Home Other Building Blocks 117091-64-2
117091-64-2,MFCD00270859
Catalog No.:AA00JKEI

117091-64-2 | Etoposide phosphate

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5mg
99% (HPLC)
in stock  
$148.00   $104.00
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10mg
99% (HPLC)
in stock  
$206.00   $144.00
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25mg
99% (HPLC)
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$364.00   $255.00
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50mg
99% (HPLC)
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$575.00   $403.00
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100mg
99% (HPLC)
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$949.00   $664.00
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500mg
99% (HPLC)
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$2,920.00   $2,044.00
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1000mg
99% (HPLC)
in stock  
$4,634.00   $3,244.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00JKEI
Chemical Name:
Etoposide phosphate
CAS Number:
117091-64-2
Molecular Formula:
C29H33O16P
Molecular Weight:
668.5365
MDL Number:
MFCD00270859
SMILES:
COc1cc(cc(c1OP(=O)(O)O)OC)C1C2C(=O)OCC2C(c2c1cc1OCOc1c2)OC1OC2COC(OC2C(C1O)O)C
Properties
Computed Properties
 
Complexity:
1140  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
10  
Heavy Atom Count:
46  
Hydrogen Bond Acceptor Count:
16  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
7  
XLogP3:
-0.7  

Literature

Title: Utilization of human nuclear receptors as an early counter screen for off-target activity: a case study with a compendium of 615 known drugs.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20150601

Title: Anaphylactic reaction to etoposide phosphate.

Journal: Pediatric blood & cancer 20121001

Title: Wipe sampling procedure coupled to LC-MS/MS analysis for the simultaneous determination of 10 cytotoxic drugs on different surfaces.

Journal: Analytical and bioanalytical chemistry 20120301

Title: Etoposide phosphate enhances the acetylation level of translation elongation factor 1A in PLC5 cells.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20120101

Title: Recent advances in semisynthesis, biosynthesis, biological activities, mode of action, and structure-activity relationship of podophyllotoxins: an update (2008-2010).

Journal: Mini reviews in medicinal chemistry 20110901

Title: Synergistic antitumor effect of β-elemene and etoposide is mediated via induction of cell apoptosis and cell cycle arrest in non-small cell lung carcinoma cells.

Journal: Molecular medicine reports 20110101

Title: A review on hemisynthesis, biosynthesis, biological activities, mode of action, and structure-activity relationship of podophyllotoxins: 2003-2007.

Journal: Current medicinal chemistry 20090101

Title: Primary meningeal CNS lymphoma treated with intra-arterial chemotherapy and blood-brain barrier disruption.

Journal: Journal of neuro-oncology 20081201

Title: Successful treatment with etoposide phosphate in patients with previous etoposide hypersensitivity.

Journal: Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 20080301

Title: Low dose leflunomide activates PI3K/Akt signalling in erythroleukemia cells and reduces apoptosis induced by anticancer agents.

Journal: Apoptosis : an international journal on programmed cell death 20061001

Title: Paclitaxel/carboplatin/etoposide versus paclitaxel/topotecan for extensive-stage small cell lung cancer: a Minnie Pearl Cancer Research Network randomized, prospective phase II trial.

Journal: The oncologist 20051001

Title: Pharmacokinetically guided phase I trial of topotecan and etoposide phosphate in recurrent ovarian cancer.

Journal: British journal of cancer 20050711

Title: Analysis of the in vivo functions of Mrp3.

Journal: Molecular pharmacology 20050701

Title: Particular cutaneous side effects with etoposide-containing courses: is VP16 or etoposide phosphate responsible?

Journal: Cancer chemotherapy and pharmacology 20050301

Title: Podophyllotoxin: distribution, sources, applications and new cytotoxic derivatives.

Journal: Toxicon : official journal of the International Society on Toxinology 20040915

Title: Quantification of etoposide and etoposide phosphate in human plasma by micellar electrokinetic chromatography and near-field thermal lens detection.

Journal: Analytical chemistry 20040701

Title: Decreased nucleotide excision repair activity and alterations of topoisomerase IIalpha are associated with the in vivo resistance of a P388 leukemia subline to F11782, a novel catalytic inhibitor of topoisomerases I and II.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040501

Title: Pharmacokinetic study of cisplatin and infusional etoposide phosphate in advanced breast cancer with correlation of response to topoisomerase IIalpha expression.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20031015

Title: Membrane-bound alkaline phosphatase gene induces antitumor effect by G2/M arrest in etoposide phosphate-treated cancer cells.

Journal: Molecular and cellular biochemistry 20031001

Title: Comparative pharmacokinetic study of high-dose etoposide and etoposide phosphate in patients with lymphoid malignancy receiving autologous stem cell transplantation.

Journal: Bone marrow transplantation 20030401

Title: Current status and future of relapsed primary central nervous system lymphoma (PCNSL).

Journal: Leukemia & lymphoma 20030401

Title: Determination of etoposide phosphate intermediates by gradient liquid chromatography using postcolumn derivatization with cuprammonium hydroxide.

Journal: Journal of chromatography. A 20020405

Title: Safe administration of etoposide phosphate after hypersensitivity reaction to intravenous etoposide.

Journal: British journal of cancer 20020107

Title: Bioequivalence investigation of high-dose etoposide and etoposide phosphate in lymphoma patients.

Journal: Cancer chemotherapy and pharmacology 20010801

Title: Etoposide phosphate with carboplatin in the treatment of elderly patients with small-cell lung cancer: a phase II study.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20010701

Title: Simultaneous quantification of etoposide and etoposide phosphate in human plasma by capillary electrophoresis using laser-induced native fluorescence detection.

Journal: Analytical chemistry 20010515

Title: High-dose etoposide phosphate and G-CSF mobilizes peripheral blood stem cells in patients that previously failed to mobilize.

Journal: Annals of hematology 20010201

Title: Etoposide- and BMY-40481-induced sensory neuropathy in mice.

Journal: Toxicologic pathology 19940101

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