Home Other Building Blocks 1149-99-1
1149-99-1,MFCD00870487
Catalog No.:AA008SQ7

1149-99-1 | illudin S

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1mg
≥98%
in stock  
$433.00   $303.00
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5mg
≥98%
in stock  
$1,726.00   $1,208.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008SQ7
Chemical Name:
illudin S
CAS Number:
1149-99-1
Molecular Formula:
C15H20O4
Molecular Weight:
264.3169
MDL Number:
MFCD00870487
SMILES:
OC[C@]1(C)C=C2C(=C(C)C3([C@@](C2=O)(C)O)CC3)[C@H]1O
NSC Number:
400979
Properties
Computed Properties
 
Complexity:
540  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
1  
XLogP3:
0.1  

Literature

Title: Modulation of Cytotoxicity by Transcription-Coupled Nucleotide Excision Repair Is Independent of the Requirement for Bioactivation of Acylfulvene.

Journal: Chemical research in toxicology 20170320

Title: Sulfotransferase-independent genotoxicity of illudin S and its acylfulvene derivatives in bacterial and mammalian cells.

Journal: Archives of toxicology 20140101

Title: Draft genome of Omphalotus olearius provides a predictive framework for sesquiterpenoid natural product biosynthesis in Basidiomycota.

Journal: Chemistry & biology 20120622

Title: Chemical and enzymatic reductive activation of acylfulvene to isomeric cytotoxic reactive intermediates.

Journal: Chemical research in toxicology 20111121

Title: Susceptibility of the antioxidant selenoenyzmes thioredoxin reductase and glutathione peroxidase to alkylation-mediated inhibition by anticancer acylfulvenes.

Journal: Chemical research in toxicology 20110516

Title: Profiling patterns of glutathione reductase inhibition by the natural product illudin S and its acylfulvene analogues.

Journal: Molecular bioSystems 20090901

Title: NADPH alkenal/one oxidoreductase activity determines sensitivity of cancer cells to the chemotherapeutic alkylating agent irofulven.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040215

Title: Marked activity of irofulven toward human carcinoma cells: comparison with cisplatin and ecteinascidin.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030701

Title: Reaction of irofulven with zinc and acid.

Journal: Journal of natural products 20030201

Title: Anti-tumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathways.

Journal: DNA repair 20021205

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