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1146648-86-3,MFCD02178861
Catalog No.:AA01FMFD

1146648-86-3 | 4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexan-1-ol hydrochloride

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250mg
95%+
3 weeks  
$329.00   $230.00
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500mg
95%+
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$372.00   $260.00
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1g
95%+
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$440.00   $308.00
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2.5g
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01FMFD
Chemical Name:
4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexan-1-ol hydrochloride
CAS Number:
1146648-86-3
Molecular Formula:
C13H19Br2ClN2O
Molecular Weight:
414.5638
MDL Number:
MFCD02178861
SMILES:
OC1CCC(CC1)NCc1cc(Br)cc(c1N)Br.Cl
NSC Number:
758224
Properties
Computed Properties
 
Complexity:
259  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
3  

Literature

Title: Effects of ambroxol on Candida albicans growth and biofilm formation.

Journal: Mycoses 20140401

Title: [Study of sustained-matrix tablets Ambroxol hydrochloride and potential impact of different fillers on the matrix tablet's scale-up].

Journal: Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20121018

Title: β-Cyclodextrin enhanced on-line organic solvent field-amplified sample stacking in capillary zone electrophoresis for analysis of ambroxol in human plasma, following liquid-liquid extraction in the 96-well format.

Journal: Journal of pharmaceutical and biomedical analysis 20120701

Title: Effects of antenatal application of ambroxol and glucocorticoid on lung morphometry and signal transduction of bone morphogenetic protein in the fetal rat.

Journal: Molecular medicine reports 20120701

Title: Ambroxol influences voriconazole resistance of Candida parapsilosis biofilm.

Journal: FEMS yeast research 20120601

Title: [Notes on syrups and dry syrups of ambroxol hydrochloride and L-carbocysteine].

Journal: Arerugi = [Allergy] 20120501

Title: Anti-asthmatic agents alleviate pulmonary edema by upregulating AQP1 and AQP5 expression in the lungs of mice with OVA-induced asthma.

Journal: Respiratory physiology & neurobiology 20120415

Title: High-dose ambroxol reduces pulmonary complications in patients with acute cervical spinal cord injury after surgery.

Journal: Neurocritical care 20120401

Title: 9,10-Phenanthrenequinone promotes secretion of pulmonary aldo-keto reductases with surfactant.

Journal: Cell and tissue research 20120201

Title: On-line sample cleanup and enrichment chromatographic technique for the determination of ambroxol in human serum.

Journal: Journal of chromatographic science 20120201

Title: Simple transmission Raman measurements using a single multivariate model for analysis of pharmaceutical samples contained in capsules of different colors.

Journal: Talanta 20120130

Title: In vitro characterization and release study of Ambroxol hydrochloride matrix tablets prepared by direct compression.

Journal: Pharmaceutical development and technology 20120101

Title: The differential effect of intrathecal Nav1.8 blockers on the induction and maintenance of capsaicin- and peripheral ischemia-induced mechanical allodynia and thermal hyperalgesia.

Journal: Anesthesia and analgesia 20120101

Title: Recurrent acute rhinosinusitis: a single blind clinical study of N-acetylcysteine vs ambroxol associated to corticosteroid therapy.

Journal: International journal of immunopathology and pharmacology 20120101

Title: [Soluble guanylate cyclase in the molecular mechanism underlying the therapeutic action of drugs].

Journal: Biomeditsinskaia khimiia 20120101

Title: Factors affecting the bitterness intensities of ten commercial formulations of ambroxol.

Journal: Chemical & pharmaceutical bulletin 20120101

Title: Effects of guaifenesin, N-acetylcysteine, and ambroxol on MUC5AC and mucociliary transport in primary differentiated human tracheal-bronchial cells.

Journal: Respiratory research 20120101

Title: [Optimization of a floating osmotic pump system of ambroxol hydrochloride using central composite design-response surface methodology and its pharmacokinetics in Beagle dogs].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20111201

Title: [Clinical observation of mucoregulatory agents' application after chronic rhinosinusitis surgery].

Journal: Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery 20111001

Title: High performance liquid chromatographic method for the determination of cetirizine and ambroxol in human plasma and urine--a boxcar approach.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110901

Title: Design and evaluation of osmotic pump-based controlled release system of Ambroxol Hydrochloride.

Journal: Pharmaceutical development and technology 20110801

Title: Fast-track pulmonary conditioning before urgent cardiac surgery in patients with insufficiently treated chronic obstructive pulmonary disease.

Journal: The Journal of cardiovascular surgery 20110801

Title: The diabetic foot: an overview of assessment and complications.

Journal: British journal of nursing (Mark Allen Publishing) 20110801

Title: [Effects of ambroxol combined with low-dose heparin on TNF-alpha and IL-1beta in rabbits with acute lung injury].

Journal: Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20110501

Title: Possible involvement of tetrodotoxin-resistant sodium channels in cough reflex.

Journal: European journal of pharmacology 20110210

Title: [A case of pulmonary tumor thrombotic microangiopathy induced by early gastric cancer].

Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20110201

Title: Characterization of the ERAD process of the L444P mutant glucocerebrosidase variant.

Journal: Blood cells, molecules & diseases 20110115

Title: Formulation development of ambroxol hydrochloride soft gel with application of statistical experimental design and response surface methodology.

Journal: PDA journal of pharmaceutical science and technology 20110101

Title: Effect of ambroxol on pneumonia caused by Pseudomonas aeruginosa with biofilm formation in an endotracheal intubation rat model.

Journal: Chemotherapy 20110101

Title: Protective effect of ambroxol against paraquat-induced pulmonary fibrosis in rats.

Journal: Internal medicine (Tokyo, Japan) 20110101

Title: [Antenatal ambroxol administration for prevention of respiratopry distress syndrome in preterm infants: preliminary report].

Journal: Akusherstvo i ginekologiia 20110101

Title: [Treatment of preterm delivery--therapeutic algorithm].

Journal: Akusherstvo i ginekologiia 20110101

Title: Antinociceptive effect of ambroxol in rats with neuropathic spinal cord injury pain.

Journal: Pharmacology, biochemistry, and behavior 20101201

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: [Ambroxol for the prevention of respiratory distress syndrome in preterm infants: a meta analysis].

Journal: Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20101101

Title: [Effect of ambroxol on lung development of rat models with nitrofen-induced congenital diaphragmatic hernia].

Journal: Zhonghua yi xue za zhi 20100914

Title: The protective effects of ambroxol on radiation lung injury and influence on production of transforming growth factor beta1 and tumor necrosis factor alpha.

Journal: Medical oncology (Northwood, London, England) 20100901

Title: Colorimetric and atomic absorption spectrometric determination of mucolytic drug ambroxol through ion-pair formation with iron and thiocyanate.

Journal: Combinatorial chemistry & high throughput screening 20100901

Title: Ambroxol interferes with Pseudomonas aeruginosa quorum sensing.

Journal: International journal of antimicrobial agents 20100901

Title: Removal of an aspirated foreign body with a flexible cryoprobe.

Journal: Respiratory care 20100801

Title: ES936 stimulates DNA synthesis in HeLa cells independently on NAD(P)H:quinone oxidoreductase 1 inhibition, through a mechanism involving p38 MAPK.

Journal: Chemico-biological interactions 20100730

Title: Block of sensory neuronal Na+ channels by the secreolytic ambroxol is associated with an interaction with local anesthetic binding sites.

Journal: European journal of pharmacology 20100325

Title: [Obstruction of the upper respiratory tract by a subglottic expansive lesion--a case of emergency].

Journal: Laryngo- rhino- otologie 20100101

Title: An oral controlled release system for ambroxol hydrochloride containing a wax and a water insoluble polymer.

Journal: Pharmaceutical development and technology 20100101

Title: Stability-indicating HPTLC determination of ambroxol hydrochloride in bulk drug and pharmaceutical dosage form.

Journal: Journal of chromatographic science 20100101

Title: Effects of certain antioxidants on lipid peroxidation process in lung homogenates of L thyroxine-receiving rats.

Journal: Neuro endocrinology letters 20100101

Title: [Clinical research on high-dosage ambroxol hydrochloride associated with ulinastatin in improvement of lung tissue injury of patients with paraquat poisoning].

Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20100101

Title: [Effect of mucolytic therapy on the production of reactive oxygen species in the blood of patients with an exacerbation of chronic obstructive pulmonary disease].

Journal: Terapevticheskii arkhiv 20100101

Title: Clinical efficacy of farcosolvin syrup (ambroxol-theophylline-guaiphenesin mixture) in the treatment of acute exacerbation of chronic bronchitis.

Journal: International journal of chronic obstructive pulmonary disease 20100101

Title: [Efficacy of different dosages of ambroxol hydrochloride in the prevention of neonatal respiratory distress syndrome].

Journal: Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20090901

Title: Transepithelial transport of ambroxol hydrochloride across human intestinal Caco-2 cell monolayers.

Journal: General physiology and biophysics 20090901

Title: Identification and characterization of ambroxol as an enzyme enhancement agent for Gaucher disease.

Journal: The Journal of biological chemistry 20090828

Title: Unclear loss of consciousness after clobutinol intake.

Journal: Forensic science international 20090810

Title: [Effects of ambroxol on renal function in children undergoing cardiopulmonary bypass].

Journal: Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20090801

Title: Pulmonary selectivity and local pharmacokinetics of ambroxol hydrochloride dry powder inhalation in rat.

Journal: Journal of pharmaceutical sciences 20090501

Title: Ambroxol lozenges: new drug. Sore throat: better to just suck on hard candy.

Journal: Prescrire international 20090401

Title: Action of N-acylated ambroxol derivatives on secretion of chloride ions in human airway epithelia.

Journal: Biochemical and biophysical research communications 20090313

Title: Short-term perioperative treatment with ambroxol reduces pulmonary complications and hospital costs after pulmonary lobectomy: a randomized trial.

Journal: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20090301

Title: Unexpected infant deaths associated with use of cough and cold medications.

Journal: Pediatrics 20090201

Title: Photosensitivity with eosinophilia due to ambroxol and UVB.

Journal: Contact dermatitis 20090201

Title: [The cleaning system of the airways: physiology, pathophysiology and effects of ambroxol].

Journal: Medizinische Monatsschrift fur Pharmazeuten 20090201

Title: Nebulized and oral thiol derivatives for pulmonary disease in cystic fibrosis.

Journal: The Cochrane database of systematic reviews 20090121

Title: Stability study of ambroxol hydrochloride sustained release pellets coated with acrylic polymer.

Journal: Pakistan journal of pharmaceutical sciences 20090101

Title: Ambroxol-induced systemic contact dermatitis confirmed by positive patch test.

Journal: Allergologia et immunopathologia 20090101

Title: Differential modulation of IgE-dependent activation of human basophils by ambroxol and related secretolytic analogues.

Journal: International journal of immunopathology and pharmacology 20090101

Title: Development and validation of a reversed-phase HPLC method for simultaneous estimation of ambroxol hydrochloride and azithromycin in tablet dosage form.

Journal: Journal of pharmaceutical and biomedical analysis 20081215

Title: Antiinflammatory properties of ambroxol.

Journal: European journal of medical research 20081203

Title: Protective effect of ambroxol on pulmonary function after cardiopulmonary bypass.

Journal: Journal of cardiovascular pharmacology 20081201

Title: Simultaneous determination of amoxicillin and ambroxol in human plasma by LC-MS/MS: validation and application to pharmacokinetic study.

Journal: Journal of pharmaceutical and biomedical analysis 20081104

Title: Rapid and sensitive liquid chromatography tandem mass spectrometry method for the quantification of ambroxol in human plasma.

Journal: Biomedical chromatography : BMC 20081001

Title: Influence of formulation and preparation process on ambroxol hydrochloride dry powder inhalation characteristics and aerosolization properties.

Journal: Drug development and industrial pharmacy 20080901

Title: HPLC and chemometrics-assisted UV-spectroscopy methods for the simultaneous determination of ambroxol and doxycycline in capsule.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20080801

Title: [A study of the mechanism of Qingre Huatan therapy in treatment of acute exacerbation of chronic obstructive pulmonary disease by improving airway inflammation and mucus hypersecretion].

Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20080801

Title: Ambroxol in the 21st century: pharmacological and clinical update.

Journal: Expert opinion on drug metabolism & toxicology 20080801

Title: Effects of ambroxol on alginate of mature Pseudomonas aeruginosa biofilms.

Journal: Current microbiology 20080701

Title: Flow injection analysis using carbon film resistor electrodes for amperometric determination of ambroxol.

Journal: Talanta 20080630

Title: Simultaneous determination of gatifloxacin and ambroxol hydrochloride from tablet dosage form using reversed-phase high performance liquid chromatography.

Journal: Se pu = Chinese journal of chromatography 20080501

Title: Upregulation of AQP3 and AQP5 induced by dexamethasone and ambroxol in A549 cells.

Journal: Respiratory physiology & neurobiology 20080430

Title: Simultaneous determination of multi drug components Theophylline, Etofylline, Guaiphenesine and Ambroxol Hydrochloride by validated RP-HPLC method in liquid dosage form.

Journal: Pakistan journal of pharmaceutical sciences 20080401

Title: Development of the ambroxol gels for enhanced transdermal delivery.

Journal: Drug development and industrial pharmacy 20080301

Title: Ambroxol: a CNS drug?

Journal: CNS neuroscience & therapeutics 20080101

Title: [The history of antitussive and expectorants].

Journal: Pharmazie in unserer Zeit 20080101

Title: Efficacy and safety of ambroxol lozenges in the treatment of acute uncomplicated sore throat. EBM-based clinical documentation.

Journal: Arzneimittel-Forschung 20080101

Title: The potential role of natural agents in treatment of airway inflammation.

Journal: Therapeutic advances in respiratory disease 20071201

Title: [Effects of high dose ambroxol on lung injury induced by paraquat in rats].

Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20070901

Title: [Effect of large volume lavage of ambroxol hydrochloride on patients with pneumoconiosis combined with chronic bronchitis].

Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20070901

Title: Direct, non-destructive quantitative measurement of an active pharmaceutical ingredient in an intact capsule formulation using Raman spectroscopy.

Journal: Analytica chimica acta 20070829

Title: Simultaneous determination and pharmacokinetic study of roxithromycin and ambroxol hydrochloride in human plasma by LC-MS/MS.

Journal: Clinica chimica acta; international journal of clinical chemistry 20070701

Title: Spectrophotometric estimation of ambroxol and cetirizine hydrochloride from tablet dosage form.

Journal: Pakistan journal of pharmaceutical sciences 20070701

Title: Determination of ambroxol in human plasma by high performance liquid chromatography-electrospray ionization mass spectrometry (HPLC-MS/ESI).

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070615

Title: Acebrophylline: an airway mucoregulator and anti-inflammatory agent.

Journal: Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace 20070601

Title: Action of neltenexine on anion secretion in human airway epithelia.

Journal: Biochemical and biophysical research communications 20070518

Title: Solid-state chemistry of ambroxol theophylline-7-acetate.

Journal: Journal of pharmaceutical sciences 20070501

Title: Parenteral ambroxol treatment causes xanthine and calcium oxalate stones in rats.

Journal: International journal of urology : official journal of the Japanese Urological Association 20070501

Title: In situ gelling pectin formulations for oral drug delivery at high gastric pH.

Journal: International journal of pharmaceutics 20070420

Title: [Determination of ambroxol and clenbuterol in human plasma by LC-MS/MS method].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20070301

Title: Proteases essential for human influenza virus entry into cells and their inhibitors as potential therapeutic agents.

Journal: Current pharmaceutical design 20070101

Title: Uric acid plasma level and urine pH in rats treated with ambroxol.

Journal: Acta poloniae pharmaceutica 20070101

Title: [Ambroxol-induced immune hemolytic anemia].

Journal: La Revue de medecine interne 20061001

Title: Safety and usage pattern of an over-the-counter ambroxol cough syrup: a community pharmacy-based cohort study.

Journal: International journal of clinical pharmacology and therapeutics 20060901

Title: [Efficacy of intravenous or atomizing ambroxol for prevention of respiratory distress syndrome in preterm infants].

Journal: Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20060801

Title: [Atomization inhalation of ambroxol as an auxiliary therapy for severe pneumonia in neonates].

Journal: Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20060601

Title: Ambroxol for the prevention of acute upper respiratory disease.

Journal: Clinical and experimental medicine 20060601

Title: [Influence of ambroxol on paraquat-induced lung tissue injury and change of pulmonary surfactant-associated protein A in the experimental rats].

Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20060601

Title: Ambroxol-induced modification of ion transport in human airway Calu-3 epithelia.

Journal: Biochemical and biophysical research communications 20060505

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: The influence of variation of gastric pH on the gelation and release characteristics of in situ gelling pectin formulations.

Journal: International journal of pharmaceutics 20060407

Title: Comparison of the effects of four Na+ channel analgesics on TTX-resistant Na+ currents in rat sensory neurons and recombinant Nav1.2 channels.

Journal: Neuroscience letters 20060313

Title: Determination of ambroxol hydrochloride, methylparaben and benzoic acid in pharmaceutical preparations based on sequential injection technique coupled with monolithic column.

Journal: Journal of pharmaceutical and biomedical analysis 20060213

Title: [Ambroxol-induced toxicoderma].

Journal: Annales de dermatologie et de venereologie 20060201

Title: [Ambroxol].

Journal: Tuberkuloz ve toraks 20060101

Title: Ambroxol, a Nav1.8-preferring Na(+) channel blocker, effectively suppresses pain symptoms in animal models of chronic, neuropathic and inflammatory pain.

Journal: Neuropharmacology 20051201

Title: [Treatment of sore throat pain with ambroxol-containing lozenges. Results of a pharmacy supported patient questionnaire].

Journal: Medizinische Monatsschrift fur Pharmazeuten 20051101

Title: Determination of roxithromycin in rat lung tissue by liquid chromatography-mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis 20050915

Title: Nondestructive determination of the ambroxol content in tablets by Raman spectroscopy.

Journal: Journal of pharmaceutical and biomedical analysis 20050615

Title: The effect of taste masking agents on in situ gelling pectin formulations for oral sustained delivery of paracetamol and ambroxol.

Journal: International journal of pharmaceutics 20050613

Title: [Prophylactic effect of ambroxol on acute hydrochloric acid aspiration - induced lung injury].

Journal: Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20050601

Title: Determination of ambroxol in an automated multi-pumping pulsed flow system.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20050401

Title: Adsorptive stripping voltammetric determination of ambroxol.

Journal: Die Pharmazie 20050301

Title: Cell-specific modulation of surfactant proteins by ambroxol treatment.

Journal: Toxicology and applied pharmacology 20050215

Title: Effect of ambroxol, spirulina and vitamin-E in naphthalene induced cataract in female rats.

Journal: Indian journal of physiology and pharmacology 20050101

Title: The influence of ambroxol and capsaicin on the isolated rabbit bladder wall.

Journal: Acta poloniae pharmaceutica 20050101

Title: Oral ambroxol supplement in pregnant women induces fetal lung maturation.

Journal: American journal of obstetrics and gynecology 20041201

Title: In vitro and in vivo antioxidant activity of ambroxol.

Journal: Clinical and experimental medicine 20041201

Title: [Protective effects of ambroxol on lung injury during cardiacpulmonary bypass in patients undergoing valve replacement].

Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20041201

Title: Secretory leukoprotease inhibitor and pulmonary surfactant serve as principal defenses against influenza A virus infection in the airway and chemical agents up-regulating their levels may have therapeutic potential.

Journal: Biological chemistry 20041101

Title: [Oxidative and anti-oxidative effects of ambroxol on acute hydrochloric acid-induced lung injury in rats].

Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20041001

Title: Simultaneous determination of roxithromycin and ambroxol hydrochloride in a new tablet formulation by liquid chromatography.

Journal: Journal of pharmaceutical and biomedical analysis 20040903

Title: Ambroxol reduces LPS toxicity mediated by induction of alkaline phosphatases in rat lung.

Journal: Clinical biochemistry 20040801

Title: [Clinical observation on Biyan Qingdu Granule and ambroxol hydrochloride in treating secretory otitis media].

Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20040701

Title: [Comparison of the effect of ambroxol and dexamethasone on the expression of pulmonary surfactant proteins in the fetal rat lungs].

Journal: Zhonghua er ke za zhi = Chinese journal of pediatrics 20040601

Title: Oral sustained delivery of ambroxol from in situ-gelling pectin formulations.

Journal: International journal of pharmaceutics 20040301

Title: Inhibition of inflammatory responses by ambroxol, a mucolytic agent, in a murine model of acute lung injury induced by lipopolysaccharide.

Journal: Intensive care medicine 20040101

Title: Bioequivalence assessment of ambroxol tablet after a single oral dose administration to healthy male volunteers.

Journal: Pharmacological research 20040101

Title: Effect of twelve-months therapy with oral ambroxol in preventing exacerbations in patients with COPD. Double-blind, randomized, multicenter, placebo-controlled study (the AMETHIST Trial).

Journal: Pulmonary pharmacology & therapeutics 20040101

Title: [A near-infrared diffuse reflectance analysis method for the noninvasive quantitative analysis of ambroxol hydrochloride tablets].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20040101

Title: Inhibition of bleomycin-induced cell death in rat alveolar macrophages and human lung epithelial cells by ambroxol.

Journal: Biochemical pharmacology 20031001

Title: In vitro inhibition of human neutrophil histotoxicity by ambroxol: evidence for a multistep mechanism.

Journal: British journal of pharmacology 20031001

Title: Simultaneous high-throughput determination of clenbuterol, ambroxol and bromhexine in pharmaceutical formulations by HPLC with potentiometric detection.

Journal: Journal of pharmaceutical and biomedical analysis 20030808

Title: Determination of ambroxol hydrochloride in pure solutions and some of its pharmaceutical preparations under batch and FIA conditions.

Journal: Farmaco (Societa chimica italiana : 1989) 20030801

Title: Pharmacokinetic properties of single-dose loratadine and ambroxol alone and combined in tablet formulations in healthy men.

Journal: Clinical therapeutics 20030801

Title: Determination of ambroxol in human plasma using LC-MS/MS.

Journal: Journal of pharmaceutical and biomedical analysis 20030601

Title: Quantitative determination of ambroxol in tablets by derivative UV spectrophotometric method and HPLC.

Journal: Journal of pharmaceutical and biomedical analysis 20030401

Title: Depressant effects of ambroxol and erdosteine on cytokine synthesis, granule enzyme release, and free radical production in rat alveolar macrophages activated by lipopolysaccharide.

Journal: Pharmacology & toxicology 20030401

Title: [Efficacy of combined drug therapy using a macrolide antibiotic and an antihistamine for adult patients with chronic paranasal sinusitis].

Journal: The Japanese journal of antibiotics 20030401

Title: Sonolytic debromination of ambroxol process wastewater.

Journal: Water research 20030201

Title: Development of treatment for pulmonary alveolar proteinosis.

Journal: Internal medicine (Tokyo, Japan) 20021201

Title: Pulmonary alveolar proteinosis successfully treated with ambroxol.

Journal: Internal medicine (Tokyo, Japan) 20021201

Title: Inhibition of tetrodotoxin (TTX)-resistant and TTX-sensitive neuronal Na(+) channels by the secretolytic ambroxol.

Journal: Molecular pharmacology 20020901

Title: Ambroxol inhibits peroxynitrite-induced damage of alpha1-antiproteinase and free radical production in activated phagocytic cells.

Journal: Pharmacology & toxicology 20020901

Title: Effect of ambroxol on ion transport -- a model study.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20020601

Title: Ambroxol suppresses influenza-virus proliferation in the mouse airway by increasing antiviral factor levels.

Journal: The European respiratory journal 20020501

Title: [Ambroxol in etiotropic chemotherapy of pulmonary tuberculosis].

Journal: Voenno-meditsinskii zhurnal 20020501

Title: [Atelectasis following cesarean section. Personal experience].

Journal: Minerva ginecologica 20020401

Title: [Mucolytics in acute and chronic respiratory tract disorders. I. Pathophysiology and mechanisms of action].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20020301

Title: [Mucolytics in acute and chronic respiratory tract disorders. II. Uses for treatment and antioxidant properties].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20020301

Title: Depressant effect of ambroxol on stimulated functional responses and cell death in rat alveolar macrophages exposed to silica in vitro.

Journal: The Journal of pharmacology and experimental therapeutics 20020201

Title: Ambroxol inhibits platelet-derived growth factor production in human monocytic cells.

Journal: European journal of pharmacology 20020201

Title: Local anaesthetic properties of ambroxol hydrochloride lozenges in view of sore throat. Clinical proof of concept.

Journal: Arzneimittel-Forschung 20020101

Title: Efficacy and tolerability of ambroxol hydrochloride lozenges in sore throat. Randomised, double-blind, placebo-controlled trials regarding the local anaesthetic properties.

Journal: Arzneimittel-Forschung 20020101

Title: [Effect of ambroxol on lipid peroxidation in homogenates of the human placenta].

Journal: Ginekologia polska 20011001

Title: Enhanced resistance to Sendai virus infection in DBA/2J mice with a botanical drug combination (Sinupret).

Journal: International immunopharmacology 20010901

Title: [The effect of inhaled ambroxol treatment on clinical symptoms and chosen parameters of ventilation in patients with exacerbation of chronic obstructive pulmonary disease patients].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20010901

Title: Oral neltenexine in patients with obstructive airways diseases: an open, randomised, controlled comparison versus sobrerol.

Journal: Minerva medica 20010801

Title: Neltenexine tablets in smoking and non-smoking patients with COPD. A double-blind, randomised, controlled study versus placebo.

Journal: Minerva medica 20010801

Title: Attenuation by ambroxol of monochloramine-enhanced gastric carcinogenesis: a possible prevention against Helicobacter pylori-associated gastric carcinogenesis.

Journal: Cancer letters 20010726

Title: Preventing exacerbations of chronic bronchitis and COPD.

Journal: BMJ (Clinical research ed.) 20010526

Title: Validation of an HPLC method for the quantification of ambroxol hydrochloride and benzoic acid in a syrup as pharmaceutical form stress test for stability evaluation.

Journal: Journal of pharmaceutical and biomedical analysis 20010301

Title: Modulating effects of mucoregulating drugs on the attachment of Haemophilus influenzae.

Journal: Microbial pathogenesis 20010301

Title: The effect of serotonin on airway transepithelial sodium ion pathways.

Journal: European journal of pharmacology 20010126

Title: Determination of ambroxol or bromhexine in pharmaceuticals by capillary isotachophoresis.

Journal: Journal of pharmaceutical and biomedical analysis 20010101

Title: [Effects of carbocisteine on airway inflammation and related events in SO2-exposed rats].

Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20010101

Title: [Effectiveness of lasolvan in patients with chronic obstructive bronchitis and non-atopic bronchial asthma].

Journal: Terapevticheskii arkhiv 20010101

Title: [Antioxidative features of ambroxol--usefulness in COPD].

Journal: Pneumonologia i alergologia polska 20010101

Title: The effect of a single oral administration of ambroxol on the ultrastructure of the epithelium of terminal bronchioles in rabbits.

Journal: Sbornik lekarsky 20010101

Title: Effects of a short course of treatment with acebrophylline on the mucus rheological characteristics and respiratory function parameters in patients suffering from chronic obstructive pulmonary disease.

Journal: The Journal of international medical research 19960101

Title: Activity of bromhexine and ambroxol, semi-synthetic derivatives of vasicine from the Indian shrub Adhatoda vasica, against Mycobacterium tuberculosis in vitro.

Journal: Journal of ethnopharmacology 19960101

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Tags:1146648-86-3 Molecular Formula|1146648-86-3 MDL|1146648-86-3 SMILES|1146648-86-3 4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexan-1-ol hydrochloride