Home Amines 116884-64-1
116884-64-1,MFCD00128343
Catalog No.:AA000DAA

116884-64-1 | 5-Amino-1-(4-methoxyphenyl)-1h-pyrazole-4-carbonitrile

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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA000DAA
Chemical Name:
5-Amino-1-(4-methoxyphenyl)-1h-pyrazole-4-carbonitrile
CAS Number:
116884-64-1
Molecular Formula:
C11H10N4O
Molecular Weight:
214.2233
MDL Number:
MFCD00128343
SMILES:
COc1ccc(cc1)n1ncc(c1N)C#N
Properties
Computed Properties
 
Complexity:
279  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
1.8  

Downstream Synthesis Route

[1]Peat,AndrewJ.;Boucheron,JoyceA.;Dickerson,ScottH.;Garrido,Dulce;Mills,Wendy;Peckham,Jennifer;Preugschat,Frank;Smalley,Terrence;Schweiker,StephanieL.;Wilson,JaymeR.;Wang,TonyY.;Zhou,HuiqiangQ.;Thomson,StephenA.[BioorganicandMedicinalChemistryLetters,2004,vol.14,#9,p.2121-2125]

[2]Siebeneicher,Holger;Bauser,Marcus;Buchmann,Bernd;Heisler,Iring;Müller,Thomas;Neuhaus,Roland;Rehwinkel,Hartmut;Telser,Joachim;Zorn,Ludwig[BioorganicandMedicinalChemistryLetters,2016,vol.26,#7,p.1732-1737]

[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2004/9602,2004,A1Locationinpatent:Page51

[2]Colomer,JuanP.;Sciú,MaríaL.;Ramirez,CristinaL.;Soria-Castro,SilviaM.;Vera,D.MarianoA.;Moyano,ElizabethL.[EuropeanJournalofOrganicChemistry,2018,vol.2018,#13,p.1514-1524]

[3]Daniels,R.Nathan;Kim,Kwangho;Lebois,EvanP.;Muchalski,Hubert;Hughes,Mary;Lindsley,CraigW.[TetrahedronLetters,2008,vol.49,#2,p.305-310]

[4]Gupta,Sanjay;Rodrigues,LigiaM.;Esteves,AnaP.;Oliveira-Campos,AnaM.F.;Nascimento,M.SaoJose;Nazareth;Cidade,Honorina;Neves,MartaP.;Fernandes,Eduarda;Pinto,Madalena;Cerqueira,NunoM.F.S.A.;Bras,Natercia[EuropeanJournalofMedicinalChemistry,2008,vol.43,#4,p.771-780]

[5]Peat,AndrewJ.;Boucheron,JoyceA.;Dickerson,ScottH.;Garrido,Dulce;Mills,Wendy;Peckham,Jennifer;Preugschat,Frank;Smalley,Terrence;Schweiker,StephanieL.;Wilson,JaymeR.;Wang,TonyY.;Zhou,HuiqiangQ.;Thomson,StephenA.[BioorganicandMedicinalChemistryLetters,2004,vol.14,#9,p.2121-2125]

[6]Smith,CatherineJ.;Iglesias-Sigueenza,FranciscoJavier;Baxendale,IanR.;Ley,StevenV.[OrganicandBiomolecularChemistry,2007,vol.5,#17,p.2758-2761]

[7]Mishra,ChandraBhushan;Mongre,RajKumar;Kumari,Shikha;Jeong,DongKee;Tiwari,Manisha[RSCAdvances,2016,vol.6,#29,p.24491-24500]

[8]Siebeneicher,Holger;Bauser,Marcus;Buchmann,Bernd;Heisler,Iring;Müller,Thomas;Neuhaus,Roland;Rehwinkel,Hartmut;Telser,Joachim;Zorn,Ludwig[BioorganicandMedicinalChemistryLetters,2016,vol.26,#7,p.1732-1737]

[9]Alshareef,HossaFahad;Mohamed,HebaAbdElHady;Salaheldin,AbdellatifMohamed[ChemicalandPharmaceuticalBulletin,2017,vol.65,#8,p.732-738]

[10]Sciú,M.Lourdes;Sebastián-Pérez,Victor;Martinez-Gonzalez,Loreto;Benitez,Rocio;Perez,DanielI.;Pérez,Concepción;Campillo,NuriaE.;Martinez,Ana;Moyano,E.Laura[JournalofEnzymeInhibitionandMedicinalChemistry,2019,vol.34,#1,p.87-96]

[11]Gupta,Sampa;Kant,Ruchir;Pandey,Shubham;Rai,AmitKumar;Sashidhara,KoneniV.;Singh,L.Ravithej;Tamrakar,AkhileshK.[BioorganicandMedicinalChemistryLetters,2021,vol.34]

116884-64-1   
C22H20N8O2 

[1]Smith,CatherineJ.;Iglesias-Sigueenza,FranciscoJavier;Baxendale,IanR.;Ley,StevenV.[OrganicandBiomolecularChemistry,2007,vol.5,#17,p.2758-2761]

[1]Peat,AndrewJ.;Boucheron,JoyceA.;Dickerson,ScottH.;Garrido,Dulce;Mills,Wendy;Peckham,Jennifer;Preugschat,Frank;Smalley,Terrence;Schweiker,StephanieL.;Wilson,JaymeR.;Wang,TonyY.;Zhou,HuiqiangQ.;Thomson,StephenA.[BioorganicandMedicinalChemistryLetters,2004,vol.14,#9,p.2121-2125]

[2]Siebeneicher,Holger;Bauser,Marcus;Buchmann,Bernd;Heisler,Iring;Müller,Thomas;Neuhaus,Roland;Rehwinkel,Hartmut;Telser,Joachim;Zorn,Ludwig[BioorganicandMedicinalChemistryLetters,2016,vol.26,#7,p.1732-1737]

[1]Peat,AndrewJ.;Boucheron,JoyceA.;Dickerson,ScottH.;Garrido,Dulce;Mills,Wendy;Peckham,Jennifer;Preugschat,Frank;Smalley,Terrence;Schweiker,StephanieL.;Wilson,JaymeR.;Wang,TonyY.;Zhou,HuiqiangQ.;Thomson,StephenA.[BioorganicandMedicinalChemistryLetters,2004,vol.14,#9,p.2121-2125]

Literature

Title: Synthesis of N-aryl-5-amino-4-cyanopyrazole derivatives as potent xanthine oxidase inhibitors.

Journal: European journal of medicinal chemistry 20080401

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Tags:116884-64-1 Molecular Formula|116884-64-1 MDL|116884-64-1 SMILES|116884-64-1 5-Amino-1-(4-methoxyphenyl)-1h-pyrazole-4-carbonitrile