Title: Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor.
Journal: Journal of medicinal chemistry 20100923
Title: Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part II. Identification of the 1,3,8-triazaspiro[4,5]decan-4-one privileged structure that engenders PLD2 selectivity.
Journal: Bioorganic & medicinal chemistry letters 20090415
Title: Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness.
Journal: Nature chemical biology 20090201
