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113712-98-4,MFCD00929085
Catalog No.:AA0081G3

113712-98-4 | Tenatoprazole

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Purity
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5mg
≥98%
in stock  
$36.00   $25.00
- +
10mg
≥98%
in stock  
$65.00   $45.00
- +
25mg
≥98%
in stock  
$110.00   $77.00
- +
50mg
≥98%
in stock  
$168.00   $117.00
- +
250mg
98% (HPLC)
in stock  
$738.00   $517.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0081G3
Chemical Name:
Tenatoprazole
CAS Number:
113712-98-4
Molecular Formula:
C16H18N4O3S
Molecular Weight:
346.4041
MDL Number:
MFCD00929085
SMILES:
COc1ccc2c(n1)nc([nH]2)S(=O)Cc1ncc(c(c1C)OC)C
Properties
Computed Properties
 
Complexity:
455  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
Undefined Atom Stereocenter Count:
1  
XLogP3:
1.8  

Downstream Synthesis Route

[1]CurrentPatentAssignee:ALEVIUMPHARMACEUTICALS-WO2008/36201,2008,A1Locationinpatent:Page/Pagecolumn43

5-methoxy-2-(4-nitro-3,5-dimethyl-2-pyridinyl)methylsulfinylimidazo4,5-bpyridine 
  124-41-4    113712-98-4 

[1]Dai,Liyan;Fan,Dongbo;Wang,Xiaozhong;Chen,Yingqi[SyntheticCommunications,2008,vol.38,#4,p.576-582]

[1]Locationinpatent:experimentalpartSripathi,Somaiah;Bojja,RamachandraReddy;Karnati,VenugopalReddy;PrasadaRaju;Khunt,MayurD.[OrganicProcessResearchandDevelopment,2009,vol.13,#4,p.804-806]

[2]Dai,Liyan;Fan,Dongbo;Wang,Xiaozhong;Chen,Yingqi[SyntheticCommunications,2008,vol.38,#4,p.576-582]

[3]Reddy,GantaMadhusudhan;PrasadaRaju;Babu,J.Moses;Praveen;Khunt,Mayur;Mukkanti;PratapReddy,Padi[SyntheticCommunications,2008,vol.38,#11,p.1725-1736]

[4]CurrentPatentAssignee:COUNCILOFSCIENTIFICANDINDUSTRIALRESEARCH(IN)-WO2012/4802,2012,A1Locationinpatent:Page/Pagecolumn11

[5]CurrentPatentAssignee:COUNCILOFSCIENTIFICANDINDUSTRIALRESEARCH(IN)-US2012/203003,2012,A1Locationinpatent:Page/Pagecolumn4

[6]Kulkarni;Nivangune;Joshi;Joshi[OrganicProcessResearchandDevelopment,2013,vol.17,#10,p.1293-1299]

113712-98-4   
(-)5-methoxy-2-(4-methoxy-3,5-dimethyl-2-pyridyl)methylsulfinyl-1H-imidazo4,5-bpyridine 

[1]CurrentPatentAssignee:MITSUBISHICHEMICALHOLDINGSCORPORATION-WO2004/74285,2004,A1Locationinpatent:Page10

[2]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-EP1607088,2005,A1Locationinpatent:Page/Pagecolumn85-86

635751-00-7    113712-98-4   
ethyl2-5-methoxy-2-(4-methoxy-3,5-dimethyl-2-pyridyl)methylsulfinyl-3H-imidazo4,5-bpyridin-3-ylcarbonyl(methyl)aminoethylcarbonate 

[1]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-EP1607088,2005,A1Locationinpatent:Page/Pagecolumn74-75

[2]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-US2016/128945,2016,A1Locationinpatent:Paragraph0672;0673;0674

Literature

Title: Reflux revisited: advancing the role of pepsin.

Journal: International journal of otolaryngology 20120101

Title: Proton pump inhibitors inhibit metformin uptake by organic cation transporters (OCTs).

Journal: PloS one 20110101

Title: Novel approaches to inhibition of gastric acid secretion.

Journal: Current gastroenterology reports 20101201

Title: The pharmacodynamics and pharmacokinetics of S-tenatoprazole-Na 30 mg, 60 mg and 90 mg vs. esomeprazole 40 mg in healthy male subjects.

Journal: Alimentary pharmacology & therapeutics 20100301

Title: LC-UV and LC-MS evaluation of stress degradation behaviour of tenatoprazole.

Journal: Journal of pharmaceutical and biomedical analysis 20091205

Title: Determination of tenatoprazole enantiomers and their enantioselective pharmacokinetics in rats.

Journal: Chirality 20090601

Title: Application of a stability-indicating thin-layer chromatographic method to the determination of tenatoprazole in pharmaceutical dosage forms.

Journal: Journal of AOAC International 20090101

Title: Is the required therapeutic effect always achieved by racemic switch of proton-pump inhibitors?

Journal: World journal of gastroenterology 20080428

Title: Proton pump inhibitors: do differences in pharmacokinetics translate into differences in clinical outcomes?

Journal: Clinical pharmacokinetics 20080101

Title: Quantification of tenatoprazole in rat plasma by HPLC: validation and its application to pharmacokinetic studies.

Journal: Biomedical chromatography : BMC 20071201

Title: [Chiral separation of tenatoprazole enantiomers using high performance liquid chromatography on vacomycin-bonded chiral stationary phase].

Journal: Se pu = Chinese journal of chromatography 20070901

Title: A review of rabeprazole in the treatment of acid-related diseases.

Journal: Therapeutics and clinical risk management 20070601

Title: HPLC determination and pharmacokinetic study of tenatoprazole in dog plasma after oral administration of enteric-coated capsule.

Journal: Biomedical chromatography : BMC 20070101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20061001

Title: Review article: the clinical pharmacology of proton pump inhibitors.

Journal: Alimentary pharmacology & therapeutics 20060601

Title: Review article: the opportunities and benefits of extended acid suppression.

Journal: Alimentary pharmacology & therapeutics 20060601

Title: Comparison of the effects of fasting morning, fasting evening and fed bedtime administration of tenatoprazole on intragastric pH in healthy volunteers: a randomized three-way crossover study.

Journal: Alimentary pharmacology & therapeutics 20060415

Title: Characterization of the inhibitory activity of tenatoprazole on the gastric H+,K+ -ATPase in vitro and in vivo.

Journal: Biochemical pharmacology 20060314

Title: Pharmacokinetics of tenatoprazole, a newly synthesized proton pump inhibitor, in healthy male Caucasian volunteers.

Journal: Arzneimittel-Forschung 20060101

Title: Acid suppression therapy: where do we go from here?

Journal: Digestive diseases (Basel, Switzerland) 20060101

Title: Effect on intragastric pH of a PPI with a prolonged plasma half-life: comparison between tenatoprazole and esomeprazole on the duration of acid suppression in healthy male volunteers.

Journal: The American journal of gastroenterology 20050901

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20050501

Title: A comparative study of the early effects of tenatoprazole 40 mg and esomeprazole 40 mg on intragastric pH in healthy volunteers.

Journal: Alimentary pharmacology & therapeutics 20050301

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20050101

Title: Tenatoprazole, a novel proton pump inhibitor with a prolonged plasma half-life: effects on intragastric pH and comparison with esomeprazole in healthy volunteers.

Journal: Alimentary pharmacology & therapeutics 20040315

Title: [Proton pump inhibitors: Tenatoprazole (TU-199)].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20020201

Title: Tenatoprazole. Benatoprazole, TU 199.

Journal: Drugs in R&D 20020101

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