Catalog No.:AA000FFI

1149705-71-4 | XL888

Name: Name:XL888
Brand: AABLOCKS
SKU: AA000FFI
Availability: InStock
Rating: 90 (10 reviews)

Pack Size

Purity

Availability

Price(USD)

Quantity

1mg

95+%

in stock

$24.00 $17.00

- +

5mg

95+%

in stock

$60.00 $42.00

- +

10mg

95+%

in stock

$89.00 $62.00

- +

25mg

95+%

in stock

$150.00 $105.00

- +

50mg

95+%

in stock

$252.00 $177.00

- +

Technical Information
Properties
Literature
Request for Quotation
Download SDS

Technical Information
Properties
Literature

Technical Information

Catalog Number:

AA000FFI

Chemical Name:

XL888

CAS Number:

1149705-71-4

Molecular Formula:

C29H37N5O3

Molecular Weight:

503.6358

MDL Number:

MFCD22124888

SMILES:

CC[C@H](Nc1cc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3c2ccc(cn2)C(=O)C2CC2)c(cc1C(=O)N)C)C

Properties

Computed Properties

Complexity:

849

Covalently-Bonded Unit Count:

Defined Atom Stereocenter Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Rotatable Bond Count:

Undefined Atom Stereocenter Count:

XLogP3:

4.7

Literature

Title: High-content, high-throughput analysis of cell cycle perturbations induced by the HSP90 inhibitor XL888.

Journal: PloS one 20110101

Title: Haarberg HE, et al. Inhibition of Wee1, AKT, and CDK4 underlies the efficacy of the HSP90 inhibitor XL888 in an in vivo model of NRAS-mutant melanoma. Mol Cancer Ther. 2013 Jun;12(6):901-12.

Title: Paraiso KH, et al. The HSP90 inhibitor XL888 overcomes BRAF inhibitor resistance mediated through diverse mechanisms. Clin Cancer Res. 2012 May 1;18(9):2502-14.

Title: Bussenius J, et al. Discovery of XL888: a novel tropane-derived small molecule inhibitor of HSP90. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5396-404.

Quotation Request

Company Name:

Contact Person:

Email:

Quantity Required:

Country:

Additional Info:

SDS