Home Other Building Blocks 117621-64-4
117621-64-4,MFCD00673936
Catalog No.:AA0081E9

117621-64-4 | ICI 192,605

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Purity
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Price(USD)
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1mg
≥95%
in stock  
$46.00   $32.00
- +
5mg
≥95%
in stock  
$133.00   $93.00
- +
10mg
≥95%
in stock  
$238.00   $166.00
- +
25mg
≥95%
in stock  
$522.00   $365.00
- +
50mg
98%
in stock  
$961.00   $673.00
- +
  • Technical Information
  • Properties
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0081E9
Chemical Name:
ICI 192,605
CAS Number:
117621-64-4
Molecular Formula:
C22H23ClO5
Molecular Weight:
402.8680
MDL Number:
MFCD00673936
SMILES:
OC(=O)CCC=CC[C@H]1CO[C@H](O[C@H]1c1ccccc1O)c1ccccc1Cl
Properties
Computed Properties
 
Complexity:
525  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
7  
XLogP3:
4.1  

Literature

Title: Thromboxane and isoprostane share the same prostanoid receptors to increase human placental tone.

Journal: Placenta 20111201

Title: Role of Ca2+ mobilization and Ca2+ sensitization in 8-iso-PGF 2 alpha-induced contraction in airway smooth muscle.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20090201

Title: Isoprostanes inhibit vascular endothelial growth factor-induced endothelial cell migration, tube formation, and cardiac vessel sprouting in vitro, as well as angiogenesis in vivo via activation of the thromboxane A(2) receptor: a potential link between oxidative stress and impaired angiogenesis.

Journal: Circulation research 20081024

Title: Vasoconstrictor effects of 8-iso-prostaglandin E2 and 8-iso-prostaglandin F(2alpha) on human umbilical vein.

Journal: European journal of pharmacology 20040919

Title: Vasoconstrictor responses, and underlying mechanisms, to isoprostanes in human and porcine bronchial arterial smooth muscle.

Journal: British journal of pharmacology 20031001

Title: Pharmacological characterization of prostanoid receptors mediating vasoconstriction in human umbilical vein.

Journal: British journal of pharmacology 20030802

Title: Endothelium-dependent vasorelaxation induced by L-carnitine in isolated aorta from normotensive and hypertensive rats.

Journal: The Journal of pharmacy and pharmacology 20021001

Title: Hydrogen peroxide induces a greater contraction in mesenteric arteries of spontaneously hypertensive rats through thromboxane A(2) production.

Journal: British journal of pharmacology 20011201

Title: Involvement of prostanoid release in the mediation of UTP-induced cerebrovascular contraction in the rat.

Journal: Brain research 20010330

Title: Effect of 8-iso-prostaglandin F(2 alpha) on acetylcholine release from parasympathetic nerves in guinea pig airways.

Journal: European journal of pharmacology 20010330

Title: Platelet-leukocyte cross talk in whole blood.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20001201

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Tags:117621-64-4 Molecular Formula|117621-64-4 MDL|117621-64-4 SMILES|117621-64-4 ICI 192,605