransduction.

Journal: Advances in experimental medicine and biology 20030101

Title: Management of an acute exacerbation of copd: are we ignoring the evidence?

Journal: Thorax 20021001

Title: Doxapram and neurodevelopmental outcome.

Journal: The Journal of pediatrics 20020801

Title: Doxapram and perception of dyspnea.

Journal: Chest 20020401

Title: The effects of doxapram hydrochloride (dopram-V) on laryngeal function in healthy dogs.

Journal: Journal of veterinary internal medicine 20020101

Title: Isolated mental developmental delay in very low birth weight infants: association with prolonged doxapram therapy for apnea.

Journal: The Journal of pediatrics 20011201

Title: QT interval lengthening in premature infants treated with doxapram.

Journal: Clinical pharmacology and therapeutics 20011201

Title: Ultrasound measurements of fetal breathing movements in the rat.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20010701

Title: Yet more ampoule spikes.

Journal: Anaesthesia 20010601

Title: Low-dose doxapram therapy for idiopathic apnea of prematurity.

Journal: Pediatrics international : official journal of the Japan Pediatric Society 20010401

Title: Persistent respiratory irregularity in patients with panic disorder.

Journal: Biological psychiatry 20010401

Title: Doxapram treatment for apnea in preterm infants.

Journal: The Cochrane database of systematic reviews 20010101

Title: Second-degree atrioventricular heart block after doxapram administration.

Journal: The Journal of pediatrics 19980701

Title: Adverse events with continuous doxapram infusion against late postoperative hypoxaemia.

Journal: European journal of clinical pharmacology 19960101

Title: Double-blind comparison between doxapram and pethidine in the treatment of postanaesthetic shivering.

Journal: British journal of anaesthesia 19931101

Title: Panic attacks induced by doxapram.

Journal: Biological psychiatry 19930215

Title: Patient-controlled analgesia with a mixture of pethidine and doxapram hydrochloride. A comparison of the incidence of respiratory dysrhythmias with pethidine alone.

Journal: Anaesthesia 19880301

Title: Side effects of doxapram infusion.

Journal: European journal of intensive care medicine 19760901

Title: Electroencephalographic effect of doxapram hydrochloride in humans.

Journal: Acta anaesthesiologica Scandinavica. Supplementum 19660101

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