118290-27-0,MFCD00884624
Catalog No.:AA0034CY

118290-27-0 | Afdx384

This product is typically in stock,please click "Inquire" below or
contact us at [email protected] for pricing and availability information.
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA0034CY
Chemical Name:
Afdx384
CAS Number:
118290-27-0
Molecular Formula:
C28H42N6O5S
Molecular Weight:
574.7353
MDL Number:
MFCD00884624
SMILES:
CS(=O)(=O)O.CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC
Properties
Computed Properties
 
Complexity:
777  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
40  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0  
Rotatable Bond Count:
9  
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0  

Literature

Title: Early changes in M2 muscarinic acetylcholine receptors (mAChRs) induced by sarin intoxication may be linked to long lasting neurological effects.

Journal: Neurotoxicology 20180301

Title: Near-complete adaptation of the PRiMA knockout to the lack of central acetylcholinesterase.

Journal: Journal of neurochemistry 20120901

Title: Muscarinic receptor/G-protein coupling is reduced in the dorsomedial striatum of cognitively impaired aged rats.

Journal: Behavioural brain research 20120201

Title: Decreased kainate receptors in the hippocampus of apolipoprotein D knockout mice.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20100317

Title: Regional changes in the cholinergic system in mice lacking monoamine oxidase A.

Journal: Brain research bulletin 20090330

Title: Asymmetrical distributions of muscarinic receptor binding in the hippocampus of female rats.

Journal: European journal of pharmacology 20080707

Title: The effects of mercury on muscarinic cholinergic receptor subtypes (M1 and M2) in captive mink.

Journal: Neurotoxicology 20080301

Title: Olanzapine treatment decreases the density of muscarinic M2 receptors in the dorsal vagal complex of rats.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20070509

Title: Insect muscarinic acetylcholine receptor: pharmacological and toxicological profiles of antagonists and agonists.

Journal: Journal of agricultural and food chemistry 20070321

Title: Alterations of muscarinic and GABA receptor binding in the posterior cingulate cortex in schizophrenia.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20070130

Title: Cholinergic receptor subtypes in the olfactory bulbectomy model of depression.

Journal: Brain research bulletin 20060130

Title: Allosteric modulators and selective agonists of muscarinic receptors.

Journal: Journal of molecular neuroscience : MN 20060101

Title: Decreased density of muscarinic receptors in the superior temporal gyrusin schizophrenia.

Journal: Journal of neuroscience research 20050915

Title: Muscarinic M2 and M4 receptors in anterior cingulate cortex: relation to neuropsychiatric symptoms in dementia with Lewy bodies.

Journal: Behavioural brain research 20050620

Title: M2/M4 muscarinic receptor binding in the anterior cingulate cortex in schizophrenia and mood disorders.

Journal: Brain research bulletin 20050515

Title: A pentylenetetrazole-induced generalized seizure in early life enhances the efficacy of muscarinic receptor coupling to G-protein in hippocampus and neocortex of adult rat.

Journal: The European journal of neuroscience 20050401

Title: Smoking during early pregnancy affects the expression pattern of both nicotinic and muscarinic acetylcholine receptors in human first trimester brainstem and cerebellum.

Journal: Neuroscience 20050101

Title: Maternal exposure to nicotine and chlorpyrifos, alone and in combination, leads to persistently elevated expression of glial fibrillary acidic protein in the cerebellum of the offspring in late puberty.

Journal: Archives of toxicology 20040801

Title: Development of a new type of allosteric modulator of muscarinic receptors: hybrids of the antagonist AF-DX 384 and the hexamethonio derivative W84.

Journal: Journal of medicinal chemistry 20040603

Title: Co-exposure to pyridostigmine bromide, DEET, and/or permethrin causes sensorimotor deficit and alterations in brain acetylcholinesterase activity.

Journal: Pharmacology, biochemistry, and behavior 20040201

Title: Chlorpyrifos exposure during neurulation: cholinergic synaptic dysfunction and cellular alterations in brain regions at adolescence and adulthood.

Journal: Brain research. Developmental brain research 20040131

Title: Differential modulation of muscarinic receptors in the rat brain by repeated exposure to methyl parathion.

Journal: The Journal of toxicological sciences 20031201

Title: Up-regulation of spinal muscarinic receptors and increased antinociceptive effect of intrathecal muscarine in diabetic rats.

Journal: The Journal of pharmacology and experimental therapeutics 20031101

Title: Muscarinic receptors in basal ganglia in dementia with Lewy bodies, Parkinson's disease and Alzheimer's disease.

Journal: Journal of chemical neuroanatomy 20030301

Title: Loss of muscarinic M4 receptors in hippocampus of Alzheimer patients.

Journal: Brain research 20030117

Title: The colon-selective spasmolytic otilonium bromide inhibits muscarinic M(3) receptor-coupled calcium signals in isolated human colonic crypts.

Journal: British journal of pharmacology 20021201

Title: Comparative distribution of binding of the muscarinic receptor ligands pirenzepine, AF-DX 384, (R,R)-I-QNB and (R,S)-I-QNB to human brain.

Journal: Journal of chemical neuroanatomy 20020901

Title: Effect of subchronic administration of metrifonate, rivastigmine and donepezil on brain acetylcholine in aged F344 rats.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20020701

Title: Chronic treatments with tacrine and (-)-nicotine induce different changes of nicotinic and muscarinic acetylcholine receptors in the brain of aged rat.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20020301

Title: Estrogen effects on object memory and cholinergic receptors in young and old female mice.

Journal: Neurobiology of aging 20020101

Title: Locomotor and sensorimotor performance deficit in rats following exposure to pyridostigmine bromide, DEET, and permethrin, alone and in combination.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20010401

Title: Pharmacology, distribution and development of muscarinic acetylcholine receptor subtypes in the optic tectum of Rana pipiens.

Journal: Neuroscience 20010101

Title: Binding and functional selectivity of himbacine for cloned and neuronal muscarinic receptors.

Journal: The Journal of pharmacology and experimental therapeutics 19921101

Title: Binding of [3H]AF-DX 384 to cloned and native muscarinic receptors.

Journal: The Journal of pharmacology and experimental therapeutics 19911101

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Tags:118290-27-0 Molecular Formula|118290-27-0 MDL|118290-27-0 SMILES|118290-27-0 Afdx384
Catalog No.: AA0034CY
118290-27-0,MFCD00884624
118290-27-0 | Afdx384
This product is typically in stock,please click "Inquire" below or contact us at [email protected]for pricing and availability information.
Inquire
Technical Information
Catalog Number: AA0034CY
Chemical Name: Afdx384
CAS Number: 118290-27-0
Molecular Formula: C28H42N6O5S
Molecular Weight: 574.7353
MDL Number: MFCD00884624
SMILES: CS(=O)(=O)O.CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC
Properties
Complexity: 777  
Covalently-Bonded Unit Count: 2  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 40  
Hydrogen Bond Acceptor Count: 8  
Hydrogen Bond Donor Count: 3  
Isotope Atom Count: 0  
Rotatable Bond Count: 9  
Undefined Atom Stereocenter Count: 1  
Undefined Bond Stereocenter Count: 0  
Literature fold

Title: Early changes in M2 muscarinic acetylcholine receptors (mAChRs) induced by sarin intoxication may be linked to long lasting neurological effects.

Journal: Neurotoxicology20180301

Title: Near-complete adaptation of the PRiMA knockout to the lack of central acetylcholinesterase.

Journal: Journal of neurochemistry20120901

Title: Muscarinic receptor/G-protein coupling is reduced in the dorsomedial striatum of cognitively impaired aged rats.

Journal: Behavioural brain research20120201

Title: Decreased kainate receptors in the hippocampus of apolipoprotein D knockout mice.

Journal: Progress in neuro-psychopharmacology & biological psychiatry20100317

Title: Regional changes in the cholinergic system in mice lacking monoamine oxidase A.

Journal: Brain research bulletin20090330

Title: Asymmetrical distributions of muscarinic receptor binding in the hippocampus of female rats.

Journal: European journal of pharmacology20080707

Title: The effects of mercury on muscarinic cholinergic receptor subtypes (M1 and M2) in captive mink.

Journal: Neurotoxicology20080301

Title: Olanzapine treatment decreases the density of muscarinic M2 receptors in the dorsal vagal complex of rats.

Journal: Progress in neuro-psychopharmacology & biological psychiatry20070509

Title: Insect muscarinic acetylcholine receptor: pharmacological and toxicological profiles of antagonists and agonists.

Journal: Journal of agricultural and food chemistry20070321

Title: Alterations of muscarinic and GABA receptor binding in the posterior cingulate cortex in schizophrenia.

Journal: Progress in neuro-psychopharmacology & biological psychiatry20070130

Title: Cholinergic receptor subtypes in the olfactory bulbectomy model of depression.

Journal: Brain research bulletin20060130

Title: Allosteric modulators and selective agonists of muscarinic receptors.

Journal: Journal of molecular neuroscience : MN20060101

Title: Decreased density of muscarinic receptors in the superior temporal gyrusin schizophrenia.

Journal: Journal of neuroscience research20050915

Title: Muscarinic M2 and M4 receptors in anterior cingulate cortex: relation to neuropsychiatric symptoms in dementia with Lewy bodies.

Journal: Behavioural brain research20050620

Title: M2/M4 muscarinic receptor binding in the anterior cingulate cortex in schizophrenia and mood disorders.

Journal: Brain research bulletin20050515

Title: A pentylenetetrazole-induced generalized seizure in early life enhances the efficacy of muscarinic receptor coupling to G-protein in hippocampus and neocortex of adult rat.

Journal: The European journal of neuroscience20050401

Title: Smoking during early pregnancy affects the expression pattern of both nicotinic and muscarinic acetylcholine receptors in human first trimester brainstem and cerebellum.

Journal: Neuroscience20050101

Title: Maternal exposure to nicotine and chlorpyrifos, alone and in combination, leads to persistently elevated expression of glial fibrillary acidic protein in the cerebellum of the offspring in late puberty.

Journal: Archives of toxicology20040801

Title: Development of a new type of allosteric modulator of muscarinic receptors: hybrids of the antagonist AF-DX 384 and the hexamethonio derivative W84.

Journal: Journal of medicinal chemistry20040603

Title: Co-exposure to pyridostigmine bromide, DEET, and/or permethrin causes sensorimotor deficit and alterations in brain acetylcholinesterase activity.

Journal: Pharmacology, biochemistry, and behavior20040201

Title: Chlorpyrifos exposure during neurulation: cholinergic synaptic dysfunction and cellular alterations in brain regions at adolescence and adulthood.

Journal: Brain research. Developmental brain research20040131

Title: Differential modulation of muscarinic receptors in the rat brain by repeated exposure to methyl parathion.

Journal: The Journal of toxicological sciences20031201

Title: Up-regulation of spinal muscarinic receptors and increased antinociceptive effect of intrathecal muscarine in diabetic rats.

Journal: The Journal of pharmacology and experimental therapeutics20031101

Title: Muscarinic receptors in basal ganglia in dementia with Lewy bodies, Parkinson's disease and Alzheimer's disease.

Journal: Journal of chemical neuroanatomy20030301

Title: Loss of muscarinic M4 receptors in hippocampus of Alzheimer patients.

Journal: Brain research20030117

Title: The colon-selective spasmolytic otilonium bromide inhibits muscarinic M(3) receptor-coupled calcium signals in isolated human colonic crypts.

Journal: British journal of pharmacology20021201

Title: Comparative distribution of binding of the muscarinic receptor ligands pirenzepine, AF-DX 384, (R,R)-I-QNB and (R,S)-I-QNB to human brain.

Journal: Journal of chemical neuroanatomy20020901

Title: Effect of subchronic administration of metrifonate, rivastigmine and donepezil on brain acetylcholine in aged F344 rats.

Journal: Journal of neural transmission (Vienna, Austria : 1996)20020701

Title: Chronic treatments with tacrine and (-)-nicotine induce different changes of nicotinic and muscarinic acetylcholine receptors in the brain of aged rat.

Journal: Journal of neural transmission (Vienna, Austria : 1996)20020301

Title: Estrogen effects on object memory and cholinergic receptors in young and old female mice.

Journal: Neurobiology of aging20020101

Title: Locomotor and sensorimotor performance deficit in rats following exposure to pyridostigmine bromide, DEET, and permethrin, alone and in combination.

Journal: Toxicological sciences : an official journal of the Society of Toxicology20010401

Title: Pharmacology, distribution and development of muscarinic acetylcholine receptor subtypes in the optic tectum of Rana pipiens.

Journal: Neuroscience20010101

Title: Binding and functional selectivity of himbacine for cloned and neuronal muscarinic receptors.

Journal: The Journal of pharmacology and experimental therapeutics19921101

Title: Binding of [3H]AF-DX 384 to cloned and native muscarinic receptors.

Journal: The Journal of pharmacology and experimental therapeutics19911101

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