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1173023-85-2,MFCD07370137
Catalog No.:AA01DZPW

1173023-85-2 | GW583340Dihydrochloride

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Purity
Availability
Price(USD)
Quantity
  
10mg
≥97%(HPLC)
in stock  
$331.00   $232.00
- +
50mg
≥97%(HPLC)
in stock  
$1,172.00   $820.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01DZPW
Chemical Name:
GW583340Dihydrochloride
CAS Number:
1173023-85-2
Molecular Formula:
C28H27Cl3FN5O3S2
Molecular Weight:
671.0331
MDL Number:
MFCD07370137
SMILES:
Fc1cccc(c1)COc1ccc(cc1Cl)Nc1ncnc2c1cc(cc2)c1csc(n1)CNCCS(=O)(=O)C.Cl.Cl
Properties
Computed Properties
 
Complexity:
902  
Covalently-Bonded Unit Count:
3  
Heavy Atom Count:
42  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
11  

Literature

Title: Bisphenol A activates EGFR and ERK promoting proliferation, tumor spheroid formation and resistance to EGFR pathway inhibition in estrogen receptor-negative inflammatory breast cancer cells.

Journal: Carcinogenesis 20170301

Title: GW583340 and GW2974, human EGFR and HER-2 inhibitors, reverse ABCG2- and ABCB1-mediated drug resistance.

Journal: Biochemical pharmacology 20120615

Title: ErbB1/2 tyrosine kinase inhibitor mediates oxidative stress-induced apoptosis in inflammatory breast cancer cells.

Journal: Breast cancer research and treatment 20120201

Title: X-linked inhibitor of apoptosis protein inhibits apoptosis in inflammatory breast cancer cells with acquired resistance to an ErbB1/2 tyrosine kinase inhibitor.

Journal: Molecular cancer therapeutics 20100501

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SDS
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Tags:1173023-85-2 Molecular Formula|1173023-85-2 MDL|1173023-85-2 SMILES|1173023-85-2 GW583340Dihydrochloride