Home Other Building Blocks 1134822-09-5
1134822-09-5,MFCD26960946
Catalog No.:AA008TEA

1134822-09-5 | Ivacaftor benzenesulfonate

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Purity
Availability
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5mg
in stock  
$172.00   $120.00
- +
25mg
in stock  
$429.00   $300.00
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100mg
in stock  
$1,022.00   $715.00
- +
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA008TEA
Chemical Name:
Ivacaftor benzenesulfonate
CAS Number:
1134822-09-5
Molecular Formula:
C30H34N2O6S
Molecular Weight:
550.6658
MDL Number:
MFCD26960946
SMILES:
OS(=O)(=O)c1ccccc1.O=C(c1c[nH]c2c(c1=O)cccc2)Nc1cc(O)c(cc1C(C)(C)C)C(C)(C)C
Properties

Literature

Title: Delaunay JL, et al. Functional defect of variants in the adenosine triphosphate-binding sites of ABCB4 and their rescue by the cystic fibrosis transmembrane conductance regulator potentiator, ivacaftor (VX-770). Hepatology. 2017 Feb;65(2):560-570

Title: Mutyam V, et al. Therapeutic benefit observed with the CFTR potentiator, ivacaftor, in a CF patient homozygous for the W1282X CFTR nonsense mutation. J Cyst Fibros. 2017 Jan;16(1):24-29

Title: Hadida S, et al. Discovery of N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (VX-770, ivacaftor), a potent and orally bioavailable CFTR potentiator. J Med Chem. 2014 Dec 11;57(23):9776-9

Title: Van Goor F, et al. Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18825-30.

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