117857-45-1,MFCD00865331
Catalog No.:AA007QMZ

117857-45-1 | Loreclezole hydrochloride

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
97%
in stock  
$15.00   $11.00
- +
5mg
97%
in stock  
$38.00   $27.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA007QMZ
Chemical Name:
Loreclezole hydrochloride
CAS Number:
117857-45-1
Molecular Formula:
C10H7Cl4N3
Molecular Weight:
310.9947
MDL Number:
MFCD00865331
SMILES:
Clc1ccc(c(c1)Cl)/C(=C/n1cncn1)/Cl.Cl
Properties
Computed Properties
 
Complexity:
272  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
1  
Formal Charge:
0  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
0  
Isotope Atom Count:
0  
Rotatable Bond Count:
2  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
3.8  

Downstream Synthesis Route

[1]CurrentPatentAssignee:KOREARESEARCHINSTITUTEOFCHEMICALTECHNOLOGY-KR2018/57914,2018,ALocationinpatent:Paragraph0064-0065;0069-0071

[2]CurrentPatentAssignee:KOREARESEARCHINSTITUTEOFCHEMICALTECHNOLOGY-KR2020/143148,2020,ALocationinpatent:Paragraph0267;0273-0275

[1]CurrentPatentAssignee:KOREARESEARCHINSTITUTEOFCHEMICALTECHNOLOGY-KR2020/143148,2020,A

Literature

Title: Topiramate modulation of β(1)- and β(3)-homomeric GABA(A) receptors.

Journal: Pharmacological research 20110701

Title: The role of GABAbeta2 subunit-containing receptors in mediating the anticonvulsant and sedative effects of loreclezole.

Journal: The European journal of neuroscience 20060701

Title: Fast IPSCs in rat thalamic reticular nucleus require the GABAA receptor beta1 subunit.

Journal: The Journal of physiology 20060415

Title: High-affinity, slowly desensitizing GABAA receptors mediate tonic inhibition in hippocampal dentate granule cells.

Journal: Molecular pharmacology 20060201

Title: Pharmacodynamic and/or pharmacokinetic characteristics of interactions between loreclezole and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice: an isobolographic analysis.

Journal: Epilepsy & behavior : E&B 20051201

Title: Consequence of the presence of two different beta subunit isoforms in a GABA(A) receptor.

Journal: Journal of neurochemistry 20051201

Title: Pharmacodynamic and pharmacokinetic interaction studies of loreclezole with felbamate, lamotrigine, topiramate, and oxcarbazepine in the mouse maximal electroshock seizure model.

Journal: Epilepsia 20050301

Title: Critically timed ethanol exposure reduces GABAAR function on septal neurons developing in vivo but not in vitro.

Journal: Brain research 20040515

Title: Interaction of loreclezole with conventional antiepileptic drugs in amygdala-kindled rats.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20040501

Title: Major differences in inhibitory synaptic transmission onto two neocortical interneuron subclasses.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20031022

Title: Sedation and anesthesia mediated by distinct GABA(A) receptor isoforms.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20030917

Title: Effect of some convulsants on the protective activity of loreclezole and its combinations with valproate or clonazepam in amygdala-kindled rats.

Journal: Polish journal of pharmacology 20030101

Title: Functional characterization of GABA(A) receptors in neonatal hypothalamic brain slice.

Journal: Journal of neurophysiology 20021001

Title: N-Substituted 4-amino-3,3-dipropyl-2(3H)-furanones: new positive allosteric modulators of the GABA(A) receptor sharing electrophysiological properties with the anticonvulsant loreclezole.

Journal: Journal of medicinal chemistry 20020620

Title: Do antiepileptics phenytoin, carbamazepine, and loreclezole show GABA(A) receptor subtype selectivity in rat brain sections?

Journal: Neurochemical research 20010101

Title: Heterogeneity of GABA(A) receptor-mediated responses in the human IMR-32 neuroblastoma cell line.

Journal: Journal of neuroscience research 20000515

Title: Preclinical evaluation of newly approved and potential antiepileptic drugs against cocaine-induced seizures.

Journal: The Journal of pharmacology and experimental therapeutics 19990901

Title: The interactions of hexachlorocyclohexane isomers with human gamma-aminobutyric acid(A) receptors expressed in Xenopus oocytes.

Journal: The Journal of pharmacology and experimental therapeutics 19970901

Title: A novel allosteric modulatory site on the GABAA receptor beta subunit.

Journal: Neuron 19940401

Title: The novel anticonvulsant loreclezole (R 72063) does not produce diazepam-like anterograde amnesia in a passive avoidance test in rats.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 19901101

Title: Wingrove PB, et al. The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunit. Proc Natl Acad Sci U S A. 1994 May 10;91(10):4569-73.

Title: Sanna E, et al. Direct activation of GABAA receptors by loreclezole, an anticonvulsant drug with selectivity for the beta-subunit. Neuropharmacology. 1996;35(12):1753-60.

Title: Green AR, et al. A behavioural and neurochemical study in rats of the pharmacology of loreclezole, a novel allosteric modulator of the GABAA receptor. Neuropharmacology. 1996;35(9-10):1243-50.

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Tags:117857-45-1 Molecular Formula|117857-45-1 MDL|117857-45-1 SMILES|117857-45-1 Loreclezole hydrochloride
Catalog No.: AA007QMZ
117857-45-1,MFCD00865331
117857-45-1 | Loreclezole hydrochloride
Pack Size: 1mg
Purity: 97%
in stock
$15.00 $11.00
Pack Size: 5mg
Purity: 97%
in stock
$38.00 $27.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA007QMZ
Chemical Name: Loreclezole hydrochloride
CAS Number: 117857-45-1
Molecular Formula: C10H7Cl4N3
Molecular Weight: 310.9947
MDL Number: MFCD00865331
SMILES: Clc1ccc(c(c1)Cl)/C(=C/n1cncn1)/Cl.Cl
Properties
Complexity: 272  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 1  
Formal Charge: 0  
Heavy Atom Count: 16  
Hydrogen Bond Acceptor Count: 2  
Hydrogen Bond Donor Count: 0  
Isotope Atom Count: 0  
Rotatable Bond Count: 2  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 3.8  
Downstream Synthesis Route
58905-16-1    117857-45-1 

[1]CurrentPatentAssignee:KOREARESEARCHINSTITUTEOFCHEMICALTECHNOLOGY-KR2018/57914,2018,ALocationinpatent:Paragraph0064-0065;0069-0071

[2]CurrentPatentAssignee:KOREARESEARCHINSTITUTEOFCHEMICALTECHNOLOGY-KR2020/143148,2020,ALocationinpatent:Paragraph0267;0273-0275

4252-78-2    117857-45-1 

[1]CurrentPatentAssignee:KOREARESEARCHINSTITUTEOFCHEMICALTECHNOLOGY-KR2020/143148,2020,A

Literature fold

Title: Topiramate modulation of β(1)- and β(3)-homomeric GABA(A) receptors.

Journal: Pharmacological research20110701

Title: The role of GABAbeta2 subunit-containing receptors in mediating the anticonvulsant and sedative effects of loreclezole.

Journal: The European journal of neuroscience20060701

Title: Fast IPSCs in rat thalamic reticular nucleus require the GABAA receptor beta1 subunit.

Journal: The Journal of physiology20060415

Title: High-affinity, slowly desensitizing GABAA receptors mediate tonic inhibition in hippocampal dentate granule cells.

Journal: Molecular pharmacology20060201

Title: Pharmacodynamic and/or pharmacokinetic characteristics of interactions between loreclezole and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice: an isobolographic analysis.

Journal: Epilepsy & behavior : E&B20051201

Title: Consequence of the presence of two different beta subunit isoforms in a GABA(A) receptor.

Journal: Journal of neurochemistry20051201

Title: Pharmacodynamic and pharmacokinetic interaction studies of loreclezole with felbamate, lamotrigine, topiramate, and oxcarbazepine in the mouse maximal electroshock seizure model.

Journal: Epilepsia20050301

Title: Critically timed ethanol exposure reduces GABAAR function on septal neurons developing in vivo but not in vitro.

Journal: Brain research20040515

Title: Interaction of loreclezole with conventional antiepileptic drugs in amygdala-kindled rats.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology20040501

Title: Major differences in inhibitory synaptic transmission onto two neocortical interneuron subclasses.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20031022

Title: Sedation and anesthesia mediated by distinct GABA(A) receptor isoforms.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20030917

Title: Effect of some convulsants on the protective activity of loreclezole and its combinations with valproate or clonazepam in amygdala-kindled rats.

Journal: Polish journal of pharmacology20030101

Title: Functional characterization of GABA(A) receptors in neonatal hypothalamic brain slice.

Journal: Journal of neurophysiology20021001

Title: N-Substituted 4-amino-3,3-dipropyl-2(3H)-furanones: new positive allosteric modulators of the GABA(A) receptor sharing electrophysiological properties with the anticonvulsant loreclezole.

Journal: Journal of medicinal chemistry20020620

Title: Do antiepileptics phenytoin, carbamazepine, and loreclezole show GABA(A) receptor subtype selectivity in rat brain sections?

Journal: Neurochemical research20010101

Title: Heterogeneity of GABA(A) receptor-mediated responses in the human IMR-32 neuroblastoma cell line.

Journal: Journal of neuroscience research20000515

Title: Preclinical evaluation of newly approved and potential antiepileptic drugs against cocaine-induced seizures.

Journal: The Journal of pharmacology and experimental therapeutics19990901

Title: The interactions of hexachlorocyclohexane isomers with human gamma-aminobutyric acid(A) receptors expressed in Xenopus oocytes.

Journal: The Journal of pharmacology and experimental therapeutics19970901

Title: A novel allosteric modulatory site on the GABAA receptor beta subunit.

Journal: Neuron19940401

Title: The novel anticonvulsant loreclezole (R 72063) does not produce diazepam-like anterograde amnesia in a passive avoidance test in rats.

Journal: Naunyn-Schmiedeberg's archives of pharmacology19901101

Title: Wingrove PB, et al. The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunit. Proc Natl Acad Sci U S A. 1994 May 10;91(10):4569-73.

Title: Sanna E, et al. Direct activation of GABAA receptors by loreclezole, an anticonvulsant drug with selectivity for the beta-subunit. Neuropharmacology. 1996;35(12):1753-60.

Title: Green AR, et al. A behavioural and neurochemical study in rats of the pharmacology of loreclezole, a novel allosteric modulator of the GABAA receptor. Neuropharmacology. 1996;35(9-10):1243-50.

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