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745017-94-1,MFCD25976742
Catalog No.:AA003574

745017-94-1 | Monomethyl Auristatin F

Pack Size
Purity
Availability
Price(USD)
Quantity
  
2mg
98%
in stock  
$19.00   $14.00
- +
5mg
98%
in stock  
$36.00   $25.00
- +
100mg
95%
in stock  
$525.00   $368.00
- +
250mg
95%
in stock  
$779.00   $545.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003574
Chemical Name:
Monomethyl Auristatin F
CAS Number:
745017-94-1
Molecular Formula:
C39H65N5O8
Molecular Weight:
731.9621
MDL Number:
MFCD25976742
SMILES:
CN[C@H](C(=O)N[C@H](C(=O)N(C([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@H](C(=O)N[C@H](C(=O)O)Cc1ccccc1)C)OC)OC)[C@H](CC)C)C)C(C)C)C(C)C
Properties
Properties
 
Form:
Solid  
MP:
>137°C (dec.)  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
1160  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
9  
Heavy Atom Count:
52  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
21  
XLogP3:
2.1  

Literature

Title: Native intact mass determination of antibodies conjugated with monomethyl Auristatin E and F at interchain cysteine residues.

Journal: Analytical chemistry 20120320

Title: Impact of drug conjugation on pharmacokinetics and tissue distribution of anti-STEAP1 antibody-drug conjugates in rats.

Journal: Bioconjugate chemistry 20111019

Title: Antibody-drug conjugates for the treatment of non-Hodgkin's lymphoma: target and linker-drug selection.

Journal: Cancer research 20090315

Title: A human antibody-drug conjugate targeting EphA2 inhibits tumor growth in vivo.

Journal: Cancer research 20081115

Title: Anti-CD22-MCC-DM1 and MC-MMAF conjugates: impact of assay format on pharmacokinetic parameters determination.

Journal: Bioconjugate chemistry 20080801

Title: Lee JW, et al. EphA2 targeted chemotherapy using an antibody drug conjugate in endometrial carcinoma. Clin Cancer Res. 2010 May 1;16(9):2562-70.

Title: Lee JJ, et al. Enzymatic prenylation and oxime ligation for the synthesis of stable and homogeneous protein-drug conjugates for targeted therapy. Angew Chem Int Ed Engl. 2015 Oct 5;54(41):12020-4.

Title: Kim EG, et al. Strategies and Advancement in Antibody-Drug Conjugate Optimization for Targeted CancerTherapeutics.

Title: Doronina SO, et al. Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: effects of linker technology on efficacy and toxicity. Bioconjug Chem. 2006 Jan-Feb;17(1):114-24.

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