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1132935-63-7,MFCD27923655
Catalog No.:AA008TAG

1132935-63-7 | N-(6-(3-(tert-Butyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)-2-methoxyphenyl)naphthalen-2-yl)methanesulfonamide

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$8.00   $5.00
- +
25mg
98%
in stock  
$69.00   $48.00
- +
100mg
95%
in stock  
$156.00   $109.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA008TAG
Chemical Name:
N-(6-(3-(tert-Butyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)-2-methoxyphenyl)naphthalen-2-yl)methanesulfonamide
CAS Number:
1132935-63-7
Molecular Formula:
C26H27N3O5S
Molecular Weight:
493.5747
MDL Number:
MFCD27923655
SMILES:
COc1c(cc(cc1C(C)(C)C)n1ccc(=O)[nH]c1=O)c1ccc2c(c1)ccc(c2)NS(=O)(=O)C
Properties
Computed Properties
 
Complexity:
938  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
6  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
4.3  

Literature

Title: Resistance Mechanisms in Hepatitis C Virus: implications for Direct-Acting Antiviral Use.

Journal: Drugs 20170701

Title: Metabolism and Disposition of Hepatitis C Polymerase Inhibitor Dasabuvir in Humans.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20160801

Title: Dasabuvir (ABT333) for the treatment of chronic HCV genotype I: a new face of cure, an expert review.

Journal: Expert review of anti-infective therapy 20160101

Title: New direct-acting antivirals in hepatitis C therapy: a review of sofosbuvir, ledipasvir, daclatasvir, simeprevir, paritaprevir, ombitasvir and dasabuvir.

Journal: Expert review of clinical pharmacology 20160101

Title: Interferon-free therapy for hepatitis C: The hurdles amid a golden era.

Journal: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20150901

Title: Ombitasvir/paritaprevir/ritonavir and dasabuvir tablets for hepatitis C virus genotype 1 infection.

Journal: The Annals of pharmacotherapy 20150501

Title: Dasabuvir : a new direct antiviral agent for the treatment of hepatitis C.

Journal: Expert opinion on pharmacotherapy 20150301

Title: An update on the management of chronic hepatitis C: 2015 Consensus guidelines from the Canadian Association for the Study of the Liver.

Journal: Canadian journal of gastroenterology & hepatology 20150101

Title: Discovery of ABT-267, a pan-genotypic inhibitor of HCV NS5A.

Journal: Journal of medicinal chemistry 20140313

Title: Dasabuvir: A Non-Nucleoside Inhibitor of NS5B for the Treatment of Hepatitis C Virus Infection.

Journal: Reviews on recent clinical trials 20140101

Title: Kati W, et al. In vitro activity and resistance profile of dasabuvir, a nonnucleoside hepatitis C virus polymerase inhibitor. Antimicrob Agents Chemother. 2015 Mar;59(3):1505-11.

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SDS
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Tags:1132935-63-7 Molecular Formula|1132935-63-7 MDL|1132935-63-7 SMILES|1132935-63-7 N-(6-(3-(tert-Butyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)-2-methoxyphenyl)naphthalen-2-yl)methanesulfonamide
Catalog No.: AA008TAG
1132935-63-7,MFCD27923655
1132935-63-7 | N-(6-(3-(tert-Butyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)-2-methoxyphenyl)naphthalen-2-yl)methanesulfonamide
Pack Size： 1mg
Purity： 98%
in stock
$8.00 $5.00
Pack Size： 25mg
Purity： 98%
in stock
$69.00 $48.00
Pack Size： 100mg
Purity： 95%
in stock
$156.00 $109.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA008TAG
Chemical Name: N-(6-(3-(tert-Butyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)-2-methoxyphenyl)naphthalen-2-yl)methanesulfonamide
CAS Number: 1132935-63-7
Molecular Formula: C26H27N3O5S
Molecular Weight: 493.5747
MDL Number: MFCD27923655
SMILES: COc1c(cc(cc1C(C)(C)C)n1ccc(=O)[nH]c1=O)c1ccc2c(c1)ccc(c2)NS(=O)(=O)C
Properties
Complexity: 938  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 35  
Hydrogen Bond Acceptor Count: 6  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 6  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 4.3  
Literature fold

Title: Resistance Mechanisms in Hepatitis C Virus: implications for Direct-Acting Antiviral Use.

Journal: Drugs20170701

Title: Metabolism and Disposition of Hepatitis C Polymerase Inhibitor Dasabuvir in Humans.

Journal: Drug metabolism and disposition: the biological fate of chemicals20160801

Title: Dasabuvir (ABT333) for the treatment of chronic HCV genotype I: a new face of cure, an expert review.

Journal: Expert review of anti-infective therapy20160101

Title: New direct-acting antivirals in hepatitis C therapy: a review of sofosbuvir, ledipasvir, daclatasvir, simeprevir, paritaprevir, ombitasvir and dasabuvir.

Journal: Expert review of clinical pharmacology20160101

Title: Interferon-free therapy for hepatitis C: The hurdles amid a golden era.

Journal: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver20150901

Title: Ombitasvir/paritaprevir/ritonavir and dasabuvir tablets for hepatitis C virus genotype 1 infection.

Journal: The Annals of pharmacotherapy20150501

Title: Dasabuvir : a new direct antiviral agent for the treatment of hepatitis C.

Journal: Expert opinion on pharmacotherapy20150301

Title: An update on the management of chronic hepatitis C: 2015 Consensus guidelines from the Canadian Association for the Study of the Liver.

Journal: Canadian journal of gastroenterology & hepatology20150101

Title: Discovery of ABT-267, a pan-genotypic inhibitor of HCV NS5A.

Journal: Journal of medicinal chemistry20140313

Title: Dasabuvir: A Non-Nucleoside Inhibitor of NS5B for the Treatment of Hepatitis C Virus Infection.

Journal: Reviews on recent clinical trials20140101

Title: Kati W, et al. In vitro activity and resistance profile of dasabuvir, a nonnucleoside hepatitis C virus polymerase inhibitor. Antimicrob Agents Chemother. 2015 Mar;59(3):1505-11.

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