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Home Other Building Blocks 1184173-73-6
1184173-73-6
Catalog No.:AA01FVGH

1184173-73-6 | MK-8353

Pack Size
Purity
Availability
Price(USD)
Quantity
  
2mg
95%
in stock  
$37.00   $26.00
- +
5mg
95%
in stock  
$73.00   $51.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA01FVGH
Chemical Name:
MK-8353
CAS Number:
1184173-73-6
Molecular Formula:
C37H41N9O3S
Molecular Weight:
691.8449
SMILES:
CSC1(CCN(C1)CC(=O)N1CCC(=CC1)c1ccc(cc1)c1ncn(n1)C)C(=O)Nc1ccc2c(c1)c(n[nH]2)c1ccc(nc1)OC(C)C
Properties
Computed Properties
 
Complexity:
1220  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
50  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
10  
XLogP3:
4.3  

Downstream Synthesis Route
1184174-06-8   
C21H25N5O2S*C2HF3O2 
  1184173-73-6 

[1]CurrentPatentAssignee:MERCK&COINC-WO2016/100147,2016,A1Locationinpatent:Page/Pagecolumn5;9

[2]CurrentPatentAssignee:MERCK&COINC-WO2017/40362,2017,A1Locationinpatent:Page/Pagecolumn4;7

1184173-73-6   
(S)-N-(3-(6-isopropoxypyridin-3-yl)-1H-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2H)-yl)-2-oxoethyl)-3-(methylthio)pyrrolidine-3-carboxamidehydrochloride 

[1]CurrentPatentAssignee:MERCK&COINC-WO2016/100147,2016,A1Locationinpatent:Page/Pagecolumn10

[2]CurrentPatentAssignee:MERCK&COINC-WO2016/100152,2016,A1Locationinpatent:Page/Pagecolumn12

[1]CurrentPatentAssignee:MERCK&COINC-WO2016/100147,2016,A1

[2]CurrentPatentAssignee:MERCK&COINC-WO2016/100152,2016,A1

[3]CurrentPatentAssignee:MERCK&COINC-WO2017/40362,2017,A1

[4]Boga,SobhanaBabu;Deng,Yongqi;Zhu,Liang;Nan,Yang;Cooper,AlanB.;Shipps,GeraldW.;Doll,Ronald;Shih,Neng-Yang;Zhu,Hugh;Sun,Robert;Wang,Tong;Paliwal,Sunil;Tsui,Hon-Chung;Gao,Xiaolei;Yao,Xin;Desai,Jagdish;Wang,James;Alhassan,AbdulBasit;Kelly,Joseph;Patel,Mehul;Muppalla,Kiran;Gudipati,Subrahmanyam;Zhang,Li-Kang;Buevich,Alexei;Hesk,David;Carr,Donna;Dayananth,Priya;Black,Stuart;Mei,Hong;Cox,Kathleen;Sherborne,Bradley;Hruza,AlanW.;Xiao,Li;Jin,Weihong;Long,Brian;Liu,Gongjie;Taylor,StaceyA.;Kirschmeier,Paul;Windsor,WilliamT.;Bishop,Robert;Samatar,AhmedA.[ACSMedicinalChemistryLetters,2018,vol.9,#7,p.761-767]

tert-Butyl4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate 
  1184173-73-6 

[1]CurrentPatentAssignee:MERCK&COINC-WO2016/100147,2016,A1

[2]CurrentPatentAssignee:MERCK&COINC-WO2016/100152,2016,A1

[3]CurrentPatentAssignee:MERCK&COINC-WO2017/40362,2017,A1

Literature

Title: Moschos SJ, et al. Development of MK-8353, an orally administered ERK1/2 inhibitor, in patients with advanced solid tumors. JCI Insight. 2018 Feb 22;3(4). pii: 92352.

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